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RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B)

Identity

Alias_namesribonucleotide reductase M2 B (TP53 inducible)
Alias_symbol (synonym)p53R2
Other aliasMTDPS8A
MTDPS8B
P53R2
HGNC (Hugo) RRM2B
LocusID (NCBI) 50484
Atlas_Id 42176
Location 8q22.3  [Link to chromosome band 8q22]
Location_base_pair Starts at 103216729 and ends at 103251059 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ELMO1 (7p14.2) / RRM2B (8q22.3)RRM2B (8q22.3) / ZFPM2 (8q23.1)RRM2B 8q22.3 / ZFPM2 8q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RRM2B   17296
LRG (Locus Reference Genomic)LRG_788
Cards
Entrez_Gene (NCBI)RRM2B  50484  ribonucleotide reductase regulatory TP53 inducible subunit M2B
AliasesMTDPS8A; MTDPS8B; P53R2
GeneCards (Weizmann)RRM2B
Ensembl hg19 (Hinxton)ENSG00000048392 [Gene_View]  chr8:103216729-103251059 [Contig_View]  RRM2B [Vega]
Ensembl hg38 (Hinxton)ENSG00000048392 [Gene_View]  chr8:103216729-103251059 [Contig_View]  RRM2B [Vega]
ICGC DataPortalENSG00000048392
TCGA cBioPortalRRM2B
AceView (NCBI)RRM2B
Genatlas (Paris)RRM2B
WikiGenes50484
SOURCE (Princeton)RRM2B
Genetics Home Reference (NIH)RRM2B
Genomic and cartography
GoldenPath hg19 (UCSC)RRM2B  -     chr8:103216729-103251059 -  8q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RRM2B  -     8q22.3   [Description]    (hg38-Dec_2013)
EnsemblRRM2B - 8q22.3 [CytoView hg19]  RRM2B - 8q22.3 [CytoView hg38]
Mapping of homologs : NCBIRRM2B [Mapview hg19]  RRM2B [Mapview hg38]
OMIM604712   612075   613077   
Gene and transcription
Genbank (Entrez)AB036063 AB163437 AB163438 AB166669 AB166670
RefSeq transcript (Entrez)NM_001172477 NM_001172478 NM_015713
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_016617 NT_008046 NW_004929340
Consensus coding sequences : CCDS (NCBI)RRM2B
Cluster EST : UnigeneHs.512592 [ NCBI ]
CGAP (NCI)Hs.512592
Alternative Splicing GalleryENSG00000048392
Gene ExpressionRRM2B [ NCBI-GEO ]   RRM2B [ EBI - ARRAY_EXPRESS ]   RRM2B [ SEEK ]   RRM2B [ MEM ]
Gene Expression Viewer (FireBrowse)RRM2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)50484
GTEX Portal (Tissue expression)RRM2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7LG56   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7LG56  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7LG56
Splice isoforms : SwissVarQ7LG56
Catalytic activity : Enzyme1.17.4.1 [ Enzyme-Expasy ]   1.17.4.11.17.4.1 [ IntEnz-EBI ]   1.17.4.1 [ BRENDA ]   1.17.4.1 [ KEGG ]   
PhosPhoSitePlusQ7LG56
Domaine pattern : Prosite (Expaxy)RIBORED_SMALL (PS00368)   
Domains : Interpro (EBI)Ferritin-like_SF    RNR-rel    RNR_small    RNR_small_AS   
Domain families : Pfam (Sanger)Ribonuc_red_sm (PF00268)   
Domain families : Pfam (NCBI)pfam00268   
Conserved Domain (NCBI)RRM2B
DMDM Disease mutations50484
Blocks (Seattle)RRM2B
PDB (SRS)2VUX    3HF1    4DJN   
PDB (PDBSum)2VUX    3HF1    4DJN   
PDB (IMB)2VUX    3HF1    4DJN   
PDB (RSDB)2VUX    3HF1    4DJN   
Structural Biology KnowledgeBase2VUX    3HF1    4DJN   
SCOP (Structural Classification of Proteins)2VUX    3HF1    4DJN   
CATH (Classification of proteins structures)2VUX    3HF1    4DJN   
SuperfamilyQ7LG56
Human Protein AtlasENSG00000048392
Peptide AtlasQ7LG56
HPRD05276
IPIIPI00100213   IPI00741117   IPI00438859   IPI00438860   IPI00735900   IPI01013005   IPI00955945   IPI00974429   
Protein Interaction databases
DIP (DOE-UCLA)Q7LG56
IntAct (EBI)Q7LG56
FunCoupENSG00000048392
BioGRIDRRM2B
STRING (EMBL)RRM2B
ZODIACRRM2B
Ontologies - Pathways
QuickGOQ7LG56
Ontology : AmiGOkidney development  renal system process  ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor  protein binding  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  cytosol  ribonucleoside-diphosphate reductase complex  mitochondrial DNA replication  DNA repair  response to oxidative stress  deoxyribonucleoside diphosphate metabolic process  deoxyribonucleoside triphosphate metabolic process  deoxyribonucleotide biosynthetic process  response to amine  nucleobase-containing small molecule interconversion  metal ion binding  oxidation-reduction process  extracellular exosome  negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  
Ontology : EGO-EBIkidney development  renal system process  ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor  protein binding  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  cytosol  ribonucleoside-diphosphate reductase complex  mitochondrial DNA replication  DNA repair  response to oxidative stress  deoxyribonucleoside diphosphate metabolic process  deoxyribonucleoside triphosphate metabolic process  deoxyribonucleotide biosynthetic process  response to amine  nucleobase-containing small molecule interconversion  metal ion binding  oxidation-reduction process  extracellular exosome  negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    Glutathione metabolism    p53 signaling pathway   
NDEx NetworkRRM2B
Atlas of Cancer Signalling NetworkRRM2B
Wikipedia pathwaysRRM2B
Orthology - Evolution
OrthoDB50484
GeneTree (enSembl)ENSG00000048392
Phylogenetic Trees/Animal Genes : TreeFamRRM2B
HOVERGENQ7LG56
HOGENOMQ7LG56
Homologs : HomoloGeneRRM2B
Homology/Alignments : Family Browser (UCSC)RRM2B
Gene fusions - Rearrangements
Fusion : MitelmanRRM2B/ZFPM2 [8q22.3/8q23.1]  
Fusion: TCGARRM2B 8q22.3 ZFPM2 8q23.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRRM2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RRM2B
dbVarRRM2B
ClinVarRRM2B
1000_GenomesRRM2B 
Exome Variant ServerRRM2B
ExAC (Exome Aggregation Consortium)RRM2B (select the gene name)
Genetic variants : HAPMAP50484
Genomic Variants (DGV)RRM2B [DGVbeta]
DECIPHER (Syndromes)8:103216729-103251059  ENSG00000048392
CONAN: Copy Number AnalysisRRM2B 
Mutations
ICGC Data PortalRRM2B 
TCGA Data PortalRRM2B 
Broad Tumor PortalRRM2B
OASIS PortalRRM2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRRM2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRRM2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch RRM2B
DgiDB (Drug Gene Interaction Database)RRM2B
DoCM (Curated mutations)RRM2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RRM2B (select a term)
intoGenRRM2B
Cancer3DRRM2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604712    612075    613077   
Orphanet61    19796    19813    21930    8030   
MedgenRRM2B
Genetic Testing Registry RRM2B
NextProtQ7LG56 [Medical]
TSGene50484
GENETestsRRM2B
Huge Navigator RRM2B [HugePedia]
snp3D : Map Gene to Disease50484
BioCentury BCIQRRM2B
ClinGenRRM2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD50484
Chemical/Pharm GKB GenePA34866
Clinical trialRRM2B
Miscellaneous
canSAR (ICR)RRM2B (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRRM2B
EVEXRRM2B
GoPubMedRRM2B
iHOPRRM2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:18:04 CEST 2017

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