| Nomenclature |
|---|
| HGNC (Hugo) | RUNX3 10473 |
| Cards |
|---|
| Entrez_Gene (NCBI) | RUNX3 864 runt related transcription factor 3 |
| Aliases | AML2; CBFA3; PEBP2aC |
| GeneCards (Weizmann) | RUNX3 |
| Ensembl hg19 (Hinxton) | ENSG00000020633 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000020633 [Gene_View] chr1:24899511-24965010 [Contig_View] RUNX3 [Vega] |
| ICGC DataPortal | ENSG00000020633 |
| TCGA cBioPortal | RUNX3 |
| AceView (NCBI) | RUNX3 |
| Genatlas (Paris) | RUNX3 |
| WikiGenes | 864 |
| SOURCE (Princeton) | RUNX3 |
| Genetics Home Reference (NIH) | RUNX3 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | RUNX3 - chr1:24899511-24965010 - 1p36.11 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | RUNX3 - 1p36.11 [Description] (hg19-Feb_2009) |
| Ensembl | RUNX3 - 1p36.11 [CytoView hg19] RUNX3 - 1p36.11 [CytoView hg38] |
| Mapping of homologs : NCBI | RUNX3 [Mapview hg19] RUNX3 [Mapview hg38] |
| OMIM | 600210 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF022726 AI375031 AJ001432 AK091829 AK300056 |
| RefSeq transcript (Entrez) | NM_001031680 NM_001320672 NM_004350 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | RUNX3 |
| Cluster EST : Unigene | Hs.170019 [ NCBI ] |
| CGAP (NCI) | Hs.170019 |
| Alternative Splicing Gallery | ENSG00000020633 |
| Gene Expression | RUNX3 [ NCBI-GEO ] RUNX3 [ EBI - ARRAY_EXPRESS ]
RUNX3 [ SEEK ] RUNX3 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | RUNX3 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 864 |
| GTEX Portal (Tissue expression) | RUNX3 |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q13761 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q13761 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q13761 |
| Splice isoforms : SwissVar | Q13761 |
| PhosPhoSitePlus | Q13761 |
| Domaine pattern : Prosite (Expaxy) | RUNT (PS51062) |
| Domains : Interpro (EBI) | AML1_Runt p53-like_TF_DNA-bd p53/RUNT-type_TF_DNA-bd Runt_dom Runx_central_dom RunxI_C_dom |
| Domain families : Pfam (Sanger) | Runt (PF00853) RunxI (PF08504) |
| Domain families : Pfam (NCBI) | pfam00853 pfam08504 |
| Conserved Domain (NCBI) | RUNX3 |
| DMDM Disease mutations | 864 |
| Blocks (Seattle) | RUNX3 |
| Superfamily | Q13761 |
| Human Protein Atlas | ENSG00000020633 |
| Peptide Atlas | Q13761 |
| HPRD | 02565 |
| IPI | IPI00004015 IPI00218386 IPI00908417 IPI01013326 IPI00816617 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q13761 |
| IntAct (EBI) | Q13761 |
| FunCoup | ENSG00000020633 |
| BioGRID | RUNX3 |
| STRING (EMBL) | RUNX3 |
| ZODIAC | RUNX3 |
| Ontologies - Pathways |
|---|
| QuickGO | Q13761 |
| Ontology : AmiGO | negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding ossification chondrocyte differentiation transcription factor activity, sequence-specific DNA binding protein binding ATP binding nucleus nucleolus cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein phosphorylation hemopoiesis intracellular membrane-bounded organelle regulation of cell differentiation negative regulation of cell cycle positive regulation of transcription, DNA-templated peripheral nervous system neuron development negative regulation of epithelial cell proliferation response to transforming growth factor beta |
| Ontology : EGO-EBI | negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding ossification chondrocyte differentiation transcription factor activity, sequence-specific DNA binding protein binding ATP binding nucleus nucleolus cytoplasm cytosol regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein phosphorylation hemopoiesis intracellular membrane-bounded organelle regulation of cell differentiation negative regulation of cell cycle positive regulation of transcription, DNA-templated peripheral nervous system neuron development negative regulation of epithelial cell proliferation response to transforming growth factor beta |
| NDEx Network | RUNX3 |
| Atlas of Cancer Signalling Network | RUNX3 |
| Wikipedia pathways | RUNX3 |
| Orthology - Evolution |
|---|
| OrthoDB | 864 |
| GeneTree (enSembl) | ENSG00000020633 |
| Phylogenetic Trees/Animal Genes : TreeFam | RUNX3 |
| HOVERGEN | Q13761 |
| HOGENOM | Q13761 |
| Homologs : HomoloGene | RUNX3 |
| Homology/Alignments : Family Browser (UCSC) | RUNX3 |
| Gene fusions - Rearrangements |
|---|
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | RUNX3 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | RUNX3 |
| dbVar | RUNX3 |
| ClinVar | RUNX3 |
| 1000_Genomes | RUNX3 |
| Exome Variant Server | RUNX3 |
| ExAC (Exome Aggregation Consortium) | RUNX3 (select the gene name) |
| Genetic variants : HAPMAP | 864 |
| Genomic Variants (DGV) | RUNX3 [DGVbeta] |
| DECIPHER | RUNX3 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | RUNX3 |
| Mutations |
|---|
| ICGC Data Portal | RUNX3 |
| TCGA Data Portal | RUNX3 |
| Broad Tumor Portal | RUNX3 |
| OASIS Portal | RUNX3 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | RUNX3 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | RUNX3 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search RUNX3 |
| DgiDB (Drug Gene Interaction Database) | RUNX3 |
| DoCM (Curated mutations) | RUNX3 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | RUNX3 (select a term) |
| intoGen | RUNX3 |
| Cancer3D | RUNX3(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 600210 |
| Orphanet | |
| Medgen | RUNX3 |
| Genetic Testing Registry | RUNX3
|
| NextProt | Q13761 [Medical] |
| TSGene | 864 |
| GENETests | RUNX3 |
| Target Validation | RUNX3 |
| Huge Navigator |
RUNX3 [HugePedia] |
| snp3D : Map Gene to Disease | 864 |
| BioCentury BCIQ | RUNX3 |
| ClinGen | RUNX3 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 864 |
| Chemical/Pharm GKB Gene | PA34886 |
| Clinical trial | RUNX3 |
| Miscellaneous |
|---|
| canSAR (ICR) | RUNX3 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 294 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | RUNX3 |
| EVEX | RUNX3 |
| GoPubMed | RUNX3 |
| iHOP | RUNX3 |
