RPL15 (ribosomal protein L15)

2003-06-01 Affiliation

Identity

HGNC

RPL15

LOCATION

3p24.2

LOCUSID

6138

ALIAS

DBA12,EC45,L15,RPL10,RPLY10,RPYL10

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6138
MIM: 604174
HGNC: 10306
Ensembl: ENSG00000174748

Variants:

dbSNP: 6138
ClinVar: 6138
TCGA: ENSG00000174748
COSMIC: RPL15

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000174748	ENST00000307839	P61313
ENSG00000174748	ENST00000307839	A0A024R2Q4
ENSG00000174748	ENST00000354811	P61313
ENSG00000174748	ENST00000354811	A0A024R2Q4
ENSG00000174748	ENST00000412097	E7ENU7
ENSG00000174748	ENST00000413699	P61313
ENSG00000174748	ENST00000413699	A0A024R2Q4
ENSG00000174748	ENST00000415719	P61313
ENSG00000174748	ENST00000415719	A0A024R2Q4
ENSG00000174748	ENST00000422218	E7EX53
ENSG00000174748	ENST00000434031	E7EQV9
ENSG00000174748	ENST00000436146	E7ERA2
ENSG00000174748	ENST00000456530	P61313
ENSG00000174748	ENST00000611050	P61313
ENSG00000174748	ENST00000611050	A0A024R2Q4
ENSG00000174748	ENST00000643707	A0A2R8Y738
ENSG00000174748	ENST00000644185	P61313
ENSG00000174748	ENST00000644185	A0A024R2Q4
ENSG00000174748	ENST00000644684	E7ERA2
ENSG00000174748	ENST00000645079	A0A2R8YEM3

Expression (GTEx)

100

200

300

400

500

600

700

800

900

1000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ribosome	KEGG	ko03010
Ribosome	KEGG	hsa03010
Ribosome, eukaryotes	KEGG	hsa_M00177
Ribosome, eukaryotes	KEGG	M00177
Metabolism of proteins	REACTOME	R-HSA-392499
Translation	REACTOME	R-HSA-72766
Eukaryotic Translation Initiation	REACTOME	R-HSA-72613
Cap-dependent Translation Initiation	REACTOME	R-HSA-72737
Formation of a pool of free 40S subunits	REACTOME	R-HSA-72689
GTP hydrolysis and joining of the 60S ribosomal subunit	REACTOME	R-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expression	REACTOME	R-HSA-156827
SRP-dependent cotranslational protein targeting to membrane	REACTOME	R-HSA-1799339
Eukaryotic Translation Elongation	REACTOME	R-HSA-156842
Peptide chain elongation	REACTOME	R-HSA-156902
Eukaryotic Translation Termination	REACTOME	R-HSA-72764
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Influenza Infection	REACTOME	R-HSA-168254
Influenza Life Cycle	REACTOME	R-HSA-168255
Influenza Viral RNA Transcription and Replication	REACTOME	R-HSA-168273
Viral mRNA Translation	REACTOME	R-HSA-192823
Gene Expression	REACTOME	R-HSA-74160
Nonsense-Mediated Decay (NMD)	REACTOME	R-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	REACTOME	R-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	REACTOME	R-HSA-975956
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Selenoamino acid metabolism	REACTOME	R-HSA-2408522
Selenocysteine synthesis	REACTOME	R-HSA-2408557
rRNA processing	REACTOME	R-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosol	REACTOME	R-HSA-6791226
rRNA processing in the nucleus and cytosol	REACTOME	R-HSA-8868773

References

Pubmed ID	Year	Title	Citations
23812780	2013	Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia.	51
16608517	2006	Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer.	28
19834535	2009	Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.	27
26498693	2015	Downregulation of RPL15 may predict poor survival and associate with tumor progression in pancreatic ductal adenocarcinoma.	12
27612557	2016	Inhibition of Aurora kinases induces apoptosis and autophagy via AURKB/p70S6K/RPL15 axis in human leukemia cells.	9
21509594	2011	Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.	6
21612406	2011	A novel interaction between interferon-inducible protein p56 and ribosomal protein L15 in gastric cancer cells.	6
29599205	2018	Recurring mutations in <i>RPL15</i> are linked to hydrops fetalis and treatment independence in Diamond-Blackfan anemia.	3
31523176	2019	Ribosomal Protein L15 is involved in Colon Carcinogenesis.	2

Citation

Dessen P

RPL15 (ribosomal protein L15)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42150/rpl15