Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RPS6KA3 (ribosomal protein S6 kinase A3)

Identity

Alias (NCBI)CLS
HU-3
ISPK-1
MAPKAPK1B
MRX19
RSK
RSK2
S6K-alpha3
p90-RSK2
pp90RSK2
HGNC (Hugo) RPS6KA3
HGNC Alias symbRSK2
HU-3
HGNC Previous nameMRX19
 CLS
HGNC Previous nameribosomal protein S6 kinase, 90kD, polypeptide 3
LocusID (NCBI) 6197
Atlas_Id 43478
Location Xp22.12  [Link to chromosome band Xp22]
Location_base_pair Starts at 20149911 and ends at 20266909 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTR3 (2q14.1) / RPS6KA3 (Xp22.12)ANXA9 (1q21.3) / RPS6KA3 (Xp22.12)ITGA4 (2q31.3) / RPS6KA3 (Xp22.12)
LOC100505918 (1q24.2) / RPS6KA3 (Xp22.12)PTPRF (1p34.2) / RPS6KA3 (Xp22.12)RPS6KA3 (Xp22.12) / ACTR3 (2q14.1)
RPS6KA3 (Xp22.12) / DDX53 (Xp22.11)RPS6KA3 (Xp22.12) / IRF3 (19q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(X;1)(p22;p34) PTPRF/RPS6KA3
RPS6KA3/DDX53 (Xp22)

External links

Nomenclature
HGNC (Hugo)RPS6KA3   10432
Cards
Entrez_Gene (NCBI)RPS6KA3    ribosomal protein S6 kinase A3
AliasesCLS; HU-3; ISPK-1; MAPKAPK1B; 
MRX19; RSK; RSK2; S6K-alpha3; p90-RSK2; pp90RSK2
GeneCards (Weizmann)RPS6KA3
Ensembl hg19 (Hinxton)ENSG00000177189 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177189 [Gene_View]  ENSG00000177189 [Sequence]  chrX:20149911-20266909 [Contig_View]  RPS6KA3 [Vega]
ICGC DataPortalENSG00000177189
TCGA cBioPortalRPS6KA3
AceView (NCBI)RPS6KA3
Genatlas (Paris)RPS6KA3
SOURCE (Princeton)RPS6KA3
Genetics Home Reference (NIH)RPS6KA3
Genomic and cartography
GoldenPath hg38 (UCSC)RPS6KA3  -     chrX:20149911-20266909 -  Xp22.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPS6KA3  -     Xp22.12   [Description]    (hg19-Feb_2009)
GoldenPathRPS6KA3 - Xp22.12 [CytoView hg19]  RPS6KA3 - Xp22.12 [CytoView hg38]
ImmunoBaseENSG00000177189
genome Data Viewer NCBIRPS6KA3 [Mapview hg19]  
OMIM300075   300844   303600   
Gene and transcription
Genbank (Entrez)AA317826 AA858312 AB102662 AB208933 AK022869
RefSeq transcript (Entrez)NM_004586
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RPS6KA3
Alternative Splicing GalleryENSG00000177189
Gene ExpressionRPS6KA3 [ NCBI-GEO ]   RPS6KA3 [ EBI - ARRAY_EXPRESS ]   RPS6KA3 [ SEEK ]   RPS6KA3 [ MEM ]
Gene Expression Viewer (FireBrowse)RPS6KA3 [ Firebrowse - Broad ]
GenevisibleExpression of RPS6KA3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6197
GTEX Portal (Tissue expression)RPS6KA3
Human Protein AtlasENSG00000177189-RPS6KA3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51812   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51812  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51812
Splice isoforms : SwissVarP51812
PhosPhoSitePlusP51812
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom_sf    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Ribosomal_S6_kinase_II    RPS6KA3_C    RSK_N    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00069    pfam00433   
Domain families : Smart (EMBL)S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)RPS6KA3
Blocks (Seattle)RPS6KA3
PDB (RSDB)4D9T    4D9U    4JG6    4JG7    4JG8    4NUS    4NW5    4NW6    5D9K    5D9L   
PDB Europe4D9T    4D9U    4JG6    4JG7    4JG8    4NUS    4NW5    4NW6    5D9K    5D9L   
PDB (PDBSum)4D9T    4D9U    4JG6    4JG7    4JG8    4NUS    4NW5    4NW6    5D9K    5D9L   
PDB (IMB)4D9T    4D9U    4JG6    4JG7    4JG8    4NUS    4NW5    4NW6    5D9K    5D9L   
Structural Biology KnowledgeBase4D9T    4D9U    4JG6    4JG7    4JG8    4NUS    4NW5    4NW6    5D9K    5D9L   
SCOP (Structural Classification of Proteins)4D9T    4D9U    4JG6    4JG7    4JG8    4NUS    4NW5    4NW6    5D9K    5D9L   
CATH (Classification of proteins structures)4D9T    4D9U    4JG6    4JG7    4JG8    4NUS    4NW5    4NW6    5D9K    5D9L   
SuperfamilyP51812
Human Protein Atlas [tissue]ENSG00000177189-RPS6KA3 [tissue]
Peptide AtlasP51812
HPRD02092
IPIIPI00020898   IPI00641592   IPI01015791   IPI00552941   IPI00930650   
Protein Interaction databases
DIP (DOE-UCLA)P51812
IntAct (EBI)P51812
BioGRIDRPS6KA3
STRING (EMBL)RPS6KA3
ZODIACRPS6KA3
Ontologies - Pathways
QuickGOP51812
Ontology : AmiGOmagnesium ion binding  skeletal system development  toll-like receptor signaling pathway  protein kinase activity  ribosomal protein S6 kinase activity  protein binding  ATP binding  nucleoplasm  cytosol  apoptotic process  cell cycle  signal transduction  central nervous system development  peptidyl-serine phosphorylation  protein kinase binding  positive regulation of cell growth  response to lipopolysaccharide  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of translation in response to stress  regulation of DNA-templated transcription in response to stress  positive regulation of cell differentiation  positive regulation of transcription by RNA polymerase II  
Ontology : EGO-EBImagnesium ion binding  skeletal system development  toll-like receptor signaling pathway  protein kinase activity  ribosomal protein S6 kinase activity  protein binding  ATP binding  nucleoplasm  cytosol  apoptotic process  cell cycle  signal transduction  central nervous system development  peptidyl-serine phosphorylation  protein kinase binding  positive regulation of cell growth  response to lipopolysaccharide  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of translation in response to stress  regulation of DNA-templated transcription in response to stress  positive regulation of cell differentiation  positive regulation of transcription by RNA polymerase II  
Pathways : KEGGMAPK signaling pathway    Oocyte meiosis    mTOR signaling pathway    Long-term potentiation    Neurotrophin signaling pathway    Progesterone-mediated oocyte maturation   
NDEx NetworkRPS6KA3
Atlas of Cancer Signalling NetworkRPS6KA3
Wikipedia pathwaysRPS6KA3
Orthology - Evolution
OrthoDB6197
GeneTree (enSembl)ENSG00000177189
Phylogenetic Trees/Animal Genes : TreeFamRPS6KA3
HOGENOMP51812
Homologs : HomoloGeneRPS6KA3
Homology/Alignments : Family Browser (UCSC)RPS6KA3
Gene fusions - Rearrangements
Fusion : MitelmanPTPRF/RPS6KA3 [1p34.2/Xp22.12]  
Fusion : MitelmanRPS6KA3/DDX53 [Xp22.12/Xp22.11]  
Fusion : QuiverRPS6KA3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPS6KA3 [hg38]
dbVarRPS6KA3
ClinVarRPS6KA3
MonarchRPS6KA3
1000_GenomesRPS6KA3 
Exome Variant ServerRPS6KA3
GNOMAD BrowserENSG00000177189
Varsome BrowserRPS6KA3
Genomic Variants (DGV)RPS6KA3 [DGVbeta]
DECIPHERRPS6KA3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPS6KA3 
Mutations
ICGC Data PortalRPS6KA3 
TCGA Data PortalRPS6KA3 
Broad Tumor PortalRPS6KA3
OASIS PortalRPS6KA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPS6KA3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRPS6KA3
Mutations and Diseases : HGMDRPS6KA3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch RPS6KA3
DgiDB (Drug Gene Interaction Database)RPS6KA3
DoCM (Curated mutations)RPS6KA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPS6KA3 (select a term)
intoGenRPS6KA3
Cancer3DRPS6KA3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300075    300844    303600   
Orphanet240    3256   
DisGeNETRPS6KA3
MedgenRPS6KA3
Genetic Testing Registry RPS6KA3
NextProtP51812 [Medical]
GENETestsRPS6KA3
Target ValidationRPS6KA3
Huge Navigator RPS6KA3 [HugePedia]
ClinGenRPS6KA3 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeRPS6KA3
Protein Interactions : CTD
Pharm GKB GenePA34847
PharosP51812
Clinical trialRPS6KA3
Miscellaneous
canSAR (ICR)RPS6KA3 (select the gene name)
HarmonizomeRPS6KA3
DataMed IndexRPS6KA3
Probes
Litterature
PubMed192 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRPS6KA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:35:47 CET 2021
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