| Nomenclature |
|---|
| HGNC (Hugo) | RXRA 10477 |
| Cards |
|---|
| Entrez_Gene (NCBI) | RXRA 6256 retinoid X receptor alpha |
| Aliases | NR2B1 |
| GeneCards (Weizmann) | RXRA |
| Ensembl hg19 (Hinxton) | ENSG00000186350 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000186350 [Gene_View] chr9:134379295-134440586 [Contig_View] RXRA [Vega] |
| ICGC DataPortal | ENSG00000186350 |
| TCGA cBioPortal | RXRA |
| AceView (NCBI) | RXRA |
| Genatlas (Paris) | RXRA |
| WikiGenes | 6256 |
| SOURCE (Princeton) | RXRA |
| Genetics Home Reference (NIH) | RXRA |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | RXRA - chr9:134379295-134440586 + 9q34.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | RXRA - 9q34.2 [Description] (hg19-Feb_2009) |
| Ensembl | RXRA - 9q34.2 [CytoView hg19] RXRA - 9q34.2 [CytoView hg38] |
| Mapping of homologs : NCBI | RXRA [Mapview hg19] RXRA [Mapview hg38] |
| OMIM | 180245 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB307705 AF052092 AK090416 AK131081 AK131192 |
| RefSeq transcript (Entrez) | NM_001291920 NM_001291921 NM_002957 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | RXRA |
| Cluster EST : Unigene | Hs.590886 [ NCBI ] |
| CGAP (NCI) | Hs.590886 |
| Alternative Splicing Gallery | ENSG00000186350 |
| Gene Expression | RXRA [ NCBI-GEO ] RXRA [ EBI - ARRAY_EXPRESS ]
RXRA [ SEEK ] RXRA [ MEM ] |
| Gene Expression Viewer (FireBrowse) | RXRA [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 6256 |
| GTEX Portal (Tissue expression) | RXRA |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P19793 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P19793 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P19793 |
| Splice isoforms : SwissVar | P19793 |
| PhosPhoSitePlus | P19793 |
| Domaine pattern : Prosite (Expaxy) | NUCLEAR_REC_DBD_1 (PS00031) NUCLEAR_REC_DBD_2 (PS51030) |
| Domains : Interpro (EBI) | Nuc_recep-AF1 Nucl_hrmn_rcpt_lig-bd Nuclear_hrmn_rcpt Retinoid-X_rcpt/HNF4 Znf_hrmn_rcpt Znf_NHR/GATA |
| Domain families : Pfam (Sanger) | Hormone_recep (PF00104) Nuc_recep-AF1 (PF11825) zf-C4 (PF00105) |
| Domain families : Pfam (NCBI) | pfam00104 pfam11825 pfam00105 |
| Domain families : Smart (EMBL) | HOLI (SM00430) ZnF_C4 (SM00399) |
| Conserved Domain (NCBI) | RXRA |
| DMDM Disease mutations | 6256 |
| Blocks (Seattle) | RXRA |
| PDB (SRS) | ############################################################################################################################################################################################################################################################### |
| PDB (PDBSum) | ############################################################################################################################################################################################################################################################### |
| PDB (IMB) | ############################################################################################################################################################################################################################################################### |
| PDB (RSDB) | ############################################################################################################################################################################################################################################################### |
| Structural Biology KnowledgeBase | ############################################################################################################################################################################################################################################################### |
| SCOP (Structural Classification of Proteins) | ############################################################################################################################################################################################################################################################### |
| CATH (Classification of proteins structures) | ############################################################################################################################################################################################################################################################### |
| Superfamily | P19793 |
| Human Protein Atlas | ENSG00000186350 |
| Peptide Atlas | P19793 |
| HPRD | 01577 |
| IPI | IPI00418394 IPI01011260 IPI00431177 IPI00442358 IPI00386192 IPI00979550 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P19793 |
| IntAct (EBI) | P19793 |
| FunCoup | ENSG00000186350 |
| BioGRID | RXRA |
| STRING (EMBL) | RXRA |
| ZODIAC | RXRA |
| Ontologies - Pathways |
|---|
| QuickGO | P19793 |
| Ontology : AmiGO | negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding in utero embryonic development maternal placenta development retinoic acid binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity retinoic acid receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding 9-cis retinoic acid receptor activity protein binding nucleus nucleoplasm transcription initiation from RNA polymerase II promoter vitamin metabolic process embryo implantation cholesterol metabolic process zinc ion binding bile acid and bile salt transport ligand-dependent nuclear receptor binding modulation by virus of host morphology or physiology enzyme binding chromatin DNA binding response to retinoic acid peroxisome proliferator activated receptor signaling pathway peptide binding vitamin D receptor binding camera-type eye development protein complex receptor complex steroid hormone mediated signaling pathway sequence-specific DNA binding transcription regulatory region DNA binding cellular lipid metabolic process retinoic acid-responsive element binding positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation by iron protein heterodimerization activity retinoic acid receptor signaling pathway DBD domain binding LBD domain binding protein homotetramerization ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle cell differentiation cardiac muscle cell proliferation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development regulation of branching involved in prostate gland morphogenesis vitamin D response element binding RNA polymerase II transcription factor complex positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus |
| Ontology : EGO-EBI | negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding in utero embryonic development maternal placenta development retinoic acid binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity retinoic acid receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding 9-cis retinoic acid receptor activity protein binding nucleus nucleoplasm transcription initiation from RNA polymerase II promoter vitamin metabolic process embryo implantation cholesterol metabolic process zinc ion binding bile acid and bile salt transport ligand-dependent nuclear receptor binding modulation by virus of host morphology or physiology enzyme binding chromatin DNA binding response to retinoic acid peroxisome proliferator activated receptor signaling pathway peptide binding vitamin D receptor binding camera-type eye development protein complex receptor complex steroid hormone mediated signaling pathway sequence-specific DNA binding transcription regulatory region DNA binding cellular lipid metabolic process retinoic acid-responsive element binding positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation by iron protein heterodimerization activity retinoic acid receptor signaling pathway DBD domain binding LBD domain binding protein homotetramerization ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle cell differentiation cardiac muscle cell proliferation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development regulation of branching involved in prostate gland morphogenesis vitamin D response element binding RNA polymerase II transcription factor complex positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus |
| Pathways : BIOCARTA | [Genes] |
| Pathways : KEGG | |
| NDEx Network | RXRA |
| Atlas of Cancer Signalling Network | RXRA |
| Wikipedia pathways | RXRA |
| Orthology - Evolution |
|---|
| OrthoDB | 6256 |
| GeneTree (enSembl) | ENSG00000186350 |
| Phylogenetic Trees/Animal Genes : TreeFam | RXRA |
| HOVERGEN | P19793 |
| HOGENOM | P19793 |
| Homologs : HomoloGene | RXRA |
| Homology/Alignments : Family Browser (UCSC) | RXRA |
| Gene fusions - Rearrangements |
|---|
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | RXRA [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | RXRA |
| dbVar | RXRA |
| ClinVar | RXRA |
| 1000_Genomes | RXRA |
| Exome Variant Server | RXRA |
| ExAC (Exome Aggregation Consortium) | RXRA (select the gene name) |
| Genetic variants : HAPMAP | 6256 |
| Genomic Variants (DGV) | RXRA [DGVbeta] |
| DECIPHER | RXRA [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | RXRA |
| Mutations |
|---|
| ICGC Data Portal | RXRA |
| TCGA Data Portal | RXRA |
| Broad Tumor Portal | RXRA |
| OASIS Portal | RXRA [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | RXRA [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | RXRA |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | Pharmacogenomics of Infectious Diseases (PGx_IfD ) |
| BioMuta | search RXRA |
| DgiDB (Drug Gene Interaction Database) | RXRA |
| DoCM (Curated mutations) | RXRA (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | RXRA (select a term) |
| intoGen | RXRA |
| Cancer3D | RXRA(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 180245 |
| Orphanet | |
| Medgen | RXRA |
| Genetic Testing Registry | RXRA
|
| NextProt | P19793 [Medical] |
| TSGene | 6256 |
| GENETests | RXRA |
| Target Validation | RXRA |
| Huge Navigator |
RXRA [HugePedia] |
| snp3D : Map Gene to Disease | 6256 |
| BioCentury BCIQ | RXRA |
| ClinGen | RXRA |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 6256 |
| Chemical/Pharm GKB Gene | PA34890 |
| Clinical trial | RXRA |
| Miscellaneous |
|---|
| canSAR (ICR) | RXRA (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 410 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | RXRA |
| EVEX | RXRA |
| GoPubMed | RXRA |
| iHOP | RXRA |
