| Nomenclature |
|---|
| HGNC (Hugo) | RPS27A 10417 |
| Cards |
|---|
| Entrez_Gene (NCBI) | RPS27A 6233 ribosomal protein S27a |
| Aliases | CEP80; HEL112; S27A; UBA80; |
| UBC; UBCEP1; UBCEP80 |
| GeneCards (Weizmann) | RPS27A |
| Ensembl hg19 (Hinxton) | ENSG00000143947 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000143947 [Gene_View] ENSG00000143947 [Sequence] chr2:55232405-55235853 [Contig_View] RPS27A [Vega] |
| ICGC DataPortal | ENSG00000143947 |
| TCGA cBioPortal | RPS27A |
| AceView (NCBI) | RPS27A |
| Genatlas (Paris) | RPS27A |
| WikiGenes | 6233 |
| SOURCE (Princeton) | RPS27A |
| Genetics Home Reference (NIH) | RPS27A |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | RPS27A - chr2:55232405-55235853 + 2p16.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | RPS27A - 2p16.1 [Description] (hg19-Feb_2009) |
| Ensembl | RPS27A - 2p16.1 [CytoView hg19] RPS27A - 2p16.1 [CytoView hg38] |
| Mapping of homologs : NCBI | RPS27A [Mapview hg19] RPS27A [Mapview hg38] |
| OMIM | 191343 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB362574 AK093614 AK225079 AK225718 AK315695 |
| RefSeq transcript (Entrez) | NM_001135592 NM_001177413 NM_002954 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | RPS27A |
| Cluster EST : Unigene | Hs.743392 [ NCBI ] |
| CGAP (NCI) | Hs.743392 |
| Alternative Splicing Gallery | ENSG00000143947 |
| Gene Expression | RPS27A [ NCBI-GEO ] RPS27A [ EBI - ARRAY_EXPRESS ]
RPS27A [ SEEK ] RPS27A [ MEM ] |
| Gene Expression Viewer (FireBrowse) | RPS27A [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 6233 |
| GTEX Portal (Tissue expression) | RPS27A |
| Human Protein Atlas | ENSG00000143947-RPS27A [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P62979 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P62979 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P62979 |
| Splice isoforms : SwissVar | P62979 |
| PhosPhoSitePlus | P62979 |
| Domaine pattern : Prosite (Expaxy) | UBIQUITIN_1 (PS00299) UBIQUITIN_2 (PS50053) |
| Domains : Interpro (EBI) | Ribosomal_S27a Ribosomal_zn-bd S27a-like_sf Ubiquitin Ubiquitin-like_domsf Ubiquitin_CS Ubiquitin_dom |
| Domain families : Pfam (Sanger) | Ribosomal_S27 (PF01599) ubiquitin (PF00240) |
| Domain families : Pfam (NCBI) | pfam01599 pfam00240 |
| Domain families : Smart (EMBL) | Ribosomal_S27 (SM01402) UBQ (SM00213) |
| Conserved Domain (NCBI) | RPS27A |
| DMDM Disease mutations | 6233 |
| Blocks (Seattle) | RPS27A |
| PDB (SRS) | 2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5T2C 5WVO 5YDK 6EK0 6FEC |
| PDB (PDBSum) | 2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5T2C 5WVO 5YDK 6EK0 6FEC |
| PDB (IMB) | 2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5T2C 5WVO 5YDK 6EK0 6FEC |
| PDB (RSDB) | 2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5T2C 5WVO 5YDK 6EK0 6FEC |
| Structural Biology KnowledgeBase | 2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5T2C 5WVO 5YDK 6EK0 6FEC |
| SCOP (Structural Classification of Proteins) | 2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5T2C 5WVO 5YDK 6EK0 6FEC |
| CATH (Classification of proteins structures) | 2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5T2C 5WVO 5YDK 6EK0 6FEC |
| Superfamily | P62979 |
| Human Protein Atlas [tissue] | ENSG00000143947-RPS27A [tissue] |
| Peptide Atlas | P62979 |
| HPRD | 01878 |
| IPI | IPI00179330 IPI00654754 IPI00975835 IPI01013317 IPI00798155 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P62979 |
| IntAct (EBI) | P62979 |
| FunCoup | ENSG00000143947 |
| BioGRID | RPS27A |
| STRING (EMBL) | RPS27A |
| ZODIAC | RPS27A |
| Ontologies - Pathways |
|---|
| QuickGO | P62979 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II nuclear-transcribed mRNA catabolic process, nonsense-mediated decay activation of MAPK activity protein polyubiquitination nucleotide-excision repair, DNA damage recognition MyD88-dependent toll-like receptor signaling pathway RNA binding structural constituent of ribosome protein binding extracellular space nucleus nucleus nucleoplasm nucleolus cytoplasm cytoplasm mitochondrial outer membrane endoplasmic reticulum membrane cytosol plasma membrane transcription-coupled nucleotide-excision repair nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, DNA gap filling translation translational initiation SRP-dependent cotranslational protein targeting to membrane protein targeting to peroxisome transforming growth factor beta receptor signaling pathway I-kappaB kinase/NF-kappaB signaling JNK cascade endosome membrane small ribosomal subunit small ribosomal subunit membrane Wnt signaling pathway endosomal transport protein ubiquitination protein ubiquitination protein deubiquitination viral life cycle virion assembly cytokine-mediated signaling pathway modification-dependent protein catabolic process translesion synthesis cytosolic small ribosomal subunit cytosolic small ribosomal subunit cytosolic small ribosomal subunit negative regulation of transforming growth factor beta receptor signaling pathway endocytic vesicle membrane anaphase-promoting complex-dependent catabolic process protein tag ubiquitin protein ligase binding vesicle nucleotide-excision repair, DNA incision TRIF-dependent toll-like receptor signaling pathway interstrand cross-link repair error-prone translesion synthesis DNA damage response, detection of DNA damage positive regulation of apoptotic process negative regulation of apoptotic process myelin sheath regulation of mRNA stability host cell cellular protein metabolic process positive regulation of transcription by RNA polymerase II metal ion binding positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade transmembrane transport membrane organization regulation of transcription from RNA polymerase II promoter in response to hypoxia extracellular exosome nucleotide-binding oligomerization domain containing signaling pathway interleukin-1-mediated signaling pathway proteasome binding global genome nucleotide-excision repair error-free translesion synthesis intracellular transport of virus |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II nuclear-transcribed mRNA catabolic process, nonsense-mediated decay activation of MAPK activity protein polyubiquitination nucleotide-excision repair, DNA damage recognition MyD88-dependent toll-like receptor signaling pathway RNA binding structural constituent of ribosome protein binding extracellular space nucleus nucleus nucleoplasm nucleolus cytoplasm cytoplasm mitochondrial outer membrane endoplasmic reticulum membrane cytosol plasma membrane transcription-coupled nucleotide-excision repair nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, DNA gap filling translation translational initiation SRP-dependent cotranslational protein targeting to membrane protein targeting to peroxisome transforming growth factor beta receptor signaling pathway I-kappaB kinase/NF-kappaB signaling JNK cascade endosome membrane small ribosomal subunit small ribosomal subunit membrane Wnt signaling pathway endosomal transport protein ubiquitination protein ubiquitination protein deubiquitination viral life cycle virion assembly cytokine-mediated signaling pathway modification-dependent protein catabolic process translesion synthesis cytosolic small ribosomal subunit cytosolic small ribosomal subunit cytosolic small ribosomal subunit negative regulation of transforming growth factor beta receptor signaling pathway endocytic vesicle membrane anaphase-promoting complex-dependent catabolic process protein tag ubiquitin protein ligase binding vesicle nucleotide-excision repair, DNA incision TRIF-dependent toll-like receptor signaling pathway interstrand cross-link repair error-prone translesion synthesis DNA damage response, detection of DNA damage positive regulation of apoptotic process negative regulation of apoptotic process myelin sheath regulation of mRNA stability host cell cellular protein metabolic process positive regulation of transcription by RNA polymerase II metal ion binding positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade transmembrane transport membrane organization regulation of transcription from RNA polymerase II promoter in response to hypoxia extracellular exosome nucleotide-binding oligomerization domain containing signaling pathway interleukin-1-mediated signaling pathway proteasome binding global genome nucleotide-excision repair error-free translesion synthesis intracellular transport of virus |
| Pathways : KEGG | Ribosome |
| NDEx Network | RPS27A |
| Atlas of Cancer Signalling Network | RPS27A |
| Wikipedia pathways | RPS27A |
| Orthology - Evolution |
|---|
| OrthoDB | 6233 |
| GeneTree (enSembl) | ENSG00000143947 |
| Phylogenetic Trees/Animal Genes : TreeFam | RPS27A |
| HOVERGEN | P62979 |
| HOGENOM | P62979 |
| Homologs : HomoloGene | RPS27A |
| Homology/Alignments : Family Browser (UCSC) | RPS27A |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | RPS27A |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | RPS27A [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | RPS27A |
| dbVar | RPS27A |
| ClinVar | RPS27A |
| 1000_Genomes | RPS27A |
| Exome Variant Server | RPS27A |
| ExAC (Exome Aggregation Consortium) | ENSG00000143947 |
| GNOMAD Browser | ENSG00000143947 |
| Varsome Browser | RPS27A |
| Genetic variants : HAPMAP | 6233 |
| Genomic Variants (DGV) | RPS27A [DGVbeta] |
| DECIPHER | RPS27A [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | RPS27A |
| Mutations |
|---|
| ICGC Data Portal | RPS27A |
| TCGA Data Portal | RPS27A |
| Broad Tumor Portal | RPS27A |
| OASIS Portal | RPS27A [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | RPS27A [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | RPS27A |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search RPS27A |
| DgiDB (Drug Gene Interaction Database) | RPS27A |
| DoCM (Curated mutations) | RPS27A (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | RPS27A (select a term) |
| intoGen | RPS27A |
| Cancer3D | RPS27A(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 191343 |
| Orphanet | |
| DisGeNET | RPS27A |
| Medgen | RPS27A |
| Genetic Testing Registry | RPS27A
|
| NextProt | P62979 [Medical] |
| TSGene | 6233 |
| GENETests | RPS27A |
| Target Validation | RPS27A |
| Huge Navigator |
RPS27A [HugePedia] |
| snp3D : Map Gene to Disease | 6233 |
| BioCentury BCIQ | RPS27A |
| ClinGen | RPS27A |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 6233 |
| Chemical/Pharm GKB Gene | PA34821 |
| Clinical trial | RPS27A |
| Miscellaneous |
|---|
| canSAR (ICR) | RPS27A (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 108 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | RPS27A |
| EVEX | RPS27A |
| GoPubMed | RPS27A |
| iHOP | RPS27A |
