RPLP0 (ribosomal protein lateral stalk subunit P0)

2008-03-01  

Identity

HGNC
RPLP0
LOCATION
12q24.23
LOCUSID
6175
ALIAS
L10E,LP0,P0,PRLP0,RPP0
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6175
MIM: 180510
HGNC: 10371
Ensembl: ENSG00000089157

Variants:

dbSNP: 6175
ClinVar: 6175
TCGA: ENSG00000089157
COSMIC: RPLP0

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089157ENST00000228306P05388
ENSG00000089157ENST00000228306A0A024RBS2
ENSG00000089157ENST00000313104P05388
ENSG00000089157ENST00000392514P05388
ENSG00000089157ENST00000392514A0A024RBS2
ENSG00000089157ENST00000546989F8VWS0
ENSG00000089157ENST00000546990F8VZS0
ENSG00000089157ENST00000547173G3V210
ENSG00000089157ENST00000547191F8VPE8
ENSG00000089157ENST00000547211F8VW21
ENSG00000089157ENST00000547475F8VQY6
ENSG00000089157ENST00000549098F8VYN4
ENSG00000089157ENST00000550423F8VWV4
ENSG00000089157ENST00000550856F8VU65
ENSG00000089157ENST00000551150P05388
ENSG00000089157ENST00000551150A0A024RBS2
ENSG00000089157ENST00000551258F8VRK7
ENSG00000089157ENST00000551914F8VS58
ENSG00000089157ENST00000552292F8W1K8

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
4000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RibosomeKEGGko03010
RibosomeKEGGhsa03010
Ribosome, eukaryotesKEGGhsa_M00177
Ribosome, eukaryotesKEGGM00177
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Eukaryotic Translation ElongationREACTOMER-HSA-156842
Peptide chain elongationREACTOMER-HSA-156902
Eukaryotic Translation TerminationREACTOMER-HSA-72764
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral mRNA TranslationREACTOMER-HSA-192823
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Selenocysteine synthesisREACTOMER-HSA-2408557
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
210409492011Expression of the ribosomal proteins Rplp0, Rplp1, and Rplp2 in gynecologic tumors.25
207055982010Identification of genes for normalization of quantitative real-time PCR data in ovarian tissues.14
176212662008Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells.13
261762642015Disruption of the ribosomal P complex leads to stress-induced autophagy.12
254339972015Dysregulation of apoptotic signaling pathways by interaction of RPLP0 and cathepsin X/Z in gastric cancer.9
258899312015Natural humoral immune response to ribosomal P0 protein in colorectal cancer patients.6
124798702003The subcellular distribution of the human ribosomal "stalk" components: P1, P2 and P0 proteins.5
253072912015Association of anti-acidic ribosomal protein P0 and anti-galectin 3 antibodies with the development of skin lesions in systemic lupus erythematosus.4
289862212018The uL10 protein, a component of the ribosomal P-stalk, is released from the ribosome in nucleolar stress.4
153365362004Baculovirus-mediated expression and isolation of human ribosomal phosphoprotein P0 carrying a GST-tag in a functional state.2

Citation

Dessen P

RPLP0 (ribosomal protein lateral stalk subunit P0)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50046/rplp0