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RPS6KC1 (ribosomal protein S6 kinase C1)

Identity

Alias_namesribosomal protein S6 kinase
Alias_symbol (synonym)humS6PKh1
Other aliasRPK118
RSKL1
S6K-delta-1
S6PKh1
HGNC (Hugo) RPS6KC1
LocusID (NCBI) 26750
Atlas_Id 43482
Location 11q13.2  [Link to chromosome band 11q13]
Location_base_pair Starts at 213051233 and ends at 213274774 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARID4B (1q42.3) / RPS6KC1 (1q32.3)HDDC2 (6q22.31) / RPS6KC1 (1q32.3)NEK1 (4q33) / RPS6KC1 (1q32.3)
PIP4K2A (10p12.2) / RPS6KC1 (1q32.3)RCOR3 (1q32.2) / RPS6KC1 (1q32.3)RPS6KC1 (1q32.3) / C1orf101 (1q44)
RPS6KC1 (1q32.3) / CD34 (1q32.2)RPS6KC1 (1q32.3) / FLVCR1 (1q32.3)RPS6KC1 (1q32.3) / KCNH1 (1q32.2)
RPS6KC1 (1q32.3) / LYST (1q42.3)RPS6KC1 (1q32.3) / PAX8 (2q13)RPS6KC1 (1q32.3) / SDCCAG8 (1q43)
RPS6KC1 (1q32.3) / TFPI (2q32.1)RCOR3 1q32.2 / RPS6KC1 1q32.3RPS6KC1 1q32.3 / C1orf101 1q44
RPS6KC1 1q32.3 / CD34 1q32.2RPS6KC1 1q32.3 / LYST 1q42.3RPS6KC1 1q32.3 / SDCCAG8 1q43
RPS6KC1 1q32.3 / TFPI 2q32.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  inv(1)(q32q42) ARID4B/RPS6KC1


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  RCOR3/RPS6KC1 (1q32)
RPS6KC1/CD34 (1q32)
t(1;1)(q32;q42) RPS6KC1/LYST
t(1;1)(q32;q43) RPS6KC1/SDCCAG8
t(1;2)(q32;q32) RPS6KC1/TFPI


External links

Nomenclature
HGNC (Hugo)RPS6KC1   10439
Cards
Entrez_Gene (NCBI)RPS6KC1  26750  ribosomal protein S6 kinase C1
AliasesRPK118; RSKL1; S6K-delta-1; S6PKh1; 
humS6PKh1
GeneCards (Weizmann)RPS6KC1
Ensembl hg19 (Hinxton)ENSG00000136643 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136643 [Gene_View]  ENSG00000136643 [Sequence]  chr1:213051233-213274774 [Contig_View]  RPS6KC1 [Vega]
ICGC DataPortalENSG00000136643
TCGA cBioPortalRPS6KC1
AceView (NCBI)RPS6KC1
Genatlas (Paris)RPS6KC1
WikiGenes26750
SOURCE (Princeton)RPS6KC1
Genetics Home Reference (NIH)RPS6KC1
Genomic and cartography
GoldenPath hg38 (UCSC)RPS6KC1  -     chr1:213051233-213274774 +  11q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPS6KC1  -     11q13.2   [Description]    (hg19-Feb_2009)
EnsemblRPS6KC1 - 11q13.2 [CytoView hg19]  RPS6KC1 - 11q13.2 [CytoView hg38]
Mapping of homologs : NCBIRPS6KC1 [Mapview hg19]  RPS6KC1 [Mapview hg38]
OMIM617517   
Gene and transcription
Genbank (Entrez)AB070706 AF037447 AF477978 AK122921 AK122989
RefSeq transcript (Entrez)NM_001136138 NM_001287218 NM_001287219 NM_001287220 NM_001287221 NM_001349646 NM_001349647 NM_001349648 NM_001349649 NM_001349650 NM_001349651 NM_001349652 NM_001349653 NM_001349654 NM_001349657 NM_001349658 NM_001349659 NM_001349660 NM_001349661 NM_001349662 NM_001349663 NM_001349664 NM_001349665 NM_001349666 NM_001349667 NM_001349668 NM_001349669 NM_001349670 NM_001349671 NM_001349672 NM_012424
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RPS6KC1
Cluster EST : UnigeneHs.591416 [ NCBI ]
CGAP (NCI)Hs.591416
Alternative Splicing GalleryENSG00000136643
Gene ExpressionRPS6KC1 [ NCBI-GEO ]   RPS6KC1 [ EBI - ARRAY_EXPRESS ]   RPS6KC1 [ SEEK ]   RPS6KC1 [ MEM ]
Gene Expression Viewer (FireBrowse)RPS6KC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26750
GTEX Portal (Tissue expression)RPS6KC1
Human Protein AtlasENSG00000136643-RPS6KC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96S38   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96S38  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96S38
Splice isoforms : SwissVarQ96S38
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ96S38
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PX (PS50195)   
Domains : Interpro (EBI)Kinase-like_dom_sf    MIT    MIT_dom_sf    Phox    Prot_kinase_dom    PX_dom_sf    S6K-delta-1    STK_RPK118-like   
Domain families : Pfam (Sanger)MIT (PF04212)    Pkinase (PF00069)    PX (PF00787)   
Domain families : Pfam (NCBI)pfam04212    pfam00069    pfam00787   
Domain families : Smart (EMBL)MIT (SM00745)  PX (SM00312)  S_TKc (SM00220)  
Conserved Domain (NCBI)RPS6KC1
DMDM Disease mutations26750
Blocks (Seattle)RPS6KC1
SuperfamilyQ96S38
Human Protein Atlas [tissue]ENSG00000136643-RPS6KC1 [tissue]
Peptide AtlasQ96S38
HPRD10204
IPIIPI00291351   IPI01014568   IPI01014902   IPI00644021   
Protein Interaction databases
DIP (DOE-UCLA)Q96S38
IntAct (EBI)Q96S38
FunCoupENSG00000136643
BioGRIDRPS6KC1
STRING (EMBL)RPS6KC1
ZODIACRPS6KC1
Ontologies - Pathways
QuickGOQ96S38
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  early endosome  protein phosphorylation  signal transduction  membrane  phosphatidylinositol binding  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  early endosome  protein phosphorylation  signal transduction  membrane  phosphatidylinositol binding  
NDEx NetworkRPS6KC1
Atlas of Cancer Signalling NetworkRPS6KC1
Wikipedia pathwaysRPS6KC1
Orthology - Evolution
OrthoDB26750
GeneTree (enSembl)ENSG00000136643
Phylogenetic Trees/Animal Genes : TreeFamRPS6KC1
HOVERGENQ96S38
HOGENOMQ96S38
Homologs : HomoloGeneRPS6KC1
Homology/Alignments : Family Browser (UCSC)RPS6KC1
Gene fusions - Rearrangements
Fusion : MitelmanARID4B/RPS6KC1 [1q42.3/1q32.3]  [inv(1)(q32q42)]  
Fusion : MitelmanRCOR3/RPS6KC1 [1q32.2/1q32.3]  [t(1;1)(q32;q32)]  
Fusion : MitelmanRPS6KC1/C1orf101 [1q32.3/1q44]  [t(1;1)(q32;q44)]  
Fusion : MitelmanRPS6KC1/CD34 [1q32.3/1q32.2]  [t(1;1)(q32;q32)]  
Fusion : MitelmanRPS6KC1/LYST [1q32.3/1q42.3]  [t(1;1)(q32;q42)]  
Fusion : MitelmanRPS6KC1/SDCCAG8 [1q32.3/1q43]  [t(1;1)(q32;q43)]  
Fusion : MitelmanRPS6KC1/TFPI [1q32.3/2q32.1]  [t(1;2)(q32;q32)]  
Fusion PortalRCOR3 1q32.2 RPS6KC1 1q32.3 PRAD
Fusion PortalRPS6KC1 1q32.3 C1orf101 1q44 BRCA
Fusion PortalRPS6KC1 1q32.3 CD34 1q32.2 LUAD
Fusion PortalRPS6KC1 1q32.3 LYST 1q42.3 GBM
Fusion PortalRPS6KC1 1q32.3 SDCCAG8 1q43 LUAD
Fusion PortalRPS6KC1 1q32.3 TFPI 2q32.1 LUAD
Fusion : QuiverRPS6KC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPS6KC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPS6KC1
dbVarRPS6KC1
ClinVarRPS6KC1
1000_GenomesRPS6KC1 
Exome Variant ServerRPS6KC1
ExAC (Exome Aggregation Consortium)ENSG00000136643
GNOMAD BrowserENSG00000136643
Varsome BrowserRPS6KC1
Genetic variants : HAPMAP26750
Genomic Variants (DGV)RPS6KC1 [DGVbeta]
DECIPHERRPS6KC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPS6KC1 
Mutations
ICGC Data PortalRPS6KC1 
TCGA Data PortalRPS6KC1 
Broad Tumor PortalRPS6KC1
OASIS PortalRPS6KC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPS6KC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRPS6KC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPS6KC1
DgiDB (Drug Gene Interaction Database)RPS6KC1
DoCM (Curated mutations)RPS6KC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPS6KC1 (select a term)
intoGenRPS6KC1
Cancer3DRPS6KC1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617517   
Orphanet
DisGeNETRPS6KC1
MedgenRPS6KC1
Genetic Testing Registry RPS6KC1
NextProtQ96S38 [Medical]
TSGene26750
GENETestsRPS6KC1
Target ValidationRPS6KC1
Huge Navigator RPS6KC1 [HugePedia]
snp3D : Map Gene to Disease26750
BioCentury BCIQRPS6KC1
ClinGenRPS6KC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26750
Chemical/Pharm GKB GenePA34854
Clinical trialRPS6KC1
Miscellaneous
canSAR (ICR)RPS6KC1 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPS6KC1
EVEXRPS6KC1
GoPubMedRPS6KC1
iHOPRPS6KC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Aug 16 11:29:30 CEST 2018

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