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RPS6KA3 (ribosomal protein S6 kinase A3)

Identity

Other namesCLS
HU-3
ISPK-1
MAPKAPK1B
MRX19
RSK
RSK2
S6K-alpha3
p90-RSK2
pp90RSK2
HGNC (Hugo) RPS6KA3
LocusID (NCBI) 6197
Atlas_Id 43478
Location Xp22.12
Location_base_pair Starts at 20168029 and ends at 20284750 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACTR3 (2q14.1) / RPS6KA3 (Xp22.12)ANXA9 (1q21.3) / RPS6KA3 (Xp22.12)ITGA4 (2q31.3) / RPS6KA3 (Xp22.12)
LOC100505918 (1q24.2) / RPS6KA3 (Xp22.12)PTPRF (1p34.2) / RPS6KA3 (Xp22.12)RPS6KA3 (Xp22.12) / ACTR3 (2q14.1)
RPS6KA3 (Xp22.12) / DDX53 (Xp22.11)RPS6KA3 (Xp22.12) / IRF3 (19q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RPS6KA3   10432
Cards
Entrez_Gene (NCBI)RPS6KA3  6197  ribosomal protein S6 kinase A3
AliasesCLS; HU-3; ISPK-1; MAPKAPK1B; 
MRX19; RSK; RSK2; S6K-alpha3; p90-RSK2; pp90RSK2
GeneCards (Weizmann)RPS6KA3
Ensembl hg19 (Hinxton)ENSG00000177189 [Gene_View]  chrX:20168029-20284750 [Contig_View]  RPS6KA3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000177189 [Gene_View]  chrX:20168029-20284750 [Contig_View]  RPS6KA3 [Vega]
ICGC DataPortalENSG00000177189
TCGA cBioPortalRPS6KA3
AceView (NCBI)RPS6KA3
Genatlas (Paris)RPS6KA3
WikiGenes6197
SOURCE (Princeton)RPS6KA3
Genomic and cartography
GoldenPath hg19 (UCSC)RPS6KA3  -     chrX:20168029-20284750 -  Xp22.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RPS6KA3  -     Xp22.12   [Description]    (hg38-Dec_2013)
EnsemblRPS6KA3 - Xp22.12 [CytoView hg19]  RPS6KA3 - Xp22.12 [CytoView hg38]
Mapping of homologs : NCBIRPS6KA3 [Mapview hg19]  RPS6KA3 [Mapview hg38]
OMIM300075   300844   303600   
Gene and transcription
Genbank (Entrez)AA317826 AA858312 AB102662 AB208933 AK022869
RefSeq transcript (Entrez)NM_004586
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_007488 NT_167197 NW_004929438
Consensus coding sequences : CCDS (NCBI)RPS6KA3
Cluster EST : UnigeneHs.445387 [ NCBI ]
CGAP (NCI)Hs.445387
Alternative Splicing GalleryENSG00000177189
Gene ExpressionRPS6KA3 [ NCBI-GEO ]   RPS6KA3 [ EBI - ARRAY_EXPRESS ]   RPS6KA3 [ SEEK ]   RPS6KA3 [ MEM ]
Gene Expression Viewer (FireBrowse)RPS6KA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6197
GTEX Portal (Tissue expression)RPS6KA3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51812 (Uniprot)
NextProtP51812  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51812
Splice isoforms : SwissVarP51812 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusP51812
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Ribosomal_S6_kinase_II    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00069    pfam00433   
Domain families : Smart (EMBL)S_TK_X (SM00133)  S_TKc (SM00220)  
DMDM Disease mutations6197
Blocks (Seattle)RPS6KA3
PDB (SRS)4D9T    4D9U    4JG6    4JG7    4JG8    4NUS    4NW5    4NW6    5D9K    5D9L   
PDB (PDBSum)4D9T    4D9U    4JG6    4JG7    4JG8    4NUS    4NW5    4NW6    5D9K    5D9L   
PDB (IMB)4D9T    4D9U    4JG6    4JG7    4JG8    4NUS    4NW5    4NW6    5D9K    5D9L   
PDB (RSDB)4D9T    4D9U    4JG6    4JG7    4JG8    4NUS    4NW5    4NW6    5D9K    5D9L   
Structural Biology KnowledgeBase4D9T    4D9U    4JG6    4JG7    4JG8    4NUS    4NW5    4NW6    5D9K    5D9L   
SCOP (Structural Classification of Proteins)4D9T    4D9U    4JG6    4JG7    4JG8    4NUS    4NW5    4NW6    5D9K    5D9L   
CATH (Classification of proteins structures)4D9T    4D9U    4JG6    4JG7    4JG8    4NUS    4NW5    4NW6    5D9K    5D9L   
SuperfamilyP51812
Human Protein AtlasENSG00000177189
Peptide AtlasP51812
HPRD02092
IPIIPI00020898   IPI00641592   IPI01015791   IPI00552941   IPI00930650   
Protein Interaction databases
DIP (DOE-UCLA)P51812
IntAct (EBI)P51812
FunCoupENSG00000177189
BioGRIDRPS6KA3
STRING (EMBL)RPS6KA3
ZODIACRPS6KA3
Ontologies - Pathways
QuickGOP51812
Ontology : AmiGOmagnesium ion binding  skeletal system development  toll-like receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  cell cycle  signal transduction  central nervous system development  kinase activity  protein kinase binding  positive regulation of cell growth  response to lipopolysaccharide  intracellular signal transduction  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of translation in response to stress  regulation of DNA-templated transcription in response to stress  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBImagnesium ion binding  skeletal system development  toll-like receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  cell cycle  signal transduction  central nervous system development  kinase activity  protein kinase binding  positive regulation of cell growth  response to lipopolysaccharide  intracellular signal transduction  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of translation in response to stress  regulation of DNA-templated transcription in response to stress  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  
Pathways : BIOCARTASignaling Pathway from G-Protein Families [Genes]    MAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Oocyte meiosis    mTOR signaling pathway    Long-term potentiation    Neurotrophin signaling pathway    Progesterone-mediated oocyte maturation   
NDEx Network
Atlas of Cancer Signalling NetworkRPS6KA3
Wikipedia pathwaysRPS6KA3
Orthology - Evolution
OrthoDB6197
GeneTree (enSembl)ENSG00000177189
Phylogenetic Trees/Animal Genes : TreeFamRPS6KA3
Homologs : HomoloGeneRPS6KA3
Homology/Alignments : Family Browser (UCSC)RPS6KA3
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerRPS6KA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPS6KA3
dbVarRPS6KA3
ClinVarRPS6KA3
1000_GenomesRPS6KA3 
Exome Variant ServerRPS6KA3
ExAC (Exome Aggregation Consortium)RPS6KA3 (select the gene name)
Genetic variants : HAPMAP6197
Genomic Variants (DGV)RPS6KA3 [DGVbeta]
Mutations
ICGC Data PortalRPS6KA3 
TCGA Data PortalRPS6KA3 
Broad Tumor PortalRPS6KA3
OASIS PortalRPS6KA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPS6KA3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch RPS6KA3
DgiDB (Drug Gene Interaction Database)RPS6KA3
DoCM (Curated mutations)RPS6KA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPS6KA3 (select a term)
intoGenRPS6KA3
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)X:20168029-20284750  ENSG00000177189
CONAN: Copy Number AnalysisRPS6KA3 
Mutations and Diseases : HGMDRPS6KA3
OMIM300075    300844    303600   
MedgenRPS6KA3
Genetic Testing Registry RPS6KA3
NextProtP51812 [Medical]
TSGene6197
GENETestsRPS6KA3
Huge Navigator RPS6KA3 [HugePedia]
snp3D : Map Gene to Disease6197
BioCentury BCIQRPS6KA3
ClinGenRPS6KA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6197
Chemical/Pharm GKB GenePA34847
Clinical trialRPS6KA3
Miscellaneous
canSAR (ICR)RPS6KA3 (select the gene name)
Probes
Litterature
PubMed147 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPS6KA3
EVEXRPS6KA3
GoPubMedRPS6KA3
iHOPRPS6KA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:19:34 CEST 2016

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