Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

RPS3 (ribosomal protein S3)

Identity

Alias_symbol (synonym)FLJ26283
FLJ27450
MGC87870
S3
Other alias
HGNC (Hugo) RPS3
LocusID (NCBI) 6188
Atlas_Id 42164
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 75399491 and ends at 75406913 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANK3 (10q21.2) / RPS3 (11q13.4)JA040725 () / RPS3 (11q13.4)MOB2 (11p15.5) / RPS3 (11q13.4)
RPS3 (11q13.4) / ARMC5 (16p11.2)RPS3 (11q13.4) / C7orf31 (7p15.3)RPS3 (11q13.4) / CAGE1 (6p24.3)
RPS3 (11q13.4) / CLDN4 (7q11.23)SET (9q34.11) / RPS3 (11q13.4)VSIG1 (Xq22.3) / RPS3 (11q13.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RPS3   10420
Cards
Entrez_Gene (NCBI)RPS3  6188  ribosomal protein S3
AliasesS3
GeneCards (Weizmann)RPS3
Ensembl hg19 (Hinxton)ENSG00000149273 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149273 [Gene_View]  ENSG00000149273 [Sequence]  chr11:75399491-75406913 [Contig_View]  RPS3 [Vega]
ICGC DataPortalENSG00000149273
TCGA cBioPortalRPS3
AceView (NCBI)RPS3
Genatlas (Paris)RPS3
WikiGenes6188
SOURCE (Princeton)RPS3
Genetics Home Reference (NIH)RPS3
Genomic and cartography
GoldenPath hg38 (UCSC)RPS3  -     chr11:75399491-75406913 +  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPS3  -     11q13.4   [Description]    (hg19-Feb_2009)
EnsemblRPS3 - 11q13.4 [CytoView hg19]  RPS3 - 11q13.4 [CytoView hg38]
Mapping of homologs : NCBIRPS3 [Mapview hg19]  RPS3 [Mapview hg38]
OMIM600454   
Gene and transcription
Genbank (Entrez)AA976344 AB062288 AK129794 AK130960 AK223048
RefSeq transcript (Entrez)NM_001005 NM_001256802 NM_001260506 NM_001260507
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RPS3
Cluster EST : UnigeneHs.740358 [ NCBI ]
CGAP (NCI)Hs.740358
Alternative Splicing GalleryENSG00000149273
Gene ExpressionRPS3 [ NCBI-GEO ]   RPS3 [ EBI - ARRAY_EXPRESS ]   RPS3 [ SEEK ]   RPS3 [ MEM ]
Gene Expression Viewer (FireBrowse)RPS3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6188
GTEX Portal (Tissue expression)RPS3
Human Protein AtlasENSG00000149273-RPS3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23396   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23396  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23396
Splice isoforms : SwissVarP23396
PhosPhoSitePlusP23396
Domaine pattern : Prosite (Expaxy)KH_TYPE_2 (PS50823)    RIBOSOMAL_S3 (PS00548)   
Domains : Interpro (EBI)KH_dom-like_a/b    KH_dom_type_2    KH_prok-type    Ribosomal_S3_C    Ribosomal_S3_CS    Ribosomal_S3_euk/arc   
Domain families : Pfam (Sanger)KH_2 (PF07650)   
Domain families : Pfam (NCBI)pfam07650   
Conserved Domain (NCBI)RPS3
DMDM Disease mutations6188
Blocks (Seattle)RPS3
PDB (SRS)1WH9    4UG0    4V6X    5A2Q    5AJ0    5FLX    5T2C   
PDB (PDBSum)1WH9    4UG0    4V6X    5A2Q    5AJ0    5FLX    5T2C   
PDB (IMB)1WH9    4UG0    4V6X    5A2Q    5AJ0    5FLX    5T2C   
PDB (RSDB)1WH9    4UG0    4V6X    5A2Q    5AJ0    5FLX    5T2C   
Structural Biology KnowledgeBase1WH9    4UG0    4V6X    5A2Q    5AJ0    5FLX    5T2C   
SCOP (Structural Classification of Proteins)1WH9    4UG0    4V6X    5A2Q    5AJ0    5FLX    5T2C   
CATH (Classification of proteins structures)1WH9    4UG0    4V6X    5A2Q    5AJ0    5FLX    5T2C   
SuperfamilyP23396
Human Protein Atlas [tissue]ENSG00000149273-RPS3 [tissue]
Peptide AtlasP23396
HPRD10941
IPIIPI00011253   IPI00979604   IPI00983557   IPI00980283   IPI00978911   IPI00979522   IPI00939811   IPI00974484   IPI00977579   IPI00984887   IPI00978298   IPI00981193   IPI00975755   IPI00855830   IPI00980569   IPI00977127   
Protein Interaction databases
DIP (DOE-UCLA)P23396
IntAct (EBI)P23396
FunCoupENSG00000149273
BioGRIDRPS3
STRING (EMBL)RPS3
ZODIACRPS3
Ontologies - Pathways
QuickGOP23396
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, nonsense-mediated decay  RNA polymerase II regulatory region sequence-specific DNA binding  cytoplasmic translation  DNA binding  damaged DNA binding  RNA binding  RNA binding  mRNA binding  structural constituent of ribosome  structural constituent of ribosome  DNA-(apurinic or apyrimidinic site) lyase activity  endodeoxyribonuclease activity  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  cytoplasm  mitochondrial inner membrane  mitochondrial matrix  endoplasmic reticulum  cytosol  cytosol  ribosome  polysome  plasma membrane  focal adhesion  DNA repair  transcription, DNA-templated  rRNA processing  translation  translation  translational initiation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  apoptotic process  cellular response to DNA damage stimulus  response to oxidative stress  chromosome segregation  microtubule binding  transcription factor binding  positive regulation of gene expression  tubulin binding  membrane  negative regulation of translation  viral transcription  DNA N-glycosylase activity  DNA N-glycosylase activity  enzyme binding  kinase binding  protein kinase binding  cytosolic small ribosomal subunit  cytosolic small ribosomal subunit  intracellular ribonucleoprotein complex  Hsp70 protein binding  extracellular matrix  positive regulation of microtubule polymerization  positive regulation of protein complex assembly  negative regulation of protein ubiquitination  positive regulation of endodeoxyribonuclease activity  oxidized purine DNA binding  oxidized pyrimidine DNA binding  protein complex binding  ruffle membrane  positive regulation of interleukin-2 production  positive regulation of activated T cell proliferation  DNA damage response, detection of DNA damage  DNA damage response, detection of DNA damage  regulation of apoptotic process  positive regulation of JUN kinase activity  ubiquitin-like protein conjugating enzyme binding  negative regulation of DNA repair  positive regulation of DNA repair  positive regulation of T cell receptor signaling pathway  protein kinase A binding  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  spindle assembly  cell division  iron-sulfur cluster binding  Hsp90 protein binding  response to TNF agonist  extracellular exosome  small ribosomal subunit rRNA binding  cellular response to hydrogen peroxide  NF-kappaB complex  cellular response to tumor necrosis factor  mitotic spindle  supercoiled DNA binding  class I DNA-(apurinic or apyrimidinic site) lyase activity  class III/IV DNA-(apurinic or apyrimidinic site) lyase activity  positive regulation of NIK/NF-kappaB signaling  positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage  positive regulation of DNA N-glycosylase activity  positive regulation of base-excision repair  positive regulation of apoptotic signaling pathway  positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, nonsense-mediated decay  RNA polymerase II regulatory region sequence-specific DNA binding  cytoplasmic translation  DNA binding  damaged DNA binding  RNA binding  RNA binding  mRNA binding  structural constituent of ribosome  structural constituent of ribosome  DNA-(apurinic or apyrimidinic site) lyase activity  endodeoxyribonuclease activity  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  cytoplasm  mitochondrial inner membrane  mitochondrial matrix  endoplasmic reticulum  cytosol  cytosol  ribosome  polysome  plasma membrane  focal adhesion  DNA repair  transcription, DNA-templated  rRNA processing  translation  translation  translational initiation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  apoptotic process  cellular response to DNA damage stimulus  response to oxidative stress  chromosome segregation  microtubule binding  transcription factor binding  positive regulation of gene expression  tubulin binding  membrane  negative regulation of translation  viral transcription  DNA N-glycosylase activity  DNA N-glycosylase activity  enzyme binding  kinase binding  protein kinase binding  cytosolic small ribosomal subunit  cytosolic small ribosomal subunit  intracellular ribonucleoprotein complex  Hsp70 protein binding  extracellular matrix  positive regulation of microtubule polymerization  positive regulation of protein complex assembly  negative regulation of protein ubiquitination  positive regulation of endodeoxyribonuclease activity  oxidized purine DNA binding  oxidized pyrimidine DNA binding  protein complex binding  ruffle membrane  positive regulation of interleukin-2 production  positive regulation of activated T cell proliferation  DNA damage response, detection of DNA damage  DNA damage response, detection of DNA damage  regulation of apoptotic process  positive regulation of JUN kinase activity  ubiquitin-like protein conjugating enzyme binding  negative regulation of DNA repair  positive regulation of DNA repair  positive regulation of T cell receptor signaling pathway  protein kinase A binding  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  spindle assembly  cell division  iron-sulfur cluster binding  Hsp90 protein binding  response to TNF agonist  extracellular exosome  small ribosomal subunit rRNA binding  cellular response to hydrogen peroxide  NF-kappaB complex  cellular response to tumor necrosis factor  mitotic spindle  supercoiled DNA binding  class I DNA-(apurinic or apyrimidinic site) lyase activity  class III/IV DNA-(apurinic or apyrimidinic site) lyase activity  positive regulation of NIK/NF-kappaB signaling  positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage  positive regulation of DNA N-glycosylase activity  positive regulation of base-excision repair  positive regulation of apoptotic signaling pathway  positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis  
Pathways : KEGGRibosome   
NDEx NetworkRPS3
Atlas of Cancer Signalling NetworkRPS3
Wikipedia pathwaysRPS3
Orthology - Evolution
OrthoDB6188
GeneTree (enSembl)ENSG00000149273
Phylogenetic Trees/Animal Genes : TreeFamRPS3
HOVERGENP23396
HOGENOMP23396
Homologs : HomoloGeneRPS3
Homology/Alignments : Family Browser (UCSC)RPS3
Gene fusions - Rearrangements
Fusion Cancer (Beijing)JA040725 [RPS3]  -  11q13.4 [FUSC000845]  [FUSC000845]
Fusion Cancer (Beijing)RPS3 [11q13.4]  -  CAGE1 [6p24.3]  [FUSC004555]
Fusion : QuiverRPS3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPS3
dbVarRPS3
ClinVarRPS3
1000_GenomesRPS3 
Exome Variant ServerRPS3
ExAC (Exome Aggregation Consortium)ENSG00000149273
GNOMAD BrowserENSG00000149273
Genetic variants : HAPMAP6188
Genomic Variants (DGV)RPS3 [DGVbeta]
DECIPHERRPS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPS3 
Mutations
ICGC Data PortalRPS3 
TCGA Data PortalRPS3 
Broad Tumor PortalRPS3
OASIS PortalRPS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPS3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRPS3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPS3
DgiDB (Drug Gene Interaction Database)RPS3
DoCM (Curated mutations)RPS3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPS3 (select a term)
intoGenRPS3
Cancer3DRPS3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600454   
Orphanet
DisGeNETRPS3
MedgenRPS3
Genetic Testing Registry RPS3
NextProtP23396 [Medical]
TSGene6188
GENETestsRPS3
Target ValidationRPS3
Huge Navigator RPS3 [HugePedia]
snp3D : Map Gene to Disease6188
BioCentury BCIQRPS3
ClinGenRPS3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6188
Chemical/Pharm GKB GenePA34829
Clinical trialRPS3
Miscellaneous
canSAR (ICR)RPS3 (select the gene name)
Probes
Litterature
PubMed163 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPS3
EVEXRPS3
GoPubMedRPS3
iHOPRPS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:47:54 CEST 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.