RPRD1B (regulation of nuclear pre-mRNA domain containing 1B)

2012-04-01  

Identity

HGNC
LOCATION
20q11.23
LOCUSID
ALIAS
C20orf77,CREPT,K-H,Kub5-Hera,NET60,dJ1057B20.2
FUSION GENES

Other Information

Locus ID:

NCBI: 58490
MIM: 614694
HGNC: 16209
Ensembl: ENSG00000101413

Variants:

dbSNP: 58490
ClinVar: 58490
TCGA: ENSG00000101413
COSMIC: RPRD1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101413ENST00000373433Q9NQG5
ENSG00000101413ENST00000449186A2A2M0
ENSG00000101413ENST00000462548E9PQF3
ENSG00000101413ENST00000495457E9PIQ9
ENSG00000101413ENST00000614670A0A087X2D2
ENSG00000101413ENST00000622494A0A087WUK3

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
222647912012CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes.30
249976002014RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.28
245895842014Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair.19
249824242014CREPT/RPRD1B, a recently identified novel protein highly expressed in tumors, enhances the β-catenin·TCF4 transcriptional activity in response to Wnt signaling.18
286112042017Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer.17
244526362014RPRD1B promotes tumor growth by accelerating the cell cycle in endometrial cancer.14
283690912017Knocking-down of CREPT prohibits the progression of oral squamous cell carcinoma and suppresses cyclin D1 and c-Myc expression.11
288935362017CREPT regulated by miR-138 promotes breast cancer progression.11
295636082018CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation.10
254007382014CREPT expression correlates with poor prognosis in patients with retroperitoneal leiomyosarcoma.9

Citation

Dessen P

RPRD1B (regulation of nuclear pre-mRNA domain containing 1B)

Atlas Genet Cytogenet Oncol Haematol. 2012-04-01

Online version: http://atlasgeneticsoncology.org/gene/52677/rprd1b