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RPL11 (ribosomal protein L11)

Identity

Alias (NCBI)DBA7
GIG34
L11
uL5
HGNC (Hugo) RPL11
HGNC Alias symbL11
uL5
HGNC Alias name60S ribosomal protein L11
LocusID (NCBI) 6135
Atlas_Id 46411
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 23691779 and ends at 23696426 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADAMTS2 (5q35.3) / RPL11 (1p36.11)FRYL (4p11) / RPL11 (1p36.11)MIR6723 (1p36.33) / RPL11 (1p36.11)
MTATP6P1 () / RPL11 (1p36.11)NAA50 (3q13.2) / RPL11 (1p36.11)RP5-857K21.11 () / RPL11 (1p36.11)
RP5-857K21.7 () / RPL11 (1p36.11)RPL11 (1p36.11) / EPHX1 (1q42.12)RPL11 (1p36.11) / KDM5C (Xp11.22)
RPL11 (1p36.11) / MYH9 (22q12.3)RPL11 (1p36.11) / NDUFB4 (3q13.33)RPL11 (1p36.11) / RPL11 (1p36.11)
RPL11 (1p36.11) / STRN4 (19q13.32)RPL11 (1p36.11) / TCEB3 (1p36.11)RPL11 (1p36.11) / TKT (3p21.1)
RPL11 (1p36.11) / TMCO6 (5q31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Diamond-Blackfan anemia (DBA)


External links

 

Nomenclature
HGNC (Hugo)RPL11   10301
LRG (Locus Reference Genomic)LRG_1140
Cards
Entrez_Gene (NCBI)RPL11    ribosomal protein L11
AliasesDBA7; GIG34; L11; uL5
GeneCards (Weizmann)RPL11
Ensembl hg19 (Hinxton)ENSG00000142676 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142676 [Gene_View]  ENSG00000142676 [Sequence]  chr1:23691779-23696426 [Contig_View]  RPL11 [Vega]
ICGC DataPortalENSG00000142676
TCGA cBioPortalRPL11
AceView (NCBI)RPL11
Genatlas (Paris)RPL11
SOURCE (Princeton)RPL11
Genetics Home Reference (NIH)RPL11
Genomic and cartography
GoldenPath hg38 (UCSC)RPL11  -     chr1:23691779-23696426 +  1p36.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPL11  -     1p36.11   [Description]    (hg19-Feb_2009)
GoldenPathRPL11 - 1p36.11 [CytoView hg19]  RPL11 - 1p36.11 [CytoView hg38]
ImmunoBaseENSG00000142676
Genome Data Viewer NCBIRPL11 [Mapview hg19]  
OMIM604175   612562   
Gene and transcription
Genbank (Entrez)AA748897 AF432212 AK311816 AY871274 BC018970
RefSeq transcript (Entrez)NM_000975 NM_001199802
Consensus coding sequences : CCDS (NCBI)RPL11
Gene ExpressionRPL11 [ NCBI-GEO ]   RPL11 [ EBI - ARRAY_EXPRESS ]   RPL11 [ SEEK ]   RPL11 [ MEM ]
Gene Expression Viewer (FireBrowse)RPL11 [ Firebrowse - Broad ]
GenevisibleExpression of RPL11 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6135
GTEX Portal (Tissue expression)RPL11
Human Protein AtlasENSG00000142676-RPL11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62913   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62913  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62913
PhosPhoSitePlusP62913
Domaine pattern : Prosite (Expaxy)RIBOSOMAL_L5 (PS00358)   
Domains : Interpro (EBI)Ribosomal_L5    Ribosomal_L5_C    Ribosomal_L5_CS    Ribosomal_L5_dom_sf    Ribosomal_L5_N   
Domain families : Pfam (Sanger)Ribosomal_L5 (PF00281)    Ribosomal_L5_C (PF00673)   
Domain families : Pfam (NCBI)pfam00281    pfam00673   
Conserved Domain (NCBI)RPL11
PDB (RSDB)4UG0    4V6X    4XXB    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6LQM    6LSR    6LSS    6LU8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP    6W6L    6XA1    6Y0G    6Y2L    6Y57    6Y6X    6Z6L    6Z6M    6Z6N    6ZM7    6ZME    6ZMI    6ZMO   
PDB Europe4UG0    4V6X    4XXB    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6LQM    6LSR    6LSS    6LU8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP    6W6L    6XA1    6Y0G    6Y2L    6Y57    6Y6X    6Z6L    6Z6M    6Z6N    6ZM7    6ZME    6ZMI    6ZMO   
PDB (PDBSum)4UG0    4V6X    4XXB    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6LQM    6LSR    6LSS    6LU8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP    6W6L    6XA1    6Y0G    6Y2L    6Y57    6Y6X    6Z6L    6Z6M    6Z6N    6ZM7    6ZME    6ZMI    6ZMO   
PDB (IMB)4UG0    4V6X    4XXB    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6LQM    6LSR    6LSS    6LU8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP    6W6L    6XA1    6Y0G    6Y2L    6Y57    6Y6X    6Z6L    6Z6M    6Z6N    6ZM7    6ZME    6ZMI    6ZMO   
Structural Biology KnowledgeBase4UG0    4V6X    4XXB    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6LQM    6LSR    6LSS    6LU8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP    6W6L    6XA1    6Y0G    6Y2L    6Y57    6Y6X    6Z6L    6Z6M    6Z6N    6ZM7    6ZME    6ZMI    6ZMO   
SCOP (Structural Classification of Proteins)4UG0    4V6X    4XXB    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6LQM    6LSR    6LSS    6LU8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP    6W6L    6XA1    6Y0G    6Y2L    6Y57    6Y6X    6Z6L    6Z6M    6Z6N    6ZM7    6ZME    6ZMI    6ZMO   
CATH (Classification of proteins structures)4UG0    4V6X    4XXB    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6LQM    6LSR    6LSS    6LU8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP    6W6L    6XA1    6Y0G    6Y2L    6Y57    6Y6X    6Z6L    6Z6M    6Z6N    6ZM7    6ZME    6ZMI    6ZMO   
SuperfamilyP62913
AlphaFold pdb e-kbP62913   
Human Protein Atlas [tissue]ENSG00000142676-RPL11 [tissue]
HPRD10364
Protein Interaction databases
DIP (DOE-UCLA)P62913
IntAct (EBI)P62913
BioGRIDRPL11
STRING (EMBL)RPL11
ZODIACRPL11
Ontologies - Pathways
QuickGOP62913
Ontology : AmiGOribosomal large subunit assembly  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  cytoplasmic translation  cytoplasmic translation  RNA binding  RNA binding  structural constituent of ribosome  structural constituent of ribosome  structural constituent of ribosome  structural constituent of ribosome  protein binding  nucleoplasm  nucleolus  nucleolus  cytoplasm  cytoplasm  cytosol  rRNA processing  rRNA processing  translation  translational initiation  protein targeting  SRP-dependent cotranslational protein targeting to membrane  5S rRNA binding  positive regulation of gene expression  membrane  viral transcription  cytosolic large ribosomal subunit  cytosolic large ribosomal subunit  cytosolic large ribosomal subunit  cytosolic ribosome  ubiquitin protein ligase binding  positive regulation of protein binding  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  protein-containing complex  protein localization to nucleus  ribosomal large subunit biogenesis  polysomal ribosome  protein stabilization  extracellular exosome  regulation of signal transduction by p53 class mediator  positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator  negative regulation of ubiquitin protein ligase activity  ubiquitin ligase inhibitor activity  negative regulation of ubiquitin-dependent protein catabolic process  negative regulation of protein neddylation  
Ontology : EGO-EBIribosomal large subunit assembly  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  cytoplasmic translation  cytoplasmic translation  RNA binding  RNA binding  structural constituent of ribosome  structural constituent of ribosome  structural constituent of ribosome  structural constituent of ribosome  protein binding  nucleoplasm  nucleolus  nucleolus  cytoplasm  cytoplasm  cytosol  rRNA processing  rRNA processing  translation  translational initiation  protein targeting  SRP-dependent cotranslational protein targeting to membrane  5S rRNA binding  positive regulation of gene expression  membrane  viral transcription  cytosolic large ribosomal subunit  cytosolic large ribosomal subunit  cytosolic large ribosomal subunit  cytosolic ribosome  ubiquitin protein ligase binding  positive regulation of protein binding  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  protein-containing complex  protein localization to nucleus  ribosomal large subunit biogenesis  polysomal ribosome  protein stabilization  extracellular exosome  regulation of signal transduction by p53 class mediator  positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator  negative regulation of ubiquitin protein ligase activity  ubiquitin ligase inhibitor activity  negative regulation of ubiquitin-dependent protein catabolic process  negative regulation of protein neddylation  
Pathways : KEGGRibosome   
NDEx NetworkRPL11
Atlas of Cancer Signalling NetworkRPL11
Wikipedia pathwaysRPL11
Orthology - Evolution
OrthoDB6135
GeneTree (enSembl)ENSG00000142676
Phylogenetic Trees/Animal Genes : TreeFamRPL11
Homologs : HomoloGeneRPL11
Homology/Alignments : Family Browser (UCSC)RPL11
Gene fusions - Rearrangements
Fusion Cancer (Beijing)MTATP6P1 [-]  -  RPL11 [1p36.11]  [FUSC000984]
Fusion Cancer (Beijing)RP5-857K21.11 [RPL11]  -  1p36.11 [FUSC000970]
Fusion Cancer (Beijing)RP5-857K21.7 [RPL11]  -  1p36.11 [FUSC000532]  [FUSC000532]
Fusion Cancer (Beijing)MIR6723 [RPL11]  -  1p36.11 [FUSC000734]  [FUSC000734]  [FUSC000734]
Fusion : QuiverRPL11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPL11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPL11
dbVarRPL11
ClinVarRPL11
MonarchRPL11
1000_GenomesRPL11 
Exome Variant ServerRPL11
GNOMAD BrowserENSG00000142676
Varsome BrowserRPL11
ACMGRPL11 variants
VarityP62913
Genomic Variants (DGV)RPL11 [DGVbeta]
DECIPHERRPL11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPL11 
Mutations
ICGC Data PortalRPL11 
TCGA Data PortalRPL11 
Broad Tumor PortalRPL11
OASIS PortalRPL11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPL11  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRPL11
Mutations and Diseases : HGMDRPL11
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRPL11
DgiDB (Drug Gene Interaction Database)RPL11
DoCM (Curated mutations)RPL11
CIViC (Clinical Interpretations of Variants in Cancer)RPL11
Cancer3DRPL11
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604175    612562   
Orphanet429   
DisGeNETRPL11
MedgenRPL11
Genetic Testing Registry RPL11
NextProtP62913 [Medical]
GENETestsRPL11
Target ValidationRPL11
Huge Navigator RPL11 [HugePedia]
ClinGenRPL11
Clinical trials, drugs, therapy
MyCancerGenomeRPL11
Protein Interactions : CTDRPL11
Pharm GKB GenePA34664
PharosP62913
Clinical trialRPL11
Miscellaneous
canSAR (ICR)RPL11
HarmonizomeRPL11
DataMed IndexRPL11
Probes
Litterature
PubMed221 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRPL11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:29:27 CEST 2021

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