RSPO2 (R-spondin 2)

2007-04-01  

Identity

HGNC
LOCATION
8q23.1
LOCUSID
ALIAS
CRISTIN2,HHRRD,TETAMS2
FUSION GENES

Other Information

Locus ID:

NCBI: 340419
MIM: 610575
HGNC: 28583
Ensembl: ENSG00000147655

Variants:

dbSNP: 340419
ClinVar: 340419
TCGA: ENSG00000147655
COSMIC: RSPO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147655ENST00000276659Q6UXX9
ENSG00000147655ENST00000517781Q6UXX9
ENSG00000147655ENST00000517939Q6UXX9
ENSG00000147655ENST00000521956E5RH25
ENSG00000147655ENST00000522333E5RGU9
ENSG00000147655ENST00000666252A0A590UJ52

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Regulation of FZD by ubiquitinationREACTOMER-HSA-4641263

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
228951932012Recurrent R-spondin fusions in colon cancer.349
244766262014RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer.32
297697202018RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.24
248477612014RSPO fusion transcripts in colorectal cancer in Japanese population.18
275723182016RSPOs facilitated HSC activation and promoted hepatic fibrogenesis.9
286001102017RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt pathway.9
302500442018Identification of RSPO2 Fusion Mutations and Target Therapy Using a Porcupine Inhibitor.6
286512342017MicroRNA-493 suppresses hepatocellular carcinoma tumorigenesis through down-regulation of anthrax toxin receptor 1 (ANTXR1) and R-Spondin 2 (RSPO2).4
309163652019EIF3E-RSPO2 and PIEZO1-RSPO2 fusions in colorectal traditional serrated adenoma.3
275717042016Rspo2 suppresses CD36-mediated apoptosis in oxidized low density lipoprotein-induced macrophages.2

Citation

Dessen P

RSPO2 (R-spondin 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47520/rspo2