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RSPO3 (R-spondin 3)

Identity

Alias (NCBI)CRISTIN1
PWTSR
THSD2
HGNC (Hugo) RSPO3
HGNC Alias symbFLJ14440
HGNC Previous nameTHSD2
HGNC Previous namethrombospondin, type I, domain containing 2
 R-spondin 3 homolog (Xenopus laevis)
LocusID (NCBI) 84870
Atlas_Id 52917
Location 6q22.33  [Link to chromosome band 6q22]
Location_base_pair Starts at 127118671 and ends at 127199481 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PTPRK (6q22.33) / RSPO3 (6q22.33)TBC1D32 (6q22.31) / RSPO3 (6q22.33)PTPRK 6q22.33 / RSPO3 6q22.33
C6orf170 RSPO3 6q22.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RSPO3   20866
Cards
Entrez_Gene (NCBI)RSPO3    R-spondin 3
AliasesCRISTIN1; PWTSR; THSD2
GeneCards (Weizmann)RSPO3
Ensembl hg19 (Hinxton)ENSG00000146374 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146374 [Gene_View]  ENSG00000146374 [Sequence]  chr6:127118671-127199481 [Contig_View]  RSPO3 [Vega]
ICGC DataPortalENSG00000146374
TCGA cBioPortalRSPO3
AceView (NCBI)RSPO3
Genatlas (Paris)RSPO3
SOURCE (Princeton)RSPO3
Genetics Home Reference (NIH)RSPO3
Genomic and cartography
GoldenPath hg38 (UCSC)RSPO3  -     chr6:127118671-127199481 +  6q22.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RSPO3  -     6q22.33   [Description]    (hg19-Feb_2009)
GoldenPathRSPO3 - 6q22.33 [CytoView hg19]  RSPO3 - 6q22.33 [CytoView hg38]
ImmunoBaseENSG00000146374
Genome Data Viewer NCBIRSPO3 [Mapview hg19]  
OMIM610574   
Gene and transcription
Genbank (Entrez)AA568446 AF086298 AF251057 AI095468 AK314912
RefSeq transcript (Entrez)NM_032784
Consensus coding sequences : CCDS (NCBI)RSPO3
Gene ExpressionRSPO3 [ NCBI-GEO ]   RSPO3 [ EBI - ARRAY_EXPRESS ]   RSPO3 [ SEEK ]   RSPO3 [ MEM ]
Gene Expression Viewer (FireBrowse)RSPO3 [ Firebrowse - Broad ]
GenevisibleExpression of RSPO3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84870
GTEX Portal (Tissue expression)RSPO3
Human Protein AtlasENSG00000146374-RSPO3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BXY4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BXY4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BXY4
PhosPhoSitePlusQ9BXY4
Domaine pattern : Prosite (Expaxy)TSP1 (PS50092)   
Domains : Interpro (EBI)Furin_repeat    Growth_fac_rcpt_cys_sf    RSPO3    Rspo_Fu-CRD_dom    TSP1_rpt    TSP1_rpt_sf    TSP1_spondin_dom   
Domain families : Pfam (Sanger)Furin-like_2 (PF15913)    TSP1_spondin (PF19028)   
Domain families : Pfam (NCBI)pfam15913    pfam19028   
Domain families : Smart (EMBL)FU (SM00261)  TSP1 (SM00209)  
Conserved Domain (NCBI)RSPO3
SuperfamilyQ9BXY4
AlphaFold pdb e-kbQ9BXY4   
Human Protein Atlas [tissue]ENSG00000146374-RSPO3 [tissue]
HPRD18181
Protein Interaction databases
DIP (DOE-UCLA)Q9BXY4
IntAct (EBI)Q9BXY4
BioGRIDRSPO3
STRING (EMBL)RSPO3
ZODIACRSPO3
Ontologies - Pathways
QuickGOQ9BXY4
Ontology : AmiGOblood vessel remodeling  sprouting angiogenesis  signaling receptor binding  frizzled binding  extracellular region  extracellular region  heparin binding  Wnt signaling pathway  regulation of Wnt signaling pathway  positive regulation of Wnt signaling pathway  positive regulation of Wnt signaling pathway  branching involved in labyrinthine layer morphogenesis  positive regulation of canonical Wnt signaling pathway  positive regulation of non-canonical Wnt signaling pathway  positive regulation of Wnt signaling pathway, planar cell polarity pathway  
Ontology : EGO-EBIblood vessel remodeling  sprouting angiogenesis  signaling receptor binding  frizzled binding  extracellular region  extracellular region  heparin binding  Wnt signaling pathway  regulation of Wnt signaling pathway  positive regulation of Wnt signaling pathway  positive regulation of Wnt signaling pathway  branching involved in labyrinthine layer morphogenesis  positive regulation of canonical Wnt signaling pathway  positive regulation of non-canonical Wnt signaling pathway  positive regulation of Wnt signaling pathway, planar cell polarity pathway  
NDEx NetworkRSPO3
Atlas of Cancer Signalling NetworkRSPO3
Wikipedia pathwaysRSPO3
Orthology - Evolution
OrthoDB84870
GeneTree (enSembl)ENSG00000146374
Phylogenetic Trees/Animal Genes : TreeFamRSPO3
Homologs : HomoloGeneRSPO3
Homology/Alignments : Family Browser (UCSC)RSPO3
Gene fusions - Rearrangements
Fusion : MitelmanPTPRK/RSPO3 [6q22.33/6q22.33]  
Fusion : MitelmanTBC1D32/RSPO3 [6q22.31/6q22.33]  
Fusion : QuiverRSPO3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRSPO3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RSPO3
dbVarRSPO3
ClinVarRSPO3
MonarchRSPO3
1000_GenomesRSPO3 
Exome Variant ServerRSPO3
GNOMAD BrowserENSG00000146374
Varsome BrowserRSPO3
ACMGRSPO3 variants
VarityQ9BXY4
Genomic Variants (DGV)RSPO3 [DGVbeta]
DECIPHERRSPO3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRSPO3 
Mutations
ICGC Data PortalRSPO3 
TCGA Data PortalRSPO3 
Broad Tumor PortalRSPO3
OASIS PortalRSPO3 [ Somatic mutations - Copy number]
Cancer Gene: CensusRSPO3 
Somatic Mutations in Cancer : COSMICRSPO3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRSPO3
Mutations and Diseases : HGMDRSPO3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRSPO3
DgiDB (Drug Gene Interaction Database)RSPO3
DoCM (Curated mutations)RSPO3
CIViC (Clinical Interpretations of Variants in Cancer)RSPO3
Cancer3DRSPO3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610574   
Orphanet
DisGeNETRSPO3
MedgenRSPO3
Genetic Testing Registry RSPO3
NextProtQ9BXY4 [Medical]
GENETestsRSPO3
Target ValidationRSPO3
Huge Navigator RSPO3 [HugePedia]
ClinGenRSPO3
Clinical trials, drugs, therapy
MyCancerGenomeRSPO3
Protein Interactions : CTDRSPO3
Pharm GKB GenePA134885289
PharosQ9BXY4
Clinical trialRSPO3
Miscellaneous
canSAR (ICR)RSPO3
HarmonizomeRSPO3
DataMed IndexRSPO3
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRSPO3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:29:46 CEST 2021

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