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RPL4 (ribosomal protein L4)

Identity

Alias (NCBI)L4
HGNC (Hugo) RPL4
HGNC Alias symbL4
HGNC Alias name60S ribosomal protein L4
LocusID (NCBI) 6124
Atlas_Id 72836
Location 15q22.31  [Link to chromosome band 15q22]
Location_base_pair Starts at 66499315 and ends at 66504855 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDK4 (12q14.1) / RPL4 (15q22.31)RPL4 (15q22.31) / ACTN1 (14q24.1)RPL4 (15q22.31) / HS6ST3 (13q32.1)
RPL4 (15q22.31) / KRT222 (17q21.2)RPL4 (15q22.31) / LOC100505761 ()RPL4 (15q22.31) / LOC653739 ()
RPL4 (15q22.31) / OGFOD2 (12q24.31)SPCS1 (3p21.1) / RPL4 (15q22.31)TMSB10 (2p11.2) / RPL4 (15q22.31)
TMTC3 (12q21.32) / RPL4 (15q22.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RPL4   10353
Cards
Entrez_Gene (NCBI)RPL4  6124  ribosomal protein L4
AliasesL4
GeneCards (Weizmann)RPL4
Ensembl hg19 (Hinxton)ENSG00000174444 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174444 [Gene_View]  ENSG00000174444 [Sequence]  chr15:66499315-66504855 [Contig_View]  RPL4 [Vega]
ICGC DataPortalENSG00000174444
TCGA cBioPortalRPL4
AceView (NCBI)RPL4
Genatlas (Paris)RPL4
WikiGenes6124
SOURCE (Princeton)RPL4
Genetics Home Reference (NIH)RPL4
Genomic and cartography
GoldenPath hg38 (UCSC)RPL4  -     chr15:66499315-66504855 -  15q22.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPL4  -     15q22.31   [Description]    (hg19-Feb_2009)
GoldenPathRPL4 - 15q22.31 [CytoView hg19]  RPL4 - 15q22.31 [CytoView hg38]
ImmunoBaseENSG00000174444
genome Data Viewer NCBIRPL4 [Mapview hg19]  
OMIM180479   
Gene and transcription
Genbank (Entrez)AB208977 AK125772 AK130784 AK223057 AK291117
RefSeq transcript (Entrez)NM_000968
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RPL4
Alternative Splicing GalleryENSG00000174444
Gene ExpressionRPL4 [ NCBI-GEO ]   RPL4 [ EBI - ARRAY_EXPRESS ]   RPL4 [ SEEK ]   RPL4 [ MEM ]
Gene Expression Viewer (FireBrowse)RPL4 [ Firebrowse - Broad ]
GenevisibleExpression of RPL4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6124
GTEX Portal (Tissue expression)RPL4
Human Protein AtlasENSG00000174444-RPL4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36578   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36578  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36578
Splice isoforms : SwissVarP36578
PhosPhoSitePlusP36578
Domaine pattern : Prosite (Expaxy)RIBOSOMAL_L1E (PS00939)   
Domains : Interpro (EBI)Ribos_L4_C_dom    Ribosomal_L4/L1e    Ribosomal_L4/L1e_euk/arc_CS    Ribosomal_L4_dom_sf   
Domain families : Pfam (Sanger)Ribos_L4_asso_C (PF14374)    Ribosomal_L4 (PF00573)   
Domain families : Pfam (NCBI)pfam14374    pfam00573   
Conserved Domain (NCBI)RPL4
DMDM Disease mutations6124
Blocks (Seattle)RPL4
PDB (RSDB)4UG0    4V6X    5A8L    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
PDB Europe4UG0    4V6X    5A8L    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
PDB (PDBSum)4UG0    4V6X    5A8L    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
PDB (IMB)4UG0    4V6X    5A8L    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
Structural Biology KnowledgeBase4UG0    4V6X    5A8L    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
SCOP (Structural Classification of Proteins)4UG0    4V6X    5A8L    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
CATH (Classification of proteins structures)4UG0    4V6X    5A8L    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
SuperfamilyP36578
Human Protein Atlas [tissue]ENSG00000174444-RPL4 [tissue]
Peptide AtlasP36578
HPRD01607
IPIIPI00003918   IPI00908662   IPI00795303   IPI00908376   
Protein Interaction databases
DIP (DOE-UCLA)P36578
IntAct (EBI)P36578
FunCoupENSG00000174444
BioGRIDRPL4
STRING (EMBL)RPL4
ZODIACRPL4
Ontologies - Pathways
QuickGOP36578
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, nonsense-mediated decay  RNA binding  structural constituent of ribosome  structural constituent of ribosome  protein binding  nucleus  nucleus  nucleolus  cytoplasm  rough endoplasmic reticulum  cytosol  focal adhesion  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  membrane  viral transcription  cytosolic large ribosomal subunit  cytosolic large ribosomal subunit  extracellular exosome  ribonucleoprotein complex  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, nonsense-mediated decay  RNA binding  structural constituent of ribosome  structural constituent of ribosome  protein binding  nucleus  nucleus  nucleolus  cytoplasm  rough endoplasmic reticulum  cytosol  focal adhesion  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  membrane  viral transcription  cytosolic large ribosomal subunit  cytosolic large ribosomal subunit  extracellular exosome  ribonucleoprotein complex  
Pathways : KEGGRibosome   
NDEx NetworkRPL4
Atlas of Cancer Signalling NetworkRPL4
Wikipedia pathwaysRPL4
Orthology - Evolution
OrthoDB6124
GeneTree (enSembl)ENSG00000174444
Phylogenetic Trees/Animal Genes : TreeFamRPL4
HOGENOMP36578
Homologs : HomoloGeneRPL4
Homology/Alignments : Family Browser (UCSC)RPL4
Gene fusions - Rearrangements
Fusion : QuiverRPL4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPL4
dbVarRPL4
ClinVarRPL4
1000_GenomesRPL4 
Exome Variant ServerRPL4
GNOMAD BrowserENSG00000174444
Varsome BrowserRPL4
Genetic variants : HAPMAP6124
Genomic Variants (DGV)RPL4 [DGVbeta]
DECIPHERRPL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPL4 
Mutations
ICGC Data PortalRPL4 
TCGA Data PortalRPL4 
Broad Tumor PortalRPL4
OASIS PortalRPL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPL4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRPL4
Mutations and Diseases : HGMDRPL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPL4
DgiDB (Drug Gene Interaction Database)RPL4
DoCM (Curated mutations)RPL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPL4 (select a term)
intoGenRPL4
Cancer3DRPL4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180479   
Orphanet
DisGeNETRPL4
MedgenRPL4
Genetic Testing Registry RPL4
NextProtP36578 [Medical]
TSGene6124
GENETestsRPL4
Target ValidationRPL4
Huge Navigator RPL4 [HugePedia]
snp3D : Map Gene to Disease6124
BioCentury BCIQRPL4
ClinGenRPL4
Clinical trials, drugs, therapy
Protein Interactions : CTD6124
Pharm GKB GenePA34749
Clinical trialRPL4
Miscellaneous
canSAR (ICR)RPL4 (select the gene name)
HarmonizomeRPL4
DataMed IndexRPL4
Probes
Litterature
PubMed137 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPL4
EVEXRPL4
GoPubMedRPL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 16:26:13 CEST 2020

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