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RPL8 (ribosomal protein L8)

Identity

Alias_symbol (synonym)L8
Other alias
HGNC (Hugo) RPL8
LocusID (NCBI) 6132
Atlas_Id 51112
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 146015150 and ends at 146017831 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DAPK2 (15q22.31) / RPL8 (8q24.3)LBH (2p23.1) / RPL8 (8q24.3)MTX2 (2q31.1) / RPL8 (8q24.3)
NRGN (11q24.2) / RPL8 (8q24.3)NVL (1q42.11) / RPL8 (8q24.3)PRR13 (12q13.13) / RPL8 (8q24.3)
RP1-15D7.1 () / RPL8 (8q24.3)RPL8 (8q24.3) / ACIN1 (14q11.2)RPL8 (8q24.3) / ACTG1 (17q25.3)
RPL8 (8q24.3) / CEP131 (17q25.3)RPL8 (8q24.3) / CFB (6p21.33)RPL8 (8q24.3) / KRT4 (12q13.13)
RPL8 (8q24.3) / LHFPL3 (7q22.2)RPL8 (8q24.3) / NCALD (8q22.3)RPL8 (8q24.3) / NOVA1 (14q12)
RPL8 (8q24.3) / RABEP1 (17p13.2)RPL8 (8q24.3) / SNW1 (14q24.3)RPL8 (8q24.3) / TM9SF4 (20q11.21)
RPL8 (8q24.3) / UQCRC2 (16p12.2)RPL8 8q24.3 / CFB 6p21.33RPL8 8q24.3 / NCALD 8q22.3
RPL8 8q24.3 / NOVA1 14q12RPL8 8q24.3 / RABEP1 17p13.2RPL8 8q24.3 / SNW1 14q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RPL8   10368
Cards
Entrez_Gene (NCBI)RPL8  6132  ribosomal protein L8
AliasesL8
GeneCards (Weizmann)RPL8
Ensembl hg19 (Hinxton)ENSG00000161016 [Gene_View]  chr8:146015150-146017831 [Contig_View]  RPL8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000161016 [Gene_View]  chr8:146015150-146017831 [Contig_View]  RPL8 [Vega]
ICGC DataPortalENSG00000161016
TCGA cBioPortalRPL8
AceView (NCBI)RPL8
Genatlas (Paris)RPL8
WikiGenes6132
SOURCE (Princeton)RPL8
Genetics Home Reference (NIH)RPL8
Genomic and cartography
GoldenPath hg19 (UCSC)RPL8  -     chr8:146015150-146017831 -  8q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RPL8  -     8q24.3   [Description]    (hg38-Dec_2013)
EnsemblRPL8 - 8q24.3 [CytoView hg19]  RPL8 - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBIRPL8 [Mapview hg19]  RPL8 [Mapview hg38]
OMIM604177   
Gene and transcription
Genbank (Entrez)AK289459 AK301073 AK309619 BC000047 BC000077
RefSeq transcript (Entrez)NM_000973 NM_001317771 NM_001317782 NM_033301
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_008046 NW_004929341
Consensus coding sequences : CCDS (NCBI)RPL8
Cluster EST : UnigeneHs.178551 [ NCBI ]
CGAP (NCI)Hs.178551
Alternative Splicing GalleryENSG00000161016
Gene ExpressionRPL8 [ NCBI-GEO ]   RPL8 [ EBI - ARRAY_EXPRESS ]   RPL8 [ SEEK ]   RPL8 [ MEM ]
Gene Expression Viewer (FireBrowse)RPL8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6132
GTEX Portal (Tissue expression)RPL8
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62917   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62917  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62917
Splice isoforms : SwissVarP62917
PhosPhoSitePlusP62917
Domaine pattern : Prosite (Expaxy)RIBOSOMAL_L2 (PS00467)   
Domains : Interpro (EBI)NA-bd_OB-fold    Rbsml_prot_L2_RNA-bd_dom    Rib_L2_dom2    Ribosomal_L2    Ribosomal_L2_arc    Ribosomal_L2_C    Ribosomal_L2_CS    Ribosomal_L2_dom3    Translation_prot_SH3-like   
Domain families : Pfam (Sanger)Ribosomal_L2 (PF00181)    Ribosomal_L2_C (PF03947)   
Domain families : Pfam (NCBI)pfam00181    pfam03947   
Conserved Domain (NCBI)RPL8
DMDM Disease mutations6132
Blocks (Seattle)RPL8
PDB (SRS)4CCM    4CCN    4CCO    4UG0    4V6X    4Y3O    5AJ0   
PDB (PDBSum)4CCM    4CCN    4CCO    4UG0    4V6X    4Y3O    5AJ0   
PDB (IMB)4CCM    4CCN    4CCO    4UG0    4V6X    4Y3O    5AJ0   
PDB (RSDB)4CCM    4CCN    4CCO    4UG0    4V6X    4Y3O    5AJ0   
Structural Biology KnowledgeBase4CCM    4CCN    4CCO    4UG0    4V6X    4Y3O    5AJ0   
SCOP (Structural Classification of Proteins)4CCM    4CCN    4CCO    4UG0    4V6X    4Y3O    5AJ0   
CATH (Classification of proteins structures)4CCM    4CCN    4CCO    4UG0    4V6X    4Y3O    5AJ0   
SuperfamilyP62917
Human Protein AtlasENSG00000161016
Peptide AtlasP62917
HPRD16044
IPIIPI00012772   IPI00909884   IPI00983708   IPI00792050   IPI00976899   IPI00975850   IPI00976256   IPI01015034   
Protein Interaction databases
DIP (DOE-UCLA)P62917
IntAct (EBI)P62917
FunCoupENSG00000161016
BioGRIDRPL8
STRING (EMBL)RPL8
ZODIACRPL8
Ontologies - Pathways
QuickGOP62917
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, nonsense-mediated decay  cytoplasmic translation  RNA binding  structural constituent of ribosome  nucleolus  cytoplasm  cytosol  focal adhesion  rRNA processing  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  membrane  viral transcription  rRNA binding  cytosolic large ribosomal subunit  poly(A) RNA binding  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, nonsense-mediated decay  cytoplasmic translation  RNA binding  structural constituent of ribosome  nucleolus  cytoplasm  cytosol  focal adhesion  rRNA processing  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  membrane  viral transcription  rRNA binding  cytosolic large ribosomal subunit  poly(A) RNA binding  
Pathways : KEGGRibosome   
NDEx NetworkRPL8
Atlas of Cancer Signalling NetworkRPL8
Wikipedia pathwaysRPL8
Orthology - Evolution
OrthoDB6132
GeneTree (enSembl)ENSG00000161016
Phylogenetic Trees/Animal Genes : TreeFamRPL8
HOVERGENP62917
HOGENOMP62917
Homologs : HomoloGeneRPL8
Homology/Alignments : Family Browser (UCSC)RPL8
Gene fusions - Rearrangements
Fusion : MitelmanRPL8/CFB [8q24.3/6p21.33]  
Fusion : MitelmanRPL8/KRT4 [8q24.3/12q13.13]  [t(8;12)(q24;q13)]  
Fusion : MitelmanRPL8/NCALD [8q24.3/8q22.3]  [t(8;8)(q22;q24)]  
Fusion : MitelmanRPL8/NOVA1 [8q24.3/14q12]  [t(8;14)(q24;q12)]  
Fusion : MitelmanRPL8/RABEP1 [8q24.3/17p13.2]  [t(8;17)(q24;p13)]  
Fusion : MitelmanRPL8/SNW1 [8q24.3/14q24.3]  [t(8;14)(q24;q24)]  
Fusion: TCGARPL8 8q24.3 CFB 6p21.33 LUAD
Fusion: TCGARPL8 8q24.3 NCALD 8q22.3 LUSC
Fusion: TCGARPL8 8q24.3 NOVA1 14q12 LGG
Fusion: TCGARPL8 8q24.3 RABEP1 17p13.2 HNSC
Fusion: TCGARPL8 8q24.3 SNW1 14q24.3 BRCA
Fusion Cancer (Beijing)RP1-15D7.1 [RPL8]  -  8q24.3 [FUSC001047]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPL8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPL8
dbVarRPL8
ClinVarRPL8
1000_GenomesRPL8 
Exome Variant ServerRPL8
ExAC (Exome Aggregation Consortium)RPL8 (select the gene name)
Genetic variants : HAPMAP6132
Genomic Variants (DGV)RPL8 [DGVbeta]
DECIPHER (Syndromes)8:146015150-146017831  ENSG00000161016
CONAN: Copy Number AnalysisRPL8 
Mutations
ICGC Data PortalRPL8 
TCGA Data PortalRPL8 
Broad Tumor PortalRPL8
OASIS PortalRPL8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPL8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRPL8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPL8
DgiDB (Drug Gene Interaction Database)RPL8
DoCM (Curated mutations)RPL8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPL8 (select a term)
intoGenRPL8
Cancer3DRPL8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604177   
Orphanet
MedgenRPL8
Genetic Testing Registry RPL8
NextProtP62917 [Medical]
TSGene6132
GENETestsRPL8
Huge Navigator RPL8 [HugePedia]
snp3D : Map Gene to Disease6132
BioCentury BCIQRPL8
ClinGenRPL8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6132
Chemical/Pharm GKB GenePA34768
Clinical trialRPL8
Miscellaneous
canSAR (ICR)RPL8 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPL8
EVEXRPL8
GoPubMedRPL8
iHOPRPL8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:17:56 CEST 2017

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