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RPS6KA3 (ribosomal protein S6 kinase, 90kDa, polypeptide 3)

Identity

Other namesCLS
HU-3
ISPK-1
MAPKAPK1B
MRX19
RSK
RSK2
S6K-alpha3
p90-RSK2
pp90RSK2
HGNC (Hugo) RPS6KA3
LocusID (NCBI) 6197
Location Xp22.12
Location_base_pair Starts at 20168029 and ends at 20284750 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RPS6KA3   10432
Cards
Entrez_Gene (NCBI)RPS6KA3  6197  ribosomal protein S6 kinase, 90kDa, polypeptide 3
GeneCards (Weizmann)RPS6KA3
Ensembl (Hinxton)ENSG00000177189 [Gene_View]  chrX:20168029-20284750 [Contig_View]  RPS6KA3 [Vega]
AceView (NCBI)RPS6KA3
Genatlas (Paris)RPS6KA3
WikiGenes6197
SOURCE (Princeton)NM_004586
Genomic and cartography
GoldenPath (UCSC)RPS6KA3  -  Xp22.12   chrX:20168029-20284750 -  Xp22.12   [Description]    (hg19-Feb_2009)
EnsemblRPS6KA3 - Xp22.12 [CytoView]
Mapping of homologs : NCBIRPS6KA3 [Mapview]
OMIM300075   300844   303600   
Gene and transcription
Genbank (Entrez)AA317826 AA858312 AB102662 AB208933 AK022869
RefSeq transcript (Entrez)NM_004586
RefSeq genomic (Entrez)AC_000155 NC_000023 NC_018934 NG_007488 NT_167197 NW_001842360 NW_004929438
Consensus coding sequences : CCDS (NCBI)RPS6KA3
Cluster EST : UnigeneHs.445387 [ NCBI ]
CGAP (NCI)Hs.445387
Alternative Splicing : Fast-db (Paris)GSHG0032011
Alternative Splicing GalleryENSG00000177189
Gene ExpressionRPS6KA3 [ NCBI-GEO ]     RPS6KA3 [ SEEK ]   RPS6KA3 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51812 (Uniprot)
NextProtP51812  [Medical]
With graphics : InterProP51812
Splice isoforms : SwissVarP51812 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Ribosomal_S6_kinase_II    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Related proteins : CluSTrP51812
Domain families : Pfam (Sanger)Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00069    pfam00433   
Domain families : Smart (EMBL)S_TK_X (SM00133)  S_TKc (SM00220)  
DMDM Disease mutations6197
Blocks (Seattle)P51812
PDB (SRS)4D9T    4D9U    4JG6    4JG7    4JG8   
PDB (PDBSum)4D9T    4D9U    4JG6    4JG7    4JG8   
PDB (IMB)4D9T    4D9U    4JG6    4JG7    4JG8   
PDB (RSDB)4D9T    4D9U    4JG6    4JG7    4JG8   
Human Protein AtlasENSG00000177189
Peptide AtlasP51812
HPRD02092
IPIIPI00020898   IPI00641592   IPI01015791   IPI00552941   IPI00930650   
Protein Interaction databases
DIP (DOE-UCLA)P51812
IntAct (EBI)P51812
FunCoupENSG00000177189
BioGRIDRPS6KA3
InParanoidP51812
Interologous Interaction database P51812
IntegromeDBRPS6KA3
STRING (EMBL)RPS6KA3
Ontologies - Pathways
Ontology : AmiGOmagnesium ion binding  skeletal system development  toll-like receptor signaling pathway  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  ATP binding  nucleoplasm  cytosol  cell cycle  signal transduction  synaptic transmission  axon guidance  central nervous system development  protein kinase binding  positive regulation of cell growth  response to lipopolysaccharide  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of translation in response to stress  regulation of DNA-dependent transcription in response to stress  innate immune response  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  neurotrophin TRK receptor signaling pathway  stress-activated MAPK cascade  
Ontology : EGO-EBImagnesium ion binding  skeletal system development  toll-like receptor signaling pathway  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  ATP binding  nucleoplasm  cytosol  cell cycle  signal transduction  synaptic transmission  axon guidance  central nervous system development  protein kinase binding  positive regulation of cell growth  response to lipopolysaccharide  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  regulation of translation in response to stress  regulation of DNA-dependent transcription in response to stress  innate immune response  positive regulation of cell differentiation  positive regulation of transcription from RNA polymerase II promoter  neurotrophin TRK receptor signaling pathway  stress-activated MAPK cascade  
Pathways : BIOCARTASignaling Pathway from G-Protein Families [Genes]    MAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Oocyte meiosis    mTOR signaling pathway    Long-term potentiation    Neurotrophin signaling pathway    Progesterone-mediated oocyte maturation   
REACTOMERPS6KA3
Protein Interaction DatabaseRPS6KA3
Wikipedia pathwaysRPS6KA3
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)RPS6KA3
SNP (GeneSNP Utah)RPS6KA3
SNP : HGBaseRPS6KA3
Genetic variants : HAPMAPRPS6KA3
1000_GenomesRPS6KA3 
ICGC programENSG00000177189 
Somatic Mutations in Cancer : COSMICRPS6KA3 
CONAN: Copy Number AnalysisRPS6KA3 
Mutations and Diseases : HGMDRPS6KA3
OMIM300075    300844    303600   
GENETestsRPS6KA3
Disease Genetic AssociationRPS6KA3
Huge Navigator RPS6KA3 [HugePedia]  RPS6KA3 [HugeCancerGEM]
Genomic VariantsRPS6KA3  RPS6KA3 [DGVbeta]
Exome VariantRPS6KA3
dbVarRPS6KA3
ClinVarRPS6KA3
snp3D : Map Gene to Disease6197
General knowledge
Homologs : HomoloGeneRPS6KA3
Homology/Alignments : Family Browser (UCSC)RPS6KA3
Phylogenetic Trees/Animal Genes : TreeFamRPS6KA3
Chemical/Protein Interactions : CTD6197
Chemical/Pharm GKB GenePA34847
Clinical trialRPS6KA3
Cancer Resource (Charite)ENSG00000177189
Other databases
Probes
Litterature
PubMed129 Pubmed reference(s) in Entrez
CoreMineRPS6KA3
iHOPRPS6KA3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Mar 31 09:15:14 CEST 2014

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