Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RSPO2 (R-spondin 2)

Identity

Alias (NCBI)CRISTIN2
HHRRD
TETAMS2
HGNC (Hugo) RSPO2
HGNC Alias symbMGC35555
HGNC Previous nameR-spondin 2 homolog (Xenopus laevis)
LocusID (NCBI) 340419
Atlas_Id 47520
Location 8q23.1  [Link to chromosome band 8q23]
Location_base_pair Starts at 107899316 and ends at 108083620 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EIF3E (8q23.1) / RSPO2 (8q23.1)OXR1 (8q23.1) / RSPO2 (8q23.1)RBM12B (8q22.1) / RSPO2 (8q23.1)
RSPO2 (8q23.1) / OXR1 (8q23.1)EIF3E 8q23.1 / RSPO2 8q23.1RBM12B 8q22.1 / RSPO2 8q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RSPO2   28583
Cards
Entrez_Gene (NCBI)RSPO2    R-spondin 2
AliasesCRISTIN2; HHRRD; TETAMS2
GeneCards (Weizmann)RSPO2
Ensembl hg19 (Hinxton)ENSG00000147655 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147655 [Gene_View]  ENSG00000147655 [Sequence]  chr8:107899316-108083620 [Contig_View]  RSPO2 [Vega]
ICGC DataPortalENSG00000147655
TCGA cBioPortalRSPO2
AceView (NCBI)RSPO2
Genatlas (Paris)RSPO2
SOURCE (Princeton)RSPO2
Genetics Home Reference (NIH)RSPO2
Genomic and cartography
GoldenPath hg38 (UCSC)RSPO2  -     chr8:107899316-108083620 -  8q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RSPO2  -     8q23.1   [Description]    (hg19-Feb_2009)
GoldenPathRSPO2 - 8q23.1 [CytoView hg19]  RSPO2 - 8q23.1 [CytoView hg38]
ImmunoBaseENSG00000147655
Genome Data Viewer NCBIRSPO2 [Mapview hg19]  
OMIM610575   618021   618022   
Gene and transcription
Genbank (Entrez)AK123023 AK123027 AY358166 BC027938 BC036554
RefSeq transcript (Entrez)NM_001282863 NM_001317942 NM_178565
Consensus coding sequences : CCDS (NCBI)RSPO2
Gene ExpressionRSPO2 [ NCBI-GEO ]   RSPO2 [ EBI - ARRAY_EXPRESS ]   RSPO2 [ SEEK ]   RSPO2 [ MEM ]
Gene Expression Viewer (FireBrowse)RSPO2 [ Firebrowse - Broad ]
GenevisibleExpression of RSPO2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)340419
GTEX Portal (Tissue expression)RSPO2
Human Protein AtlasENSG00000147655-RSPO2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6UXX9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6UXX9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6UXX9
PhosPhoSitePlusQ6UXX9
Domaine pattern : Prosite (Expaxy)TSP1 (PS50092)   
Domains : Interpro (EBI)Furin_repeat    Growth_fac_rcpt_cys_sf    RSPO2/4    Rspo_Fu-CRD_dom    TSP1_rpt    TSP1_rpt_sf   
Domain families : Pfam (Sanger)Furin-like_2 (PF15913)   
Domain families : Pfam (NCBI)pfam15913   
Domain families : Smart (EMBL)FU (SM00261)  TSP1 (SM00209)  
Conserved Domain (NCBI)RSPO2
SuperfamilyQ6UXX9
AlphaFold pdb e-kbQ6UXX9   
Human Protein Atlas [tissue]ENSG00000147655-RSPO2 [tissue]
HPRD17536
Protein Interaction databases
DIP (DOE-UCLA)Q6UXX9
IntAct (EBI)Q6UXX9
BioGRIDRSPO2
STRING (EMBL)RSPO2
ZODIACRSPO2
Ontologies - Pathways
QuickGOQ6UXX9
Ontology : AmiGOosteoblast differentiation  signaling receptor binding  protein binding  extracellular region  extracellular region  heparin binding  cell surface  Wnt signaling pathway  positive regulation of Wnt signaling pathway  positive regulation of Wnt signaling pathway  bone mineralization  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  negative regulation of odontogenesis of dentin-containing tooth  limb development  lung growth  epithelial tube branching involved in lung morphogenesis  trachea cartilage morphogenesis  dopaminergic neuron differentiation  positive regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBIosteoblast differentiation  signaling receptor binding  protein binding  extracellular region  extracellular region  heparin binding  cell surface  Wnt signaling pathway  positive regulation of Wnt signaling pathway  positive regulation of Wnt signaling pathway  bone mineralization  embryonic forelimb morphogenesis  embryonic hindlimb morphogenesis  negative regulation of odontogenesis of dentin-containing tooth  limb development  lung growth  epithelial tube branching involved in lung morphogenesis  trachea cartilage morphogenesis  dopaminergic neuron differentiation  positive regulation of canonical Wnt signaling pathway  
NDEx NetworkRSPO2
Atlas of Cancer Signalling NetworkRSPO2
Wikipedia pathwaysRSPO2
Orthology - Evolution
OrthoDB340419
GeneTree (enSembl)ENSG00000147655
Phylogenetic Trees/Animal Genes : TreeFamRSPO2
Homologs : HomoloGeneRSPO2
Homology/Alignments : Family Browser (UCSC)RSPO2
Gene fusions - Rearrangements
Fusion : MitelmanEIF3E/RSPO2 [8q23.1/8q23.1]  
Fusion : MitelmanOXR1/RSPO2 [8q23.1/8q23.1]  
Fusion : MitelmanRBM12B/RSPO2 [8q22.1/8q23.1]  
Fusion : MitelmanRSPO2/OXR1 [8q23.1/8q23.1]  
Fusion : QuiverRSPO2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRSPO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RSPO2
dbVarRSPO2
ClinVarRSPO2
MonarchRSPO2
1000_GenomesRSPO2 
Exome Variant ServerRSPO2
GNOMAD BrowserENSG00000147655
Varsome BrowserRSPO2
ACMGRSPO2 variants
VarityQ6UXX9
Genomic Variants (DGV)RSPO2 [DGVbeta]
DECIPHERRSPO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRSPO2 
Mutations
ICGC Data PortalRSPO2 
TCGA Data PortalRSPO2 
Broad Tumor PortalRSPO2
OASIS PortalRSPO2 [ Somatic mutations - Copy number]
Cancer Gene: CensusRSPO2 
Somatic Mutations in Cancer : COSMICRSPO2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRSPO2
Mutations and Diseases : HGMDRSPO2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRSPO2
DgiDB (Drug Gene Interaction Database)RSPO2
DoCM (Curated mutations)RSPO2
CIViC (Clinical Interpretations of Variants in Cancer)RSPO2
Cancer3DRSPO2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610575    618021    618022   
Orphanet
DisGeNETRSPO2
MedgenRSPO2
Genetic Testing Registry RSPO2
NextProtQ6UXX9 [Medical]
GENETestsRSPO2
Target ValidationRSPO2
Huge Navigator RSPO2 [HugePedia]
ClinGenRSPO2
Clinical trials, drugs, therapy
MyCancerGenomeRSPO2
Protein Interactions : CTDRSPO2
Pharm GKB GenePA142670968
PharosQ6UXX9
Clinical trialRSPO2
Miscellaneous
canSAR (ICR)RSPO2
HarmonizomeRSPO2
DataMed IndexRSPO2
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRSPO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:29:46 CEST 2021

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