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RSPO3 (R-spondin 3)

Identity

Alias_namesTHSD2
thrombospondin, type I, domain containing 2
R-spondin 3 homolog (Xenopus laevis)
Alias_symbol (synonym)FLJ14440
Other aliasCRISTIN1
PWTSR
HGNC (Hugo) RSPO3
LocusID (NCBI) 84870
Atlas_Id 52917
Location 6q22.33  [Link to chromosome band 6q22]
Location_base_pair Starts at 127118903 and ends at 127199481 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PTPRK (6q22.33) / RSPO3 (6q22.33)TBC1D32 (6q22.31) / RSPO3 (6q22.33)PTPRK RSPO3
C6orf170 RSPO3 6q22.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  PTPRK/RSPO3 (6q22)
TBC1D32/RSPO3 (6q22)


External links

Nomenclature
HGNC (Hugo)RSPO3   20866
Cards
Entrez_Gene (NCBI)RSPO3  84870  R-spondin 3
AliasesCRISTIN1; PWTSR; THSD2
GeneCards (Weizmann)RSPO3
Ensembl hg19 (Hinxton)ENSG00000146374 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146374 [Gene_View]  ENSG00000146374 [Sequence]  chr6:127118903-127199481 [Contig_View]  RSPO3 [Vega]
ICGC DataPortalENSG00000146374
TCGA cBioPortalRSPO3
AceView (NCBI)RSPO3
Genatlas (Paris)RSPO3
WikiGenes84870
SOURCE (Princeton)RSPO3
Genetics Home Reference (NIH)RSPO3
Genomic and cartography
GoldenPath hg38 (UCSC)RSPO3  -     chr6:127118903-127199481 +  6q22.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RSPO3  -     6q22.33   [Description]    (hg19-Feb_2009)
EnsemblRSPO3 - 6q22.33 [CytoView hg19]  RSPO3 - 6q22.33 [CytoView hg38]
Mapping of homologs : NCBIRSPO3 [Mapview hg19]  RSPO3 [Mapview hg38]
OMIM610574   
Gene and transcription
Genbank (Entrez)AA568446 AF086298 AF251057 AI095468 AK314912
RefSeq transcript (Entrez)NM_032784
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RSPO3
Cluster EST : UnigeneHs.135254 [ NCBI ]
CGAP (NCI)Hs.135254
Alternative Splicing GalleryENSG00000146374
Gene ExpressionRSPO3 [ NCBI-GEO ]   RSPO3 [ EBI - ARRAY_EXPRESS ]   RSPO3 [ SEEK ]   RSPO3 [ MEM ]
Gene Expression Viewer (FireBrowse)RSPO3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84870
GTEX Portal (Tissue expression)RSPO3
Human Protein AtlasENSG00000146374-RSPO3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BXY4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BXY4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BXY4
Splice isoforms : SwissVarQ9BXY4
PhosPhoSitePlusQ9BXY4
Domaine pattern : Prosite (Expaxy)TSP1 (PS50092)   
Domains : Interpro (EBI)Furin_repeat    Growth_fac_rcpt_cys_sf    TSP1_rpt    TSP1_rpt_sf   
Domain families : Pfam (Sanger)Furin-like_2 (PF15913)   
Domain families : Pfam (NCBI)pfam15913   
Domain families : Smart (EMBL)FU (SM00261)  TSP1 (SM00209)  
Conserved Domain (NCBI)RSPO3
DMDM Disease mutations84870
Blocks (Seattle)RSPO3
SuperfamilyQ9BXY4
Human Protein Atlas [tissue]ENSG00000146374-RSPO3 [tissue]
Peptide AtlasQ9BXY4
HPRD18181
IPIIPI00396633   IPI00306643   
Protein Interaction databases
DIP (DOE-UCLA)Q9BXY4
IntAct (EBI)Q9BXY4
FunCoupENSG00000146374
BioGRIDRSPO3
STRING (EMBL)RSPO3
ZODIACRSPO3
Ontologies - Pathways
QuickGOQ9BXY4
Ontology : AmiGOblood vessel remodeling  sprouting angiogenesis  signaling receptor binding  frizzled binding  extracellular region  extracellular region  extracellular space  heparin binding  Wnt signaling pathway  regulation of Wnt signaling pathway  positive regulation of Wnt signaling pathway  branching involved in labyrinthine layer morphogenesis  positive regulation of canonical Wnt signaling pathway  positive regulation of non-canonical Wnt signaling pathway  positive regulation of Wnt signaling pathway, planar cell polarity pathway  
Ontology : EGO-EBIblood vessel remodeling  sprouting angiogenesis  signaling receptor binding  frizzled binding  extracellular region  extracellular region  extracellular space  heparin binding  Wnt signaling pathway  regulation of Wnt signaling pathway  positive regulation of Wnt signaling pathway  branching involved in labyrinthine layer morphogenesis  positive regulation of canonical Wnt signaling pathway  positive regulation of non-canonical Wnt signaling pathway  positive regulation of Wnt signaling pathway, planar cell polarity pathway  
NDEx NetworkRSPO3
Atlas of Cancer Signalling NetworkRSPO3
Wikipedia pathwaysRSPO3
Orthology - Evolution
OrthoDB84870
GeneTree (enSembl)ENSG00000146374
Phylogenetic Trees/Animal Genes : TreeFamRSPO3
HOVERGENQ9BXY4
HOGENOMQ9BXY4
Homologs : HomoloGeneRSPO3
Homology/Alignments : Family Browser (UCSC)RSPO3
Gene fusions - Rearrangements
Fusion : MitelmanPTPRK/RSPO3 [6q22.33/6q22.33]  [inv(6)(q22q22)]  
Fusion : MitelmanTBC1D32/RSPO3 [6q22.31/6q22.33]  [t(6;6)(q22;q22)]  
Fusion PortalC6orf170 RSPO3 6q22.33 BLCA
Fusion : QuiverRSPO3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRSPO3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RSPO3
dbVarRSPO3
ClinVarRSPO3
1000_GenomesRSPO3 
Exome Variant ServerRSPO3
ExAC (Exome Aggregation Consortium)ENSG00000146374
GNOMAD BrowserENSG00000146374
Varsome BrowserRSPO3
Genetic variants : HAPMAP84870
Genomic Variants (DGV)RSPO3 [DGVbeta]
DECIPHERRSPO3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRSPO3 
Mutations
ICGC Data PortalRSPO3 
TCGA Data PortalRSPO3 
Broad Tumor PortalRSPO3
OASIS PortalRSPO3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRSPO3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRSPO3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RSPO3
DgiDB (Drug Gene Interaction Database)RSPO3
DoCM (Curated mutations)RSPO3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RSPO3 (select a term)
intoGenRSPO3
Cancer3DRSPO3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610574   
Orphanet
DisGeNETRSPO3
MedgenRSPO3
Genetic Testing Registry RSPO3
NextProtQ9BXY4 [Medical]
TSGene84870
GENETestsRSPO3
Target ValidationRSPO3
Huge Navigator RSPO3 [HugePedia]
snp3D : Map Gene to Disease84870
BioCentury BCIQRSPO3
ClinGenRSPO3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84870
Chemical/Pharm GKB GenePA134885289
Clinical trialRSPO3
Miscellaneous
canSAR (ICR)RSPO3 (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRSPO3
EVEXRSPO3
GoPubMedRSPO3
iHOPRSPO3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:36:47 CET 2018

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