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RPS6KA5 (ribosomal protein S6 kinase A5)

Identity

Alias_namesribosomal protein S6 kinase
Alias_symbol (synonym)MSK1
RLPK
Other aliasMSPK1
HGNC (Hugo) RPS6KA5
LocusID (NCBI) 9252
Atlas_Id 43480
Location 14q32.11  [Link to chromosome band 14q32]
Location_base_pair Starts at 90868122 and ends at 91060649 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
RPS6KA5 (14q32.11) / C14orf132 (14q32.2)RPS6KA5 (14q32.11) / CA5BP1 (Xp22.2)RPS6KA5 (14q32.11) / DDX24 (14q32.12)
RPS6KA5 (14q32.11) / ZBP1 (20q13.31)SOGA1 (20q11.23) / RPS6KA5 (14q32.11)TTC7B (14q32.11) / RPS6KA5 (14q32.11)
KIAA0889 RPS6KA5 14q32.11RPS6KA5 14q32.11 / C14orf132 14q32.2TTC7B 14q32.11 / RPS6KA5 14q32.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RPS6KA5   10434
Cards
Entrez_Gene (NCBI)RPS6KA5  9252  ribosomal protein S6 kinase A5
AliasesMSK1; MSPK1; RLPK
GeneCards (Weizmann)RPS6KA5
Ensembl hg19 (Hinxton)ENSG00000100784 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100784 [Gene_View]  chr14:90868122-91060649 [Contig_View]  RPS6KA5 [Vega]
ICGC DataPortalENSG00000100784
TCGA cBioPortalRPS6KA5
AceView (NCBI)RPS6KA5
Genatlas (Paris)RPS6KA5
WikiGenes9252
SOURCE (Princeton)RPS6KA5
Genetics Home Reference (NIH)RPS6KA5
Genomic and cartography
GoldenPath hg38 (UCSC)RPS6KA5  -     chr14:90868122-91060649 -  14q32.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPS6KA5  -     14q32.11   [Description]    (hg19-Feb_2009)
EnsemblRPS6KA5 - 14q32.11 [CytoView hg19]  RPS6KA5 - 14q32.11 [CytoView hg38]
Mapping of homologs : NCBIRPS6KA5 [Mapview hg19]  RPS6KA5 [Mapview hg38]
OMIM603607   
Gene and transcription
Genbank (Entrez)AF074393 AF080000 AF090421 AK295266 AK309925
RefSeq transcript (Entrez)NM_001322227 NM_001322228 NM_001322229 NM_001322230 NM_001322231 NM_001322232 NM_001322233 NM_001322234 NM_001322235 NM_001322236 NM_001322237 NM_001322238 NM_004755 NM_182398
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RPS6KA5
Cluster EST : UnigeneHs.510225 [ NCBI ]
CGAP (NCI)Hs.510225
Alternative Splicing GalleryENSG00000100784
Gene ExpressionRPS6KA5 [ NCBI-GEO ]   RPS6KA5 [ EBI - ARRAY_EXPRESS ]   RPS6KA5 [ SEEK ]   RPS6KA5 [ MEM ]
Gene Expression Viewer (FireBrowse)RPS6KA5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9252
GTEX Portal (Tissue expression)RPS6KA5
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75582   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75582  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75582
Splice isoforms : SwissVarO75582
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusO75582
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Ribosomal_S6_kinase_II    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00069    pfam00433   
Domain families : Smart (EMBL)S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)RPS6KA5
DMDM Disease mutations9252
Blocks (Seattle)RPS6KA5
PDB (SRS)1VZO    3KN5    3KN6   
PDB (PDBSum)1VZO    3KN5    3KN6   
PDB (IMB)1VZO    3KN5    3KN6   
PDB (RSDB)1VZO    3KN5    3KN6   
Structural Biology KnowledgeBase1VZO    3KN5    3KN6   
SCOP (Structural Classification of Proteins)1VZO    3KN5    3KN6   
CATH (Classification of proteins structures)1VZO    3KN5    3KN6   
SuperfamilyO75582
Human Protein AtlasENSG00000100784
Peptide AtlasO75582
HPRD06789
IPIIPI00335101   IPI01011281   IPI01025430   IPI01025059   IPI01025148   IPI00335248   
Protein Interaction databases
DIP (DOE-UCLA)O75582
IntAct (EBI)O75582
FunCoupENSG00000100784
BioGRIDRPS6KA5
STRING (EMBL)RPS6KA5
ZODIACRPS6KA5
Ontologies - Pathways
QuickGOO75582
Ontology : AmiGOmagnesium ion binding  negative regulation of cytokine production  stimulatory C-type lectin receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  regulation of transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  inflammatory response  epidermal growth factor receptor signaling pathway  axon guidance  histone phosphorylation  histone phosphorylation  positive regulation of CREB transcription factor activity  positive regulation of histone phosphorylation  positive regulation of histone acetylation  intracellular signal transduction  histone H3-S10 phosphorylation  histone H3-S28 phosphorylation  histone H2A-S1 phosphorylation  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of NF-kappaB transcription factor activity  interleukin-1-mediated signaling pathway  
Ontology : EGO-EBImagnesium ion binding  negative regulation of cytokine production  stimulatory C-type lectin receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  regulation of transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  inflammatory response  epidermal growth factor receptor signaling pathway  axon guidance  histone phosphorylation  histone phosphorylation  positive regulation of CREB transcription factor activity  positive regulation of histone phosphorylation  positive regulation of histone acetylation  intracellular signal transduction  histone H3-S10 phosphorylation  histone H3-S28 phosphorylation  histone H2A-S1 phosphorylation  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of NF-kappaB transcription factor activity  interleukin-1-mediated signaling pathway  
Pathways : BIOCARTAp38 MAPK Signaling Pathway [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    MAPKinase Signaling Pathway [Genes]    Transcription factor CREB and its extracellular signals [Genes]   
Pathways : KEGGMAPK signaling pathway    Adrenergic signaling in cardiomyocytes    TNF signaling pathway    Circadian entrainment    Neurotrophin signaling pathway    MicroRNAs in cancer    Bladder cancer   
NDEx NetworkRPS6KA5
Atlas of Cancer Signalling NetworkRPS6KA5
Wikipedia pathwaysRPS6KA5
Orthology - Evolution
OrthoDB9252
GeneTree (enSembl)ENSG00000100784
Phylogenetic Trees/Animal Genes : TreeFamRPS6KA5
HOVERGENO75582
HOGENOMO75582
Homologs : HomoloGeneRPS6KA5
Homology/Alignments : Family Browser (UCSC)RPS6KA5
Gene fusions - Rearrangements
Fusion : MitelmanRPS6KA5/C14orf132 [14q32.11/14q32.2]  
Fusion : MitelmanSOGA1/RPS6KA5 [20q11.23/14q32.11]  [t(14;20)(q32;q11)]  
Fusion : MitelmanTTC7B/RPS6KA5 [14q32.11/14q32.11]  [t(14;14)(q32;q32)]  
Fusion: TCGAKIAA0889 RPS6KA5 14q32.11 BLCA
Fusion: TCGARPS6KA5 14q32.11 C14orf132 14q32.2 BRCA
Fusion: TCGATTC7B 14q32.11 RPS6KA5 14q32.11 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPS6KA5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPS6KA5
dbVarRPS6KA5
ClinVarRPS6KA5
1000_GenomesRPS6KA5 
Exome Variant ServerRPS6KA5
ExAC (Exome Aggregation Consortium)RPS6KA5 (select the gene name)
Genetic variants : HAPMAP9252
Genomic Variants (DGV)RPS6KA5 [DGVbeta]
DECIPHERRPS6KA5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPS6KA5 
Mutations
ICGC Data PortalRPS6KA5 
TCGA Data PortalRPS6KA5 
Broad Tumor PortalRPS6KA5
OASIS PortalRPS6KA5 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDRPS6KA5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPS6KA5
DgiDB (Drug Gene Interaction Database)RPS6KA5
DoCM (Curated mutations)RPS6KA5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPS6KA5 (select a term)
intoGenRPS6KA5
Cancer3DRPS6KA5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603607   
Orphanet
MedgenRPS6KA5
Genetic Testing Registry RPS6KA5
NextProtO75582 [Medical]
TSGene9252
GENETestsRPS6KA5
Target ValidationRPS6KA5
Huge Navigator RPS6KA5 [HugePedia]
snp3D : Map Gene to Disease9252
BioCentury BCIQRPS6KA5
ClinGenRPS6KA5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9252
Chemical/Pharm GKB GenePA34849
Clinical trialRPS6KA5
Miscellaneous
canSAR (ICR)RPS6KA5 (select the gene name)
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPS6KA5
EVEXRPS6KA5
GoPubMedRPS6KA5
iHOPRPS6KA5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 14:06:18 CEST 2017

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