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RPP40 (ribonuclease P/MRP subunit p40)

Identity

Alias_namesRNASEP1
ribonuclease P1
ribonuclease P 40kDa subunit
ribonuclease P/MRP 40kDa subunit
Alias_symbol (synonym)bA428J1.3
Other alias
HGNC (Hugo) RPP40
LocusID (NCBI) 10799
Atlas_Id 72847
Location 6p25.1  [Link to chromosome band 6p25]
Location_base_pair Starts at 4995046 and ends at 5004063 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RPP40 (6p25.1) / LYRM4 (6p25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p25;p25) RPP40/LYRM4


External links

Nomenclature
HGNC (Hugo)RPP40   20992
Cards
Entrez_Gene (NCBI)RPP40  10799  ribonuclease P/MRP subunit p40
AliasesRNASEP1; bA428J1.3
GeneCards (Weizmann)RPP40
Ensembl hg19 (Hinxton)ENSG00000124787 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124787 [Gene_View]  ENSG00000124787 [Sequence]  chr6:4995046-5004063 [Contig_View]  RPP40 [Vega]
ICGC DataPortalENSG00000124787
TCGA cBioPortalRPP40
AceView (NCBI)RPP40
Genatlas (Paris)RPP40
WikiGenes10799
SOURCE (Princeton)RPP40
Genetics Home Reference (NIH)RPP40
Genomic and cartography
GoldenPath hg38 (UCSC)RPP40  -     chr6:4995046-5004063 -  6p25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPP40  -     6p25.1   [Description]    (hg19-Feb_2009)
EnsemblRPP40 - 6p25.1 [CytoView hg19]  RPP40 - 6p25.1 [CytoView hg38]
Mapping of homologs : NCBIRPP40 [Mapview hg19]  RPP40 [Mapview hg38]
OMIM606117   
Gene and transcription
Genbank (Entrez)BC017871 BG430780 BM015573 BM827175 BQ220155
RefSeq transcript (Entrez)NM_001286132 NM_001286133 NM_006638
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RPP40
Cluster EST : UnigeneHs.511756 [ NCBI ]
CGAP (NCI)Hs.511756
Alternative Splicing GalleryENSG00000124787
Gene ExpressionRPP40 [ NCBI-GEO ]   RPP40 [ EBI - ARRAY_EXPRESS ]   RPP40 [ SEEK ]   RPP40 [ MEM ]
Gene Expression Viewer (FireBrowse)RPP40 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10799
GTEX Portal (Tissue expression)RPP40
Human Protein AtlasENSG00000124787-RPP40 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75818   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75818  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75818
Splice isoforms : SwissVarO75818
Catalytic activity : Enzyme3.1.26.5 [ Enzyme-Expasy ]   3.1.26.53.1.26.5 [ IntEnz-EBI ]   3.1.26.5 [ BRENDA ]   3.1.26.5 [ KEGG ]   
PhosPhoSitePlusO75818
Domains : Interpro (EBI)RNase_P_Rpp40   
Domain families : Pfam (Sanger)Ribonuc_P_40 (PF08584)   
Domain families : Pfam (NCBI)pfam08584   
Conserved Domain (NCBI)RPP40
DMDM Disease mutations10799
Blocks (Seattle)RPP40
SuperfamilyO75818
Human Protein Atlas [tissue]ENSG00000124787-RPP40 [tissue]
Peptide AtlasO75818
HPRD09361
IPIIPI00478496   IPI00332091   IPI00945805   IPI01014400   
Protein Interaction databases
DIP (DOE-UCLA)O75818
IntAct (EBI)O75818
FunCoupENSG00000124787
BioGRIDRPP40
STRING (EMBL)RPP40
ZODIACRPP40
Ontologies - Pathways
QuickGOO75818
Ontology : AmiGOtRNA 5'-leader removal  ribonuclease P activity  nucleus  nucleoplasm  nucleolar ribonuclease P complex  rRNA processing  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBItRNA 5'-leader removal  ribonuclease P activity  nucleus  nucleoplasm  nucleolar ribonuclease P complex  rRNA processing  RNA phosphodiester bond hydrolysis, endonucleolytic  
NDEx NetworkRPP40
Atlas of Cancer Signalling NetworkRPP40
Wikipedia pathwaysRPP40
Orthology - Evolution
OrthoDB10799
GeneTree (enSembl)ENSG00000124787
Phylogenetic Trees/Animal Genes : TreeFamRPP40
HOVERGENO75818
HOGENOMO75818
Homologs : HomoloGeneRPP40
Homology/Alignments : Family Browser (UCSC)RPP40
Gene fusions - Rearrangements
Fusion : QuiverRPP40
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPP40 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPP40
dbVarRPP40
ClinVarRPP40
1000_GenomesRPP40 
Exome Variant ServerRPP40
ExAC (Exome Aggregation Consortium)ENSG00000124787
GNOMAD BrowserENSG00000124787
Varsome BrowserRPP40
Genetic variants : HAPMAP10799
Genomic Variants (DGV)RPP40 [DGVbeta]
DECIPHERRPP40 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPP40 
Mutations
ICGC Data PortalRPP40 
TCGA Data PortalRPP40 
Broad Tumor PortalRPP40
OASIS PortalRPP40 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPP40  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRPP40
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPP40
DgiDB (Drug Gene Interaction Database)RPP40
DoCM (Curated mutations)RPP40 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPP40 (select a term)
intoGenRPP40
Cancer3DRPP40(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606117   
Orphanet
DisGeNETRPP40
MedgenRPP40
Genetic Testing Registry RPP40
NextProtO75818 [Medical]
TSGene10799
GENETestsRPP40
Target ValidationRPP40
Huge Navigator RPP40 [HugePedia]
snp3D : Map Gene to Disease10799
BioCentury BCIQRPP40
ClinGenRPP40
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10799
Chemical/Pharm GKB GenePA134911809
Clinical trialRPP40
Miscellaneous
canSAR (ICR)RPP40 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPP40
EVEXRPP40
GoPubMedRPP40
iHOPRPP40
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 14:27:34 CEST 2018

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