RUSC2 (RUN and SH3 domain containing 2)

2014-08-01  

Identity

HGNC
LOCATION
9p13.3
LOCUSID
ALIAS
Iporin,MRT61
FUSION GENES

Other Information

Locus ID:

NCBI: 9853
MIM: 611053
HGNC: 23625
Ensembl: ENSG00000198853

Variants:

dbSNP: 9853
ClinVar: 9853
TCGA: ENSG00000198853
COSMIC: RUSC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198853ENST00000361226Q8N2Y8
ENSG00000198853ENST00000455600Q8N2Y8

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
302628842018AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.21
272385702016EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.10
157967812005Identification and characterization of Iporin as a novel interaction partner for rab1.8
276121862016Loss-of-function mutation in RUSC2 causes intellectual disability and secondary microcephaly.3
311998892019Circ_RUSC2 upregulates the expression of miR-661 target gene SYK and regulates the function of vascular smooth muscle cells.3
309056722019Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase.2

Citation

Dessen P

RUSC2 (RUN and SH3 domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54597/rusc2