RPL11 (ribosomal protein L11)

2007-02-01  

Identity

HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
DBA7,GIG34,L11,uL5
FUSION GENES

Other Information

Locus ID:

NCBI: 6135
MIM: 604175
HGNC: 10301
Ensembl: ENSG00000142676

Variants:

dbSNP: 6135
ClinVar: 6135
TCGA: ENSG00000142676
COSMIC: RPL11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142676ENST00000374550P62913
ENSG00000142676ENST00000458455Q5VVC8
ENSG00000142676ENST00000467075A0A2R8Y447
ENSG00000142676ENST00000643754P62913
ENSG00000142676ENST00000643754Q5VVD0

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
RibosomeKEGGko03010
RibosomeKEGGhsa03010
Ribosome, eukaryotesKEGGhsa_M00177
Ribosome, eukaryotesKEGGM00177
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Eukaryotic Translation ElongationREACTOMER-HSA-156842
Peptide chain elongationREACTOMER-HSA-156902
Eukaryotic Translation TerminationREACTOMER-HSA-72764
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral mRNA TranslationREACTOMER-HSA-192823
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Selenocysteine synthesisREACTOMER-HSA-2408557
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
146124272003Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway.233
153086432004Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5.224
190619852008Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients.162
192873752009Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction.131
151521932004Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation.118
175990652007Inhibition of c-Myc activity by ribosomal protein L11.74
171166892007Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation.70
231696652012Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress.69
168039022006Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism.65
185603572008Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway.58

Citation

Dessen P

RPL11 (ribosomal protein L11)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46411/rpl11