Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RPS6 (ribosomal protein S6)

Identity

Alias (NCBI)S6
HGNC (Hugo) RPS6
HGNC Alias symbS6
HGNC Alias name40S ribosomal protein S6
 phosphoprotein NP33
LocusID (NCBI) 6194
Atlas_Id 42166
Location 9p22.1  [Link to chromosome band 9p22]
Location_base_pair Starts at 19375716 and ends at 19380236 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CNTLN (9p22.2) / RPS6 (9p22.1)CSDE1 (1p13.2) / RPS6 (9p22.1)JA040723 () / RPS6 (9p22.1)
MALAT1 (11q13.1) / RPS6 (9p22.1)NUP160 (11p11.2) / RPS6 (9p22.1)RNPC3 (1p21.1) / RPS6 (9p22.1)
RPS6 (9p22.1) / C14orf132 (14q32.2)RPS6 (9p22.1) / CASP8 (2q33.1)RPS6 (9p22.1) / GANAB (11q12.3)
RPS6 (9p22.1) / IVL (1q21.3)RPS6 (9p22.1) / MALAT1 (11q13.1)RPS6 (9p22.1) / MAP2K1 (15q22.31)
RPS6 (9p22.1) / MSMB (10q11.23)RPS6 (9p22.1) / MTATP6P1 ()RPS6 (9p22.1) / NARS2 (11q14.1)
RPS6 (9p22.1) / NDST3 (4q26)RPS6 (9p22.1) / NPAS2 (2q11.2)RPS6 (9p22.1) / OAZ1 (19p13.3)
RPS6 (9p22.1) / POSTN (13q13.3)RPS6 (9p22.1) / RACK1 (5q35.3)RPS6 (9p22.1) / RPL27 (17q21.31)
RPS6 (9p22.1) / RPS6 (9p22.1)RPS6 9p22.1 / GNB2L1 5q35.3RPS6 9p22.1 / OAZ1 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(9;19)(p22;p13) RPS6/OAZ1


External links

Nomenclature
HGNC (Hugo)RPS6   10429
Cards
Entrez_Gene (NCBI)RPS6  6194  ribosomal protein S6
AliasesS6
GeneCards (Weizmann)RPS6
Ensembl hg19 (Hinxton)ENSG00000137154 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137154 [Gene_View]  ENSG00000137154 [Sequence]  chr9:19375716-19380236 [Contig_View]  RPS6 [Vega]
ICGC DataPortalENSG00000137154
TCGA cBioPortalRPS6
AceView (NCBI)RPS6
Genatlas (Paris)RPS6
WikiGenes6194
SOURCE (Princeton)RPS6
Genetics Home Reference (NIH)RPS6
Genomic and cartography
GoldenPath hg38 (UCSC)RPS6  -     chr9:19375716-19380236 -  9p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPS6  -     9p22.1   [Description]    (hg19-Feb_2009)
GoldenPathRPS6 - 9p22.1 [CytoView hg19]  RPS6 - 9p22.1 [CytoView hg38]
ImmunoBaseENSG00000137154
genome Data Viewer NCBIRPS6 [Mapview hg19]  
OMIM180460   
Gene and transcription
Genbank (Entrez)AB062123 AK093634 AK291517 AK311861 BC000524
RefSeq transcript (Entrez)NM_001010
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RPS6
Alternative Splicing GalleryENSG00000137154
Gene ExpressionRPS6 [ NCBI-GEO ]   RPS6 [ EBI - ARRAY_EXPRESS ]   RPS6 [ SEEK ]   RPS6 [ MEM ]
Gene Expression Viewer (FireBrowse)RPS6 [ Firebrowse - Broad ]
GenevisibleExpression of RPS6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6194
GTEX Portal (Tissue expression)RPS6
Human Protein AtlasENSG00000137154-RPS6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62753   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62753  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62753
Splice isoforms : SwissVarP62753
PhosPhoSitePlusP62753
Domaine pattern : Prosite (Expaxy)RIBOSOMAL_S6E (PS00578)   
Domains : Interpro (EBI)Ribosomal_S6_euk    Ribosomal_S6e    Ribosomal_S6e_CS   
Domain families : Pfam (Sanger)Ribosomal_S6e (PF01092)   
Domain families : Pfam (NCBI)pfam01092   
Domain families : Smart (EMBL)Ribosomal_S6e (SM01405)  
Conserved Domain (NCBI)RPS6
DMDM Disease mutations6194
Blocks (Seattle)RPS6
PDB (RSDB)4UG0    4V6X    5A2Q    5AJ0    5FLX    5LKS    5OA3    5T2C    5VYC    6EK0    6F4P    6F4Q    6FEC    6G18    6G4S    6G4W    6G51    6G53    6G5H    6G5I    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
PDB Europe4UG0    4V6X    5A2Q    5AJ0    5FLX    5LKS    5OA3    5T2C    5VYC    6EK0    6F4P    6F4Q    6FEC    6G18    6G4S    6G4W    6G51    6G53    6G5H    6G5I    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
PDB (PDBSum)4UG0    4V6X    5A2Q    5AJ0    5FLX    5LKS    5OA3    5T2C    5VYC    6EK0    6F4P    6F4Q    6FEC    6G18    6G4S    6G4W    6G51    6G53    6G5H    6G5I    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
PDB (IMB)4UG0    4V6X    5A2Q    5AJ0    5FLX    5LKS    5OA3    5T2C    5VYC    6EK0    6F4P    6F4Q    6FEC    6G18    6G4S    6G4W    6G51    6G53    6G5H    6G5I    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
Structural Biology KnowledgeBase4UG0    4V6X    5A2Q    5AJ0    5FLX    5LKS    5OA3    5T2C    5VYC    6EK0    6F4P    6F4Q    6FEC    6G18    6G4S    6G4W    6G51    6G53    6G5H    6G5I    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
SCOP (Structural Classification of Proteins)4UG0    4V6X    5A2Q    5AJ0    5FLX    5LKS    5OA3    5T2C    5VYC    6EK0    6F4P    6F4Q    6FEC    6G18    6G4S    6G4W    6G51    6G53    6G5H    6G5I    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
CATH (Classification of proteins structures)4UG0    4V6X    5A2Q    5AJ0    5FLX    5LKS    5OA3    5T2C    5VYC    6EK0    6F4P    6F4Q    6FEC    6G18    6G4S    6G4W    6G51    6G53    6G5H    6G5I    6IP5    6IP6    6IP8    6OLE    6OLF    6OLG    6OLI    6OLZ    6OM0    6OM7    6QZP   
SuperfamilyP62753
Human Protein Atlas [tissue]ENSG00000137154-RPS6 [tissue]
Peptide AtlasP62753
HPRD01592
IPIIPI00021840   IPI00643522   IPI00640929   
Protein Interaction databases
DIP (DOE-UCLA)P62753
IntAct (EBI)P62753
FunCoupENSG00000137154
BioGRIDRPS6
STRING (EMBL)RPS6
ZODIACRPS6
Ontologies - Pathways
QuickGOP62753
Ontology : AmiGOnuclear-transcribed mRNA catabolic process, nonsense-mediated decay  RNA binding  structural constituent of ribosome  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  endoplasmic reticulum  cytosol  cytosol  rRNA processing  rRNA processing  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  small ribosomal subunit  membrane  viral transcription  protein kinase binding  cytosolic small ribosomal subunit  cytosolic small ribosomal subunit  cytosolic small ribosomal subunit  dendrite  TOR signaling  cytoplasmic ribonucleoprotein granule  ribosomal small subunit biogenesis  glucose homeostasis  positive regulation of apoptotic process  cell body  ribonucleoprotein complex  
Ontology : EGO-EBInuclear-transcribed mRNA catabolic process, nonsense-mediated decay  RNA binding  structural constituent of ribosome  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  endoplasmic reticulum  cytosol  cytosol  rRNA processing  rRNA processing  translation  translational initiation  SRP-dependent cotranslational protein targeting to membrane  small ribosomal subunit  membrane  viral transcription  protein kinase binding  cytosolic small ribosomal subunit  cytosolic small ribosomal subunit  cytosolic small ribosomal subunit  dendrite  TOR signaling  cytoplasmic ribonucleoprotein granule  ribosomal small subunit biogenesis  glucose homeostasis  positive regulation of apoptotic process  cell body  ribonucleoprotein complex  
Pathways : KEGGRibosome    HIF-1 signaling pathway    mTOR signaling pathway    PI3K-Akt signaling pathway    Insulin signaling pathway    Proteoglycans in cancer   
NDEx NetworkRPS6
Atlas of Cancer Signalling NetworkRPS6
Wikipedia pathwaysRPS6
Orthology - Evolution
OrthoDB6194
GeneTree (enSembl)ENSG00000137154
Phylogenetic Trees/Animal Genes : TreeFamRPS6
HOGENOMP62753
Homologs : HomoloGeneRPS6
Homology/Alignments : Family Browser (UCSC)RPS6
Gene fusions - Rearrangements
Fusion : MitelmanRPS6/GNB2L1 [9p22.1/5q35.3]  
Fusion : MitelmanRPS6/OAZ1 [9p22.1/19p13.3]  
Fusion PortalRPS6 9p22.1 GNB2L1 5q35.3 PRAD
Fusion PortalRPS6 9p22.1 OAZ1 19p13.3 PRAD
Fusion Cancer (Beijing)CSDE1 [1p13.2]  -  RPS6 [9p22.1]  [FUSC000939]
Fusion Cancer (Beijing)JA040723 [RPS6]  -  9p22.1 [FUSC001175]
Fusion Cancer (Beijing)RNPC3 [1p21.1]  -  RPS6 [9p22.1]  [FUSC001061]  [FUSC001061]  [FUSC001061]  [FUSC001061]  [FUSC001061]  [FUSC001061]
Fusion Cancer (Beijing)RPS6 [9p22.1]  -  MSMB [10q11.23]  [FUSC004556]
Fusion Cancer (Beijing)RPS6 [9p22.1]  -  MTATP6P1 [-]  [FUSC001097]
Fusion : QuiverRPS6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPS6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPS6
dbVarRPS6
ClinVarRPS6
1000_GenomesRPS6 
Exome Variant ServerRPS6
GNOMAD BrowserENSG00000137154
Varsome BrowserRPS6
Genetic variants : HAPMAP6194
Genomic Variants (DGV)RPS6 [DGVbeta]
DECIPHERRPS6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPS6 
Mutations
ICGC Data PortalRPS6 
TCGA Data PortalRPS6 
Broad Tumor PortalRPS6
OASIS PortalRPS6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPS6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRPS6
Mutations and Diseases : HGMDRPS6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPS6
DgiDB (Drug Gene Interaction Database)RPS6
DoCM (Curated mutations)RPS6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPS6 (select a term)
intoGenRPS6
Cancer3DRPS6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180460   
Orphanet
DisGeNETRPS6
MedgenRPS6
Genetic Testing Registry RPS6
NextProtP62753 [Medical]
TSGene6194
GENETestsRPS6
Target ValidationRPS6
Huge Navigator RPS6 [HugePedia]
snp3D : Map Gene to Disease6194
BioCentury BCIQRPS6
ClinGenRPS6
Clinical trials, drugs, therapy
Protein Interactions : CTD6194
Pharm GKB GenePA34844
Clinical trialRPS6
Miscellaneous
canSAR (ICR)RPS6 (select the gene name)
HarmonizomeRPS6
DataMed IndexRPS6
Probes
Litterature
PubMed210 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPS6
EVEXRPS6
GoPubMedRPS6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:34:07 CEST 2020

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