RRAGA (Ras related GTP binding A)

2014-11-01  

Identity

HGNC
LOCATION
9p22.1
LOCUSID
ALIAS
FIP-1,FIP1,RAGA
FUSION GENES

Other Information

Locus ID:

NCBI: 10670
MIM: 612194
HGNC: 16963
Ensembl: ENSG00000155876

Variants:

dbSNP: 10670
ClinVar: 10670
TCGA: ENSG00000155876
COSMIC: RRAGA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155876ENST00000380527Q7L523

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
mTOR signaling pathwayKEGGko04150
Autophagy - animalKEGGhsa04140
mTOR signaling pathwayKEGGhsa04150
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
PI3K CascadeREACTOMER-HSA-109704
PKB-mediated eventsREACTOMER-HSA-109703
mTOR signallingREACTOMER-HSA-165159
mTORC1-mediated signallingREACTOMER-HSA-166208
Energy dependent regulation of mTOR by LKB1-AMPKREACTOMER-HSA-380972
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Protein ubiquitinationREACTOMER-HSA-8852135
E3 ubiquitin ligases ubiquitinate target proteinsREACTOMER-HSA-8866654

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
259368022015The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation.44
260511792015Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1.31
291075382017Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.22
295900902018Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.17
290563222017Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.16
316017082019Structural basis for the docking of mTORC1 on the lysosomal surface.9
272942652016Mutations of RagA GTPase in mTORC1 Pathway Are Associated with Autosomal Dominant Cataracts.6
306513522019Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.5
316017642019Architecture of human Rag GTPase heterodimers and their complex with mTORC1.5
262276142015DYNLT (Tctex-1) forms a tripartite complex with dynein intermediate chain and RagA, hence linking this small GTPase to the dynein motor.3

Citation

Dessen P

RRAGA (Ras related GTP binding A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72885/rraga