Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RTKN2 (rhotekin 2)

Identity

Alias_namesPLEKHK1
pleckstrin homology domain containing, family K member 1
Alias_symbol (synonym)Em:AC024597.2
bA531F24.1
FLJ39352
Other alias
HGNC (Hugo) RTKN2
LocusID (NCBI) 219790
Atlas_Id 72925
Location 10q21.2  [Link to chromosome band 10q21]
Location_base_pair Starts at 63997909 and ends at 64028622 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADAMTS17 (15q26.3) / RTKN2 (10q21.2)KAT6B (10q22.2) / RTKN2 (10q21.2)KCNMB4 (12q15) / RTKN2 (10q21.2)
RTKN2 (10q21.2) / KIAA0100 (17q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RTKN2   19364
Cards
Entrez_Gene (NCBI)RTKN2  219790  rhotekin 2
AliasesPLEKHK1; bA531F24.1
GeneCards (Weizmann)RTKN2
Ensembl hg19 (Hinxton)ENSG00000182010 [Gene_View]  chr10:63997909-64028622 [Contig_View]  RTKN2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000182010 [Gene_View]  chr10:63997909-64028622 [Contig_View]  RTKN2 [Vega]
ICGC DataPortalENSG00000182010
TCGA cBioPortalRTKN2
AceView (NCBI)RTKN2
Genatlas (Paris)RTKN2
WikiGenes219790
SOURCE (Princeton)RTKN2
Genetics Home Reference (NIH)RTKN2
Genomic and cartography
GoldenPath hg19 (UCSC)RTKN2  -     chr10:63997909-64028622 -  10q21.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RTKN2  -     10q21.2   [Description]    (hg38-Dec_2013)
EnsemblRTKN2 - 10q21.2 [CytoView hg19]  RTKN2 - 10q21.2 [CytoView hg38]
Mapping of homologs : NCBIRTKN2 [Mapview hg19]  RTKN2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK096671 AY150309 BC025765 BC048002 BC141821
RefSeq transcript (Entrez)NM_001282941 NM_145307
RefSeq genomic (Entrez)NC_000010 NC_018921 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)RTKN2
Cluster EST : UnigeneHs.58559 [ NCBI ]
CGAP (NCI)Hs.58559
Alternative Splicing GalleryENSG00000182010
Gene ExpressionRTKN2 [ NCBI-GEO ]   RTKN2 [ EBI - ARRAY_EXPRESS ]   RTKN2 [ SEEK ]   RTKN2 [ MEM ]
Gene Expression Viewer (FireBrowse)RTKN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)219790
GTEX Portal (Tissue expression)RTKN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IZC4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IZC4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IZC4
Splice isoforms : SwissVarQ8IZC4
PhosPhoSitePlusQ8IZC4
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)DUF1709    HR1_rho-bd    PH_domain    PH_like_dom    RTKN2   
Domain families : Pfam (Sanger)Anillin (PF08174)    PH (PF00169)   
Domain families : Pfam (NCBI)pfam08174    pfam00169   
Domain families : Smart (EMBL)Hr1 (SM00742)  PH (SM00233)  
Conserved Domain (NCBI)RTKN2
DMDM Disease mutations219790
Blocks (Seattle)RTKN2
SuperfamilyQ8IZC4
Human Protein AtlasENSG00000182010
Peptide AtlasQ8IZC4
HPRD17863
IPIIPI00217970   IPI00872530   IPI00645727   
Protein Interaction databases
DIP (DOE-UCLA)Q8IZC4
IntAct (EBI)Q8IZC4
FunCoupENSG00000182010
BioGRIDRTKN2
STRING (EMBL)RTKN2
ZODIACRTKN2
Ontologies - Pathways
QuickGOQ8IZC4
Ontology : AmiGOplasma membrane  signal transduction  positive regulation of cell proliferation  hemopoiesis  
Ontology : EGO-EBIplasma membrane  signal transduction  positive regulation of cell proliferation  hemopoiesis  
NDEx NetworkRTKN2
Atlas of Cancer Signalling NetworkRTKN2
Wikipedia pathwaysRTKN2
Orthology - Evolution
OrthoDB219790
GeneTree (enSembl)ENSG00000182010
Phylogenetic Trees/Animal Genes : TreeFamRTKN2
HOVERGENQ8IZC4
HOGENOMQ8IZC4
Homologs : HomoloGeneRTKN2
Homology/Alignments : Family Browser (UCSC)RTKN2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRTKN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RTKN2
dbVarRTKN2
ClinVarRTKN2
1000_GenomesRTKN2 
Exome Variant ServerRTKN2
ExAC (Exome Aggregation Consortium)RTKN2 (select the gene name)
Genetic variants : HAPMAP219790
Genomic Variants (DGV)RTKN2 [DGVbeta]
DECIPHER (Syndromes)10:63997909-64028622  ENSG00000182010
CONAN: Copy Number AnalysisRTKN2 
Mutations
ICGC Data PortalRTKN2 
TCGA Data PortalRTKN2 
Broad Tumor PortalRTKN2
OASIS PortalRTKN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRTKN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRTKN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RTKN2
DgiDB (Drug Gene Interaction Database)RTKN2
DoCM (Curated mutations)RTKN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RTKN2 (select a term)
intoGenRTKN2
Cancer3DRTKN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenRTKN2
Genetic Testing Registry RTKN2
NextProtQ8IZC4 [Medical]
TSGene219790
GENETestsRTKN2
Huge Navigator RTKN2 [HugePedia]
snp3D : Map Gene to Disease219790
BioCentury BCIQRTKN2
ClinGenRTKN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD219790
Chemical/Pharm GKB GenePA162402276
Clinical trialRTKN2
Miscellaneous
canSAR (ICR)RTKN2 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRTKN2
EVEXRTKN2
GoPubMedRTKN2
iHOPRTKN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:42:07 CET 2017

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