RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator)

2003-02-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
RAD,RAD1,REM3

Other Information

Locus ID:

NCBI: 6236
MIM: 179503
HGNC: 10446
Ensembl: ENSG00000166592

Variants:

dbSNP: 6236
ClinVar: 6236
TCGA: ENSG00000166592
COSMIC: RRAD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166592ENST00000299759P55042
ENSG00000166592ENST00000299759A0A024R6X0
ENSG00000166592ENST00000420652P55042
ENSG00000166592ENST00000420652A0A024R6X0
ENSG00000166592ENST00000566577J3KSM6
ENSG00000166592ENST00000568915J3KRG9

Expression (GTEx)

0
50
100
150
200
250
300
350

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
175253702007Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart.34
180565282007Rad GTPase deficiency leads to cardiac hypertrophy.30
251140382014Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD.30
200794272010Oxidative stress in skeletal muscle stimulates early expression of Rad in a mouse model of amyotrophic lateral sclerosis.23
176729182007Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.17
224877792012Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma.17
171950882007Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers.16
258933812015RRAD inhibits the Warburg effect through negative regulation of the NF-κB signaling.14
253130112014RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant glioblastoma.13
246485192014Ras-induced epigenetic inactivation of the RRAD (Ras-related associated with diabetes) gene promotes glucose uptake in a human ovarian cancer model.11

Citation

Dessen P

RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/277/rrad