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RXRA (retinoid X receptor alpha)

Identity

Alias (NCBI)NR2B1
HGNC (Hugo) RXRA
HGNC Alias symbNR2B1
HGNC Alias namenuclear receptor subfamily 2 group B member 1
HGNC Previous nameretinoid X receptor, alpha
LocusID (NCBI) 6256
Atlas_Id 42186
Location 9q34.2  [Link to chromosome band 9q34]
Location_base_pair Starts at 134326455 and ends at 134440585 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RXRA (9q34.2) / LRBA (4q31.3)RXRA (9q34.2) / RXRA (9q34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  M3/M3v acute myeloid leukemia (AML M3/M3v)
::Acute promyelocytic leukemia (APL)
::Acute promyelocytic leukemia (APL) PML/RARA

t(12;12)(p13;q13) ETV6/BAZ2A


External links

 

Nomenclature
HGNC (Hugo)RXRA   10477
Cards
Entrez_Gene (NCBI)RXRA    retinoid X receptor alpha
AliasesNR2B1
GeneCards (Weizmann)RXRA
Ensembl hg19 (Hinxton)ENSG00000186350 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186350 [Gene_View]  ENSG00000186350 [Sequence]  chr9:134326455-134440585 [Contig_View]  RXRA [Vega]
ICGC DataPortalENSG00000186350
TCGA cBioPortalRXRA
AceView (NCBI)RXRA
Genatlas (Paris)RXRA
SOURCE (Princeton)RXRA
Genetics Home Reference (NIH)RXRA
Genomic and cartography
GoldenPath hg38 (UCSC)RXRA  -     chr9:134326455-134440585 +  9q34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RXRA  -     9q34.2   [Description]    (hg19-Feb_2009)
GoldenPathRXRA - 9q34.2 [CytoView hg19]  RXRA - 9q34.2 [CytoView hg38]
ImmunoBaseENSG00000186350
Genome Data Viewer NCBIRXRA [Mapview hg19]  
OMIM180245   
Gene and transcription
Genbank (Entrez)AB307705 AF052092 AK090416 AK131081 AK131192
RefSeq transcript (Entrez)NM_001291920 NM_001291921 NM_002957
Consensus coding sequences : CCDS (NCBI)RXRA
Gene ExpressionRXRA [ NCBI-GEO ]   RXRA [ EBI - ARRAY_EXPRESS ]   RXRA [ SEEK ]   RXRA [ MEM ]
Gene Expression Viewer (FireBrowse)RXRA [ Firebrowse - Broad ]
GenevisibleExpression of RXRA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6256
GTEX Portal (Tissue expression)RXRA
Human Protein AtlasENSG00000186350-RXRA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19793   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP19793  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19793
PhosPhoSitePlusP19793
Domaine pattern : Prosite (Expaxy)NR_LBD (PS51843)    NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)NHR-like_dom_sf    Nuc_recep-AF1    Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt    Retinoid-X_rcpt/HNF4    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    Nuc_recep-AF1 (PF11825)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam11825    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
Conserved Domain (NCBI)RXRA
PDB (RSDB)1BY4    1DSZ    1FBY    1FM6    1FM9    1G1U    1G5Y    1K74    1MV9    1MVC    1MZN    1R0N    1RDT    1RXR    1XLS    1XV9    1XVP    1YNW    2ACL    2NLL    2P1T    2P1U    2P1V    2ZXZ    2ZY0    3DZU    3DZY    3E00    3E94    3FAL    3FC6    3FUG    3H0A    3KWY    3NSP    3NSQ    3OAP    3OZJ    3PCU    3R29    3R2A    3R5M    3UVV    4CN2    4CN3    4CN5    4CN7    4J5W    4J5X    4K4J    4K6I    4M8E    4M8H    4N5G    4N8R    4NQA    4OC7    4POH    4POJ    4PP3    4PP5    4RFW    4RMC    4RMD    4RME    4ZO1    4ZSH    5EC9    5JI0    5LYQ    5MJ5    5MK4    5MKJ    5MKU    5MMW    5TBP    5UAN    5Z12    5ZQU    6A5Y    6A5Z    6A60    6FBQ    6FBR    6HN6    6JNO    6JNR    6L6K    6SJM    6STI    6XWG    6XWH    7A77   
PDB Europe1BY4    1DSZ    1FBY    1FM6    1FM9    1G1U    1G5Y    1K74    1MV9    1MVC    1MZN    1R0N    1RDT    1RXR    1XLS    1XV9    1XVP    1YNW    2ACL    2NLL    2P1T    2P1U    2P1V    2ZXZ    2ZY0    3DZU    3DZY    3E00    3E94    3FAL    3FC6    3FUG    3H0A    3KWY    3NSP    3NSQ    3OAP    3OZJ    3PCU    3R29    3R2A    3R5M    3UVV    4CN2    4CN3    4CN5    4CN7    4J5W    4J5X    4K4J    4K6I    4M8E    4M8H    4N5G    4N8R    4NQA    4OC7    4POH    4POJ    4PP3    4PP5    4RFW    4RMC    4RMD    4RME    4ZO1    4ZSH    5EC9    5JI0    5LYQ    5MJ5    5MK4    5MKJ    5MKU    5MMW    5TBP    5UAN    5Z12    5ZQU    6A5Y    6A5Z    6A60    6FBQ    6FBR    6HN6    6JNO    6JNR    6L6K    6SJM    6STI    6XWG    6XWH    7A77   
PDB (PDBSum)1BY4    1DSZ    1FBY    1FM6    1FM9    1G1U    1G5Y    1K74    1MV9    1MVC    1MZN    1R0N    1RDT    1RXR    1XLS    1XV9    1XVP    1YNW    2ACL    2NLL    2P1T    2P1U    2P1V    2ZXZ    2ZY0    3DZU    3DZY    3E00    3E94    3FAL    3FC6    3FUG    3H0A    3KWY    3NSP    3NSQ    3OAP    3OZJ    3PCU    3R29    3R2A    3R5M    3UVV    4CN2    4CN3    4CN5    4CN7    4J5W    4J5X    4K4J    4K6I    4M8E    4M8H    4N5G    4N8R    4NQA    4OC7    4POH    4POJ    4PP3    4PP5    4RFW    4RMC    4RMD    4RME    4ZO1    4ZSH    5EC9    5JI0    5LYQ    5MJ5    5MK4    5MKJ    5MKU    5MMW    5TBP    5UAN    5Z12    5ZQU    6A5Y    6A5Z    6A60    6FBQ    6FBR    6HN6    6JNO    6JNR    6L6K    6SJM    6STI    6XWG    6XWH    7A77   
PDB (IMB)1BY4    1DSZ    1FBY    1FM6    1FM9    1G1U    1G5Y    1K74    1MV9    1MVC    1MZN    1R0N    1RDT    1RXR    1XLS    1XV9    1XVP    1YNW    2ACL    2NLL    2P1T    2P1U    2P1V    2ZXZ    2ZY0    3DZU    3DZY    3E00    3E94    3FAL    3FC6    3FUG    3H0A    3KWY    3NSP    3NSQ    3OAP    3OZJ    3PCU    3R29    3R2A    3R5M    3UVV    4CN2    4CN3    4CN5    4CN7    4J5W    4J5X    4K4J    4K6I    4M8E    4M8H    4N5G    4N8R    4NQA    4OC7    4POH    4POJ    4PP3    4PP5    4RFW    4RMC    4RMD    4RME    4ZO1    4ZSH    5EC9    5JI0    5LYQ    5MJ5    5MK4    5MKJ    5MKU    5MMW    5TBP    5UAN    5Z12    5ZQU    6A5Y    6A5Z    6A60    6FBQ    6FBR    6HN6    6JNO    6JNR    6L6K    6SJM    6STI    6XWG    6XWH    7A77   
Structural Biology KnowledgeBase1BY4    1DSZ    1FBY    1FM6    1FM9    1G1U    1G5Y    1K74    1MV9    1MVC    1MZN    1R0N    1RDT    1RXR    1XLS    1XV9    1XVP    1YNW    2ACL    2NLL    2P1T    2P1U    2P1V    2ZXZ    2ZY0    3DZU    3DZY    3E00    3E94    3FAL    3FC6    3FUG    3H0A    3KWY    3NSP    3NSQ    3OAP    3OZJ    3PCU    3R29    3R2A    3R5M    3UVV    4CN2    4CN3    4CN5    4CN7    4J5W    4J5X    4K4J    4K6I    4M8E    4M8H    4N5G    4N8R    4NQA    4OC7    4POH    4POJ    4PP3    4PP5    4RFW    4RMC    4RMD    4RME    4ZO1    4ZSH    5EC9    5JI0    5LYQ    5MJ5    5MK4    5MKJ    5MKU    5MMW    5TBP    5UAN    5Z12    5ZQU    6A5Y    6A5Z    6A60    6FBQ    6FBR    6HN6    6JNO    6JNR    6L6K    6SJM    6STI    6XWG    6XWH    7A77   
SCOP (Structural Classification of Proteins)1BY4    1DSZ    1FBY    1FM6    1FM9    1G1U    1G5Y    1K74    1MV9    1MVC    1MZN    1R0N    1RDT    1RXR    1XLS    1XV9    1XVP    1YNW    2ACL    2NLL    2P1T    2P1U    2P1V    2ZXZ    2ZY0    3DZU    3DZY    3E00    3E94    3FAL    3FC6    3FUG    3H0A    3KWY    3NSP    3NSQ    3OAP    3OZJ    3PCU    3R29    3R2A    3R5M    3UVV    4CN2    4CN3    4CN5    4CN7    4J5W    4J5X    4K4J    4K6I    4M8E    4M8H    4N5G    4N8R    4NQA    4OC7    4POH    4POJ    4PP3    4PP5    4RFW    4RMC    4RMD    4RME    4ZO1    4ZSH    5EC9    5JI0    5LYQ    5MJ5    5MK4    5MKJ    5MKU    5MMW    5TBP    5UAN    5Z12    5ZQU    6A5Y    6A5Z    6A60    6FBQ    6FBR    6HN6    6JNO    6JNR    6L6K    6SJM    6STI    6XWG    6XWH    7A77   
CATH (Classification of proteins structures)1BY4    1DSZ    1FBY    1FM6    1FM9    1G1U    1G5Y    1K74    1MV9    1MVC    1MZN    1R0N    1RDT    1RXR    1XLS    1XV9    1XVP    1YNW    2ACL    2NLL    2P1T    2P1U    2P1V    2ZXZ    2ZY0    3DZU    3DZY    3E00    3E94    3FAL    3FC6    3FUG    3H0A    3KWY    3NSP    3NSQ    3OAP    3OZJ    3PCU    3R29    3R2A    3R5M    3UVV    4CN2    4CN3    4CN5    4CN7    4J5W    4J5X    4K4J    4K6I    4M8E    4M8H    4N5G    4N8R    4NQA    4OC7    4POH    4POJ    4PP3    4PP5    4RFW    4RMC    4RMD    4RME    4ZO1    4ZSH    5EC9    5JI0    5LYQ    5MJ5    5MK4    5MKJ    5MKU    5MMW    5TBP    5UAN    5Z12    5ZQU    6A5Y    6A5Z    6A60    6FBQ    6FBR    6HN6    6JNO    6JNR    6L6K    6SJM    6STI    6XWG    6XWH    7A77   
SuperfamilyP19793
AlphaFold pdb e-kbP19793   
Human Protein Atlas [tissue]ENSG00000186350-RXRA [tissue]
HPRD01577
Protein Interaction databases
DIP (DOE-UCLA)P19793
IntAct (EBI)P19793
BioGRIDRXRA
STRING (EMBL)RXRA
ZODIACRXRA
Ontologies - Pathways
QuickGOP19793
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  chromatin  chromatin  transcription cis-regulatory region binding  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  retinoic acid binding  double-stranded DNA binding  DNA-binding transcription factor activity  steroid hormone receptor activity  nuclear receptor activity  nuclear receptor activity  nuclear receptor activity  protein binding  nucleus  nucleoplasm  mitochondrion  cytosol  regulation of transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  cholesterol metabolic process  zinc ion binding  positive regulation of cholesterol efflux  bile acid and bile salt transport  nuclear receptor binding  modulation by virus of host process  regulation of lipid metabolic process  enzyme binding  cell differentiation  intracellular receptor signaling pathway  granulocyte differentiation  positive regulation of transporter activity  response to retinoic acid  response to retinoic acid  peroxisome proliferator activated receptor signaling pathway  peptide binding  identical protein binding  vitamin D receptor binding  receptor complex  steroid hormone mediated signaling pathway  sequence-specific DNA binding  retinoic acid-responsive element binding  retinoic acid-responsive element binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  retinoic acid receptor signaling pathway  retinoic acid receptor signaling pathway  anatomical structure development  DNA binding domain binding  LBD domain binding  vitamin D response element binding  RNA polymerase II transcription regulator complex  RNA polymerase II transcription regulator complex  sequence-specific double-stranded DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  chromatin  chromatin  transcription cis-regulatory region binding  RNA polymerase II transcription regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  retinoic acid binding  double-stranded DNA binding  DNA-binding transcription factor activity  steroid hormone receptor activity  nuclear receptor activity  nuclear receptor activity  nuclear receptor activity  protein binding  nucleus  nucleoplasm  mitochondrion  cytosol  regulation of transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  cholesterol metabolic process  zinc ion binding  positive regulation of cholesterol efflux  bile acid and bile salt transport  nuclear receptor binding  modulation by virus of host process  regulation of lipid metabolic process  enzyme binding  cell differentiation  intracellular receptor signaling pathway  granulocyte differentiation  positive regulation of transporter activity  response to retinoic acid  response to retinoic acid  peroxisome proliferator activated receptor signaling pathway  peptide binding  identical protein binding  vitamin D receptor binding  receptor complex  steroid hormone mediated signaling pathway  sequence-specific DNA binding  retinoic acid-responsive element binding  retinoic acid-responsive element binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  retinoic acid receptor signaling pathway  retinoic acid receptor signaling pathway  anatomical structure development  DNA binding domain binding  LBD domain binding  vitamin D response element binding  RNA polymerase II transcription regulator complex  RNA polymerase II transcription regulator complex  sequence-specific double-stranded DNA binding  
Pathways : BIOCARTAMechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells [Genes]    Control of Gene Expression by Vitamin D Receptor [Genes]    Map Kinase Inactivation of SMRT Corepressor [Genes]    Role of PPAR-gamma Coactivators in Obesity and Thermogenesis [Genes]    Degradation of the RAR and RXR by the proteasome [Genes]    FXR and LXR Regulation of Cholesterol Metabolism [Genes]    Visceral Fat Deposits and the Metabolic Syndrome [Genes]    Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression [Genes]    Transcription Regulation by Methyltransferase of CARM1 [Genes]   
Pathways : KEGGPPAR signaling pathway    PI3K-Akt signaling pathway    Thyroid hormone signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Bile secretion    Hepatitis C    Pathways in cancer    Transcriptional misregulation in cancer    Thyroid cancer    Small cell lung cancer    Non-small cell lung cancer   
NDEx NetworkRXRA
Atlas of Cancer Signalling NetworkRXRA
Wikipedia pathwaysRXRA
Orthology - Evolution
OrthoDB6256
GeneTree (enSembl)ENSG00000186350
Phylogenetic Trees/Animal Genes : TreeFamRXRA
Homologs : HomoloGeneRXRA
Homology/Alignments : Family Browser (UCSC)RXRA
Gene fusions - Rearrangements
Fusion : QuiverRXRA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRXRA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RXRA
dbVarRXRA
ClinVarRXRA
MonarchRXRA
1000_GenomesRXRA 
Exome Variant ServerRXRA
GNOMAD BrowserENSG00000186350
Varsome BrowserRXRA
ACMGRXRA variants
VarityP19793
Genomic Variants (DGV)RXRA [DGVbeta]
DECIPHERRXRA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRXRA 
Mutations
ICGC Data PortalRXRA 
TCGA Data PortalRXRA 
Broad Tumor PortalRXRA
OASIS PortalRXRA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRXRA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRXRA
Mutations and Diseases : HGMDRXRA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRXRA
DgiDB (Drug Gene Interaction Database)RXRA
DoCM (Curated mutations)RXRA
CIViC (Clinical Interpretations of Variants in Cancer)RXRA
Cancer3DRXRA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180245   
Orphanet
DisGeNETRXRA
MedgenRXRA
Genetic Testing Registry RXRA
NextProtP19793 [Medical]
GENETestsRXRA
Target ValidationRXRA
Huge Navigator RXRA [HugePedia]
ClinGenRXRA
Clinical trials, drugs, therapy
MyCancerGenomeRXRA
Protein Interactions : CTDRXRA
Pharm GKB GenePA34890
PharosP19793
Clinical trialRXRA
Miscellaneous
canSAR (ICR)RXRA
HarmonizomeRXRA
DataMed IndexRXRA
Probes
Litterature
PubMed478 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRXRA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:29:53 CEST 2021

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