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RPL5 (ribosomal protein L5)

Identity

Other namesDBA6
L5
MSTP030
PPP1R135
HGNC (Hugo) RPL5
LocusID (NCBI) 6125
Atlas_Id 42157
Location 1p22.1
Location_base_pair Starts at 93297594 and ends at 93307481 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
MTF2 1p22.1 / RPL5 1p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas)
  Diamond-Blackfan anemia (DBA)

External links

Nomenclature
HGNC (Hugo)RPL5   10360
Cards
Entrez_Gene (NCBI)RPL5  6125  ribosomal protein L5
GeneCards (Weizmann)RPL5
Ensembl hg19 (Hinxton)ENSG00000122406 [Gene_View]  chr1:93297594-93307481 [Contig_View]  RPL5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000122406 [Gene_View]  chr1:93297594-93307481 [Contig_View]  RPL5 [Vega]
ICGC DataPortalENSG00000122406
TCGA cBioPortalRPL5
AceView (NCBI)RPL5
Genatlas (Paris)RPL5
WikiGenes6125
SOURCE (Princeton)RPL5
Genomic and cartography
GoldenPath hg19 (UCSC)RPL5  -     chr1:93297594-93307481 +  1p22.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RPL5  -     1p22.1   [Description]    (hg38-Dec_2013)
EnsemblRPL5 - 1p22.1 [CytoView hg19]  RPL5 - 1p22.1 [CytoView hg38]
Mapping of homologs : NCBIRPL5 [Mapview hg19]  RPL5 [Mapview hg38]
OMIM603634   612561   
Gene and transcription
Genbank (Entrez)AB055762 AB208980 AF113210 AK092963 AK095815
RefSeq transcript (Entrez)NM_000969
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_011779 NG_033051 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)RPL5
Cluster EST : UnigeneHs.532359 [ NCBI ]
CGAP (NCI)Hs.532359
Alternative Splicing : Fast-db (Paris)GSHG0000702
Alternative Splicing GalleryENSG00000122406
Gene ExpressionRPL5 [ NCBI-GEO ]     RPL5 [ SEEK ]   RPL5 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)6125
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46777 (Uniprot)
NextProtP46777  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46777
Splice isoforms : SwissVarP46777 (Swissvar)
PhosPhoSitePlusP46777
Domains : Interpro (EBI)Rbsml_L5_euk/L18_arc    Rbsml_L5e/L18P_C    Ribosomal_L18/L5   
Domain families : Pfam (Sanger)Ribosomal_L18_c (PF14204)    Ribosomal_L18p (PF00861)   
Domain families : Pfam (NCBI)pfam14204    pfam00861   
DMDM Disease mutations6125
Blocks (Seattle)RPL5
PDB (SRS)4V6X    5AJ0   
PDB (PDBSum)4V6X    5AJ0   
PDB (IMB)4V6X    5AJ0   
PDB (RSDB)4V6X    5AJ0   
Structural Biology KnowledgeBase4V6X    5AJ0   
SCOP (Structural Classification of Proteins)4V6X    5AJ0   
CATH (Classification of proteins structures)4V6X    5AJ0   
Human Protein AtlasENSG00000122406
Peptide AtlasP46777
HPRD04699
IPIIPI00000494   IPI00640037   
Protein Interaction databases
DIP (DOE-UCLA)P46777
IntAct (EBI)P46777
FunCoupENSG00000122406
BioGRIDRPL5
IntegromeDBRPL5
STRING (EMBL)RPL5
ZODIACRPL5
Ontologies - Pathways
QuickGOP46777
Ontology : AmiGOribosomal large subunit assembly  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  RNA binding  structural constituent of ribosome  protein binding  nucleus  nucleolus  cytoplasm  cytosol  focal adhesion  rRNA processing  translation  translation  translational initiation  translational elongation  translational termination  SRP-dependent cotranslational protein targeting to membrane  5S rRNA binding  gene expression  membrane  viral process  viral life cycle  viral transcription  cytosolic large ribosomal subunit  intracellular ribonucleoprotein complex  ribosomal large subunit biogenesis  cellular protein metabolic process  poly(A) RNA binding  extracellular exosome  
Ontology : EGO-EBIribosomal large subunit assembly  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  RNA binding  structural constituent of ribosome  protein binding  nucleus  nucleolus  cytoplasm  cytosol  focal adhesion  rRNA processing  translation  translation  translational initiation  translational elongation  translational termination  SRP-dependent cotranslational protein targeting to membrane  5S rRNA binding  gene expression  membrane  viral process  viral life cycle  viral transcription  cytosolic large ribosomal subunit  intracellular ribonucleoprotein complex  ribosomal large subunit biogenesis  cellular protein metabolic process  poly(A) RNA binding  extracellular exosome  
Pathways : KEGGRibosome   
Protein Interaction DatabaseRPL5
Atlas of Cancer Signalling NetworkRPL5
Wikipedia pathwaysRPL5
Orthology - Evolution
OrthoDB6125
GeneTree (enSembl)ENSG00000122406
Phylogenetic Trees/Animal Genes : TreeFamRPL5
Homologs : HomoloGeneRPL5
Homology/Alignments : Family Browser (UCSC)RPL5
Gene fusions - Rearrangements
Fusion: TCGAMTF2 1p22.1 RPL5 1p22.1 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerRPL5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPL5
dbVarRPL5
ClinVarRPL5
1000_GenomesRPL5 
Exome Variant ServerRPL5
Exome Aggregation Consortium (ExAC)ENSG00000122406
SNP (GeneSNP Utah)RPL5
SNP : HGBaseRPL5
Genetic variants : HAPMAPRPL5
Genomic Variants (DGV)RPL5 [DGVbeta]
Mutations
ICGC Data PortalRPL5 
TCGA Data PortalRPL5 
Tumor PortalRPL5
TCGA Copy Number PortalRPL5
Cancer Gene: CensusRPL5 
Somatic Mutations in Cancer : COSMICRPL5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)Diamond-Blackfan Anemia
BioMutasearch RPL5
DgiDB (Drug Gene Interaction Database)RPL5
DoCM (Curated mutations)RPL5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPL5 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:93297594-93307481
CONAN: Copy Number AnalysisRPL5 
Mutations and Diseases : HGMDRPL5
OMIM603634    612561   
MedgenRPL5
NextProtP46777 [Medical]
TSGene6125
GENETestsRPL5
Huge Navigator RPL5 [HugePedia]  RPL5 [HugeCancerGEM]
snp3D : Map Gene to Disease6125
BioCentury BCIQRPL5
General knowledge
Chemical/Protein Interactions : CTD6125
Chemical/Pharm GKB GenePA34755
Clinical trialRPL5
Other databases
Probes
Litterature
PubMed121 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPL5
GoPubMedRPL5
iHOPRPL5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jan 16 19:25:33 CET 2016

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