RPS3 (ribosomal protein S3)

2003-06-01  

Identity

HGNC
LOCATION
11q13.4
LOCUSID
ALIAS
S3
FUSION GENES

Other Information

Locus ID:

NCBI: 6188
MIM: 600454
HGNC: 10420
Ensembl: ENSG00000149273

Variants:

dbSNP: 6188
ClinVar: 6188
TCGA: ENSG00000149273
COSMIC: RPS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149273ENST00000278572P23396
ENSG00000149273ENST00000422465E9PSF4
ENSG00000149273ENST00000524851P23396
ENSG00000149273ENST00000525690H0YES8
ENSG00000149273ENST00000525933H0YEU2
ENSG00000149273ENST00000526248H0YCJ7
ENSG00000149273ENST00000526608E9PL09
ENSG00000149273ENST00000527273E9PK82
ENSG00000149273ENST00000527446P23396
ENSG00000149273ENST00000528439E9PQ96
ENSG00000149273ENST00000528847E9PJN9
ENSG00000149273ENST00000530164F2Z2S8
ENSG00000149273ENST00000530170H0YF32
ENSG00000149273ENST00000530721E9PQX2
ENSG00000149273ENST00000531188P23396
ENSG00000149273ENST00000532872E9PJH4
ENSG00000149273ENST00000534440E9PPU1

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
RibosomeKEGGko03010
RibosomeKEGGhsa03010
Ribosome, eukaryotesKEGGhsa_M00177
Ribosome, eukaryotesKEGGM00177
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complexREACTOMER-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Eukaryotic Translation ElongationREACTOMER-HSA-156842
Peptide chain elongationREACTOMER-HSA-156902
Eukaryotic Translation TerminationREACTOMER-HSA-72764
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral mRNA TranslationREACTOMER-HSA-192823
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Selenocysteine synthesisREACTOMER-HSA-2408557
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180455352007Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation.136
196567442009Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain.57
213996392011IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7.56
149880022004RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis.27
190594392009PKCdelta-dependent functional switch of rpS3 between translation and DNA repair.24
155185712004Human ribosomal protein S3 interacts with DNA base excision repair proteins hAPE/Ref-1 and hOGG1.22
231888282013Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells.18
231315512012Ribosomal protein S3 localizes on the mitotic spindle and functions as a microtubule associated protein in mitosis.17
239115372013Cytoplasmic ribosomal protein S3 (rpS3) plays a pivotal role in mitochondrial DNA damage surveillance.17
231152422012Identification of an N-terminal truncation of the NF-κB p65 subunit that specifically modulates ribosomal protein S3-dependent NF-κB gene expression.16

Citation

Dessen P

RPS3 (ribosomal protein S3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42164/rps3