RSAD2 (radical S-adenosyl methionine domain containing 2)

2014-08-01  

Identity

HGNC
RSAD2
LOCATION
2p25.2
LOCUSID
91543
ALIAS
cig33,cig5,vig1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 91543
MIM: 607810
HGNC: 30908
Ensembl: ENSG00000134321

Variants:

dbSNP: 91543
ClinVar: 91543
TCGA: ENSG00000134321
COSMIC: RSAD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134321ENST00000382040Q8WXG1
ENSG00000134321ENST00000442639C9J674

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
205348632010Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections.175
180057242007The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts.168
180777282008Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus.123
161080592005Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector.92
199201762009The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix.84
215276752011Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity.82
220456692011The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A.75
231601992012Viperin restricts chikungunya virus replication and pathology.68
190744332009The N-terminal amphipathic alpha-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibits protein secretion.56
168493202006Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1.50

Citation

Dessen P

RSAD2 (radical S-adenosyl methionine domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54594/rsad2