Identity
HGNC
LOCATION
Xp22.12
LOCUSID
ALIAS
CLS,HU-3,ISPK-1,MAPKAPK1B,MRX19,RSK,RSK2,S6K-alpha3,p90-RSK2,pp90RSK2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6197
MIM: 300075
HGNC: 10432
Ensembl: ENSG00000177189
Variants:
dbSNP: 6197
ClinVar: 6197
TCGA: ENSG00000177189
COSMIC: RPS6KA3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37149146 | 2023 | The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling. | 3 |
| 37201672 | 2023 | RSK2 inactivation cooperates with AXIN1 inactivation or β-catenin activation to promote hepatocarcinogenesis. | 1 |
| 37285335 | 2023 | A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction. | 2 |
| 37149146 | 2023 | The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling. | 3 |
| 37201672 | 2023 | RSK2 inactivation cooperates with AXIN1 inactivation or β-catenin activation to promote hepatocarcinogenesis. | 1 |
| 37285335 | 2023 | A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction. | 2 |
| 35078976 | 2022 | A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host. | 8 |
| 35888677 | 2022 | Coffin-Lowry Syndrome Induced by RPS6KA3 Gene Variation in China: A Case Report in Twins. | 1 |
| 35078976 | 2022 | A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host. | 8 |
| 35888677 | 2022 | Coffin-Lowry Syndrome Induced by RPS6KA3 Gene Variation in China: A Case Report in Twins. | 1 |
| 32918955 | 2021 | RSK2-inactivating mutations potentiate MAPK signaling and support cholesterol metabolism in hepatocellular carcinoma. | 26 |
| 33069758 | 2021 | VGLL1 phosphorylation and activation promotes gastric cancer malignancy via TGF-β/ERK/RSK2 signaling. | 8 |
| 34373588 | 2021 | Activation of RSK2 upregulates SOX8 to promote methotrexate resistance in gestational trophoblastic neoplasia. | 3 |
| 34411141 | 2021 | The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling. | 0 |
| 32918955 | 2021 | RSK2-inactivating mutations potentiate MAPK signaling and support cholesterol metabolism in hepatocellular carcinoma. | 26 |
Citation
Dessen P
RPS6KA3 (ribosomal protein S6 kinase A3)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43478/rps6ka3
