RUNX3 (RUNX family transcription factor 3)

2003-02-01  

Identity

HGNC
RUNX3
LOCATION
1p36.11
LOCUSID
864
ALIAS
AML2,CBFA3,PEBP2aC
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 864
MIM: 600210
HGNC: 10473
Ensembl: ENSG00000020633

Variants:

dbSNP: 864
ClinVar: 864
TCGA: ENSG00000020633
COSMIC: RUNX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000020633ENST00000308873Q13761
ENSG00000020633ENST00000338888Q13761
ENSG00000020633ENST00000338888A0A024RAH4
ENSG00000020633ENST00000399916Q13761
ENSG00000020633ENST00000399916A0A024RAH4

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
201907522010Multiple common variants for celiac disease influencing immune gene expression.351
171958452007Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells.202
175919292007Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample.156
158247392005Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk.81
187721122008RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis.80
184307392008Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation.72
183492822008DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients.71
161409422005RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization.70
260040682015RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma.68
199177732009Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells.67

Citation

Dessen P

RUNX3 (RUNX family transcription factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42184/runx3