Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RSPO2 (R-spondin 2)

Identity

Alias_namesR-spondin 2 homolog (Xenopus laevis)
Alias_symbol (synonym)MGC35555
Other aliasCRISTIN2
HHRRD
TETAMS2
HGNC (Hugo) RSPO2
LocusID (NCBI) 340419
Atlas_Id 47520
Location 8q23.1  [Link to chromosome band 8q23]
Location_base_pair Starts at 107899316 and ends at 108083685 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EIF3E (8q23.1) / RSPO2 (8q23.1)OXR1 (8q23.1) / RSPO2 (8q23.1)RBM12B (8q22.1) / RSPO2 (8q23.1)
RSPO2 (8q23.1) / OXR1 (8q23.1)EIF3E RSPO2RBM12B 8q22.1 / RSPO2 8q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(8;8)(q22;q23) RBM12B/RSPO2
EIF3E/RSPO2 (8q23)
RSPO2/OXR1 (8q23)
OXR1/RSPO2 (8q23)

External links

Nomenclature
HGNC (Hugo)RSPO2   28583
Cards
Entrez_Gene (NCBI)RSPO2  340419  R-spondin 2
AliasesCRISTIN2; HHRRD; TETAMS2
GeneCards (Weizmann)RSPO2
Ensembl hg19 (Hinxton)ENSG00000147655 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147655 [Gene_View]  ENSG00000147655 [Sequence]  chr8:107899316-108083685 [Contig_View]  RSPO2 [Vega]
ICGC DataPortalENSG00000147655
TCGA cBioPortalRSPO2
AceView (NCBI)RSPO2
Genatlas (Paris)RSPO2
WikiGenes340419
SOURCE (Princeton)RSPO2
Genetics Home Reference (NIH)RSPO2
Genomic and cartography
GoldenPath hg38 (UCSC)RSPO2  -     chr8:107899316-108083685 -  8q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RSPO2  -     8q23.1   [Description]    (hg19-Feb_2009)
EnsemblRSPO2 - 8q23.1 [CytoView hg19]  RSPO2 - 8q23.1 [CytoView hg38]
Mapping of homologs : NCBIRSPO2 [Mapview hg19]  RSPO2 [Mapview hg38]
OMIM610575   618021   618022   
Gene and transcription
Genbank (Entrez)AK123023 AK123027 AY358166 BC027938 BC036554
RefSeq transcript (Entrez)NM_001282863 NM_001317942 NM_178565
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RSPO2
Cluster EST : UnigeneHs.444834 [ NCBI ]
CGAP (NCI)Hs.444834
Alternative Splicing GalleryENSG00000147655
Gene ExpressionRSPO2 [ NCBI-GEO ]   RSPO2 [ EBI - ARRAY_EXPRESS ]   RSPO2 [ SEEK ]   RSPO2 [ MEM ]
Gene Expression Viewer (FireBrowse)RSPO2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)340419
GTEX Portal (Tissue expression)RSPO2
Human Protein AtlasENSG00000147655-RSPO2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UXX9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UXX9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UXX9
Splice isoforms : SwissVarQ6UXX9
PhosPhoSitePlusQ6UXX9
Domaine pattern : Prosite (Expaxy)TSP1 (PS50092)   
Domains : Interpro (EBI)Furin_repeat    Growth_fac_rcpt_cys_sf    TSP1_rpt    TSP1_rpt_sf   
Domain families : Pfam (Sanger)Furin-like_2 (PF15913)   
Domain families : Pfam (NCBI)pfam15913   
Domain families : Smart (EMBL)FU (SM00261)  TSP1 (SM00209)  
Conserved Domain (NCBI)RSPO2
DMDM Disease mutations340419
Blocks (Seattle)RSPO2
SuperfamilyQ6UXX9
Human Protein Atlas [tissue]ENSG00000147655-RSPO2 [tissue]
Peptide AtlasQ6UXX9
HPRD17536
IPIIPI00167122   IPI00747330   IPI00640775   IPI01010113   IPI00978235   IPI00980304   IPI00979628   IPI00978922   
Protein Interaction databases
DIP (DOE-UCLA)Q6UXX9
IntAct (EBI)Q6UXX9
FunCoupENSG00000147655
BioGRIDRSPO2
STRING (EMBL)RSPO2
ZODIACRSPO2
Ontologies - Pathways
QuickGOQ6UXX9
Ontology : AmiGOosteoblast differentiation  signaling receptor binding  frizzled binding  protein binding  extracellular region  extracellular region  extracellular space  heparin binding  cell surface  Wnt signaling pathway  positive regulation of Wnt signaling pathway  positive regulation of Wnt signaling pathway  bone mineralization  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  negative regulation of odontogenesis of dentin-containing tooth  limb development  lung growth  epithelial tube branching involved in lung morphogenesis  trachea cartilage morphogenesis  dopaminergic neuron differentiation  positive regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIosteoblast differentiation  signaling receptor binding  frizzled binding  protein binding  extracellular region  extracellular region  extracellular space  heparin binding  cell surface  Wnt signaling pathway  positive regulation of Wnt signaling pathway  positive regulation of Wnt signaling pathway  bone mineralization  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  negative regulation of odontogenesis of dentin-containing tooth  limb development  lung growth  epithelial tube branching involved in lung morphogenesis  trachea cartilage morphogenesis  dopaminergic neuron differentiation  positive regulation of canonical Wnt signaling pathway  
NDEx NetworkRSPO2
Atlas of Cancer Signalling NetworkRSPO2
Wikipedia pathwaysRSPO2
Orthology - Evolution
OrthoDB340419
GeneTree (enSembl)ENSG00000147655
Phylogenetic Trees/Animal Genes : TreeFamRSPO2
HOGENOMQ6UXX9
Homologs : HomoloGeneRSPO2
Homology/Alignments : Family Browser (UCSC)RSPO2
Gene fusions - Rearrangements
Fusion : MitelmanEIF3E/RSPO2 [8q23.1/8q23.1]  [del(8)(q23q23)]  
Fusion : MitelmanOXR1/RSPO2 [8q23.1/8q23.1]  [t(8;8)(q23;q23)]  
Fusion : MitelmanRBM12B/RSPO2 [8q22.1/8q23.1]  [t(8;8)(q22;q23)]  
Fusion : MitelmanRSPO2/OXR1 [8q23.1/8q23.1]  [t(8;8)(q23;q23)]  
Fusion PortalRBM12B 8q22.1 RSPO2 8q23.1 LUSC
Fusion : QuiverRSPO2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRSPO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RSPO2
dbVarRSPO2
ClinVarRSPO2
1000_GenomesRSPO2 
Exome Variant ServerRSPO2
ExAC (Exome Aggregation Consortium)ENSG00000147655
GNOMAD BrowserENSG00000147655
Varsome BrowserRSPO2
Genetic variants : HAPMAP340419
Genomic Variants (DGV)RSPO2 [DGVbeta]
DECIPHERRSPO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRSPO2 
Mutations
ICGC Data PortalRSPO2 
TCGA Data PortalRSPO2 
Broad Tumor PortalRSPO2
OASIS PortalRSPO2 [ Somatic mutations - Copy number]
Cancer Gene: CensusRSPO2 
Somatic Mutations in Cancer : COSMICRSPO2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRSPO2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RSPO2
DgiDB (Drug Gene Interaction Database)RSPO2
DoCM (Curated mutations)RSPO2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RSPO2 (select a term)
intoGenRSPO2
Cancer3DRSPO2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610575    618021    618022   
Orphanet
DisGeNETRSPO2
MedgenRSPO2
Genetic Testing Registry RSPO2
NextProtQ6UXX9 [Medical]
TSGene340419
GENETestsRSPO2
Target ValidationRSPO2
Huge Navigator RSPO2 [HugePedia]
snp3D : Map Gene to Disease340419
BioCentury BCIQRSPO2
ClinGenRSPO2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD340419
Chemical/Pharm GKB GenePA142670968
Clinical trialRSPO2
Miscellaneous
canSAR (ICR)RSPO2 (select the gene name)
DataMed IndexRSPO2
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRSPO2
EVEXRSPO2
GoPubMedRSPO2
iHOPRSPO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:36:20 CET 2019
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