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RPL23 (ribosomal protein L23)

Identity

Alias_symbol (synonym)rpL17
L23
Other alias
HGNC (Hugo) RPL23
LocusID (NCBI) 9349
Atlas_Id 42151
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 38850068 and ends at 38853800 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARHGEF3 (3p14.3) / RPL23 (17q12)GAPDH (12p13.31) / RPL23 (17q12)JARID2 (6p22.3) / RPL23 (17q12)
PALLD (4q32.3) / RPL23 (17q12)PRR14 (16p11.2) / RPL23 (17q12)RPL23 (17q12) / ARL8B (3p26.1)
RPL23 (17q12) / CD164 (6q21)RPL23 (17q12) / CENPF (1q41)RPL23 (17q12) / DFFA (1p36.22)
RPL23 (17q12) / EDRF1 (10q26.13)RPL23 (17q12) / JARID2 (6p22.3)RPL23 (17q12) / MED30 (8q24.11)
RPL23 (17q12) / MRPL10 (17q21.32)RPL23 (17q12) / MUCL1 (12q13.2)SERPINA1 (14q32.13) / RPL23 (17q12)
SERPINA3 (14q32.13) / RPL23 (17q12)ZDHHC7 (16q24.1) / RPL23 (17q12)SERPINA3 14q32.13 / RPL23 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RPL23   10316
Cards
Entrez_Gene (NCBI)RPL23  9349  ribosomal protein L23
AliasesL23; rpL17
GeneCards (Weizmann)RPL23
Ensembl hg19 (Hinxton)ENSG00000125691 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125691 [Gene_View]  chr17:38850068-38853800 [Contig_View]  RPL23 [Vega]
ICGC DataPortalENSG00000125691
TCGA cBioPortalRPL23
AceView (NCBI)RPL23
Genatlas (Paris)RPL23
WikiGenes9349
SOURCE (Princeton)RPL23
Genetics Home Reference (NIH)RPL23
Genomic and cartography
GoldenPath hg38 (UCSC)RPL23  -     chr17:38850068-38853800 -  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPL23  -     17q12   [Description]    (hg19-Feb_2009)
EnsemblRPL23 - 17q12 [CytoView hg19]  RPL23 - 17q12 [CytoView hg38]
Mapping of homologs : NCBIRPL23 [Mapview hg19]  RPL23 [Mapview hg38]
OMIM603662   
Gene and transcription
Genbank (Entrez)AK024749 BC003518 BC010114 BC034378 BC062716
RefSeq transcript (Entrez)NM_000978
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RPL23
Cluster EST : UnigeneHs.406300 [ NCBI ]
CGAP (NCI)Hs.406300
Alternative Splicing GalleryENSG00000125691
Gene ExpressionRPL23 [ NCBI-GEO ]   RPL23 [ EBI - ARRAY_EXPRESS ]   RPL23 [ SEEK ]   RPL23 [ MEM ]
Gene Expression Viewer (FireBrowse)RPL23 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9349
GTEX Portal (Tissue expression)RPL23
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62829   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62829  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62829
Splice isoforms : SwissVarP62829
PhosPhoSitePlusP62829
Domaine pattern : Prosite (Expaxy)RIBOSOMAL_L14 (PS00049)   
Domains : Interpro (EBI)Ribosomal_L14P    Ribosomal_L14P_CS   
Domain families : Pfam (Sanger)Ribosomal_L14 (PF00238)   
Domain families : Pfam (NCBI)pfam00238   
Domain families : Smart (EMBL)Ribosomal_L14 (SM01374)  
Conserved Domain (NCBI)RPL23
DMDM Disease mutations9349
Blocks (Seattle)RPL23
PDB (SRS)4UG0    4V6X    5AJ0    5T2C   
PDB (PDBSum)4UG0    4V6X    5AJ0    5T2C   
PDB (IMB)4UG0    4V6X    5AJ0    5T2C   
PDB (RSDB)4UG0    4V6X    5AJ0    5T2C   
Structural Biology KnowledgeBase4UG0    4V6X    5AJ0    5T2C   
SCOP (Structural Classification of Proteins)4UG0    4V6X    5AJ0    5T2C   
CATH (Classification of proteins structures)4UG0    4V6X    5AJ0    5T2C   
SuperfamilyP62829
Human Protein AtlasENSG00000125691
Peptide AtlasP62829
HPRD04716
IPIIPI00010153   IPI00794091   IPI00795751   
Protein Interaction databases
DIP (DOE-UCLA)P62829
IntAct (EBI)P62829
FunCoupENSG00000125691
BioGRIDRPL23
STRING (EMBL)RPL23
ZODIACRPL23
Ontologies - Pathways
QuickGOP62829
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  transcription coactivator binding  RNA binding  structural constituent of ribosome  structural constituent of ribosome  protein binding  nucleoplasm  nucleolus  cytoplasm  cytosol  ribosome  focal adhesion  rRNA processing  translation  translational initiation  ribosomal protein import into nucleus  SRP-dependent cotranslational protein targeting to membrane  positive regulation of cell proliferation  positive regulation of gene expression  membrane  viral transcription  cytosolic large ribosomal subunit  extracellular matrix  ubiquitin protein ligase binding  protein-DNA complex disassembly  protein complex  protein complex  positive regulation of transcription from RNA polymerase II promoter  protein stabilization  extracellular exosome  large ribosomal subunit rRNA binding  negative regulation of cell cycle arrest  positive regulation of cell cycle arrest  cellular response to actinomycin D  positive regulation of signal transduction by p53 class mediator  negative regulation of ubiquitin protein ligase activity  ubiquitin ligase inhibitor activity  negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  transcription coactivator binding  RNA binding  structural constituent of ribosome  structural constituent of ribosome  protein binding  nucleoplasm  nucleolus  cytoplasm  cytosol  ribosome  focal adhesion  rRNA processing  translation  translational initiation  ribosomal protein import into nucleus  SRP-dependent cotranslational protein targeting to membrane  positive regulation of cell proliferation  positive regulation of gene expression  membrane  viral transcription  cytosolic large ribosomal subunit  extracellular matrix  ubiquitin protein ligase binding  protein-DNA complex disassembly  protein complex  protein complex  positive regulation of transcription from RNA polymerase II promoter  protein stabilization  extracellular exosome  large ribosomal subunit rRNA binding  negative regulation of cell cycle arrest  positive regulation of cell cycle arrest  cellular response to actinomycin D  positive regulation of signal transduction by p53 class mediator  negative regulation of ubiquitin protein ligase activity  ubiquitin ligase inhibitor activity  negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
Pathways : KEGGRibosome   
NDEx NetworkRPL23
Atlas of Cancer Signalling NetworkRPL23
Wikipedia pathwaysRPL23
Orthology - Evolution
OrthoDB9349
GeneTree (enSembl)ENSG00000125691
Phylogenetic Trees/Animal Genes : TreeFamRPL23
HOVERGENP62829
HOGENOMP62829
Homologs : HomoloGeneRPL23
Homology/Alignments : Family Browser (UCSC)RPL23
Gene fusions - Rearrangements
Fusion : MitelmanRPL23/MUCL1 [17q12/12q13.2]  
Fusion : MitelmanSERPINA3/RPL23 [14q32.13/17q12]  [t(14;17)(q32;q12)]  
Fusion: TCGASERPINA3 14q32.13 RPL23 17q12 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPL23 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPL23
dbVarRPL23
ClinVarRPL23
1000_GenomesRPL23 
Exome Variant ServerRPL23
ExAC (Exome Aggregation Consortium)RPL23 (select the gene name)
Genetic variants : HAPMAP9349
Genomic Variants (DGV)RPL23 [DGVbeta]
DECIPHERRPL23 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPL23 
Mutations
ICGC Data PortalRPL23 
TCGA Data PortalRPL23 
Broad Tumor PortalRPL23
OASIS PortalRPL23 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPL23  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRPL23
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPL23
DgiDB (Drug Gene Interaction Database)RPL23
DoCM (Curated mutations)RPL23 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPL23 (select a term)
intoGenRPL23
Cancer3DRPL23(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603662   
Orphanet
MedgenRPL23
Genetic Testing Registry RPL23
NextProtP62829 [Medical]
TSGene9349
GENETestsRPL23
Target ValidationRPL23
Huge Navigator RPL23 [HugePedia]
snp3D : Map Gene to Disease9349
BioCentury BCIQRPL23
ClinGenRPL23
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9349
Chemical/Pharm GKB GenePA34690
Clinical trialRPL23
Miscellaneous
canSAR (ICR)RPL23 (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPL23
EVEXRPL23
GoPubMedRPL23
iHOPRPL23
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:29:21 CEST 2017

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