RRP1B (ribosomal RNA processing 1B)

2008-03-01  

Identity

HGNC
RRP1B
LOCATION
21q22.3
LOCUSID
23076
ALIAS
KIAA0179,NNP1L,Nnp1,PPP1R136,RRP1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23076
MIM: 610654
HGNC: 23818
Ensembl: ENSG00000160208

Variants:

dbSNP: 23076
ClinVar: 23076
TCGA: ENSG00000160208
COSMIC: RRP1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160208ENST00000340648Q14684

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD31327267
PA448499atenololChemicalClinicalAnnotationassociatedPD31327267

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
180814272007Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis.47
180814272007Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis.47
198251792009Distinct inherited metastasis susceptibility exists for different breast cancer subtypes: a prognosis study.30
242604712013BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane.24
197100152009The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.17
209266882010RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits.16
200405992010Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B.11
250929152014Metastasis-associated protein ribosomal RNA processing 1 homolog B (RRP1B) modulates metastasis through regulation of histone methylation.9
263118762015A Nucleolar Protein, Ribosomal RNA Processing 1 Homolog B (RRP1B), Enhances the Recruitment of Cellular mRNA in Influenza Virus Transcription.4

Citation

Dessen P

RRP1B (ribosomal RNA processing 1B)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50041/rrp1b