RPLP2 (ribosomal protein lateral stalk subunit P2)

2007-02-01  

Identity

HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
D11S2243E,LP2,P2,RPP2
FUSION GENES

Other Information

Locus ID:

NCBI: 6181
MIM: 180530
HGNC: 10377
Ensembl: ENSG00000177600

Variants:

dbSNP: 6181
ClinVar: 6181
TCGA: ENSG00000177600
COSMIC: RPLP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177600ENST00000321153P05387
ENSG00000177600ENST00000321153A0A024RCA7
ENSG00000177600ENST00000530398H0YDD8
ENSG00000177600ENST00000530797P05387
ENSG00000177600ENST00000530797A0A024RCA7

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500

Pathways

PathwaySourceExternal ID
RibosomeKEGGko03010
RibosomeKEGGhsa03010
Ribosome, eukaryotesKEGGhsa_M00177
Ribosome, eukaryotesKEGGM00177
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Eukaryotic Translation ElongationREACTOMER-HSA-156842
Peptide chain elongationREACTOMER-HSA-156902
Eukaryotic Translation TerminationREACTOMER-HSA-72764
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral mRNA TranslationREACTOMER-HSA-192823
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Selenocysteine synthesisREACTOMER-HSA-2408557
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
169206972007Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease.43
210409492011Expression of the ribosomal proteins Rplp0, Rplp1, and Rplp2 in gynecologic tumors.25
203856032010Solution structure of the dimerization domain of ribosomal protein P2 provides insights for the structural organization of eukaryotic stalk.20
184224832008Functional characterization of ribosomal P1/P2 proteins in human cells.19
229093822012The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cells.19
261762642015Disruption of the ribosomal P complex leads to stress-induced autophagy.12
186758072008Internal translation initiation on the foot-and-mouth disease virus IRES is affected by ribosomal stalk conformation.11
123791282002Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2.9
124798702003The subcellular distribution of the human ribosomal "stalk" components: P1, P2 and P0 proteins.5
149818962003Ribosomal protein P2: a potential molecular target for antisense therapy of human malignancies.4

Citation

Dessen P

RPLP2 (ribosomal protein lateral stalk subunit P2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43723/rplp2