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RSAD2 (radical S-adenosyl methionine domain containing 2)

Identity

Alias (NCBI)cig33
cig5
vig1
HGNC (Hugo) RSAD2
HGNC Alias symbcig5
vig1
Viperin
HGNC Alias namevirus-inhibitory protein, endoplasmic reticulum–associated, interferon-inducible
LocusID (NCBI) 91543
Atlas_Id 54594
Location 2p25.2  [Link to chromosome band 2p25]
Location_base_pair Starts at 6877777 and ends at 6898239 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LYZ (12q15) / RSAD2 (2p25.2)RSAD2 (2p25.2) / ELMOD3 (2p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;2)(p11;p25) RSAD2/ELMOD3


External links

 

Nomenclature
HGNC (Hugo)RSAD2   30908
Cards
Entrez_Gene (NCBI)RSAD2    radical S-adenosyl methionine domain containing 2
Aliasescig33; cig5; vig1
GeneCards (Weizmann)RSAD2
Ensembl hg19 (Hinxton)ENSG00000134321 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134321 [Gene_View]  ENSG00000134321 [Sequence]  chr2:6877777-6898239 [Contig_View]  RSAD2 [Vega]
ICGC DataPortalENSG00000134321
TCGA cBioPortalRSAD2
AceView (NCBI)RSAD2
Genatlas (Paris)RSAD2
SOURCE (Princeton)RSAD2
Genetics Home Reference (NIH)RSAD2
Genomic and cartography
GoldenPath hg38 (UCSC)RSAD2  -     chr2:6877777-6898239 +  2p25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RSAD2  -     2p25.2   [Description]    (hg19-Feb_2009)
GoldenPathRSAD2 - 2p25.2 [CytoView hg19]  RSAD2 - 2p25.2 [CytoView hg38]
ImmunoBaseENSG00000134321
Genome Data Viewer NCBIRSAD2 [Mapview hg19]  
OMIM607810   
Gene and transcription
Genbank (Entrez)AF026942 AF442151 AK300085 AK312670 BC017969
RefSeq transcript (Entrez)NM_080657
Consensus coding sequences : CCDS (NCBI)RSAD2
Gene ExpressionRSAD2 [ NCBI-GEO ]   RSAD2 [ EBI - ARRAY_EXPRESS ]   RSAD2 [ SEEK ]   RSAD2 [ MEM ]
Gene Expression Viewer (FireBrowse)RSAD2 [ Firebrowse - Broad ]
GenevisibleExpression of RSAD2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)91543
GTEX Portal (Tissue expression)RSAD2
Human Protein AtlasENSG00000134321-RSAD2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WXG1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WXG1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WXG1
PhosPhoSitePlusQ8WXG1
Domaine pattern : Prosite (Expaxy)RADICAL_SAM (PS51918)   
Domains : Interpro (EBI)Aldolase_TIM    Elp3/MiaB/NifB    rSAM   
Domain families : Pfam (Sanger)Radical_SAM (PF04055)   
Domain families : Pfam (NCBI)pfam04055   
Domain families : Smart (EMBL)Elp3 (SM00729)  
Conserved Domain (NCBI)RSAD2
SuperfamilyQ8WXG1
AlphaFold pdb e-kbQ8WXG1   
Human Protein Atlas [tissue]ENSG00000134321-RSAD2 [tissue]
HPRD07423
Protein Interaction databases
DIP (DOE-UCLA)Q8WXG1
IntAct (EBI)Q8WXG1
BioGRIDRSAD2
STRING (EMBL)RSAD2
ZODIACRSAD2
Ontologies - Pathways
QuickGOQ8WXG1
Ontology : AmiGOfibrillar center  protein binding  mitochondrion  mitochondrion  mitochondrial outer membrane  mitochondrial inner membrane  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  Golgi apparatus  lipid droplet  response to virus  lyase activity  positive regulation of toll-like receptor 7 signaling pathway  positive regulation of toll-like receptor 9 signaling pathway  CD4-positive, alpha-beta T cell activation  CD4-positive, alpha-beta T cell differentiation  protein self-association  negative regulation of viral genome replication  metal ion binding  negative regulation of protein secretion  positive regulation of immune response  4 iron, 4 sulfur cluster binding  4 iron, 4 sulfur cluster binding  defense response to virus  defense response to virus  type I interferon signaling pathway  positive regulation of T-helper 2 cell cytokine production  
Ontology : EGO-EBIfibrillar center  protein binding  mitochondrion  mitochondrion  mitochondrial outer membrane  mitochondrial inner membrane  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  Golgi apparatus  lipid droplet  response to virus  lyase activity  positive regulation of toll-like receptor 7 signaling pathway  positive regulation of toll-like receptor 9 signaling pathway  CD4-positive, alpha-beta T cell activation  CD4-positive, alpha-beta T cell differentiation  protein self-association  negative regulation of viral genome replication  metal ion binding  negative regulation of protein secretion  positive regulation of immune response  4 iron, 4 sulfur cluster binding  4 iron, 4 sulfur cluster binding  defense response to virus  defense response to virus  type I interferon signaling pathway  positive regulation of T-helper 2 cell cytokine production  
Pathways : KEGGInfluenza A   
NDEx NetworkRSAD2
Atlas of Cancer Signalling NetworkRSAD2
Wikipedia pathwaysRSAD2
Orthology - Evolution
OrthoDB91543
GeneTree (enSembl)ENSG00000134321
Phylogenetic Trees/Animal Genes : TreeFamRSAD2
Homologs : HomoloGeneRSAD2
Homology/Alignments : Family Browser (UCSC)RSAD2
Gene fusions - Rearrangements
Fusion : MitelmanRSAD2/ELMOD3 [2p25.2/2p11.2]  
Fusion : QuiverRSAD2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRSAD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RSAD2
dbVarRSAD2
ClinVarRSAD2
MonarchRSAD2
1000_GenomesRSAD2 
Exome Variant ServerRSAD2
GNOMAD BrowserENSG00000134321
Varsome BrowserRSAD2
ACMGRSAD2 variants
VarityQ8WXG1
Genomic Variants (DGV)RSAD2 [DGVbeta]
DECIPHERRSAD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRSAD2 
Mutations
ICGC Data PortalRSAD2 
TCGA Data PortalRSAD2 
Broad Tumor PortalRSAD2
OASIS PortalRSAD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRSAD2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRSAD2
Mutations and Diseases : HGMDRSAD2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRSAD2
DgiDB (Drug Gene Interaction Database)RSAD2
DoCM (Curated mutations)RSAD2
CIViC (Clinical Interpretations of Variants in Cancer)RSAD2
Cancer3DRSAD2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607810   
Orphanet
DisGeNETRSAD2
MedgenRSAD2
Genetic Testing Registry RSAD2
NextProtQ8WXG1 [Medical]
GENETestsRSAD2
Target ValidationRSAD2
Huge Navigator RSAD2 [HugePedia]
ClinGenRSAD2
Clinical trials, drugs, therapy
MyCancerGenomeRSAD2
Protein Interactions : CTDRSAD2
Pharm GKB GenePA134937442
PharosQ8WXG1
Clinical trialRSAD2
Miscellaneous
canSAR (ICR)RSAD2
HarmonizomeRSAD2
DataMed IndexRSAD2
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRSAD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:29:45 CEST 2021

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