RTN3 (reticulon 3)

2007-06-01  

Identity

HGNC
RTN3
LOCATION
11q13.1
LOCUSID
10313
ALIAS
ASYIP,HAP,NSPL2,NSPLII,RTN3-A1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10313
MIM: 604249
HGNC: 10469
Ensembl: ENSG00000133318

Variants:

dbSNP: 10313
ClinVar: 10313
TCGA: ENSG00000133318
COSMIC: RTN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133318ENST00000339997O95197
ENSG00000133318ENST00000341307O95197
ENSG00000133318ENST00000354497O95197
ENSG00000133318ENST00000356000O95197
ENSG00000133318ENST00000377819O95197
ENSG00000133318ENST00000536011B7Z4M1
ENSG00000133318ENST00000537981O95197
ENSG00000133318ENST00000537981A0A024R5C4
ENSG00000133318ENST00000540798O95197
ENSG00000133318ENST00000542238F5H617
ENSG00000133318ENST00000543552F5H891
ENSG00000133318ENST00000545432F5GWG7

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Alzheimer's diseaseKEGGko05010
Alzheimer's diseaseKEGGhsa05010
Neuronal SystemREACTOMER-HSA-112316
SALM protein interactions at the synapsesREACTOMER-HSA-8849932
Protein-protein interactions at synapsesREACTOMER-HSA-6794362

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
286172412017Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy.74
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
284957472017Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis.32
160548852005Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi.27
176995232007The membrane topology of RTN3 and its effect on binding of RTN3 to BACE1.17
253196922014Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition.14
171911232007Reticulon 3 mediates Bcl-2 accumulation in mitochondria in response to endoplasmic reticulum stress.13
193869062009The occurrence of aging-dependent reticulon 3 immunoreactive dystrophic neurites decreases cognitive function.13
248987292014Reticulon 3 interacts with NS4B of the hepatitis C virus and negatively regulates viral replication by disrupting NS4B self-interaction.12

Citation

Dessen P

RTN3 (reticulon 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-06-01

Online version: http://atlasgeneticsoncology.org/gene/47562/rtn3