Atlas of Genetics and Cytogenetics in Oncology and Haematology


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RTN4R (reticulon 4 receptor)

Identity

Alias_symbol (synonym)NOGOR
Other aliasNGR
HGNC (Hugo) RTN4R
LocusID (NCBI) 65078
Atlas_Id 51564
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 20241415 and ends at 20268293 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RTN4R (22q11.21) / SLC35G2 (3q22.3)RTN4R 22q11.21 TMEM22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hug´)RTN4R   18601
Cards
Entrez_Gene (NCBI)RTN4R  65078  reticulon 4 receptor
AliasesNGR; NOGOR
GeneCards (Weizmann)RTN4R
Ensembl hg19 (Hinxton)ENSG00000040608 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000040608 [Gene_View]  chr22:20241415-20268293 [Contig_View]  RTN4R [Vega]
ICGC DataPortalENSG00000040608
TCGA cBioPortalRTN4R
AceView (NCBI)RTN4R
Genatlas (Paris)RTN4R
WikiGenes65078
SOURCE (Princeton)RTN4R
Genetics Home Reference (NIH)RTN4R
Genomic and cartography
GoldenPath hg38 (UCSC)RTN4R  -     chr22:20241415-20268293 -  22q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RTN4R  -     22q11.21   [Description]    (hg19-Feb_2009)
EnsemblRTN4R - 22q11.21 [CytoView hg19]  RTN4R - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBIRTN4R [Mapview hg19]  RTN4R [Mapview hg38]
OMIM181500   605566   
Gene and transcription
Genbank (Entrez)AF283463 AK054602 AL834449 AM393268 BC011787
RefSeq transcript (Entrez)NM_023004
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RTN4R
Cluster EST : UnigeneHs.30868 [ NCBI ]
CGAP (NCI)Hs.30868
Alternative Splicing GalleryENSG00000040608
Gene ExpressionRTN4R [ NCBI-GEO ]   RTN4R [ EBI - ARRAY_EXPRESS ]   RTN4R [ SEEK ]   RTN4R [ MEM ]
Gene Expression Viewer (FireBrowse)RTN4R [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)65078
GTEX Portal (Tissue expression)RTN4R
Human Protein AtlasENSG00000040608-RTN4R [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZR6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BZR6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BZR6
Splice isoforms : SwissVarQ9BZR6
PhosPhoSitePlusQ9BZR6
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp   
Domain families : Pfam (Sanger)LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam13855   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  LRRCT (SM00082)  
Conserved Domain (NCBI)RTN4R
DMDM Disease mutations65078
Blocks (Seattle)RTN4R
PDB (SRS)1OZN    1P8T   
PDB (PDBSum)1OZN    1P8T   
PDB (IMB)1OZN    1P8T   
PDB (RSDB)1OZN    1P8T   
Structural Biology KnowledgeBase1OZN    1P8T   
SCOP (Structural Classification of Proteins)1OZN    1P8T   
CATH (Classification of proteins structures)1OZN    1P8T   
SuperfamilyQ9BZR6
Human Protein Atlas [tissue]ENSG00000040608-RTN4R [tissue]
Peptide AtlasQ9BZR6
HPRD16123
IPIIPI00289204   IPI00878568   IPI00878024   
Protein Interaction databases
DIP (DOE-UCLA)Q9BZR6
IntAct (EBI)Q9BZR6
FunCoupENSG00000040608
BioGRIDRTN4R
STRING (EMBL)RTN4R
ZODIACRTN4R
Ontologies - Pathways
QuickGOQ9BZR6
Ontology : AmiGOprotein kinase inhibitor activity  receptor activity  receptor activity  protein binding  cytoplasm  endoplasmic reticulum  plasma membrane  integral component of plasma membrane  negative regulation of protein kinase activity  cell surface receptor signaling pathway  axonogenesis  heparin binding  cell surface  negative regulation of neuron projection development  cytokine-mediated signaling pathway  corpus callosum development  neuronal signal transduction  negative regulation of axon extension  anchored component of external side of plasma membrane  positive regulation of Rho protein signal transduction  chondroitin sulfate binding  neuregulin receptor activity  neuron projection  neuronal cell body  dendritic shaft  perikaryon  positive regulation of GTPase activity  axonal growth cone  membrane raft  negative regulation of JAK-STAT cascade  negative regulation of axon regeneration  negative regulation of axonogenesis  extracellular exosome  ganglioside GM1 binding  ganglioside GT1b binding  
Ontology : EGO-EBIprotein kinase inhibitor activity  receptor activity  receptor activity  protein binding  cytoplasm  endoplasmic reticulum  plasma membrane  integral component of plasma membrane  negative regulation of protein kinase activity  cell surface receptor signaling pathway  axonogenesis  heparin binding  cell surface  negative regulation of neuron projection development  cytokine-mediated signaling pathway  corpus callosum development  neuronal signal transduction  negative regulation of axon extension  anchored component of external side of plasma membrane  positive regulation of Rho protein signal transduction  chondroitin sulfate binding  neuregulin receptor activity  neuron projection  neuronal cell body  dendritic shaft  perikaryon  positive regulation of GTPase activity  axonal growth cone  membrane raft  negative regulation of JAK-STAT cascade  negative regulation of axon regeneration  negative regulation of axonogenesis  extracellular exosome  ganglioside GM1 binding  ganglioside GT1b binding  
NDEx NetworkRTN4R
Atlas of Cancer Signalling NetworkRTN4R
Wikipedia pathwaysRTN4R
Orthology - Evolution
OrthoDB65078
GeneTree (enSembl)ENSG00000040608
Phylogenetic Trees/Animal Genes : TreeFamRTN4R
HOVERGENQ9BZR6
HOGENOMQ9BZR6
Homologs : HomoloGeneRTN4R
Homology/Alignments : Family Browser (UCSC)RTN4R
Gene fusions - Rearrangements
Fusion : MitelmanRTN4R/SLC35G2 [22q11.21/3q22.3]  
Fusion: TCGA_MDACCRTN4R 22q11.21 TMEM22 LUSC
Tumor Fusion PortalRTN4R
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRTN4R [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RTN4R
dbVarRTN4R
ClinVarRTN4R
1000_GenomesRTN4R 
Exome Variant ServerRTN4R
ExAC (Exome Aggregation Consortium)ENSG00000040608
GNOMAD BrowserENSG00000040608
Genetic variants : HAPMAP65078
Genomic Variants (DGV)RTN4R [DGVbeta]
DECIPHERRTN4R [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRTN4R 
Mutations
ICGC Data PortalRTN4R 
TCGA Data PortalRTN4R 
Broad Tumor PortalRTN4R
OASIS PortalRTN4R [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRTN4R  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRTN4R
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RTN4R
DgiDB (Drug Gene Interaction Database)RTN4R
DoCM (Curated mutations)RTN4R (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RTN4R (select a term)
intoGenRTN4R
Cancer3DRTN4R(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM181500    605566   
Orphanet
DisGeNETRTN4R
MedgenRTN4R
Genetic Testing Registry RTN4R
NextProtQ9BZR6 [Medical]
TSGene65078
GENETestsRTN4R
Target ValidationRTN4R
Huge Navigator RTN4R [HugePedia]
snp3D : Map Gene to Disease65078
BioCentury BCIQRTN4R
ClinGenRTN4R
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD65078
Chemical/Pharm GKB GenePA38600
Clinical trialRTN4R
Miscellaneous
canSAR (ICR)RTN4R (select the gene name)
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRTN4R
EVEXRTN4R
GoPubMedRTN4R
iHOPRTN4R
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:33:16 CET 2017

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