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RPL22 (ribosomal protein L22)

Identity

Alias_symbol (synonym)EAP
L22
Other aliasHBP15
HBP15/L22
HGNC (Hugo) RPL22
LocusID (NCBI) 6146
Atlas_Id 136
Location 1p36.31  [Link to chromosome band 1p36]
Location_base_pair Starts at 6185020 and ends at 6199619 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MAP3K2 (2q14.3) / RPL22 (1p36.31)MECOM (3q26.2) / RPL22 (1p36.31)RPL22 (1p36.31) / DLC1 (8p22)
RPL22 (1p36.31) / MECOM (3q26.2)RPL22 (1p36.31) / PCSK6 (15q26.3)RPL22 (1p36.31) / RUNX1 (21q22.12)
RUNX1 (21q22.12) / RPL22 (1p36.31)cytochrome_b () / RPL22 (1p36.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(X;21)(p22;q22) RUNX1/PRDX4


External links

Nomenclature
HGNC (Hugo)RPL22   10315
Cards
Entrez_Gene (NCBI)RPL22  6146  ribosomal protein L22
AliasesEAP; HBP15; HBP15/L22; L22
GeneCards (Weizmann)RPL22
Ensembl hg19 (Hinxton)ENSG00000116251 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116251 [Gene_View]  chr1:6185020-6199619 [Contig_View]  RPL22 [Vega]
ICGC DataPortalENSG00000116251
TCGA cBioPortalRPL22
AceView (NCBI)RPL22
Genatlas (Paris)RPL22
WikiGenes6146
SOURCE (Princeton)RPL22
Genetics Home Reference (NIH)RPL22
Genomic and cartography
GoldenPath hg38 (UCSC)RPL22  -     chr1:6185020-6199619 -  1p36.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPL22  -     1p36.31   [Description]    (hg19-Feb_2009)
EnsemblRPL22 - 1p36.31 [CytoView hg19]  RPL22 - 1p36.31 [CytoView hg38]
Mapping of homologs : NCBIRPL22 [Mapview hg19]  RPL22 [Mapview hg38]
OMIM180474   
Gene and transcription
Genbank (Entrez)AF113701 AK097075 AK311749 AL110153 BC011829
RefSeq transcript (Entrez)NM_000983
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RPL22
Cluster EST : UnigeneHs.554762 [ NCBI ]
CGAP (NCI)Hs.554762
Alternative Splicing GalleryENSG00000116251
Gene ExpressionRPL22 [ NCBI-GEO ]   RPL22 [ EBI - ARRAY_EXPRESS ]   RPL22 [ SEEK ]   RPL22 [ MEM ]
Gene Expression Viewer (FireBrowse)RPL22 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6146
GTEX Portal (Tissue expression)RPL22
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35268   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35268  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35268
Splice isoforms : SwissVarP35268
PhosPhoSitePlusP35268
Domains : Interpro (EBI)Ribosomal_L22e   
Domain families : Pfam (Sanger)Ribosomal_L22e (PF01776)   
Domain families : Pfam (NCBI)pfam01776   
Conserved Domain (NCBI)RPL22
DMDM Disease mutations6146
Blocks (Seattle)RPL22
PDB (SRS)4UG0    4V6X    5AJ0    5T2C   
PDB (PDBSum)4UG0    4V6X    5AJ0    5T2C   
PDB (IMB)4UG0    4V6X    5AJ0    5T2C   
PDB (RSDB)4UG0    4V6X    5AJ0    5T2C   
Structural Biology KnowledgeBase4UG0    4V6X    5AJ0    5T2C   
SCOP (Structural Classification of Proteins)4UG0    4V6X    5AJ0    5T2C   
CATH (Classification of proteins structures)4UG0    4V6X    5AJ0    5T2C   
SuperfamilyP35268
Human Protein AtlasENSG00000116251
Peptide AtlasP35268
HPRD01602
IPIIPI00219153   
Protein Interaction databases
DIP (DOE-UCLA)P35268
IntAct (EBI)P35268
FunCoupENSG00000116251
BioGRIDRPL22
STRING (EMBL)RPL22
ZODIACRPL22
Ontologies - Pathways
QuickGOP35268
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, nonsense-mediated decay  cytoplasmic translation  RNA binding  structural constituent of ribosome  structural constituent of ribosome  protein binding  nucleus  cytoplasm  cytosol  focal adhesion  rRNA processing  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  heparin binding  viral transcription  cytosolic large ribosomal subunit  intracellular ribonucleoprotein complex  extracellular matrix  alpha-beta T cell differentiation  extracellular exosome  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, nonsense-mediated decay  cytoplasmic translation  RNA binding  structural constituent of ribosome  structural constituent of ribosome  protein binding  nucleus  cytoplasm  cytosol  focal adhesion  rRNA processing  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  heparin binding  viral transcription  cytosolic large ribosomal subunit  intracellular ribonucleoprotein complex  extracellular matrix  alpha-beta T cell differentiation  extracellular exosome  
Pathways : KEGGRibosome   
NDEx NetworkRPL22
Atlas of Cancer Signalling NetworkRPL22
Wikipedia pathwaysRPL22
Orthology - Evolution
OrthoDB6146
GeneTree (enSembl)ENSG00000116251
Phylogenetic Trees/Animal Genes : TreeFamRPL22
HOVERGENP35268
HOGENOMP35268
Homologs : HomoloGeneRPL22
Homology/Alignments : Family Browser (UCSC)RPL22
Gene fusions - Rearrangements
Fusion Cancer (Beijing)cytochrome_b [RPL22]  -  1p36.31 [FUSC000623]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPL22 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPL22
dbVarRPL22
ClinVarRPL22
1000_GenomesRPL22 
Exome Variant ServerRPL22
ExAC (Exome Aggregation Consortium)RPL22 (select the gene name)
Genetic variants : HAPMAP6146
Genomic Variants (DGV)RPL22 [DGVbeta]
DECIPHERRPL22 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPL22 
Mutations
ICGC Data PortalRPL22 
TCGA Data PortalRPL22 
Broad Tumor PortalRPL22
OASIS PortalRPL22 [ Somatic mutations - Copy number]
Cancer Gene: CensusRPL22 
Somatic Mutations in Cancer : COSMICRPL22  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRPL22
intOGen PortalRPL22
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPL22
DgiDB (Drug Gene Interaction Database)RPL22
DoCM (Curated mutations)RPL22 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPL22 (select a term)
intoGenRPL22
Cancer3DRPL22(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180474   
Orphanet
MedgenRPL22
Genetic Testing Registry RPL22
NextProtP35268 [Medical]
TSGene6146
GENETestsRPL22
Huge Navigator RPL22 [HugePedia]
snp3D : Map Gene to Disease6146
BioCentury BCIQRPL22
ClinGenRPL22
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6146
Chemical/Pharm GKB GenePA34688
Clinical trialRPL22
Miscellaneous
canSAR (ICR)RPL22 (select the gene name)
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPL22
EVEXRPL22
GoPubMedRPL22
iHOPRPL22
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:35:30 CEST 2017

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