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RRN3 (RRN3 homolog, RNA polymerase I transcription factor)

Identity

Alias_namesRRN3 RNA polymerase I transcription factor homolog (yeast)
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
Alias_symbol (synonym)DKFZp566E104
TIF-IA
Other aliasA-270G1.2
TIFIA
HGNC (Hugo) RRN3
LocusID (NCBI) 54700
Atlas_Id 50094
Location 16p13.11  [Link to chromosome band 16p13]
Location_base_pair Starts at 15060022 and ends at 15094335 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PARN (16p13.12) / RRN3 (16p13.11)PARN 16p13.12 / RRN3 16p13.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RRN3   30346
Cards
Entrez_Gene (NCBI)RRN3  54700  RRN3 homolog, RNA polymerase I transcription factor
AliasesA-270G1.2; TIFIA
GeneCards (Weizmann)RRN3
Ensembl hg19 (Hinxton)ENSG00000085721 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000085721 [Gene_View]  chr16:15060022-15094335 [Contig_View]  RRN3 [Vega]
ICGC DataPortalENSG00000085721
TCGA cBioPortalRRN3
AceView (NCBI)RRN3
Genatlas (Paris)RRN3
WikiGenes54700
SOURCE (Princeton)RRN3
Genetics Home Reference (NIH)RRN3
Genomic and cartography
GoldenPath hg38 (UCSC)RRN3  -     chr16:15060022-15094335 -  16p13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RRN3  -     16p13.11   [Description]    (hg19-Feb_2009)
EnsemblRRN3 - 16p13.11 [CytoView hg19]  RRN3 - 16p13.11 [CytoView hg38]
Mapping of homologs : NCBIRRN3 [Mapview hg19]  RRN3 [Mapview hg38]
OMIM605121   
Gene and transcription
Genbank (Entrez)AF227156 AJ272050 AK225662 AK295486 AK300253
RefSeq transcript (Entrez)NM_001301064 NM_018427
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_187607
Consensus coding sequences : CCDS (NCBI)RRN3
Cluster EST : UnigeneHs.720348 [ NCBI ]
CGAP (NCI)Hs.720348
Alternative Splicing GalleryENSG00000085721
Gene ExpressionRRN3 [ NCBI-GEO ]   RRN3 [ EBI - ARRAY_EXPRESS ]   RRN3 [ SEEK ]   RRN3 [ MEM ]
Gene Expression Viewer (FireBrowse)RRN3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54700
GTEX Portal (Tissue expression)RRN3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYV6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NYV6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NYV6
Splice isoforms : SwissVarQ9NYV6
PhosPhoSitePlusQ9NYV6
Domains : Interpro (EBI)RNA_pol_I_trans_ini_fac_RRN3   
Domain families : Pfam (Sanger)RRN3 (PF05327)   
Domain families : Pfam (NCBI)pfam05327   
Conserved Domain (NCBI)RRN3
DMDM Disease mutations54700
Blocks (Seattle)RRN3
SuperfamilyQ9NYV6
Human Protein AtlasENSG00000085721
Peptide AtlasQ9NYV6
HPRD12004
IPIIPI00152960   IPI00889193   IPI01009215   IPI01010341   IPI00910549   
Protein Interaction databases
DIP (DOE-UCLA)Q9NYV6
IntAct (EBI)Q9NYV6
FunCoupENSG00000085721
BioGRIDRRN3
STRING (EMBL)RRN3
ZODIACRRN3
Ontologies - Pathways
QuickGOQ9NYV6
Ontology : AmiGORNA polymerase I core binding  RNA polymerase I CORE element sequence-specific DNA binding  transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript  transcription factor activity, core RNA polymerase I binding  in utero embryonic development  nucleus  nucleus  nucleoplasm  nucleolus  regulation of transcription from RNA polymerase I promoter  transcription initiation from RNA polymerase I promoter  nucleolus organization  cytoplasm organization  cell proliferation  positive regulation of neuron projection development  ribosome biogenesis  positive regulation of transcription, DNA-templated  homeostasis of number of cells  negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  regulation of DNA-templated transcription, initiation  
Ontology : EGO-EBIRNA polymerase I core binding  RNA polymerase I CORE element sequence-specific DNA binding  transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript  transcription factor activity, core RNA polymerase I binding  in utero embryonic development  nucleus  nucleus  nucleoplasm  nucleolus  regulation of transcription from RNA polymerase I promoter  transcription initiation from RNA polymerase I promoter  nucleolus organization  cytoplasm organization  cell proliferation  positive regulation of neuron projection development  ribosome biogenesis  positive regulation of transcription, DNA-templated  homeostasis of number of cells  negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator  regulation of DNA-templated transcription, initiation  
NDEx NetworkRRN3
Atlas of Cancer Signalling NetworkRRN3
Wikipedia pathwaysRRN3
Orthology - Evolution
OrthoDB54700
GeneTree (enSembl)ENSG00000085721
Phylogenetic Trees/Animal Genes : TreeFamRRN3
HOVERGENQ9NYV6
HOGENOMQ9NYV6
Homologs : HomoloGeneRRN3
Homology/Alignments : Family Browser (UCSC)RRN3
Gene fusions - Rearrangements
Fusion : MitelmanPARN/RRN3 [16p13.12/16p13.11]  [t(16;16)(p13;p13)]  
Fusion: TCGAPARN 16p13.12 RRN3 16p13.11 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRRN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RRN3
dbVarRRN3
ClinVarRRN3
1000_GenomesRRN3 
Exome Variant ServerRRN3
ExAC (Exome Aggregation Consortium)RRN3 (select the gene name)
Genetic variants : HAPMAP54700
Genomic Variants (DGV)RRN3 [DGVbeta]
DECIPHERRRN3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRRN3 
Mutations
ICGC Data PortalRRN3 
TCGA Data PortalRRN3 
Broad Tumor PortalRRN3
OASIS PortalRRN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRRN3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRRN3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RRN3
DgiDB (Drug Gene Interaction Database)RRN3
DoCM (Curated mutations)RRN3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RRN3 (select a term)
intoGenRRN3
Cancer3DRRN3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605121   
Orphanet
MedgenRRN3
Genetic Testing Registry RRN3
NextProtQ9NYV6 [Medical]
TSGene54700
GENETestsRRN3
Huge Navigator RRN3 [HugePedia]
snp3D : Map Gene to Disease54700
BioCentury BCIQRRN3
ClinGenRRN3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54700
Chemical/Pharm GKB GenePA134878601
Clinical trialRRN3
Miscellaneous
canSAR (ICR)RRN3 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRRN3
EVEXRRN3
GoPubMedRRN3
iHOPRRN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:35:46 CEST 2017

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