RXFP2 (relaxin family peptide receptor 2)

2011-09-01  

Identity

HGNC
LOCATION
13q13.1
LOCUSID
ALIAS
GPR106,GREAT,INSL3R,LGR8,LGR8.1,RXFPR2

Other Information

Locus ID:

NCBI: 122042
MIM: 606655
HGNC: 17318
Ensembl: ENSG00000133105

Variants:

dbSNP: 122042
ClinVar: 122042
TCGA: ENSG00000133105
COSMIC: RXFP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133105ENST00000298386Q8WXD0
ENSG00000133105ENST00000380314Q8WXD0

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Relaxin receptorsREACTOMER-HSA-444821
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

References

Pubmed IDYearTitleCitations
372088612023Bi-allelic variants in INSL3 and RXFP2 cause bilateral cryptorchidism and male infertility.1
372088612023Bi-allelic variants in INSL3 and RXFP2 cause bilateral cryptorchidism and male infertility.1
344549452021Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2.6
344549452021Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2.6
321263852020Human amniotic fluid-based exposure levels of phthalates and bisphenol A mixture reduce INSL3/RXFP2 signaling.8
325577602020Expression of RXFP2 receptor on human spermatozoa and the anti-apoptotic and antioxidant effects of insulin-like factor 3.1
321263852020Human amniotic fluid-based exposure levels of phthalates and bisphenol A mixture reduce INSL3/RXFP2 signaling.8
325577602020Expression of RXFP2 receptor on human spermatozoa and the anti-apoptotic and antioxidant effects of insulin-like factor 3.1
311677972019Familial bilateral cryptorchidism is caused by recessive variants in RXFP2.10
311677972019Familial bilateral cryptorchidism is caused by recessive variants in RXFP2.10
280813712017GWAS Identifies New Loci for Painful Temporomandibular Disorder: Hispanic Community Health Study/Study of Latinos.16
280813712017GWAS Identifies New Loci for Painful Temporomandibular Disorder: Hispanic Community Health Study/Study of Latinos.16
249837022014Mapping key regions of the RXFP2 low-density lipoprotein class-A module that are involved in signal activation.6
249837022014Mapping key regions of the RXFP2 low-density lipoprotein class-A module that are involved in signal activation.6
235395102013Insulin-like factor 3 promotes wound healing at the ocular surface.10

Citation

Dessen P

RXFP2 (relaxin family peptide receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-09-01

Online version: http://atlasgeneticsoncology.org/gene/52389/rxfp2