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RPS6 (ribosomal protein S6)

Identity

Alias (NCBI)S6
HGNC (Hugo) RPS6
HGNC Alias symbS6
HGNC Alias name40S ribosomal protein S6
 phosphoprotein NP33
LocusID (NCBI) 6194
Atlas_Id 42166
Location 9p22.1  [Link to chromosome band 9p22]
Location_base_pair Starts at 19375716 and ends at 19380236 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CNTLN (9p22.2) / RPS6 (9p22.1)CSDE1 (1p13.2) / RPS6 (9p22.1)JA040723 () / RPS6 (9p22.1)
MALAT1 (11q13.1) / RPS6 (9p22.1)NUP160 (11p11.2) / RPS6 (9p22.1)RNPC3 (1p21.1) / RPS6 (9p22.1)
RPS6 (9p22.1) / C14orf132 (14q32.2)RPS6 (9p22.1) / CASP8 (2q33.1)RPS6 (9p22.1) / GANAB (11q12.3)
RPS6 (9p22.1) / IVL (1q21.3)RPS6 (9p22.1) / MALAT1 (11q13.1)RPS6 (9p22.1) / MAP2K1 (15q22.31)
RPS6 (9p22.1) / MSMB (10q11.23)RPS6 (9p22.1) / MTATP6P1 ()RPS6 (9p22.1) / NARS2 (11q14.1)
RPS6 (9p22.1) / NDST3 (4q26)RPS6 (9p22.1) / NPAS2 (2q11.2)RPS6 (9p22.1) / OAZ1 (19p13.3)
RPS6 (9p22.1) / POSTN (13q13.3)RPS6 (9p22.1) / RACK1 (5q35.3)RPS6 (9p22.1) / RPL27 (17q21.31)
RPS6 (9p22.1) / RPS6 (9p22.1)RPS6 9p22.1 / GNB2L1 5q35.3RPS6 9p22.1 / OAZ1 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RPS6   10429
Cards
Entrez_Gene (NCBI)RPS6    ribosomal protein S6
AliasesS6
GeneCards (Weizmann)RPS6
Ensembl hg19 (Hinxton)ENSG00000137154 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137154 [Gene_View]  ENSG00000137154 [Sequence]  chr9:19375716-19380236 [Contig_View]  RPS6 [Vega]
ICGC DataPortalENSG00000137154
TCGA cBioPortalRPS6
AceView (NCBI)RPS6
Genatlas (Paris)RPS6
SOURCE (Princeton)RPS6
Genetics Home Reference (NIH)RPS6
Genomic and cartography
GoldenPath hg38 (UCSC)RPS6  -     chr9:19375716-19380236 -  9p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPS6  -     9p22.1   [Description]    (hg19-Feb_2009)
GoldenPathRPS6 - 9p22.1 [CytoView hg19]  RPS6 - 9p22.1 [CytoView hg38]
ImmunoBaseENSG00000137154
Genome Data Viewer NCBIRPS6 [Mapview hg19]  
OMIM180460   
Gene and transcription
Genbank (Entrez)AB062123 AK093634 AK291517 AK311861 BC000524
RefSeq transcript (Entrez)NM_001010
Consensus coding sequences : CCDS (NCBI)RPS6
Gene ExpressionRPS6 [ NCBI-GEO ]   RPS6 [ EBI - ARRAY_EXPRESS ]   RPS6 [ SEEK ]   RPS6 [ MEM ]
Gene Expression Viewer (FireBrowse)RPS6 [ Firebrowse - Broad ]
GenevisibleExpression of RPS6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6194
GTEX Portal (Tissue expression)RPS6
Human Protein AtlasENSG00000137154-RPS6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62753   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62753  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62753
PhosPhoSitePlusP62753
Domaine pattern : Prosite (Expaxy)RIBOSOMAL_S6E (PS00578)   
Domains : Interpro (EBI)Ribosomal_S6_euk    Ribosomal_S6e    Ribosomal_S6e_CS   
Domain families : Pfam (Sanger)Ribosomal_S6e (PF01092)   
Domain families : Pfam (NCBI)pfam01092   
Domain families : Smart (EMBL)Ribosomal_S6e (SM01405)  
Conserved Domain (NCBI)RPS6
PDB (RSDB)4UG0    4V6X    5A2Q    5AJ0    5FLX    5LKS    5OA3    5T2C    5VYC    6EK0    6F4P    6F4Q    6FEC    6G18    6G4S    6G4W    6G51    6G53    6G5H    6G5I    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP    6XA1    6Y0G    6Y2L    6Y57    6YBW    6Z6L    6Z6M    6Z6N    6ZLW    6ZM7    6ZME    6ZMI    6ZMO    6ZMT    6ZMW    6ZN5    6ZOJ    6ZOK    6ZON    6ZP4    6ZVH    6ZVJ    7A09    7K5I   
PDB Europe4UG0    4V6X    5A2Q    5AJ0    5FLX    5LKS    5OA3    5T2C    5VYC    6EK0    6F4P    6F4Q    6FEC    6G18    6G4S    6G4W    6G51    6G53    6G5H    6G5I    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP    6XA1    6Y0G    6Y2L    6Y57    6YBW    6Z6L    6Z6M    6Z6N    6ZLW    6ZM7    6ZME    6ZMI    6ZMO    6ZMT    6ZMW    6ZN5    6ZOJ    6ZOK    6ZON    6ZP4    6ZVH    6ZVJ    7A09    7K5I   
PDB (PDBSum)4UG0    4V6X    5A2Q    5AJ0    5FLX    5LKS    5OA3    5T2C    5VYC    6EK0    6F4P    6F4Q    6FEC    6G18    6G4S    6G4W    6G51    6G53    6G5H    6G5I    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP    6XA1    6Y0G    6Y2L    6Y57    6YBW    6Z6L    6Z6M    6Z6N    6ZLW    6ZM7    6ZME    6ZMI    6ZMO    6ZMT    6ZMW    6ZN5    6ZOJ    6ZOK    6ZON    6ZP4    6ZVH    6ZVJ    7A09    7K5I   
PDB (IMB)4UG0    4V6X    5A2Q    5AJ0    5FLX    5LKS    5OA3    5T2C    5VYC    6EK0    6F4P    6F4Q    6FEC    6G18    6G4S    6G4W    6G51    6G53    6G5H    6G5I    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP    6XA1    6Y0G    6Y2L    6Y57    6YBW    6Z6L    6Z6M    6Z6N    6ZLW    6ZM7    6ZME    6ZMI    6ZMO    6ZMT    6ZMW    6ZN5    6ZOJ    6ZOK    6ZON    6ZP4    6ZVH    6ZVJ    7A09    7K5I   
Structural Biology KnowledgeBase4UG0    4V6X    5A2Q    5AJ0    5FLX    5LKS    5OA3    5T2C    5VYC    6EK0    6F4P    6F4Q    6FEC    6G18    6G4S    6G4W    6G51    6G53    6G5H    6G5I    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP    6XA1    6Y0G    6Y2L    6Y57    6YBW    6Z6L    6Z6M    6Z6N    6ZLW    6ZM7    6ZME    6ZMI    6ZMO    6ZMT    6ZMW    6ZN5    6ZOJ    6ZOK    6ZON    6ZP4    6ZVH    6ZVJ    7A09    7K5I   
SCOP (Structural Classification of Proteins)4UG0    4V6X    5A2Q    5AJ0    5FLX    5LKS    5OA3    5T2C    5VYC    6EK0    6F4P    6F4Q    6FEC    6G18    6G4S    6G4W    6G51    6G53    6G5H    6G5I    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP    6XA1    6Y0G    6Y2L    6Y57    6YBW    6Z6L    6Z6M    6Z6N    6ZLW    6ZM7    6ZME    6ZMI    6ZMO    6ZMT    6ZMW    6ZN5    6ZOJ    6ZOK    6ZON    6ZP4    6ZVH    6ZVJ    7A09    7K5I   
CATH (Classification of proteins structures)4UG0    4V6X    5A2Q    5AJ0    5FLX    5LKS    5OA3    5T2C    5VYC    6EK0    6F4P    6F4Q    6FEC    6G18    6G4S    6G4W    6G51    6G53    6G5H    6G5I    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP    6XA1    6Y0G    6Y2L    6Y57    6YBW    6Z6L    6Z6M    6Z6N    6ZLW    6ZM7    6ZME    6ZMI    6ZMO    6ZMT    6ZMW    6ZN5    6ZOJ    6ZOK    6ZON    6ZP4    6ZVH    6ZVJ    7A09    7K5I   
SuperfamilyP62753
AlphaFold pdb e-kbP62753   
Human Protein Atlas [tissue]ENSG00000137154-RPS6 [tissue]
HPRD01592
Protein Interaction databases
DIP (DOE-UCLA)P62753
IntAct (EBI)P62753
BioGRIDRPS6
STRING (EMBL)RPS6
ZODIACRPS6
Ontologies - Pathways
QuickGOP62753
Ontology : AmiGOG1/S transition of mitotic cell cycle  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  placenta development  cytoplasmic translation  T cell proliferation involved in immune response  RNA binding  structural constituent of ribosome  structural constituent of ribosome  structural constituent of ribosome  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  endoplasmic reticulum  cytosol  cytosol  polysome  rRNA processing  rRNA processing  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  activation-induced cell death of T cells  gastrulation  positive regulation of cell population proliferation  small ribosomal subunit  membrane  viral transcription  protein kinase binding  mammalian oogenesis stage  cytosolic ribosome  cytosolic small ribosomal subunit  cytosolic small ribosomal subunit  cytosolic small ribosomal subunit  dendrite  TOR signaling  T cell differentiation in thymus  cytoplasmic ribonucleoprotein granule  ribosomal small subunit biogenesis  glucose homeostasis  positive regulation of apoptotic process  negative regulation of apoptotic process  cell body  perinuclear region of cytoplasm  erythrocyte development  ribonucleoprotein complex  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  placenta development  cytoplasmic translation  T cell proliferation involved in immune response  RNA binding  structural constituent of ribosome  structural constituent of ribosome  structural constituent of ribosome  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  endoplasmic reticulum  cytosol  cytosol  polysome  rRNA processing  rRNA processing  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  activation-induced cell death of T cells  gastrulation  positive regulation of cell population proliferation  small ribosomal subunit  membrane  viral transcription  protein kinase binding  mammalian oogenesis stage  cytosolic ribosome  cytosolic small ribosomal subunit  cytosolic small ribosomal subunit  cytosolic small ribosomal subunit  dendrite  TOR signaling  T cell differentiation in thymus  cytoplasmic ribonucleoprotein granule  ribosomal small subunit biogenesis  glucose homeostasis  positive regulation of apoptotic process  negative regulation of apoptotic process  cell body  perinuclear region of cytoplasm  erythrocyte development  ribonucleoprotein complex  
Pathways : KEGGRibosome    HIF-1 signaling pathway    mTOR signaling pathway    PI3K-Akt signaling pathway    Insulin signaling pathway    Proteoglycans in cancer   
NDEx NetworkRPS6
Atlas of Cancer Signalling NetworkRPS6
Wikipedia pathwaysRPS6
Orthology - Evolution
OrthoDB6194
GeneTree (enSembl)ENSG00000137154
Phylogenetic Trees/Animal Genes : TreeFamRPS6
Homologs : HomoloGeneRPS6
Homology/Alignments : Family Browser (UCSC)RPS6
Gene fusions - Rearrangements
Fusion : MitelmanRPS6/GNB2L1 [9p22.1/5q35.3]  
Fusion : MitelmanRPS6/OAZ1 [9p22.1/19p13.3]  
Fusion Cancer (Beijing)CSDE1 [1p13.2]  -  RPS6 [9p22.1]  [FUSC000939]
Fusion Cancer (Beijing)JA040723 [RPS6]  -  9p22.1 [FUSC001175]
Fusion Cancer (Beijing)RNPC3 [1p21.1]  -  RPS6 [9p22.1]  [FUSC001061]  [FUSC001061]  [FUSC001061]  [FUSC001061]  [FUSC001061]  [FUSC001061]
Fusion Cancer (Beijing)RPS6 [9p22.1]  -  MSMB [10q11.23]  [FUSC004556]
Fusion Cancer (Beijing)RPS6 [9p22.1]  -  MTATP6P1 [-]  [FUSC001097]
Fusion : QuiverRPS6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPS6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPS6
dbVarRPS6
ClinVarRPS6
MonarchRPS6
1000_GenomesRPS6 
Exome Variant ServerRPS6
GNOMAD BrowserENSG00000137154
Varsome BrowserRPS6
ACMGRPS6 variants
VarityP62753
Genomic Variants (DGV)RPS6 [DGVbeta]
DECIPHERRPS6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPS6 
Mutations
ICGC Data PortalRPS6 
TCGA Data PortalRPS6 
Broad Tumor PortalRPS6
OASIS PortalRPS6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPS6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRPS6
Mutations and Diseases : HGMDRPS6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRPS6
DgiDB (Drug Gene Interaction Database)RPS6
DoCM (Curated mutations)RPS6
CIViC (Clinical Interpretations of Variants in Cancer)RPS6
Cancer3DRPS6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180460   
Orphanet
DisGeNETRPS6
MedgenRPS6
Genetic Testing Registry RPS6
NextProtP62753 [Medical]
GENETestsRPS6
Target ValidationRPS6
Huge Navigator RPS6 [HugePedia]
ClinGenRPS6
Clinical trials, drugs, therapy
MyCancerGenomeRPS6
Protein Interactions : CTDRPS6
Pharm GKB GenePA34844
PharosP62753
Clinical trialRPS6
Miscellaneous
canSAR (ICR)RPS6
HarmonizomeRPS6
DataMed IndexRPS6
Probes
Litterature
PubMed233 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRPS6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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