RPN1 (ribophorin I)

2014-07-01  

Identity

HGNC
RPN1
LOCATION
3q21.3
LOCUSID
6184
ALIAS
OST1,RBPH1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6184
MIM: 180470
HGNC: 10381
Ensembl: ENSG00000163902

Variants:

dbSNP: 6184
ClinVar: 6184
TCGA: ENSG00000163902
COSMIC: RPN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163902ENST00000296255P04843
ENSG00000163902ENST00000476931F8WF32
ENSG00000163902ENST00000497289B7Z4L4

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
N-glycosylation by oligosaccharyltransferaseKEGGhsa_M00072
N-glycosylation by oligosaccharyltransferaseKEGGM00072
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
336178812021Polyubiquitin and ubiquitin-like signals share common recognition sites on proteasomal subunit Rpn1.3
336178812021Polyubiquitin and ubiquitin-like signals share common recognition sites on proteasomal subunit Rpn1.3
318438882020Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function.18
318438882020Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function.18
254512652014Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion.18
254512652014Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion.18
229882432012Malectin forms a complex with ribophorin I for enhanced association with misfolded glycoproteins.31
229882432012Malectin forms a complex with ribophorin I for enhanced association with misfolded glycoproteins.31
186070032008Ribophorin I regulates substrate delivery to the oligosaccharyltransferase core.29
190645712008Polymorphisms in mitochondrial genes and prostate cancer risk.22
186070032008Ribophorin I regulates substrate delivery to the oligosaccharyltransferase core.29
190645712008Polymorphisms in mitochondrial genes and prostate cancer risk.22

Citation

Dessen P

RPN1 (ribophorin I)

Atlas Genet Cytogenet Oncol Haematol. 2014-07-01

Online version: http://atlasgeneticsoncology.org/gene/54063/rpn1