RRBP1 (ribosome binding protein 1)

2009-08-01  

Identity

HGNC
LOCATION
20p12.1
LOCUSID
ALIAS
ES/130,ES130,RRp,hES,p180
FUSION GENES

Other Information

Locus ID:

NCBI: 6238
MIM: 601418
HGNC: 10448
Ensembl: ENSG00000125844

Variants:

dbSNP: 6238
ClinVar: 6238
TCGA: ENSG00000125844
COSMIC: RRBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125844ENST00000246043Q9P2E9
ENSG00000125844ENST00000360807Q9P2E9
ENSG00000125844ENST00000377807Q9P2E9
ENSG00000125844ENST00000377813Q9P2E9
ENSG00000125844ENST00000398782A2A2S5
ENSG00000125844ENST00000455029F8W7S5
ENSG00000125844ENST00000470422A0A087WU26
ENSG00000125844ENST00000495501V9GY78
ENSG00000125844ENST00000610403A0A087WVV2

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
211112372010Mechanisms determining the morphology of the peripheral ER.167
226793912012p180 promotes the ribosome-independent localization of a subset of mRNA to the endoplasmic reticulum.39
176342872007p180 is involved in the interaction between the endoplasmic reticulum and microtubules through a novel microtubule-binding and bundling domain.27
233184532013Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78.25
151840792004The ribosome receptor, p180, interacts with kinesin heavy chain, KIF5B.20
190371052009Knockdown of p180 eliminates the terminal differentiation of a secretory cell line.20
206473062010Enhancement of procollagen biosynthesis by p180 through augmented ribosome association on the endoplasmic reticulum in response to stimulated secretion.19
261961852015Endoplasmic reticulum ribosome-binding protein 1, RRBP1, promotes progression of colorectal cancer and predicts an unfavourable prognosis.14
194255022009[Colorectal cancer 2D-proteomics: identification of altered protein expression].11
240195142013Identification of a region within the placental alkaline phosphatase mRNA that mediates p180-dependent targeting to the endoplasmic reticulum.9

Citation

Dessen P

RRBP1 (ribosome binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51043/rrbp1