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RPS27A (ribosomal protein S27a)

Identity

Alias_symbol (synonym)UBCEP80
Uba80
S27A
Other aliasCEP80
HEL112
UBA80
UBC
UBCEP1
HGNC (Hugo) RPS27A
LocusID (NCBI) 6233
Atlas_Id 43598
Location 2p16.1  [Link to chromosome band 2p16]
Location_base_pair Starts at 55231903 and ends at 55235853 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EEFSEC (3q21.3) / RPS27A (2p16.1)GPD2 (2q24.1) / RPS27A (2p16.1)MACF1 (1p34.3) / RPS27A (2p16.1)
RPS27A (2p16.1) / LIPH (3q27.2)RPS27A (2p16.1) / UBE3C (7q36.3)TOX4 (14q11.2) / RPS27A (2p16.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RPS27A   10417
Cards
Entrez_Gene (NCBI)RPS27A  6233  ribosomal protein S27a
AliasesCEP80; HEL112; S27A; UBA80; 
UBC; UBCEP1; UBCEP80
GeneCards (Weizmann)RPS27A
Ensembl hg19 (Hinxton)ENSG00000143947 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143947 [Gene_View]  chr2:55231903-55235853 [Contig_View]  RPS27A [Vega]
ICGC DataPortalENSG00000143947
TCGA cBioPortalRPS27A
AceView (NCBI)RPS27A
Genatlas (Paris)RPS27A
WikiGenes6233
SOURCE (Princeton)RPS27A
Genetics Home Reference (NIH)RPS27A
Genomic and cartography
GoldenPath hg38 (UCSC)RPS27A  -     chr2:55231903-55235853 +  2p16.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPS27A  -     2p16.1   [Description]    (hg19-Feb_2009)
EnsemblRPS27A - 2p16.1 [CytoView hg19]  RPS27A - 2p16.1 [CytoView hg38]
Mapping of homologs : NCBIRPS27A [Mapview hg19]  RPS27A [Mapview hg38]
OMIM191343   
Gene and transcription
Genbank (Entrez)AB362574 AK093614 AK225079 AK225718 AK315695
RefSeq transcript (Entrez)NM_001135592 NM_001177413 NM_002954
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RPS27A
Cluster EST : UnigeneHs.743392 [ NCBI ]
CGAP (NCI)Hs.743392
Alternative Splicing GalleryENSG00000143947
Gene ExpressionRPS27A [ NCBI-GEO ]   RPS27A [ EBI - ARRAY_EXPRESS ]   RPS27A [ SEEK ]   RPS27A [ MEM ]
Gene Expression Viewer (FireBrowse)RPS27A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6233
GTEX Portal (Tissue expression)RPS27A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62979   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62979  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62979
Splice isoforms : SwissVarP62979
PhosPhoSitePlusP62979
Domaine pattern : Prosite (Expaxy)UBIQUITIN_1 (PS00299)    UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)Ribosomal_S27a    Ribosomal_zn-bd    Ubiquitin    Ubiquitin-rel_dom    Ubiquitin_CS    Ubiquitin_dom   
Domain families : Pfam (Sanger)Ribosomal_S27 (PF01599)    ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam01599    pfam00240   
Domain families : Smart (EMBL)Ribosomal_S27 (SM01402)  UBQ (SM00213)  
Conserved Domain (NCBI)RPS27A
DMDM Disease mutations6233
Blocks (Seattle)RPS27A
PDB (SRS)2KHW    2KOX    2KTF    2KWU    2KWV    2L0F    2L0T    2XK5    3AXC    3I3T    3K9P    3N30    3N32    3NHE    3NOB    3NS8    3PHD    3PHW    3TBL    3VDZ    4R62    4UG0    4V6X    5A2Q    5AJ0    5FLX    5T2C   
PDB (PDBSum)2KHW    2KOX    2KTF    2KWU    2KWV    2L0F    2L0T    2XK5    3AXC    3I3T    3K9P    3N30    3N32    3NHE    3NOB    3NS8    3PHD    3PHW    3TBL    3VDZ    4R62    4UG0    4V6X    5A2Q    5AJ0    5FLX    5T2C   
PDB (IMB)2KHW    2KOX    2KTF    2KWU    2KWV    2L0F    2L0T    2XK5    3AXC    3I3T    3K9P    3N30    3N32    3NHE    3NOB    3NS8    3PHD    3PHW    3TBL    3VDZ    4R62    4UG0    4V6X    5A2Q    5AJ0    5FLX    5T2C   
PDB (RSDB)2KHW    2KOX    2KTF    2KWU    2KWV    2L0F    2L0T    2XK5    3AXC    3I3T    3K9P    3N30    3N32    3NHE    3NOB    3NS8    3PHD    3PHW    3TBL    3VDZ    4R62    4UG0    4V6X    5A2Q    5AJ0    5FLX    5T2C   
Structural Biology KnowledgeBase2KHW    2KOX    2KTF    2KWU    2KWV    2L0F    2L0T    2XK5    3AXC    3I3T    3K9P    3N30    3N32    3NHE    3NOB    3NS8    3PHD    3PHW    3TBL    3VDZ    4R62    4UG0    4V6X    5A2Q    5AJ0    5FLX    5T2C   
SCOP (Structural Classification of Proteins)2KHW    2KOX    2KTF    2KWU    2KWV    2L0F    2L0T    2XK5    3AXC    3I3T    3K9P    3N30    3N32    3NHE    3NOB    3NS8    3PHD    3PHW    3TBL    3VDZ    4R62    4UG0    4V6X    5A2Q    5AJ0    5FLX    5T2C   
CATH (Classification of proteins structures)2KHW    2KOX    2KTF    2KWU    2KWV    2L0F    2L0T    2XK5    3AXC    3I3T    3K9P    3N30    3N32    3NHE    3NOB    3NS8    3PHD    3PHW    3TBL    3VDZ    4R62    4UG0    4V6X    5A2Q    5AJ0    5FLX    5T2C   
SuperfamilyP62979
Human Protein AtlasENSG00000143947
Peptide AtlasP62979
HPRD01878
IPIIPI00179330   IPI00654754   IPI00975835   IPI01013317   IPI00798155   
Protein Interaction databases
DIP (DOE-UCLA)P62979
IntAct (EBI)P62979
FunCoupENSG00000143947
BioGRIDRPS27A
STRING (EMBL)RPS27A
ZODIACRPS27A
Ontologies - Pathways
QuickGOP62979
Ontology : AmiGOG2/M transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  MAPK cascade  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  activation of MAPK activity  protein polyubiquitination  nucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  stimulatory C-type lectin receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  RNA binding  structural constituent of ribosome  protein binding  extracellular space  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrial outer membrane  cytosol  plasma membrane  glycogen biosynthetic process  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  rRNA processing  translation  translational initiation  protein folding  SRP-dependent cotranslational protein targeting to membrane  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  transforming growth factor beta receptor signaling pathway  Notch signaling pathway  I-kappaB kinase/NF-kappaB signaling  JNK cascade  fibroblast growth factor receptor signaling pathway  endosome membrane  regulation of tumor necrosis factor-mediated signaling pathway  negative regulation of G2/M transition of mitotic cell cycle  small ribosomal subunit  membrane  Wnt signaling pathway  endosomal transport  macroautophagy  protein ubiquitination  protein deubiquitination  viral life cycle  virion assembly  viral transcription  translesion synthesis  cytosolic small ribosomal subunit  negative regulation of transforming growth factor beta receptor signaling pathway  endocytic vesicle membrane  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  vesicle  regulation of type I interferon production  negative regulation of type I interferon production  tumor necrosis factor-mediated signaling pathway  nucleotide-excision repair, DNA incision  ion transmembrane transport  entry of bacterium into host cell  TRIF-dependent toll-like receptor signaling pathway  interstrand cross-link repair  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  ERBB2 signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  error-prone translesion synthesis  DNA damage response, detection of DNA damage  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  positive regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  proteasome-mediated ubiquitin-dependent protein catabolic process  myelin sheath  regulation of mRNA stability  cellular protein metabolic process  endoplasmic reticulum quality control compartment  innate immune response  positive regulation of epidermal growth factor receptor signaling pathway  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  stress-activated MAPK cascade  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of necroptotic process  membrane organization  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  nucleotide-binding oligomerization domain containing signaling pathway  global genome nucleotide-excision repair  error-free translesion synthesis  intracellular transport of virus  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of signal transduction by p53 class mediator  endoplasmic reticulum mannose trimming  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  MAPK cascade  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  activation of MAPK activity  protein polyubiquitination  nucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  stimulatory C-type lectin receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  RNA binding  structural constituent of ribosome  protein binding  extracellular space  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrial outer membrane  cytosol  plasma membrane  glycogen biosynthetic process  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  rRNA processing  translation  translational initiation  protein folding  SRP-dependent cotranslational protein targeting to membrane  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  transforming growth factor beta receptor signaling pathway  Notch signaling pathway  I-kappaB kinase/NF-kappaB signaling  JNK cascade  fibroblast growth factor receptor signaling pathway  endosome membrane  regulation of tumor necrosis factor-mediated signaling pathway  negative regulation of G2/M transition of mitotic cell cycle  small ribosomal subunit  membrane  Wnt signaling pathway  endosomal transport  macroautophagy  protein ubiquitination  protein deubiquitination  viral life cycle  virion assembly  viral transcription  translesion synthesis  cytosolic small ribosomal subunit  negative regulation of transforming growth factor beta receptor signaling pathway  endocytic vesicle membrane  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  vesicle  regulation of type I interferon production  negative regulation of type I interferon production  tumor necrosis factor-mediated signaling pathway  nucleotide-excision repair, DNA incision  ion transmembrane transport  entry of bacterium into host cell  TRIF-dependent toll-like receptor signaling pathway  interstrand cross-link repair  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  ERBB2 signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  error-prone translesion synthesis  DNA damage response, detection of DNA damage  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  positive regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  proteasome-mediated ubiquitin-dependent protein catabolic process  myelin sheath  regulation of mRNA stability  cellular protein metabolic process  endoplasmic reticulum quality control compartment  innate immune response  positive regulation of epidermal growth factor receptor signaling pathway  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  stress-activated MAPK cascade  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of necroptotic process  membrane organization  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  nucleotide-binding oligomerization domain containing signaling pathway  global genome nucleotide-excision repair  error-free translesion synthesis  intracellular transport of virus  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of signal transduction by p53 class mediator  endoplasmic reticulum mannose trimming  
Pathways : KEGGRibosome   
NDEx NetworkRPS27A
Atlas of Cancer Signalling NetworkRPS27A
Wikipedia pathwaysRPS27A
Orthology - Evolution
OrthoDB6233
GeneTree (enSembl)ENSG00000143947
Phylogenetic Trees/Animal Genes : TreeFamRPS27A
HOVERGENP62979
HOGENOMP62979
Homologs : HomoloGeneRPS27A
Homology/Alignments : Family Browser (UCSC)RPS27A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPS27A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPS27A
dbVarRPS27A
ClinVarRPS27A
1000_GenomesRPS27A 
Exome Variant ServerRPS27A
ExAC (Exome Aggregation Consortium)RPS27A (select the gene name)
Genetic variants : HAPMAP6233
Genomic Variants (DGV)RPS27A [DGVbeta]
DECIPHERRPS27A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPS27A 
Mutations
ICGC Data PortalRPS27A 
TCGA Data PortalRPS27A 
Broad Tumor PortalRPS27A
OASIS PortalRPS27A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPS27A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRPS27A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPS27A
DgiDB (Drug Gene Interaction Database)RPS27A
DoCM (Curated mutations)RPS27A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPS27A (select a term)
intoGenRPS27A
Cancer3DRPS27A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191343   
Orphanet
MedgenRPS27A
Genetic Testing Registry RPS27A
NextProtP62979 [Medical]
TSGene6233
GENETestsRPS27A
Target ValidationRPS27A
Huge Navigator RPS27A [HugePedia]
snp3D : Map Gene to Disease6233
BioCentury BCIQRPS27A
ClinGenRPS27A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6233
Chemical/Pharm GKB GenePA34821
Clinical trialRPS27A
Miscellaneous
canSAR (ICR)RPS27A (select the gene name)
Probes
Litterature
PubMed99 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPS27A
EVEXRPS27A
GoPubMedRPS27A
iHOPRPS27A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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