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RUNX3 (runt related transcription factor 3)

Identity

Alias_namesCBFA3
runt-related transcription factor 3
Alias_symbol (synonym)AML2
PEBP2A3
Other aliasPEBP2aC
HGNC (Hugo) RUNX3
LocusID (NCBI) 864
Atlas_Id 42184
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 25226002 and ends at 25291501 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RUNX3 (1p36.11) / RUNX3 (1p36.11)RUNX3 (1p36.11) / ZNF682 (19p12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Gastric Tumors: an overview


External links

Nomenclature
HGNC (Hugo)RUNX3   10473
Cards
Entrez_Gene (NCBI)RUNX3  864  runt related transcription factor 3
AliasesAML2; CBFA3; PEBP2aC
GeneCards (Weizmann)RUNX3
Ensembl hg19 (Hinxton)ENSG00000020633 [Gene_View]  chr1:25226002-25291501 [Contig_View]  RUNX3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000020633 [Gene_View]  chr1:25226002-25291501 [Contig_View]  RUNX3 [Vega]
ICGC DataPortalENSG00000020633
TCGA cBioPortalRUNX3
AceView (NCBI)RUNX3
Genatlas (Paris)RUNX3
WikiGenes864
SOURCE (Princeton)RUNX3
Genetics Home Reference (NIH)RUNX3
Genomic and cartography
GoldenPath hg19 (UCSC)RUNX3  -     chr1:25226002-25291501 -  1p36.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RUNX3  -     1p36.11   [Description]    (hg38-Dec_2013)
EnsemblRUNX3 - 1p36.11 [CytoView hg19]  RUNX3 - 1p36.11 [CytoView hg38]
Mapping of homologs : NCBIRUNX3 [Mapview hg19]  RUNX3 [Mapview hg38]
OMIM600210   
Gene and transcription
Genbank (Entrez)AF022726 AI375031 AJ001432 AK091829 AK300056
RefSeq transcript (Entrez)NM_001031680 NM_001320672 NM_004350
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929289
Consensus coding sequences : CCDS (NCBI)RUNX3
Cluster EST : UnigeneHs.170019 [ NCBI ]
CGAP (NCI)Hs.170019
Alternative Splicing GalleryENSG00000020633
Gene ExpressionRUNX3 [ NCBI-GEO ]   RUNX3 [ EBI - ARRAY_EXPRESS ]   RUNX3 [ SEEK ]   RUNX3 [ MEM ]
Gene Expression Viewer (FireBrowse)RUNX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)864
GTEX Portal (Tissue expression)RUNX3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13761   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13761  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13761
Splice isoforms : SwissVarQ13761
PhosPhoSitePlusQ13761
Domaine pattern : Prosite (Expaxy)RUNT (PS51062)   
Domains : Interpro (EBI)AML1_Runt    p53-like_TF_DNA-bd    p53/RUNT-type_TF_DNA-bd    Runt_dom    Runx_central_dom    RunxI_C_dom   
Domain families : Pfam (Sanger)Runt (PF00853)    RunxI (PF08504)   
Domain families : Pfam (NCBI)pfam00853    pfam08504   
Conserved Domain (NCBI)RUNX3
DMDM Disease mutations864
Blocks (Seattle)RUNX3
SuperfamilyQ13761
Human Protein AtlasENSG00000020633
Peptide AtlasQ13761
HPRD02565
IPIIPI00004015   IPI00218386   IPI00908417   IPI01013326   IPI00816617   
Protein Interaction databases
DIP (DOE-UCLA)Q13761
IntAct (EBI)Q13761
FunCoupENSG00000020633
BioGRIDRUNX3
STRING (EMBL)RUNX3
ZODIACRUNX3
Ontologies - Pathways
QuickGOQ13761
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  ossification  chondrocyte differentiation  transcription factor activity, sequence-specific DNA binding  protein binding  ATP binding  nucleus  cytoplasm  regulation of transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  protein phosphorylation  hemopoiesis  regulation of cell differentiation  negative regulation of cell cycle  positive regulation of transcription, DNA-templated  peripheral nervous system neuron development  negative regulation of epithelial cell proliferation  response to transforming growth factor beta  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  ossification  chondrocyte differentiation  transcription factor activity, sequence-specific DNA binding  protein binding  ATP binding  nucleus  cytoplasm  regulation of transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  protein phosphorylation  hemopoiesis  regulation of cell differentiation  negative regulation of cell cycle  positive regulation of transcription, DNA-templated  peripheral nervous system neuron development  negative regulation of epithelial cell proliferation  response to transforming growth factor beta  
NDEx NetworkRUNX3
Atlas of Cancer Signalling NetworkRUNX3
Wikipedia pathwaysRUNX3
Orthology - Evolution
OrthoDB864
GeneTree (enSembl)ENSG00000020633
Phylogenetic Trees/Animal Genes : TreeFamRUNX3
HOVERGENQ13761
HOGENOMQ13761
Homologs : HomoloGeneRUNX3
Homology/Alignments : Family Browser (UCSC)RUNX3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRUNX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RUNX3
dbVarRUNX3
ClinVarRUNX3
1000_GenomesRUNX3 
Exome Variant ServerRUNX3
ExAC (Exome Aggregation Consortium)RUNX3 (select the gene name)
Genetic variants : HAPMAP864
Genomic Variants (DGV)RUNX3 [DGVbeta]
DECIPHER (Syndromes)1:25226002-25291501  ENSG00000020633
CONAN: Copy Number AnalysisRUNX3 
Mutations
ICGC Data PortalRUNX3 
TCGA Data PortalRUNX3 
Broad Tumor PortalRUNX3
OASIS PortalRUNX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRUNX3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRUNX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RUNX3
DgiDB (Drug Gene Interaction Database)RUNX3
DoCM (Curated mutations)RUNX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RUNX3 (select a term)
intoGenRUNX3
Cancer3DRUNX3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600210   
Orphanet
MedgenRUNX3
Genetic Testing Registry RUNX3
NextProtQ13761 [Medical]
TSGene864
GENETestsRUNX3
Huge Navigator RUNX3 [HugePedia]
snp3D : Map Gene to Disease864
BioCentury BCIQRUNX3
ClinGenRUNX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD864
Chemical/Pharm GKB GenePA34886
Clinical trialRUNX3
Miscellaneous
canSAR (ICR)RUNX3 (select the gene name)
Probes
Litterature
PubMed270 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRUNX3
EVEXRUNX3
GoPubMedRUNX3
iHOPRUNX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:18:10 CEST 2017

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