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RXFP2 (relaxin/insulin-like family peptide receptor 2)

Identity

Other namesGPR106
GREAT
INSL3R
LGR8
LGR8.1
RXFPR2
HGNC (Hugo) RXFP2
LocusID (NCBI) 122042
Location 13q13.1
Location_base_pair Starts at 32313679 and ends at 32377009 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)RXFP2   17318
Entrez_Gene (NCBI)RXFP2  122042  relaxin/insulin-like family peptide receptor 2
Cards
GeneCards (Weizmann)RXFP2
Ensembl (Hinxton)ENSG00000133105 [Gene_View]  chr13:32313679-32377009 [Contig_View]  RXFP2 [Vega]
AceView (NCBI)RXFP2
Genatlas (Paris)RXFP2
SOURCE (Stanford)NM_001166058 NM_130806
Genomic and cartography
GoldenPath (UCSC)RXFP2  -  13q13.1   chr13:32313679-32377009 +  13q13.1   [Description]    (hg19-Feb_2009)
EnsemblRXFP2 - 13q13.1 [CytoView]
Mapping of homologs : NCBIRXFP2 [Mapview]
OMIM219050   606655   
Gene and transcription
Genbank (Entrez)AF403384 AF453828 AY899851 BC146279 BC148729
RefSeq transcript (SRS)NM_001166058 NM_130806
RefSeq transcript (Entrez)NM_001166058 NM_130806
RefSeq genomic (SRS)AC_000145 NC_000013 NC_018924 NG_015819 NT_024524 NW_001838072 NW_004929388
RefSeq genomic (Entrez)AC_000145 NC_000013 NC_018924 NG_015819 NT_024524 NW_001838072 NW_004929388
Consensus coding sequences : CCDS (NCBI)RXFP2
Cluster EST : UnigeneHs.680763 [ SRS ] Hs.680763 [ NCBI ]
CGAP (NCI)Hs.680763
Alternative Splicing : Fast-db (Paris)GSHG0008029
Alternative Splicing GalleryENSG00000133105
Gene ExpressionRXFP2 [ NCBI-GEO ]   RXFP2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WXD0 (SRS) Q8WXD0 (Uniprot)
NextProtQ8WXD0  [Medical]
With graphics : InterProQ8WXD0
Splice isoforms : SwissVarQ8WXD0(Swissvar)
Domaine pattern : Prosite (SRS)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)    LDLRA_1 (PS01209)    LDLRA_2 (PS50068)    LRR (PS51450)   
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)    LDLRA_1 (PS01209)    LDLRA_2 (PS50068)    LRR (PS51450)   
Domains : Interpro (SRS)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    LDLR_class-A_CS    LDrepeatLR_classA_rpt    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR-contain_N    Relaxin_rcpt   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    LDLR_class-A_CS    LDrepeatLR_classA_rpt    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR-contain_N    Relaxin_rcpt   
Related proteins : CluSTrQ8WXD0
Domain families : Pfam (SRS)7tm_1 (PF00001)    Ldl_recept_a (PF00057)   
Domain families : Pfam (Sanger)7tm_1 (PF00001)    Ldl_recept_a (PF00057)   
Domain families : Pfam (NCBI)pfam00001    pfam00057   
Domain families : Smart (EMBL)LDLa (SM00192)  LRR_TYP (SM00369)  LRRNT (SM00013)  
DMDM122042
Blocks (Seattle)Q8WXD0
Human Protein AtlasENSG00000133105
HPRD05976
IPIIPI00103510   IPI00654597   
Protein Interaction databases
DIP (DOE-UCLA)Q8WXD0
IntAct (EBI)Q8WXD0
FunCoupENSG00000133105
REACTOMERXFP2
Protein Interaction Database122042
BioGRIDRXFP2
InParanoidQ8WXD0
Interologous Interaction database Q8WXD0
IntegromeDBRXFP2
Gene fusion - rearrangments
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)RXFP2
SNP (GeneSNP Utah)RXFP2
SNP : HGBaseRXFP2
Genetic variants : HAPMAPRXFP2
Somatic Mutations in Cancer : COSMICRXFP2 
CONAN: Copy Number AnalysisRXFP2 
Mutations and Diseases : HGMDRXFP2
OMIM219050    606655   
GENETests219050    606655   
Disease Genetic AssociationRXFP2
Huge Navigator RXFP2 [HugePedia]  RXFP2 [HugeCancerGEM]
Genomic VariantsRXFP2  RXFP2 [DGVbeta]
ClinVarRXFP2
snp3D : Map Gene to Disease122042
General knowledge
Homologs : HomoloGeneRXFP2
Homology/Alignments : Family Browser (UCSC)RXFP2
Phylogenetic Trees/Animal Genes : TreeFamRXFP2
Chemical/Protein Interactions : CTD122042
Chemical/Pharm GKB GenePA134918556
Clinical trialRXFP2
Cancer Resource (Charite)ENSG00000133105
Ontology : AmiGOoocyte maturation  plasma membrane  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  negative regulation of cell proliferation  male gonad development  integral to membrane  protein-hormone receptor activity  peptide hormone binding  positive regulation of cAMP biosynthetic process  negative regulation of apoptotic process  
Ontology : EGO-EBIoocyte maturation  plasma membrane  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  negative regulation of cell proliferation  male gonad development  integral to membrane  protein-hormone receptor activity  peptide hormone binding  positive regulation of cAMP biosynthetic process  negative regulation of apoptotic process  
Pathways : KEGGNeuroactive ligand-receptor interaction
Other databases
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
PubGeneRXFP2
iHOPRXFP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Dec 3 19:37:11 CET 2013
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