Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RTKN (rhotekin)

Identity

Alias_symbol (synonym)B5
Other alias-
HGNC (Hugo) RTKN
LocusID (NCBI) 6242
Atlas_Id 43808
Location 2p13.1  [Link to chromosome band 2p13]
Location_base_pair Starts at 74425861 and ends at 74440583 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CACNB4 (2q23.3) / RTKN (2p13.1)MAML2 (11q21) / RTKN (2p13.1)RTKN (2p13.1) / COX6B1 (19q13.12)
RTKN (2p13.1) / TGM2 (20q11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)RTKN   10466
Cards
Entrez_Gene (NCBI)RTKN  6242  rhotekin
Aliases
GeneCards (Weizmann)RTKN
Ensembl hg19 (Hinxton)ENSG00000114993 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114993 [Gene_View]  ENSG00000114993 [Sequence]  chr2:74425861-74440583 [Contig_View]  RTKN [Vega]
ICGC DataPortalENSG00000114993
TCGA cBioPortalRTKN
AceView (NCBI)RTKN
Genatlas (Paris)RTKN
WikiGenes6242
SOURCE (Princeton)RTKN
Genetics Home Reference (NIH)RTKN
Genomic and cartography
GoldenPath hg38 (UCSC)RTKN  -     chr2:74425861-74440583 -  2p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RTKN  -     2p13.1   [Description]    (hg19-Feb_2009)
EnsemblRTKN - 2p13.1 [CytoView hg19]  RTKN - 2p13.1 [CytoView hg38]
Mapping of homologs : NCBIRTKN [Mapview hg19]  RTKN [Mapview hg38]
OMIM602288   
Gene and transcription
Genbank (Entrez)AF049227 AF290512 AK307302 AK308519 AK310036
RefSeq transcript (Entrez)NM_001015055 NM_001015056 NM_033046
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RTKN
Cluster EST : UnigeneHs.192854 [ NCBI ]
CGAP (NCI)Hs.192854
Alternative Splicing GalleryENSG00000114993
Gene ExpressionRTKN [ NCBI-GEO ]   RTKN [ EBI - ARRAY_EXPRESS ]   RTKN [ SEEK ]   RTKN [ MEM ]
Gene Expression Viewer (FireBrowse)RTKN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6242
GTEX Portal (Tissue expression)RTKN
Human Protein AtlasENSG00000114993-RTKN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BST9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BST9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BST9
Splice isoforms : SwissVarQ9BST9
PhosPhoSitePlusQ9BST9
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)AHD    HR1_rho-bd    PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)Anillin (PF08174)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam08174    pfam00169   
Domain families : Smart (EMBL)Hr1 (SM00742)  PH (SM00233)  
Conserved Domain (NCBI)RTKN
DMDM Disease mutations6242
Blocks (Seattle)RTKN
SuperfamilyQ9BST9
Human Protein Atlas [tissue]ENSG00000114993-RTKN [tissue]
Peptide AtlasQ9BST9
HPRD03795
IPIIPI00029834   IPI00157230   IPI00386977   IPI00556419   
Protein Interaction databases
DIP (DOE-UCLA)Q9BST9
IntAct (EBI)Q9BST9
FunCoupENSG00000114993
BioGRIDRTKN
STRING (EMBL)RTKN
ZODIACRTKN
Ontologies - Pathways
QuickGOQ9BST9
Ontology : AmiGOGTPase inhibitor activity  protein binding  GTP binding  cellular_component  cytosol  apoptotic process  signal transduction  Rho protein signal transduction  GTP-Rho binding  septin cytoskeleton organization  negative regulation of GTPase activity  regulation of apoptotic process  
Ontology : EGO-EBIGTPase inhibitor activity  protein binding  GTP binding  cellular_component  cytosol  apoptotic process  signal transduction  Rho protein signal transduction  GTP-Rho binding  septin cytoskeleton organization  negative regulation of GTPase activity  regulation of apoptotic process  
NDEx NetworkRTKN
Atlas of Cancer Signalling NetworkRTKN
Wikipedia pathwaysRTKN
Orthology - Evolution
OrthoDB6242
GeneTree (enSembl)ENSG00000114993
Phylogenetic Trees/Animal Genes : TreeFamRTKN
HOVERGENQ9BST9
HOGENOMQ9BST9
Homologs : HomoloGeneRTKN
Homology/Alignments : Family Browser (UCSC)RTKN
Gene fusions - Rearrangements
Fusion : QuiverRTKN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRTKN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RTKN
dbVarRTKN
ClinVarRTKN
1000_GenomesRTKN 
Exome Variant ServerRTKN
ExAC (Exome Aggregation Consortium)ENSG00000114993
GNOMAD BrowserENSG00000114993
Genetic variants : HAPMAP6242
Genomic Variants (DGV)RTKN [DGVbeta]
DECIPHERRTKN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRTKN 
Mutations
ICGC Data PortalRTKN 
TCGA Data PortalRTKN 
Broad Tumor PortalRTKN
OASIS PortalRTKN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRTKN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRTKN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RTKN
DgiDB (Drug Gene Interaction Database)RTKN
DoCM (Curated mutations)RTKN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RTKN (select a term)
intoGenRTKN
Cancer3DRTKN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602288   
Orphanet
DisGeNETRTKN
MedgenRTKN
Genetic Testing Registry RTKN
NextProtQ9BST9 [Medical]
TSGene6242
GENETestsRTKN
Target ValidationRTKN
Huge Navigator RTKN [HugePedia]
snp3D : Map Gene to Disease6242
BioCentury BCIQRTKN
ClinGenRTKN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6242
Chemical/Pharm GKB GenePA34879
Clinical trialRTKN
Miscellaneous
canSAR (ICR)RTKN (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRTKN
EVEXRTKN
GoPubMedRTKN
iHOPRTKN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:48:05 CEST 2018
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