| Nomenclature |
|---|
| HGNC (Hugo) | RPS27A 10417 |
| Cards |
|---|
| Entrez_Gene (NCBI) | RPS27A 6233 ribosomal protein S27a |
| Aliases | CEP80; HEL112; S27A; UBA80; |
| UBC; UBCEP1; UBCEP80 |
| GeneCards (Weizmann) | RPS27A |
| Ensembl hg19 (Hinxton) | ENSG00000143947 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000143947 [Gene_View] chr2:55232405-55235853 [Contig_View] RPS27A [Vega] |
| ICGC DataPortal | ENSG00000143947 |
| TCGA cBioPortal | RPS27A |
| AceView (NCBI) | RPS27A |
| Genatlas (Paris) | RPS27A |
| WikiGenes | 6233 |
| SOURCE (Princeton) | RPS27A |
| Genetics Home Reference (NIH) | RPS27A |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | RPS27A - chr2:55232405-55235853 + 2p16.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | RPS27A - 2p16.1 [Description] (hg19-Feb_2009) |
| Ensembl | RPS27A - 2p16.1 [CytoView hg19] RPS27A - 2p16.1 [CytoView hg38] |
| Mapping of homologs : NCBI | RPS27A [Mapview hg19] RPS27A [Mapview hg38] |
| OMIM | 191343 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB362574 AK093614 AK225079 AK225718 AK315695 |
| RefSeq transcript (Entrez) | NM_001135592 NM_001177413 NM_002954 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | RPS27A |
| Cluster EST : Unigene | Hs.743392 [ NCBI ] |
| CGAP (NCI) | Hs.743392 |
| Alternative Splicing Gallery | ENSG00000143947 |
| Gene Expression | RPS27A [ NCBI-GEO ] RPS27A [ EBI - ARRAY_EXPRESS ]
RPS27A [ SEEK ] RPS27A [ MEM ] |
| Gene Expression Viewer (FireBrowse) | RPS27A [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 6233 |
| GTEX Portal (Tissue expression) | RPS27A |
| Human Protein Atlas | ENSG00000143947-RPS27A [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P62979 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P62979 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P62979 |
| Splice isoforms : SwissVar | P62979 |
| PhosPhoSitePlus | P62979 |
| Domaine pattern : Prosite (Expaxy) | UBIQUITIN_1 (PS00299) UBIQUITIN_2 (PS50053) |
| Domains : Interpro (EBI) | Ribosomal_S27a Ribosomal_zn-bd Ubiquitin Ubiquitin-rel_dom Ubiquitin_CS Ubiquitin_dom |
| Domain families : Pfam (Sanger) | Ribosomal_S27 (PF01599) ubiquitin (PF00240) |
| Domain families : Pfam (NCBI) | pfam01599 pfam00240 |
| Domain families : Smart (EMBL) | Ribosomal_S27 (SM01402) UBQ (SM00213) |
| Conserved Domain (NCBI) | RPS27A |
| DMDM Disease mutations | 6233 |
| Blocks (Seattle) | RPS27A |
| PDB (SRS) | 2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5T2C |
| PDB (PDBSum) | 2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5T2C |
| PDB (IMB) | 2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5T2C |
| PDB (RSDB) | 2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5T2C |
| Structural Biology KnowledgeBase | 2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5T2C |
| SCOP (Structural Classification of Proteins) | 2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5T2C |
| CATH (Classification of proteins structures) | 2KHW 2KOX 2KTF 2KWU 2KWV 2L0F 2L0T 2XK5 3AXC 3I3T 3K9P 3N30 3N32 3NHE 3NOB 3NS8 3PHD 3PHW 3TBL 3VDZ 4R62 4UG0 4V6X 5A2Q 5AJ0 5FLX 5T2C |
| Superfamily | P62979 |
| Human Protein Atlas [tissue] | ENSG00000143947-RPS27A [tissue] |
| Peptide Atlas | P62979 |
| HPRD | 01878 |
| IPI | IPI00179330 IPI00654754 IPI00975835 IPI01013317 IPI00798155 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P62979 |
| IntAct (EBI) | P62979 |
| FunCoup | ENSG00000143947 |
| BioGRID | RPS27A |
| STRING (EMBL) | RPS27A |
| ZODIAC | RPS27A |
| Ontologies - Pathways |
|---|
| QuickGO | P62979 |
| Ontology : AmiGO | G2/M transition of mitotic cell cycle negative regulation of transcription by RNA polymerase II MAPK cascade nuclear-transcribed mRNA catabolic process, nonsense-mediated decay activation of MAPK activity protein polyubiquitination nucleotide-excision repair, DNA damage recognition nucleotide-excision repair, DNA duplex unwinding stimulatory C-type lectin receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway RNA binding structural constituent of ribosome protein binding extracellular space nucleus nucleoplasm nucleolus cytoplasm mitochondrial outer membrane endoplasmic reticulum membrane cytosol plasma membrane glycogen biosynthetic process transcription-coupled nucleotide-excision repair nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, DNA gap filling rRNA processing translation translational initiation protein folding SRP-dependent cotranslational protein targeting to membrane cellular iron ion homeostasis DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest transforming growth factor beta receptor signaling pathway Notch signaling pathway I-kappaB kinase/NF-kappaB signaling JNK cascade fibroblast growth factor receptor signaling pathway endosome membrane regulation of tumor necrosis factor-mediated signaling pathway negative regulation of G2/M transition of mitotic cell cycle small ribosomal subunit membrane Wnt signaling pathway endosomal transport macroautophagy protein ubiquitination protein deubiquitination viral life cycle virion assembly viral transcription cytokine-mediated signaling pathway translesion synthesis cytosolic small ribosomal subunit cytosolic small ribosomal subunit negative regulation of transforming growth factor beta receptor signaling pathway endocytic vesicle membrane anaphase-promoting complex-dependent catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process vesicle regulation of type I interferon production negative regulation of type I interferon production tumor necrosis factor-mediated signaling pathway nucleotide-excision repair, DNA incision ion transmembrane transport entry of bacterium into host cell TRIF-dependent toll-like receptor signaling pathway interstrand cross-link repair NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway ERBB2 signaling pathway negative regulation of epidermal growth factor receptor signaling pathway error-prone translesion synthesis DNA damage response, detection of DNA damage protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process myelin sheath regulation of mRNA stability host cell cellular protein metabolic process endoplasmic reticulum quality control compartment innate immune response positive regulation of epidermal growth factor receptor signaling pathway negative regulation of Notch signaling pathway positive regulation of transcription by RNA polymerase II metal ion binding T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition transmembrane transport Wnt signaling pathway, planar cell polarity pathway regulation of necroptotic process membrane organization regulation of transcription from RNA polymerase II promoter in response to hypoxia extracellular exosome nucleotide-binding oligomerization domain containing signaling pathway interleukin-1-mediated signaling pathway global genome nucleotide-excision repair error-free translesion synthesis intracellular transport of virus negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of signal transduction by p53 class mediator regulation of hematopoietic stem cell differentiation endoplasmic reticulum mannose trimming |
| Ontology : EGO-EBI | G2/M transition of mitotic cell cycle negative regulation of transcription by RNA polymerase II MAPK cascade nuclear-transcribed mRNA catabolic process, nonsense-mediated decay activation of MAPK activity protein polyubiquitination nucleotide-excision repair, DNA damage recognition nucleotide-excision repair, DNA duplex unwinding stimulatory C-type lectin receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway RNA binding structural constituent of ribosome protein binding extracellular space nucleus nucleoplasm nucleolus cytoplasm mitochondrial outer membrane endoplasmic reticulum membrane cytosol plasma membrane glycogen biosynthetic process transcription-coupled nucleotide-excision repair nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 5'-to lesion nucleotide-excision repair, DNA gap filling rRNA processing translation translational initiation protein folding SRP-dependent cotranslational protein targeting to membrane cellular iron ion homeostasis DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest transforming growth factor beta receptor signaling pathway Notch signaling pathway I-kappaB kinase/NF-kappaB signaling JNK cascade fibroblast growth factor receptor signaling pathway endosome membrane regulation of tumor necrosis factor-mediated signaling pathway negative regulation of G2/M transition of mitotic cell cycle small ribosomal subunit membrane Wnt signaling pathway endosomal transport macroautophagy protein ubiquitination protein deubiquitination viral life cycle virion assembly viral transcription cytokine-mediated signaling pathway translesion synthesis cytosolic small ribosomal subunit cytosolic small ribosomal subunit negative regulation of transforming growth factor beta receptor signaling pathway endocytic vesicle membrane anaphase-promoting complex-dependent catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process vesicle regulation of type I interferon production negative regulation of type I interferon production tumor necrosis factor-mediated signaling pathway nucleotide-excision repair, DNA incision ion transmembrane transport entry of bacterium into host cell TRIF-dependent toll-like receptor signaling pathway interstrand cross-link repair NIK/NF-kappaB signaling Fc-epsilon receptor signaling pathway ERBB2 signaling pathway negative regulation of epidermal growth factor receptor signaling pathway error-prone translesion synthesis DNA damage response, detection of DNA damage protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process myelin sheath regulation of mRNA stability host cell cellular protein metabolic process endoplasmic reticulum quality control compartment innate immune response positive regulation of epidermal growth factor receptor signaling pathway negative regulation of Notch signaling pathway positive regulation of transcription by RNA polymerase II metal ion binding T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition transmembrane transport Wnt signaling pathway, planar cell polarity pathway regulation of necroptotic process membrane organization regulation of transcription from RNA polymerase II promoter in response to hypoxia extracellular exosome nucleotide-binding oligomerization domain containing signaling pathway interleukin-1-mediated signaling pathway global genome nucleotide-excision repair error-free translesion synthesis intracellular transport of virus negative regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of signal transduction by p53 class mediator regulation of hematopoietic stem cell differentiation endoplasmic reticulum mannose trimming |
| Pathways : KEGG | Ribosome |
| NDEx Network | RPS27A |
| Atlas of Cancer Signalling Network | RPS27A |
| Wikipedia pathways | RPS27A |
| Orthology - Evolution |
|---|
| OrthoDB | 6233 |
| GeneTree (enSembl) | ENSG00000143947 |
| Phylogenetic Trees/Animal Genes : TreeFam | RPS27A |
| HOVERGEN | P62979 |
| HOGENOM | P62979 |
| Homologs : HomoloGene | RPS27A |
| Homology/Alignments : Family Browser (UCSC) | RPS27A |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | RPS27A |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | RPS27A [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | RPS27A |
| dbVar | RPS27A |
| ClinVar | RPS27A |
| 1000_Genomes | RPS27A |
| Exome Variant Server | RPS27A |
| ExAC (Exome Aggregation Consortium) | ENSG00000143947 |
| GNOMAD Browser | ENSG00000143947 |
| Genetic variants : HAPMAP | 6233 |
| Genomic Variants (DGV) | RPS27A [DGVbeta] |
| DECIPHER | RPS27A [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | RPS27A |
| Mutations |
|---|
| ICGC Data Portal | RPS27A |
| TCGA Data Portal | RPS27A |
| Broad Tumor Portal | RPS27A |
| OASIS Portal | RPS27A [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | RPS27A [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | RPS27A |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search RPS27A |
| DgiDB (Drug Gene Interaction Database) | RPS27A |
| DoCM (Curated mutations) | RPS27A (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | RPS27A (select a term) |
| intoGen | RPS27A |
| Cancer3D | RPS27A(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 191343 |
| Orphanet | |
| DisGeNET | RPS27A |
| Medgen | RPS27A |
| Genetic Testing Registry | RPS27A
|
| NextProt | P62979 [Medical] |
| TSGene | 6233 |
| GENETests | RPS27A |
| Target Validation | RPS27A |
| Huge Navigator |
RPS27A [HugePedia] |
| snp3D : Map Gene to Disease | 6233 |
| BioCentury BCIQ | RPS27A |
| ClinGen | RPS27A |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 6233 |
| Chemical/Pharm GKB Gene | PA34821 |
| Clinical trial | RPS27A |
| Miscellaneous |
|---|
| canSAR (ICR) | RPS27A (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 106 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | RPS27A |
| EVEX | RPS27A |
| GoPubMed | RPS27A |
| iHOP | RPS27A |
