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RPS6KA2 (ribosomal protein S6 kinase A2)

Identity

Alias_namesribosomal protein S6 kinase
Alias_symbol (synonym)RSK
RSK3
HU-2
Other aliasMAPKAPK1C
S6K-alpha
S6K-alpha2
p90-RSK3
p90RSK2
pp90RSK3
HGNC (Hugo) RPS6KA2
LocusID (NCBI) 6196
Atlas_Id 42167
Location 6q27  [Link to chromosome band 6q27]
Location_base_pair Starts at 166409364 and ends at 166627277 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KIF1B (1p36.22) / RPS6KA2 (6q27)MRPL9 (1q21.3) / RPS6KA2 (6q27)RNASET2 (6q27) / RPS6KA2 (6q27)
RPS6KA2 (6q27) / MCHR2 (6q16.2)RPS6KA2 (6q27) / PSMG4 (6p25.2)RPS6KA2 (6q27) / PYGB (20p11.21)
RPS6KA2 (6q27) / RPS6KA2 (6q27)RPS6KA2 (6q27) / TRA ()SFTPB (2p11.2) / RPS6KA2 (6q27)
RPS6KA2 6q27 / MCHR2 6q16.2RPS6KA2 6q27 / PSMG4 6p25.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;6)(p25;q27) RPS6KA2/PSMG4
t(6;6)(q16;q27) RPS6KA2/MCHR2


External links

Nomenclature
HGNC (Hugo)RPS6KA2   10431
Cards
Entrez_Gene (NCBI)RPS6KA2  6196  ribosomal protein S6 kinase A2
AliasesHU-2; MAPKAPK1C; RSK; RSK3; 
S6K-alpha; S6K-alpha2; p90-RSK3; p90RSK2; pp90RSK3
GeneCards (Weizmann)RPS6KA2
Ensembl hg19 (Hinxton)ENSG00000071242 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000071242 [Gene_View]  ENSG00000071242 [Sequence]  chr6:166409364-166627277 [Contig_View]  RPS6KA2 [Vega]
ICGC DataPortalENSG00000071242
TCGA cBioPortalRPS6KA2
AceView (NCBI)RPS6KA2
Genatlas (Paris)RPS6KA2
WikiGenes6196
SOURCE (Princeton)RPS6KA2
Genetics Home Reference (NIH)RPS6KA2
Genomic and cartography
GoldenPath hg38 (UCSC)RPS6KA2  -     chr6:166409364-166627277 -  6q27   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPS6KA2  -     6q27   [Description]    (hg19-Feb_2009)
EnsemblRPS6KA2 - 6q27 [CytoView hg19]  RPS6KA2 - 6q27 [CytoView hg38]
Mapping of homologs : NCBIRPS6KA2 [Mapview hg19]  RPS6KA2 [Mapview hg38]
OMIM601685   
Gene and transcription
Genbank (Entrez)AA588877 AB073884 AB209116 AF140710 AK027727
RefSeq transcript (Entrez)NM_001006932 NM_001318936 NM_001318937 NM_001318938 NM_021135
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RPS6KA2
Cluster EST : UnigeneHs.655277 [ NCBI ]
CGAP (NCI)Hs.655277
Alternative Splicing GalleryENSG00000071242
Gene ExpressionRPS6KA2 [ NCBI-GEO ]   RPS6KA2 [ EBI - ARRAY_EXPRESS ]   RPS6KA2 [ SEEK ]   RPS6KA2 [ MEM ]
Gene Expression Viewer (FireBrowse)RPS6KA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6196
GTEX Portal (Tissue expression)RPS6KA2
Human Protein AtlasENSG00000071242-RPS6KA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15349   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15349  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15349
Splice isoforms : SwissVarQ15349
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ15349
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Ribosomal_S6_kinase_II    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00069    pfam00433   
Domain families : Smart (EMBL)S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)RPS6KA2
DMDM Disease mutations6196
Blocks (Seattle)RPS6KA2
SuperfamilyQ15349
Human Protein Atlas [tissue]ENSG00000071242-RPS6KA2 [tissue]
Peptide AtlasQ15349
HPRD03403
IPIIPI00300321   IPI00478653   IPI00513934   IPI00966051   IPI00967123   IPI00966502   IPI00965760   IPI00966870   IPI00966245   IPI00967630   
Protein Interaction databases
DIP (DOE-UCLA)Q15349
IntAct (EBI)Q15349
FunCoupENSG00000071242
BioGRIDRPS6KA2
STRING (EMBL)RPS6KA2
ZODIACRPS6KA2
Ontologies - Pathways
QuickGOQ15349
Ontology : AmiGOmagnesium ion binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  signal transduction  negative regulation of cell proliferation  kinase activity  intracellular signal transduction  positive regulation of apoptotic process  negative regulation of cell cycle  
Ontology : EGO-EBImagnesium ion binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  signal transduction  negative regulation of cell proliferation  kinase activity  intracellular signal transduction  positive regulation of apoptotic process  negative regulation of cell cycle  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGLong-term potentiation    mTOR signaling pathway    MAPK signaling pathway   
NDEx NetworkRPS6KA2
Atlas of Cancer Signalling NetworkRPS6KA2
Wikipedia pathwaysRPS6KA2
Orthology - Evolution
OrthoDB6196
GeneTree (enSembl)ENSG00000071242
Phylogenetic Trees/Animal Genes : TreeFamRPS6KA2
HOVERGENQ15349
HOGENOMQ15349
Homologs : HomoloGeneRPS6KA2
Homology/Alignments : Family Browser (UCSC)RPS6KA2
Gene fusions - Rearrangements
Fusion : MitelmanRPS6KA2/MCHR2 [6q27/6q16.2]  
Fusion : MitelmanRPS6KA2/PSMG4 [6q27/6p25.2]  [t(6;6)(p25;q27)]  
Fusion PortalRPS6KA2 6q27 MCHR2 6q16.2 LGG
Fusion PortalRPS6KA2 6q27 PSMG4 6p25.2 BRCA
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  RPS6KA2 [6q27]  [FUSC003304]
Fusion : QuiverRPS6KA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPS6KA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPS6KA2
dbVarRPS6KA2
ClinVarRPS6KA2
1000_GenomesRPS6KA2 
Exome Variant ServerRPS6KA2
ExAC (Exome Aggregation Consortium)ENSG00000071242
GNOMAD BrowserENSG00000071242
Genetic variants : HAPMAP6196
Genomic Variants (DGV)RPS6KA2 [DGVbeta]
DECIPHERRPS6KA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPS6KA2 
Mutations
ICGC Data PortalRPS6KA2 
TCGA Data PortalRPS6KA2 
Broad Tumor PortalRPS6KA2
OASIS PortalRPS6KA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPS6KA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRPS6KA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPS6KA2
DgiDB (Drug Gene Interaction Database)RPS6KA2
DoCM (Curated mutations)RPS6KA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPS6KA2 (select a term)
intoGenRPS6KA2
Cancer3DRPS6KA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601685   
Orphanet
DisGeNETRPS6KA2
MedgenRPS6KA2
Genetic Testing Registry RPS6KA2
NextProtQ15349 [Medical]
TSGene6196
GENETestsRPS6KA2
Target ValidationRPS6KA2
Huge Navigator RPS6KA2 [HugePedia]
snp3D : Map Gene to Disease6196
BioCentury BCIQRPS6KA2
ClinGenRPS6KA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6196
Chemical/Pharm GKB GenePA34846
Clinical trialRPS6KA2
Miscellaneous
canSAR (ICR)RPS6KA2 (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPS6KA2
EVEXRPS6KA2
GoPubMedRPS6KA2
iHOPRPS6KA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:47:55 CEST 2018

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