Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RPL5 (ribosomal protein L5)

Identity

Alias (NCBI)L5
MSTP030
PPP1R135
uL18
HGNC (Hugo) RPL5
HGNC Alias symbL5
PPP1R135
uL18
HGNC Alias nameprotein phosphatase 1, regulatory subunit 135
LocusID (NCBI) 6125
Atlas_Id 42157
Location 1p22.1  [Link to chromosome band 1p22]
Location_base_pair Starts at 92832040 and ends at 92841924 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM50A (Xq28) / RPL5 (1p22.1)MTF2 (1p22.1) / RPL5 (1p22.1)RPL5 (1p22.1) / MINK1 (17p13.2)
RPL5 (1p22.1) / WDR76 (15q15.3)MTF2 1p22.1 / RPL5 1p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  MTF2/RPL5 (1p22)

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Diamond-Blackfan anemia (DBA)

External links

Nomenclature
HGNC (Hugo)RPL5   10360
LRG (Locus Reference Genomic)LRG_1155
Cards
Entrez_Gene (NCBI)RPL5    ribosomal protein L5
AliasesL5; MSTP030; PPP1R135; uL18
GeneCards (Weizmann)RPL5
Ensembl hg19 (Hinxton)ENSG00000122406 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122406 [Gene_View]  ENSG00000122406 [Sequence]  chr1:92832040-92841924 [Contig_View]  RPL5 [Vega]
ICGC DataPortalENSG00000122406
TCGA cBioPortalRPL5
AceView (NCBI)RPL5
Genatlas (Paris)RPL5
SOURCE (Princeton)RPL5
Genetics Home Reference (NIH)RPL5
Genomic and cartography
GoldenPath hg38 (UCSC)RPL5  -     chr1:92832040-92841924 +  1p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPL5  -     1p22.1   [Description]    (hg19-Feb_2009)
GoldenPathRPL5 - 1p22.1 [CytoView hg19]  RPL5 - 1p22.1 [CytoView hg38]
ImmunoBaseENSG00000122406
genome Data Viewer NCBIRPL5 [Mapview hg19]  
OMIM603634   612561   
Gene and transcription
Genbank (Entrez)AB055762 AB208980 AF113210 AK092963 AK095815
RefSeq transcript (Entrez)NM_000969
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RPL5
Alternative Splicing GalleryENSG00000122406
Gene ExpressionRPL5 [ NCBI-GEO ]   RPL5 [ EBI - ARRAY_EXPRESS ]   RPL5 [ SEEK ]   RPL5 [ MEM ]
Gene Expression Viewer (FireBrowse)RPL5 [ Firebrowse - Broad ]
GenevisibleExpression of RPL5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6125
GTEX Portal (Tissue expression)RPL5
Human Protein AtlasENSG00000122406-RPL5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46777   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46777  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46777
Splice isoforms : SwissVarP46777
PhosPhoSitePlusP46777
Domains : Interpro (EBI)Rbsml_L5_euk/L18_arc    Rbsml_L5e/L18P_C   
Domain families : Pfam (Sanger)Ribosomal_L18_c (PF14204)    Ribosomal_L5e (PF17144)   
Domain families : Pfam (NCBI)pfam14204    pfam17144   
Conserved Domain (NCBI)RPL5
Blocks (Seattle)RPL5
PDB (RSDB)4UG0    4V6X    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
PDB Europe4UG0    4V6X    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
PDB (PDBSum)4UG0    4V6X    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
PDB (IMB)4UG0    4V6X    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
Structural Biology KnowledgeBase4UG0    4V6X    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
SCOP (Structural Classification of Proteins)4UG0    4V6X    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
CATH (Classification of proteins structures)4UG0    4V6X    5AJ0    5LKS    5T2C    6EK0    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
SuperfamilyP46777
Human Protein Atlas [tissue]ENSG00000122406-RPL5 [tissue]
Peptide AtlasP46777
HPRD04699
IPIIPI00000494   IPI00640037   
Protein Interaction databases
DIP (DOE-UCLA)P46777
IntAct (EBI)P46777
BioGRIDRPL5
STRING (EMBL)RPL5
ZODIACRPL5
Ontologies - Pathways
QuickGOP46777
Ontology : AmiGOribosomal large subunit assembly  ribosomal large subunit assembly  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  RNA binding  RNA binding  mRNA 3'-UTR binding  structural constituent of ribosome  protein binding  nucleus  nucleoplasm  nucleolus  nucleolus  cytoplasm  cytoplasm  endoplasmic reticulum  cytosol  cytosol  focal adhesion  rRNA processing  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  5S rRNA binding  5S rRNA binding  positive regulation of gene expression  membrane  viral transcription  cytosolic large ribosomal subunit  cytosolic large ribosomal subunit  ubiquitin protein ligase binding  protein-containing complex  ribosomal large subunit biogenesis  synapse  positive regulation of translation  mRNA 5'-UTR binding  protein stabilization  extracellular exosome  regulation of signal transduction by p53 class mediator  negative regulation of ubiquitin protein ligase activity  ribonucleoprotein complex  ubiquitin ligase inhibitor activity  negative regulation of ubiquitin-dependent protein catabolic process  negative regulation of protein neddylation  
Ontology : EGO-EBIribosomal large subunit assembly  ribosomal large subunit assembly  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  RNA binding  RNA binding  mRNA 3'-UTR binding  structural constituent of ribosome  protein binding  nucleus  nucleoplasm  nucleolus  nucleolus  cytoplasm  cytoplasm  endoplasmic reticulum  cytosol  cytosol  focal adhesion  rRNA processing  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  5S rRNA binding  5S rRNA binding  positive regulation of gene expression  membrane  viral transcription  cytosolic large ribosomal subunit  cytosolic large ribosomal subunit  ubiquitin protein ligase binding  protein-containing complex  ribosomal large subunit biogenesis  synapse  positive regulation of translation  mRNA 5'-UTR binding  protein stabilization  extracellular exosome  regulation of signal transduction by p53 class mediator  negative regulation of ubiquitin protein ligase activity  ribonucleoprotein complex  ubiquitin ligase inhibitor activity  negative regulation of ubiquitin-dependent protein catabolic process  negative regulation of protein neddylation  
Pathways : KEGGRibosome   
NDEx NetworkRPL5
Atlas of Cancer Signalling NetworkRPL5
Wikipedia pathwaysRPL5
Orthology - Evolution
OrthoDB6125
GeneTree (enSembl)ENSG00000122406
Phylogenetic Trees/Animal Genes : TreeFamRPL5
HOGENOMP46777
Homologs : HomoloGeneRPL5
Homology/Alignments : Family Browser (UCSC)RPL5
Gene fusions - Rearrangements
Fusion : MitelmanMTF2/RPL5 [1p22.1/1p22.1]  
Fusion PortalMTF2 1p22.1 RPL5 1p22.1 BRCA
Fusion : QuiverRPL5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPL5 [hg38]
dbVarRPL5
ClinVarRPL5
MonarchRPL5
1000_GenomesRPL5 
Exome Variant ServerRPL5
GNOMAD BrowserENSG00000122406
Varsome BrowserRPL5
Genomic Variants (DGV)RPL5 [DGVbeta]
DECIPHERRPL5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPL5 
Mutations
ICGC Data PortalRPL5 
TCGA Data PortalRPL5 
Broad Tumor PortalRPL5
OASIS PortalRPL5 [ Somatic mutations - Copy number]
Cancer Gene: CensusRPL5 
Somatic Mutations in Cancer : COSMICRPL5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRPL5
Mutations and Diseases : HGMDRPL5
intOGen PortalRPL5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)Diamond-Blackfan Anemia
BioMutasearch RPL5
DgiDB (Drug Gene Interaction Database)RPL5
DoCM (Curated mutations)RPL5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPL5 (select a term)
intoGenRPL5
Cancer3DRPL5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603634    612561   
Orphanet429   
DisGeNETRPL5
MedgenRPL5
Genetic Testing Registry RPL5
NextProtP46777 [Medical]
GENETestsRPL5
Target ValidationRPL5
Huge Navigator RPL5 [HugePedia]
ClinGenRPL5
Clinical trials, drugs, therapy
MyCancerGenomeRPL5
Protein Interactions : CTD
Pharm GKB GenePA34755
PharosP46777
Clinical trialRPL5
Miscellaneous
canSAR (ICR)RPL5 (select the gene name)
HarmonizomeRPL5
DataMed IndexRPL5
Probes
Litterature
PubMed202 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRPL5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:35:39 CET 2021
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