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RUNX3 (RUNX family transcription factor 3)

Identity

Alias (NCBI)AML2
CBFA3
PEBP2aC
HGNC (Hugo) RUNX3
HGNC Alias symbAML2
PEBP2A3
HGNC Previous nameCBFA3
HGNC Previous namerunt-related transcription factor 3
 runt related transcription factor 3
LocusID (NCBI) 864
Atlas_Id 42184
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 24899511 and ends at 24930276 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RUNX3 (1p36.11) / RUNX3 (1p36.11)RUNX3 (1p36.11) / ZNF682 (19p12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)RUNX3   10473
Cards
Entrez_Gene (NCBI)RUNX3    RUNX family transcription factor 3
AliasesAML2; CBFA3; PEBP2aC
GeneCards (Weizmann)RUNX3
Ensembl hg19 (Hinxton)ENSG00000020633 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000020633 [Gene_View]  ENSG00000020633 [Sequence]  chr1:24899511-24930276 [Contig_View]  RUNX3 [Vega]
ICGC DataPortalENSG00000020633
TCGA cBioPortalRUNX3
AceView (NCBI)RUNX3
Genatlas (Paris)RUNX3
SOURCE (Princeton)RUNX3
Genetics Home Reference (NIH)RUNX3
Genomic and cartography
GoldenPath hg38 (UCSC)RUNX3  -     chr1:24899511-24930276 -  1p36.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RUNX3  -     1p36.11   [Description]    (hg19-Feb_2009)
GoldenPathRUNX3 - 1p36.11 [CytoView hg19]  RUNX3 - 1p36.11 [CytoView hg38]
ImmunoBaseENSG00000020633
Genome Data Viewer NCBIRUNX3 [Mapview hg19]  
OMIM600210   
Gene and transcription
Genbank (Entrez)AF022726 AI375031 AJ001432 AK091829 AK300056
RefSeq transcript (Entrez)NM_001031680 NM_001320672 NM_004350
Consensus coding sequences : CCDS (NCBI)RUNX3
Gene ExpressionRUNX3 [ NCBI-GEO ]   RUNX3 [ EBI - ARRAY_EXPRESS ]   RUNX3 [ SEEK ]   RUNX3 [ MEM ]
Gene Expression Viewer (FireBrowse)RUNX3 [ Firebrowse - Broad ]
GenevisibleExpression of RUNX3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)864
GTEX Portal (Tissue expression)RUNX3
Human Protein AtlasENSG00000020633-RUNX3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13761   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13761  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13761
PhosPhoSitePlusQ13761
Domaine pattern : Prosite (Expaxy)RUNT (PS51062)   
Domains : Interpro (EBI)AML1_Runt    p53-like_TF_DNA-bd    p53/RUNT-type_TF_DNA-bd_sf    Runt_dom    RunxI_C_dom    TF_Runt-rel_RUNX   
Domain families : Pfam (Sanger)Runt (PF00853)    RunxI (PF08504)   
Domain families : Pfam (NCBI)pfam00853    pfam08504   
Conserved Domain (NCBI)RUNX3
PDB (RSDB)5W69   
PDB Europe5W69   
PDB (PDBSum)5W69   
PDB (IMB)5W69   
Structural Biology KnowledgeBase5W69   
SCOP (Structural Classification of Proteins)5W69   
CATH (Classification of proteins structures)5W69   
SuperfamilyQ13761
AlphaFold pdb e-kbQ13761   
Human Protein Atlas [tissue]ENSG00000020633-RUNX3 [tissue]
HPRD02565
Protein Interaction databases
DIP (DOE-UCLA)Q13761
IntAct (EBI)Q13761
BioGRIDRUNX3
STRING (EMBL)RUNX3
ZODIACRUNX3
Ontologies - Pathways
QuickGOQ13761
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  chromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  ossification  chondrocyte differentiation  DNA-binding transcription factor activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  cytosol  cytosol  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  protein phosphorylation  core-binding factor complex  hemopoiesis  neuron differentiation  intracellular membrane-bounded organelle  negative regulation of CD4-positive, alpha-beta T cell differentiation  positive regulation of CD8-positive, alpha-beta T cell differentiation  regulation of cell differentiation  negative regulation of cell cycle  positive regulation of transcription, DNA-templated  peripheral nervous system neuron development  negative regulation of epithelial cell proliferation  response to transforming growth factor beta  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  chromatin  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  ossification  chondrocyte differentiation  DNA-binding transcription factor activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  cytosol  cytosol  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  protein phosphorylation  core-binding factor complex  hemopoiesis  neuron differentiation  intracellular membrane-bounded organelle  negative regulation of CD4-positive, alpha-beta T cell differentiation  positive regulation of CD8-positive, alpha-beta T cell differentiation  regulation of cell differentiation  negative regulation of cell cycle  positive regulation of transcription, DNA-templated  peripheral nervous system neuron development  negative regulation of epithelial cell proliferation  response to transforming growth factor beta  sequence-specific double-stranded DNA binding  
NDEx NetworkRUNX3
Atlas of Cancer Signalling NetworkRUNX3
Wikipedia pathwaysRUNX3
Orthology - Evolution
OrthoDB864
GeneTree (enSembl)ENSG00000020633
Phylogenetic Trees/Animal Genes : TreeFamRUNX3
Homologs : HomoloGeneRUNX3
Homology/Alignments : Family Browser (UCSC)RUNX3
Gene fusions - Rearrangements
Fusion : QuiverRUNX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRUNX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RUNX3
dbVarRUNX3
ClinVarRUNX3
MonarchRUNX3
1000_GenomesRUNX3 
Exome Variant ServerRUNX3
GNOMAD BrowserENSG00000020633
Varsome BrowserRUNX3
ACMGRUNX3 variants
VarityQ13761
Genomic Variants (DGV)RUNX3 [DGVbeta]
DECIPHERRUNX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRUNX3 
Mutations
ICGC Data PortalRUNX3 
TCGA Data PortalRUNX3 
Broad Tumor PortalRUNX3
OASIS PortalRUNX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRUNX3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRUNX3
Mutations and Diseases : HGMDRUNX3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRUNX3
DgiDB (Drug Gene Interaction Database)RUNX3
DoCM (Curated mutations)RUNX3
CIViC (Clinical Interpretations of Variants in Cancer)RUNX3
Cancer3DRUNX3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600210   
Orphanet
DisGeNETRUNX3
MedgenRUNX3
Genetic Testing Registry RUNX3
NextProtQ13761 [Medical]
GENETestsRUNX3
Target ValidationRUNX3
Huge Navigator RUNX3 [HugePedia]
ClinGenRUNX3
Clinical trials, drugs, therapy
MyCancerGenomeRUNX3
Protein Interactions : CTDRUNX3
Pharm GKB GenePA34886
PharosQ13761
Clinical trialRUNX3
Miscellaneous
canSAR (ICR)RUNX3
HarmonizomeRUNX3
DataMed IndexRUNX3
Probes
Litterature
PubMed387 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRUNX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:29:51 CEST 2021

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