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RRAS2 (related RAS viral (r-ras) oncogene homolog 2)

Identity

Alias_symbol (synonym)TC21
HGNC (Hugo) RRAS2
LocusID (NCBI) 22800
Atlas_Id 42173
Location 11p15.2  [Link to chromosome band 11p15]
Location_base_pair Starts at 14299466 and ends at 14380073 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RRAS2 (11p15.2) / COPB1 (11p15.2)RRAS2 (11p15.2) / FHIT (3p14.2)RRAS2 (11p15.2) / PSMA1 (11p15.2)
RRAS2 11p15.2 / FHIT 3p14.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RRAS2   17271
Cards
Entrez_Gene (NCBI)RRAS2  22800  related RAS viral (r-ras) oncogene homolog 2
AliasesTC21
GeneCards (Weizmann)RRAS2
Ensembl hg19 (Hinxton)ENSG00000133818 [Gene_View]  chr11:14299466-14380073 [Contig_View]  RRAS2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000133818 [Gene_View]  chr11:14299466-14380073 [Contig_View]  RRAS2 [Vega]
ICGC DataPortalENSG00000133818
TCGA cBioPortalRRAS2
AceView (NCBI)RRAS2
Genatlas (Paris)RRAS2
WikiGenes22800
SOURCE (Princeton)RRAS2
Genetics Home Reference (NIH)RRAS2
Genomic and cartography
GoldenPath hg19 (UCSC)RRAS2  -     chr11:14299466-14380073 -  11p15.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RRAS2  -     11p15.2   [Description]    (hg38-Dec_2013)
EnsemblRRAS2 - 11p15.2 [CytoView hg19]  RRAS2 - 11p15.2 [CytoView hg38]
Mapping of homologs : NCBIRRAS2 [Mapview hg19]  RRAS2 [Mapview hg38]
OMIM600098   
Gene and transcription
Genbank (Entrez)AA873016 AF493924 AK299606 AK300103 AK302033
RefSeq transcript (Entrez)NM_001102669 NM_001177314 NM_001177315 NM_012250
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_017058 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)RRAS2
Cluster EST : UnigeneHs.712835 [ NCBI ]
CGAP (NCI)Hs.712835
Alternative Splicing GalleryENSG00000133818
Gene ExpressionRRAS2 [ NCBI-GEO ]   RRAS2 [ EBI - ARRAY_EXPRESS ]   RRAS2 [ SEEK ]   RRAS2 [ MEM ]
Gene Expression Viewer (FireBrowse)RRAS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22800
GTEX Portal (Tissue expression)RRAS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62070   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62070  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62070
Splice isoforms : SwissVarP62070
PhosPhoSitePlusP62070
Domaine pattern : Prosite (Expaxy)RAS (PS51421)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase    Small_GTPase_Ras   
Domain families : Pfam (Sanger)Ras (PF00071)   
Domain families : Pfam (NCBI)pfam00071   
Domain families : Smart (EMBL)RAS (SM00173)  
Conserved Domain (NCBI)RRAS2
DMDM Disease mutations22800
Blocks (Seattle)RRAS2
PDB (SRS)2ERY   
PDB (PDBSum)2ERY   
PDB (IMB)2ERY   
PDB (RSDB)2ERY   
Structural Biology KnowledgeBase2ERY   
SCOP (Structural Classification of Proteins)2ERY   
CATH (Classification of proteins structures)2ERY   
SuperfamilyP62070
Human Protein AtlasENSG00000133818
Peptide AtlasP62070
HPRD02518
IPIIPI01011983   IPI00012512   IPI00956295   IPI00856004   IPI00983298   IPI00982471   IPI00985118   IPI00981826   
Protein Interaction databases
DIP (DOE-UCLA)P62070
IntAct (EBI)P62070
FunCoupENSG00000133818
BioGRIDRRAS2
STRING (EMBL)RRAS2
ZODIACRRAS2
Ontologies - Pathways
QuickGOP62070
Ontology : AmiGOosteoblast differentiation  GTPase activity  protein binding  GTP binding  endoplasmic reticulum  plasma membrane  focal adhesion  intracellular protein transport  nucleocytoplasmic transport  Ras protein signal transduction  metabolic process  membrane  positive regulation of cell migration  extracellular exosome  regulation of neuron death  
Ontology : EGO-EBIosteoblast differentiation  GTPase activity  protein binding  GTP binding  endoplasmic reticulum  plasma membrane  focal adhesion  intracellular protein transport  nucleocytoplasmic transport  Ras protein signal transduction  metabolic process  membrane  positive regulation of cell migration  extracellular exosome  regulation of neuron death  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Tight junction    Regulation of actin cytoskeleton    HTLV-I infection    Proteoglycans in cancer   
NDEx NetworkRRAS2
Atlas of Cancer Signalling NetworkRRAS2
Wikipedia pathwaysRRAS2
Orthology - Evolution
OrthoDB22800
GeneTree (enSembl)ENSG00000133818
Phylogenetic Trees/Animal Genes : TreeFamRRAS2
HOVERGENP62070
HOGENOMP62070
Homologs : HomoloGeneRRAS2
Homology/Alignments : Family Browser (UCSC)RRAS2
Gene fusions - Rearrangements
Fusion : MitelmanRRAS2/FHIT [11p15.2/3p14.2]  
Fusion: TCGARRAS2 11p15.2 FHIT 3p14.2 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRRAS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RRAS2
dbVarRRAS2
ClinVarRRAS2
1000_GenomesRRAS2 
Exome Variant ServerRRAS2
ExAC (Exome Aggregation Consortium)RRAS2 (select the gene name)
Genetic variants : HAPMAP22800
Genomic Variants (DGV)RRAS2 [DGVbeta]
DECIPHER (Syndromes)11:14299466-14380073  ENSG00000133818
CONAN: Copy Number AnalysisRRAS2 
Mutations
ICGC Data PortalRRAS2 
TCGA Data PortalRRAS2 
Broad Tumor PortalRRAS2
OASIS PortalRRAS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRRAS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRRAS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RRAS2
DgiDB (Drug Gene Interaction Database)RRAS2
DoCM (Curated mutations)RRAS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RRAS2 (select a term)
intoGenRRAS2
Cancer3DRRAS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600098   
Orphanet
MedgenRRAS2
Genetic Testing Registry RRAS2
NextProtP62070 [Medical]
TSGene22800
GENETestsRRAS2
Huge Navigator RRAS2 [HugePedia]
snp3D : Map Gene to Disease22800
BioCentury BCIQRRAS2
ClinGenRRAS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22800
Chemical/Pharm GKB GenePA34862
Clinical trialRRAS2
Miscellaneous
canSAR (ICR)RRAS2 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRRAS2
EVEXRRAS2
GoPubMedRRAS2
iHOPRRAS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:50:25 CET 2016

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