RPN2 (ribophorin II)

2008-12-01  

Identity

HGNC
LOCATION
20q11.23
LOCUSID
ALIAS
RIBIIR,RPN-II,RPNII,SWP1
FUSION GENES

Other Information

Locus ID:

NCBI: 6185
MIM: 180490
HGNC: 10382
Ensembl: ENSG00000118705

Variants:

dbSNP: 6185
ClinVar: 6185
TCGA: ENSG00000118705
COSMIC: RPN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118705ENST00000237530P04844
ENSG00000118705ENST00000373622P04844
ENSG00000118705ENST00000373632Q5JYR7
ENSG00000118705ENST00000437329Q5JYR3
ENSG00000118705ENST00000456102Q5JYR4
ENSG00000118705ENST00000456400H0Y5M1
ENSG00000118705ENST00000462163F2Z3K5

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
N-glycosylation by oligosaccharyltransferaseKEGGhsa_M00072
N-glycosylation by oligosaccharyltransferaseKEGGM00072
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
204719462010Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2.55
187243782008RPN2 gene confers docetaxel resistance in breast cancer.54
195497812009S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal function.32
285984142017Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets.28
196173452009Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response.26
248849602014RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy.23
239591742013Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3β.19
243864252013Microarray gene expression analysis of tumorigenesis and regional lymph node metastasis in laryngeal squamous cell carcinoma.13
255959012015Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer.11

Citation

Dessen P

RPN2 (ribophorin II)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50506/rpn2