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RUBCN (RUN and cysteine rich domain containing beclin 1 interacting protein)

Identity

Alias_namesKIAA0226
KIAA0226
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
Alias_symbol (synonym)rubicon
rundataxin
Other aliasRUBICON
SCAR15
HGNC (Hugo) RUBCN
LocusID (NCBI) 9711
Atlas_Id 77965
Location 3q29  [Link to chromosome band 3q29]
Location_base_pair Starts at 197668867 and ends at 197749699 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DOCK4 (7q31.1) / RUBCN (3q29)RUBCN (3q29) / S100B (21q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RUBCN   28991
LRG (Locus Reference Genomic)LRG_1093
Cards
Entrez_Gene (NCBI)RUBCN  9711  RUN and cysteine rich domain containing beclin 1 interacting protein
AliasesKIAA0226; RUBICON; SCAR15
GeneCards (Weizmann)RUBCN
Ensembl hg19 (Hinxton)ENSG00000145016 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145016 [Gene_View]  chr3:197668867-197749699 [Contig_View]  RUBCN [Vega]
ICGC DataPortalENSG00000145016
TCGA cBioPortalRUBCN
AceView (NCBI)RUBCN
Genatlas (Paris)RUBCN
WikiGenes9711
SOURCE (Princeton)RUBCN
Genetics Home Reference (NIH)RUBCN
Genomic and cartography
GoldenPath hg38 (UCSC)RUBCN  -     chr3:197668867-197749699 -  3q29   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RUBCN  -     3q29   [Description]    (hg19-Feb_2009)
EnsemblRUBCN - 3q29 [CytoView hg19]  RUBCN - 3q29 [CytoView hg38]
Mapping of homologs : NCBIRUBCN [Mapview hg19]  RUBCN [Mapview hg38]
OMIM613516   615705   
Gene and transcription
Genbank (Entrez)AI796534 AK295625 BC014173 BC033615 BC160011
RefSeq transcript (Entrez)NM_001145642 NM_001346873 NM_014687
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RUBCN
Cluster EST : UnigeneHs.478868 [ NCBI ]
CGAP (NCI)Hs.478868
Alternative Splicing GalleryENSG00000145016
Gene ExpressionRUBCN [ NCBI-GEO ]   RUBCN [ EBI - ARRAY_EXPRESS ]   RUBCN [ SEEK ]   RUBCN [ MEM ]
Gene Expression Viewer (FireBrowse)RUBCN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9711
GTEX Portal (Tissue expression)RUBCN
Human Protein AtlasENSG00000145016-RUBCN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92622   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92622  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92622
Splice isoforms : SwissVarQ92622
PhosPhoSitePlusQ92622
Domaine pattern : Prosite (Expaxy)RUN (PS50826)   
Domains : Interpro (EBI)Run_dom    Zf-RING_9   
Domain families : Pfam (Sanger)RUN (PF02759)    zf-RING_9 (PF13901)   
Domain families : Pfam (NCBI)pfam02759    pfam13901   
Domain families : Smart (EMBL)DUF4206 (SM01175)  RUN (SM00593)  
Conserved Domain (NCBI)RUBCN
DMDM Disease mutations9711
Blocks (Seattle)RUBCN
SuperfamilyQ92622
Human Protein Atlas [tissue]ENSG00000145016-RUBCN [tissue]
Peptide AtlasQ92622
IPIIPI00853404   IPI00924876   IPI00060439   IPI00022496   IPI00925566   IPI00925817   
Protein Interaction databases
DIP (DOE-UCLA)Q92622
IntAct (EBI)Q92622
FunCoupENSG00000145016
BioGRIDRUBCN
STRING (EMBL)RUBCN
ZODIACRUBCN
Ontologies - Pathways
QuickGOQ92622
Ontology : AmiGOimmune system process  protein binding  nucleoplasm  lysosome  early endosome  late endosome  Golgi apparatus  cytosol  phagocytosis  autophagy  negative regulation of autophagy  intracellular membrane-bounded organelle  negative regulation of phosphatidylinositol 3-kinase activity  negative regulation of endocytosis  multivesicular body sorting pathway  negative regulation of autophagosome maturation  negative regulation of autophagosome maturation  
Ontology : EGO-EBIimmune system process  protein binding  nucleoplasm  lysosome  early endosome  late endosome  Golgi apparatus  cytosol  phagocytosis  autophagy  negative regulation of autophagy  intracellular membrane-bounded organelle  negative regulation of phosphatidylinositol 3-kinase activity  negative regulation of endocytosis  multivesicular body sorting pathway  negative regulation of autophagosome maturation  negative regulation of autophagosome maturation  
NDEx NetworkRUBCN
Atlas of Cancer Signalling NetworkRUBCN
Wikipedia pathwaysRUBCN
Orthology - Evolution
OrthoDB9711
GeneTree (enSembl)ENSG00000145016
Phylogenetic Trees/Animal Genes : TreeFamRUBCN
HOVERGENQ92622
HOGENOMQ92622
Homologs : HomoloGeneRUBCN
Homology/Alignments : Family Browser (UCSC)RUBCN
Gene fusions - Rearrangements
Fusion: Tumor Portal RUBCN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRUBCN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RUBCN
dbVarRUBCN
ClinVarRUBCN
1000_GenomesRUBCN 
Exome Variant ServerRUBCN
ExAC (Exome Aggregation Consortium)ENSG00000145016
GNOMAD BrowserENSG00000145016
Genetic variants : HAPMAP9711
Genomic Variants (DGV)RUBCN [DGVbeta]
DECIPHERRUBCN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRUBCN 
Mutations
ICGC Data PortalRUBCN 
TCGA Data PortalRUBCN 
Broad Tumor PortalRUBCN
OASIS PortalRUBCN [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDRUBCN
BioMutasearch RUBCN
DgiDB (Drug Gene Interaction Database)RUBCN
DoCM (Curated mutations)RUBCN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RUBCN (select a term)
intoGenRUBCN
Cancer3DRUBCN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613516    615705   
Orphanet22931   
MedgenRUBCN
Genetic Testing Registry RUBCN
NextProtQ92622 [Medical]
TSGene9711
GENETestsRUBCN
Target ValidationRUBCN
Huge Navigator RUBCN [HugePedia]
snp3D : Map Gene to Disease9711
BioCentury BCIQRUBCN
ClinGenRUBCN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9711
Chemical/Pharm GKB GenePA134887849
Clinical trialRUBCN
Miscellaneous
canSAR (ICR)RUBCN (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRUBCN
EVEXRUBCN
GoPubMedRUBCN
iHOPRUBCN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:26:08 CET 2017

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