RUSC1 (RUN and SH3 domain containing 1)

2019-08-01  

Identity

HGNC
RUSC1
LOCATION
1q22
LOCUSID
23623
ALIAS
NESCA

Other Information

Locus ID:

NCBI: 23623
MIM: 617318
HGNC: 17153
Ensembl: ENSG00000160753

Variants:

dbSNP: 23623
ClinVar: 23623
TCGA: ENSG00000160753
COSMIC: RUSC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160753ENST00000292254Q9BVN2
ENSG00000160753ENST00000368347Q9BVN2
ENSG00000160753ENST00000368349Q9BVN2
ENSG00000160753ENST00000368352Q9BVN2
ENSG00000160753ENST00000368354Q9BVN2
ENSG00000160753ENST00000468764A0A087WYU8
ENSG00000160753ENST00000471876A0A087WZ68
ENSG00000160753ENST00000479924A0A087WX95
ENSG00000160753ENST00000485924A0A087WYB2
ENSG00000160753ENST00000489860A0A087WVK5
ENSG00000160753ENST00000490373Q68CX2
ENSG00000160753ENST00000497930A0A087WW20

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
302628842018AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.21
224044292012Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre-synaptic membrane protein, syntaxin-1, in hippocampal neurons.7
228210142012Crystal structure and functional implication of the RUN domain of human NESCA.3
193658082009NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein.2
305690972019Long noncoding RNA RUSC1‑AS‑N promotes cell proliferation and metastasis through Wnt/β‑catenin signaling in human breast cancer.0

Citation

Dessen P

RUSC1 (RUN and SH3 domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58042/rusc1