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RUSC2 (RUN and SH3 domain containing 2)

Identity

Alias_symbol (synonym)KIAA0375
Other aliasIporin
HGNC (Hugo) RUSC2
LocusID (NCBI) 9853
Atlas_Id 54597
Location 9p13.3  [Link to chromosome band 9p13]
Location_base_pair Starts at 35538632 and ends at 35561898 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLSTN1 (1p36.22) / RUSC2 (9p13.3)PLAA (9p21.2) / RUSC2 (9p13.3)RUSC2 (9p13.3) / ABAT (16p13.2)
RUSC2 (9p13.3) / GH2 (17q23.3)RUSC2 (9p13.3) / RUSC2 (9p13.3)USP22 (17p11.2) / RUSC2 (9p13.3)
RUSC2 9p13.3 / ABAT 16p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)RUSC2   23625
Cards
Entrez_Gene (NCBI)RUSC2  9853  RUN and SH3 domain containing 2
AliasesIporin
GeneCards (Weizmann)RUSC2
Ensembl hg19 (Hinxton)ENSG00000198853 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198853 [Gene_View]  chr9:35538632-35561898 [Contig_View]  RUSC2 [Vega]
ICGC DataPortalENSG00000198853
TCGA cBioPortalRUSC2
AceView (NCBI)RUSC2
Genatlas (Paris)RUSC2
WikiGenes9853
SOURCE (Princeton)RUSC2
Genetics Home Reference (NIH)RUSC2
Genomic and cartography
GoldenPath hg38 (UCSC)RUSC2  -     chr9:35538632-35561898 +  9p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RUSC2  -     9p13.3   [Description]    (hg19-Feb_2009)
EnsemblRUSC2 - 9p13.3 [CytoView hg19]  RUSC2 - 9p13.3 [CytoView hg38]
Mapping of homologs : NCBIRUSC2 [Mapview hg19]  RUSC2 [Mapview hg38]
OMIM611053   
Gene and transcription
Genbank (Entrez)AB002373 AI818507 AK299805 BC029647 BC064843
RefSeq transcript (Entrez)NM_001135999 NM_001330740 NM_014806
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RUSC2
Cluster EST : UnigeneHs.493796 [ NCBI ]
CGAP (NCI)Hs.493796
Alternative Splicing GalleryENSG00000198853
Gene ExpressionRUSC2 [ NCBI-GEO ]   RUSC2 [ EBI - ARRAY_EXPRESS ]   RUSC2 [ SEEK ]   RUSC2 [ MEM ]
Gene Expression Viewer (FireBrowse)RUSC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9853
GTEX Portal (Tissue expression)RUSC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N2Y8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N2Y8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N2Y8
Splice isoforms : SwissVarQ8N2Y8
PhosPhoSitePlusQ8N2Y8
Domaine pattern : Prosite (Expaxy)RUN (PS50826)    SH3 (PS50002)   
Domains : Interpro (EBI)Run_dom    SH3_2    SH3_domain   
Domain families : Pfam (Sanger)RUN (PF02759)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam02759    pfam07653   
Domain families : Smart (EMBL)RUN (SM00593)  SH3 (SM00326)  
Conserved Domain (NCBI)RUSC2
DMDM Disease mutations9853
Blocks (Seattle)RUSC2
SuperfamilyQ8N2Y8
Human Protein AtlasENSG00000198853
Peptide AtlasQ8N2Y8
HPRD18009
IPIIPI00444656   IPI01011693   
Protein Interaction databases
DIP (DOE-UCLA)Q8N2Y8
IntAct (EBI)Q8N2Y8
FunCoupENSG00000198853
BioGRIDRUSC2
STRING (EMBL)RUSC2
ZODIACRUSC2
Ontologies - Pathways
QuickGOQ8N2Y8
Ontology : AmiGOprotein binding  cytosol  biological_process  Rab GTPase binding  cytoplasmic vesicle  extracellular exosome  
Ontology : EGO-EBIprotein binding  cytosol  biological_process  Rab GTPase binding  cytoplasmic vesicle  extracellular exosome  
NDEx NetworkRUSC2
Atlas of Cancer Signalling NetworkRUSC2
Wikipedia pathwaysRUSC2
Orthology - Evolution
OrthoDB9853
GeneTree (enSembl)ENSG00000198853
Phylogenetic Trees/Animal Genes : TreeFamRUSC2
HOVERGENQ8N2Y8
HOGENOMQ8N2Y8
Homologs : HomoloGeneRUSC2
Homology/Alignments : Family Browser (UCSC)RUSC2
Gene fusions - Rearrangements
Fusion : MitelmanPLAA/RUSC2 [9p21.2/9p13.3]  [t(9;9)(p13;p21)]  
Fusion : MitelmanRUSC2/ABAT [9p13.3/16p13.2]  [t(9;16)(p13;p13)]  
Fusion: TCGARUSC2 9p13.3 ABAT 16p13.2 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRUSC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RUSC2
dbVarRUSC2
ClinVarRUSC2
1000_GenomesRUSC2 
Exome Variant ServerRUSC2
ExAC (Exome Aggregation Consortium)RUSC2 (select the gene name)
Genetic variants : HAPMAP9853
Genomic Variants (DGV)RUSC2 [DGVbeta]
DECIPHERRUSC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRUSC2 
Mutations
ICGC Data PortalRUSC2 
TCGA Data PortalRUSC2 
Broad Tumor PortalRUSC2
OASIS PortalRUSC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRUSC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRUSC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RUSC2
DgiDB (Drug Gene Interaction Database)RUSC2
DoCM (Curated mutations)RUSC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RUSC2 (select a term)
intoGenRUSC2
Cancer3DRUSC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611053   
Orphanet
MedgenRUSC2
Genetic Testing Registry RUSC2
NextProtQ8N2Y8 [Medical]
TSGene9853
GENETestsRUSC2
Target ValidationRUSC2
Huge Navigator RUSC2 [HugePedia]
snp3D : Map Gene to Disease9853
BioCentury BCIQRUSC2
ClinGenRUSC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9853
Chemical/Pharm GKB GenePA134956488
Clinical trialRUSC2
Miscellaneous
canSAR (ICR)RUSC2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRUSC2
EVEXRUSC2
GoPubMedRUSC2
iHOPRUSC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:29:45 CEST 2017

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