RPAP3 (RNA polymerase II associated protein 3)

2011-03-01  

Identity

HGNC
RPAP3
LOCATION
12q13.11
LOCUSID
79657
ALIAS
Tah1,hSpagh
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79657
MIM: 611477
HGNC: 26151
Ensembl: ENSG00000005175

Variants:

dbSNP: 79657
ClinVar: 79657
TCGA: ENSG00000005175
COSMIC: RPAP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005175ENST00000005386Q9H6T3
ENSG00000005175ENST00000380650Q9H6T3
ENSG00000005175ENST00000432584Q9H6T3

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208640382010HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II.112
194506872009High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes.42
185386702008Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains.15
296620612018RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.13
191805752009RPAP3 interacts with Reptin to regulate UV-induced phosphorylation of H2AX and DNA damage.9
231596232013RPAP3 splicing variant isoform 1 interacts with PIH1D1 to compose R2TP complex for cell survival.8
300332182018Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex.6
211847422011RPAP3 enhances cytotoxicity of doxorubicin by impairing NF-kappa B pathway.2

Citation

Dessen P

RPAP3 (RNA polymerase II associated protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52136/rpap3