RPN1 (ribophorin I)

2014-07-01  

Identity

HGNC
LOCATION
3q21.3
LOCUSID
ALIAS
OST1,RBPH1
FUSION GENES

Other Information

Locus ID:

NCBI: 6184
MIM: 180470
HGNC: 10381
Ensembl: ENSG00000163902

Variants:

dbSNP: 6184
ClinVar: 6184
TCGA: ENSG00000163902
COSMIC: RPN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163902ENST00000296255P04843
ENSG00000163902ENST00000476931F8WF32
ENSG00000163902ENST00000497289B7Z4L4

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
N-glycosylation by oligosaccharyltransferaseKEGGhsa_M00072
N-glycosylation by oligosaccharyltransferaseKEGGM00072
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186070032008Ribophorin I regulates substrate delivery to the oligosaccharyltransferase core.25
229882432012Malectin forms a complex with ribophorin I for enhanced association with misfolded glycoproteins.24
190645712008Polymorphisms in mitochondrial genes and prostate cancer risk.20
254512652014Association of malectin with ribophorin I is crucial for attenuation of misfolded glycoprotein secretion.9
318438882020Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function.1

Citation

Dessen P

RPN1 (ribophorin I)

Atlas Genet Cytogenet Oncol Haematol. 2014-07-01

Online version: http://atlasgeneticsoncology.org/gene/54063/rpn1