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RXFP2 (relaxin/insulin-like family peptide receptor 2)

Identity

Other namesGPR106
GREAT
INSL3R
LGR8
LGR8.1
RXFPR2
HGNC (Hugo) RXFP2
LocusID (NCBI) 122042
Location 13q13.1
Location_base_pair Starts at 32313679 and ends at 32377009 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)RXFP2   17318
Cards
Entrez_Gene (NCBI)RXFP2  122042  relaxin/insulin-like family peptide receptor 2
GeneCards (Weizmann)RXFP2
Ensembl hg19 (Hinxton)ENSG00000133105 [Gene_View]  chr13:32313679-32377009 [Contig_View]  RXFP2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000133105 [Gene_View]  chr13:32313679-32377009 [Contig_View]  RXFP2 [Vega]
ICGC DataPortalENSG00000133105
cBioPortalRXFP2
AceView (NCBI)RXFP2
Genatlas (Paris)RXFP2
WikiGenes122042
SOURCE (Princeton)RXFP2
Genomic and cartography
GoldenPath hg19 (UCSC)RXFP2  -     chr13:32313679-32377009 +  13q13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RXFP2  -     13q13.1   [Description]    (hg38-Dec_2013)
EnsemblRXFP2 - 13q13.1 [CytoView hg19]  RXFP2 - 13q13.1 [CytoView hg38]
Mapping of homologs : NCBIRXFP2 [Mapview hg19]  RXFP2 [Mapview hg38]
OMIM219050   606655   
Gene and transcription
Genbank (Entrez)AF403384 AF453828 AY899851 BC146279 BC148729
RefSeq transcript (Entrez)NM_001166058 NM_130806
RefSeq genomic (Entrez)AC_000145 NC_000013 NC_018924 NG_015819 NT_024524 NW_001838072 NW_004929388
Consensus coding sequences : CCDS (NCBI)RXFP2
Cluster EST : UnigeneHs.680763 [ NCBI ]
CGAP (NCI)Hs.680763
Alternative Splicing : Fast-db (Paris)GSHG0008029
Alternative Splicing GalleryENSG00000133105
Gene ExpressionRXFP2 [ NCBI-GEO ]     RXFP2 [ SEEK ]   RXFP2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WXD0 (Uniprot)
NextProtQ8WXD0  [Medical]
With graphics : InterProQ8WXD0
Splice isoforms : SwissVarQ8WXD0 (Swissvar)
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_2 (PS50262)    LDLRA_1 (PS01209)    LDLRA_2 (PS50068)    LRR (PS51450)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    LDLR_class-A_CS    LDrepeatLR_classA_rpt    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR-contain_N    Relaxin_rcpt   
Related proteins : CluSTrQ8WXD0
Domain families : Pfam (Sanger)7tm_1 (PF00001)    Ldl_recept_a (PF00057)    LRR_8 (PF13855)   
Domain families : Pfam (NCBI)pfam00001    pfam00057    pfam13855   
Domain families : Smart (EMBL)LDLa (SM00192)  LRR_TYP (SM00369)  LRRNT (SM00013)  
DMDM Disease mutations122042
Blocks (Seattle)Q8WXD0
Human Protein AtlasENSG00000133105
Peptide AtlasQ8WXD0
HPRD05976
IPIIPI00103510   IPI00654597   
Protein Interaction databases
DIP (DOE-UCLA)Q8WXD0
IntAct (EBI)Q8WXD0
FunCoupENSG00000133105
BioGRIDRXFP2
IntegromeDBRXFP2
STRING (EMBL)RXFP2
Ontologies - Pathways
QuickGOQ8WXD0
Ontology : AmiGOoocyte maturation  plasma membrane  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  negative regulation of cell proliferation  male gonad development  integral component of membrane  protein-hormone receptor activity  peptide hormone binding  positive regulation of cAMP biosynthetic process  negative regulation of apoptotic process  
Ontology : EGO-EBIoocyte maturation  plasma membrane  adenylate cyclase-activating G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  negative regulation of cell proliferation  male gonad development  integral component of membrane  protein-hormone receptor activity  peptide hormone binding  positive regulation of cAMP biosynthetic process  negative regulation of apoptotic process  
Pathways : KEGGNeuroactive ligand-receptor interaction   
Protein Interaction DatabaseRXFP2
DoCM (Curated mutations)RXFP2
Wikipedia pathwaysRXFP2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerRXFP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RXFP2
dbVarRXFP2
ClinVarRXFP2
1000_GenomesRXFP2 
Exome Variant ServerRXFP2
SNP (GeneSNP Utah)RXFP2
SNP : HGBaseRXFP2
Genetic variants : HAPMAPRXFP2
Genomic VariantsRXFP2  RXFP2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000133105 
Somatic Mutations in Cancer : COSMICRXFP2 
CONAN: Copy Number AnalysisRXFP2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)13:32313679-32377009
Mutations and Diseases : HGMDRXFP2
OMIM219050    606655   
MedgenRXFP2
NextProtQ8WXD0 [Medical]
GENETestsRXFP2
Disease Genetic AssociationRXFP2
Huge Navigator RXFP2 [HugePedia]  RXFP2 [HugeCancerGEM]
snp3D : Map Gene to Disease122042
DGIdb (Drug Gene Interaction db)RXFP2
General knowledge
Homologs : HomoloGeneRXFP2
Homology/Alignments : Family Browser (UCSC)RXFP2
Phylogenetic Trees/Animal Genes : TreeFamRXFP2
Chemical/Protein Interactions : CTD122042
Chemical/Pharm GKB GenePA134918556
Clinical trialRXFP2
Cancer Resource (Charite)ENSG00000133105
Other databases
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
CoreMineRXFP2
GoPubMedRXFP2
iHOPRXFP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 01:17:22 CET 2014
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