Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RPL6 (ribosomal protein L6)

Identity

Alias_namesTXREB1
Alias_symbol (synonym)TAXREB107
L6
Other aliasSHUJUN-2
HGNC (Hugo) RPL6
LocusID (NCBI) 6128
Atlas_Id 42158
Location 12q24.13  [Link to chromosome band 12q24]
Location_base_pair Starts at 112405181 and ends at 112411442 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATXN2 (12q24.12) / RPL6 (12q24.13)CTGF (6q23.2) / RPL6 (12q24.13)HTN3 (4q13.3) / RPL6 (12q24.13)
NEURL1B (5q35.1) / RPL6 (12q24.13)YLPM1 (14q24.3) / RPL6 (12q24.13)ZNF521 (18q11.2) / RPL6 (12q24.13)
ATXN2 12q24.12 / RPL6 12q24.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  ATXN2/RPL6 (12q24)


External links

Nomenclature
HGNC (Hugo)RPL6   10362
Cards
Entrez_Gene (NCBI)RPL6  6128  ribosomal protein L6
AliasesL6; SHUJUN-2; TAXREB107; TXREB1
GeneCards (Weizmann)RPL6
Ensembl hg19 (Hinxton)ENSG00000089009 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000089009 [Gene_View]  ENSG00000089009 [Sequence]  chr12:112405181-112411442 [Contig_View]  RPL6 [Vega]
ICGC DataPortalENSG00000089009
TCGA cBioPortalRPL6
AceView (NCBI)RPL6
Genatlas (Paris)RPL6
WikiGenes6128
SOURCE (Princeton)RPL6
Genetics Home Reference (NIH)RPL6
Genomic and cartography
GoldenPath hg38 (UCSC)RPL6  -     chr12:112405181-112411442 -  12q24.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPL6  -     12q24.13   [Description]    (hg19-Feb_2009)
EnsemblRPL6 - 12q24.13 [CytoView hg19]  RPL6 - 12q24.13 [CytoView hg38]
Mapping of homologs : NCBIRPL6 [Mapview hg19]  RPL6 [Mapview hg38]
OMIM603703   
Gene and transcription
Genbank (Entrez)AF261087 AI583261 AK298117 AK299470 AK308469
RefSeq transcript (Entrez)NM_000970 NM_001024662 NM_001320137 NM_001320138 NM_001320139 NM_001320140 NM_001320141 NM_001320142
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RPL6
Cluster EST : UnigeneHs.744897 [ NCBI ]
CGAP (NCI)Hs.744897
Alternative Splicing GalleryENSG00000089009
Gene ExpressionRPL6 [ NCBI-GEO ]   RPL6 [ EBI - ARRAY_EXPRESS ]   RPL6 [ SEEK ]   RPL6 [ MEM ]
Gene Expression Viewer (FireBrowse)RPL6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6128
GTEX Portal (Tissue expression)RPL6
Human Protein AtlasENSG00000089009-RPL6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02878   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02878  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02878
Splice isoforms : SwissVarQ02878
PhosPhoSitePlusQ02878
Domaine pattern : Prosite (Expaxy)RIBOSOMAL_L6E (PS01170)   
Domains : Interpro (EBI)60S_ribosomal_L6E    Rib_L2_dom2    Ribosomal_L6_N    Translation_prot_SH3-like_sf   
Domain families : Pfam (Sanger)Ribosomal_L6e (PF01159)    Ribosomal_L6e_N (PF03868)   
Domain families : Pfam (NCBI)pfam01159    pfam03868   
Conserved Domain (NCBI)RPL6
DMDM Disease mutations6128
Blocks (Seattle)RPL6
PDB (SRS)4UG0    4V6X    5AJ0    5LKS    5T2C    6EK0   
PDB (PDBSum)4UG0    4V6X    5AJ0    5LKS    5T2C    6EK0   
PDB (IMB)4UG0    4V6X    5AJ0    5LKS    5T2C    6EK0   
PDB (RSDB)4UG0    4V6X    5AJ0    5LKS    5T2C    6EK0   
Structural Biology KnowledgeBase4UG0    4V6X    5AJ0    5LKS    5T2C    6EK0   
SCOP (Structural Classification of Proteins)4UG0    4V6X    5AJ0    5LKS    5T2C    6EK0   
CATH (Classification of proteins structures)4UG0    4V6X    5AJ0    5LKS    5T2C    6EK0   
SuperfamilyQ02878
Human Protein Atlas [tissue]ENSG00000089009-RPL6 [tissue]
Peptide AtlasQ02878
HPRD04745
IPIIPI00385351   IPI00867533   IPI00790342   IPI01025005   IPI01021767   IPI01021267   IPI01021434   IPI01020969   IPI01021128   
Protein Interaction databases
DIP (DOE-UCLA)Q02878
IntAct (EBI)Q02878
FunCoupENSG00000089009
BioGRIDRPL6
STRING (EMBL)RPL6
ZODIACRPL6
Ontologies - Pathways
QuickGOQ02878
Ontology : AmiGOribosomal large subunit assembly  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  cytoplasmic translation  cytoplasmic translation  DNA binding  RNA binding  structural constituent of ribosome  structural constituent of ribosome  nucleus  nucleus  rough endoplasmic reticulum  cytosol  focal adhesion  regulation of transcription, DNA-templated  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  membrane  cytosolic large ribosomal subunit  cytosolic large ribosomal subunit  cytosolic large ribosomal subunit  cytoplasmic ribonucleoprotein granule  polysomal ribosome  cadherin binding  
Ontology : EGO-EBIribosomal large subunit assembly  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  cytoplasmic translation  cytoplasmic translation  DNA binding  RNA binding  structural constituent of ribosome  structural constituent of ribosome  nucleus  nucleus  rough endoplasmic reticulum  cytosol  focal adhesion  regulation of transcription, DNA-templated  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  membrane  cytosolic large ribosomal subunit  cytosolic large ribosomal subunit  cytosolic large ribosomal subunit  cytoplasmic ribonucleoprotein granule  polysomal ribosome  cadherin binding  
Pathways : KEGGRibosome   
NDEx NetworkRPL6
Atlas of Cancer Signalling NetworkRPL6
Wikipedia pathwaysRPL6
Orthology - Evolution
OrthoDB6128
GeneTree (enSembl)ENSG00000089009
Phylogenetic Trees/Animal Genes : TreeFamRPL6
HOVERGENQ02878
HOGENOMQ02878
Homologs : HomoloGeneRPL6
Homology/Alignments : Family Browser (UCSC)RPL6
Gene fusions - Rearrangements
Fusion : MitelmanATXN2/RPL6 [12q24.12/12q24.13]  [t(12;12)(q24;q24)]  
Fusion PortalATXN2 12q24.12 RPL6 12q24.13 GBM
Fusion : QuiverRPL6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPL6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPL6
dbVarRPL6
ClinVarRPL6
1000_GenomesRPL6 
Exome Variant ServerRPL6
ExAC (Exome Aggregation Consortium)ENSG00000089009
GNOMAD BrowserENSG00000089009
Varsome BrowserRPL6
Genetic variants : HAPMAP6128
Genomic Variants (DGV)RPL6 [DGVbeta]
DECIPHERRPL6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPL6 
Mutations
ICGC Data PortalRPL6 
TCGA Data PortalRPL6 
Broad Tumor PortalRPL6
OASIS PortalRPL6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPL6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRPL6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPL6
DgiDB (Drug Gene Interaction Database)RPL6
DoCM (Curated mutations)RPL6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPL6 (select a term)
intoGenRPL6
Cancer3DRPL6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603703   
Orphanet
DisGeNETRPL6
MedgenRPL6
Genetic Testing Registry RPL6
NextProtQ02878 [Medical]
TSGene6128
GENETestsRPL6
Target ValidationRPL6
Huge Navigator RPL6 [HugePedia]
snp3D : Map Gene to Disease6128
BioCentury BCIQRPL6
ClinGenRPL6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6128
Chemical/Pharm GKB GenePA34758
Clinical trialRPL6
Miscellaneous
canSAR (ICR)RPL6 (select the gene name)
Probes
Litterature
PubMed91 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPL6
EVEXRPL6
GoPubMedRPL6
iHOPRPL6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:49:59 CEST 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.