| Nomenclature |
|---|
| HGNC (Hugo) | RXRA 10477 |
| Cards |
|---|
| Entrez_Gene (NCBI) | RXRA 6256 retinoid X receptor alpha |
| Aliases | NR2B1 |
| GeneCards (Weizmann) | RXRA |
| Ensembl hg19 (Hinxton) | ENSG00000186350 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000186350 [Gene_View] ENSG00000186350 [Sequence] chr9:134326463-134440586 [Contig_View] RXRA [Vega] |
| ICGC DataPortal | ENSG00000186350 |
| TCGA cBioPortal | RXRA |
| AceView (NCBI) | RXRA |
| Genatlas (Paris) | RXRA |
| WikiGenes | 6256 |
| SOURCE (Princeton) | RXRA |
| Genetics Home Reference (NIH) | RXRA |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | RXRA - chr9:134326463-134440586 + 9q34.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | RXRA - 9q34.2 [Description] (hg19-Feb_2009) |
| GoldenPath | RXRA - 9q34.2 [CytoView hg19] RXRA - 9q34.2 [CytoView hg38] |
| ImmunoBase | ENSG00000186350 |
| Mapping of homologs : NCBI | RXRA [Mapview hg19] RXRA [Mapview hg38] |
| OMIM | 180245 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB307705 AF052092 AK090416 AK131081 AK131192 |
| RefSeq transcript (Entrez) | NM_001291920 NM_001291921 NM_002957 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | RXRA |
| Alternative Splicing Gallery | ENSG00000186350 |
| Gene Expression | RXRA [ NCBI-GEO ] RXRA [ EBI - ARRAY_EXPRESS ]
RXRA [ SEEK ] RXRA [ MEM ] |
| Gene Expression Viewer (FireBrowse) | RXRA [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 6256 |
| GTEX Portal (Tissue expression) | RXRA |
| Human Protein Atlas | ENSG00000186350-RXRA [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P19793 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P19793 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P19793 |
| Splice isoforms : SwissVar | P19793 |
| PhosPhoSitePlus | P19793 |
| Domaine pattern : Prosite (Expaxy) | NR_LBD (PS51843) NUCLEAR_REC_DBD_1 (PS00031) NUCLEAR_REC_DBD_2 (PS51030) |
| Domains : Interpro (EBI) | NHR-like_dom_sf Nuc_recep-AF1 Nucl_hrmn_rcpt_lig-bd Nuclear_hrmn_rcpt Retinoid-X_rcpt/HNF4 Znf_hrmn_rcpt Znf_NHR/GATA |
| Domain families : Pfam (Sanger) | Hormone_recep (PF00104) Nuc_recep-AF1 (PF11825) zf-C4 (PF00105) |
| Domain families : Pfam (NCBI) | pfam00104 pfam11825 pfam00105 |
| Domain families : Smart (EMBL) | HOLI (SM00430) ZnF_C4 (SM00399) |
| Conserved Domain (NCBI) | RXRA |
| DMDM Disease mutations | 6256 |
| Blocks (Seattle) | RXRA |
| PDB (RSDB) | 1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1MV9 1MVC 1MZN 1R0N 1RDT 1RXR 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ 2ZY0 3DZU 3DZY 3E00 3E94 3FAL 3FC6 3FUG 3H0A 3KWY 3NSP 3NSQ 3OAP 3OZJ 3PCU 3R29 3R2A 3R5M 3UVV 4CN2 4CN3 4CN5 4CN7 4J5W 4J5X 4K4J 4K6I 4M8E 4M8H 4N5G 4N8R 4NQA 4OC7 4POH 4POJ 4PP3 4PP5 4RFW 4RMC 4RMD 4RME 4ZO1 4ZSH 5EC9 5GYM 5JI0 5LYQ 5MJ5 5MK4 5MKJ 5MKU 5MMW 5TBP 5UAN 5Z12 5ZQU 6A5Y 6A5Z 6A60 6FBQ 6FBR 6HN6 6SJM |
| PDB Europe | 1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1MV9 1MVC 1MZN 1R0N 1RDT 1RXR 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ 2ZY0 3DZU 3DZY 3E00 3E94 3FAL 3FC6 3FUG 3H0A 3KWY 3NSP 3NSQ 3OAP 3OZJ 3PCU 3R29 3R2A 3R5M 3UVV 4CN2 4CN3 4CN5 4CN7 4J5W 4J5X 4K4J 4K6I 4M8E 4M8H 4N5G 4N8R 4NQA 4OC7 4POH 4POJ 4PP3 4PP5 4RFW 4RMC 4RMD 4RME 4ZO1 4ZSH 5EC9 5GYM 5JI0 5LYQ 5MJ5 5MK4 5MKJ 5MKU 5MMW 5TBP 5UAN 5Z12 5ZQU 6A5Y 6A5Z 6A60 6FBQ 6FBR 6HN6 6SJM |
| PDB (PDBSum) | 1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1MV9 1MVC 1MZN 1R0N 1RDT 1RXR 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ 2ZY0 3DZU 3DZY 3E00 3E94 3FAL 3FC6 3FUG 3H0A 3KWY 3NSP 3NSQ 3OAP 3OZJ 3PCU 3R29 3R2A 3R5M 3UVV 4CN2 4CN3 4CN5 4CN7 4J5W 4J5X 4K4J 4K6I 4M8E 4M8H 4N5G 4N8R 4NQA 4OC7 4POH 4POJ 4PP3 4PP5 4RFW 4RMC 4RMD 4RME 4ZO1 4ZSH 5EC9 5GYM 5JI0 5LYQ 5MJ5 5MK4 5MKJ 5MKU 5MMW 5TBP 5UAN 5Z12 5ZQU 6A5Y 6A5Z 6A60 6FBQ 6FBR 6HN6 6SJM |
| PDB (IMB) | 1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1MV9 1MVC 1MZN 1R0N 1RDT 1RXR 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ 2ZY0 3DZU 3DZY 3E00 3E94 3FAL 3FC6 3FUG 3H0A 3KWY 3NSP 3NSQ 3OAP 3OZJ 3PCU 3R29 3R2A 3R5M 3UVV 4CN2 4CN3 4CN5 4CN7 4J5W 4J5X 4K4J 4K6I 4M8E 4M8H 4N5G 4N8R 4NQA 4OC7 4POH 4POJ 4PP3 4PP5 4RFW 4RMC 4RMD 4RME 4ZO1 4ZSH 5EC9 5GYM 5JI0 5LYQ 5MJ5 5MK4 5MKJ 5MKU 5MMW 5TBP 5UAN 5Z12 5ZQU 6A5Y 6A5Z 6A60 6FBQ 6FBR 6HN6 6SJM |
| Structural Biology KnowledgeBase | 1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1MV9 1MVC 1MZN 1R0N 1RDT 1RXR 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ 2ZY0 3DZU 3DZY 3E00 3E94 3FAL 3FC6 3FUG 3H0A 3KWY 3NSP 3NSQ 3OAP 3OZJ 3PCU 3R29 3R2A 3R5M 3UVV 4CN2 4CN3 4CN5 4CN7 4J5W 4J5X 4K4J 4K6I 4M8E 4M8H 4N5G 4N8R 4NQA 4OC7 4POH 4POJ 4PP3 4PP5 4RFW 4RMC 4RMD 4RME 4ZO1 4ZSH 5EC9 5GYM 5JI0 5LYQ 5MJ5 5MK4 5MKJ 5MKU 5MMW 5TBP 5UAN 5Z12 5ZQU 6A5Y 6A5Z 6A60 6FBQ 6FBR 6HN6 6SJM |
| SCOP (Structural Classification of Proteins) | 1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1MV9 1MVC 1MZN 1R0N 1RDT 1RXR 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ 2ZY0 3DZU 3DZY 3E00 3E94 3FAL 3FC6 3FUG 3H0A 3KWY 3NSP 3NSQ 3OAP 3OZJ 3PCU 3R29 3R2A 3R5M 3UVV 4CN2 4CN3 4CN5 4CN7 4J5W 4J5X 4K4J 4K6I 4M8E 4M8H 4N5G 4N8R 4NQA 4OC7 4POH 4POJ 4PP3 4PP5 4RFW 4RMC 4RMD 4RME 4ZO1 4ZSH 5EC9 5GYM 5JI0 5LYQ 5MJ5 5MK4 5MKJ 5MKU 5MMW 5TBP 5UAN 5Z12 5ZQU 6A5Y 6A5Z 6A60 6FBQ 6FBR 6HN6 6SJM |
| CATH (Classification of proteins structures) | 1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1MV9 1MVC 1MZN 1R0N 1RDT 1RXR 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ 2ZY0 3DZU 3DZY 3E00 3E94 3FAL 3FC6 3FUG 3H0A 3KWY 3NSP 3NSQ 3OAP 3OZJ 3PCU 3R29 3R2A 3R5M 3UVV 4CN2 4CN3 4CN5 4CN7 4J5W 4J5X 4K4J 4K6I 4M8E 4M8H 4N5G 4N8R 4NQA 4OC7 4POH 4POJ 4PP3 4PP5 4RFW 4RMC 4RMD 4RME 4ZO1 4ZSH 5EC9 5GYM 5JI0 5LYQ 5MJ5 5MK4 5MKJ 5MKU 5MMW 5TBP 5UAN 5Z12 5ZQU 6A5Y 6A5Z 6A60 6FBQ 6FBR 6HN6 6SJM |
| Superfamily | P19793 |
| Human Protein Atlas [tissue] | ENSG00000186350-RXRA [tissue] |
| Peptide Atlas | P19793 |
| HPRD | 01577 |
| IPI | IPI00418394 IPI01011260 IPI00431177 IPI00442358 IPI00386192 IPI00979550 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P19793 |
| IntAct (EBI) | P19793 |
| FunCoup | ENSG00000186350 |
| BioGRID | RXRA |
| STRING (EMBL) | RXRA |
| ZODIAC | RXRA |
| Ontologies - Pathways |
|---|
| QuickGO | P19793 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II nuclear chromatin nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific in utero embryonic development maternal placenta development retinoic acid binding DNA binding double-stranded DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity DNA-binding transcription factor activity steroid hormone receptor activity transcription coactivator activity nuclear receptor activity nuclear receptor activity nuclear receptor activity protein binding nucleus nucleus nucleoplasm mitochondrion regulation of transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter vitamin metabolic process embryo implantation cholesterol metabolic process zinc ion binding bile acid and bile salt transport nuclear receptor binding modulation by virus of host morphology or physiology regulation of lipid metabolic process enzyme binding cell differentiation chromatin DNA binding response to retinoic acid response to retinoic acid protein-containing complex peroxisome proliferator activated receptor signaling pathway signaling receptor activity peptide binding identical protein binding vitamin D receptor binding camera-type eye development receptor complex steroid hormone mediated signaling pathway sequence-specific DNA binding transcription regulatory region DNA binding retinoic acid-responsive element binding retinoic acid-responsive element binding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of translational initiation by iron protein heterodimerization activity retinoic acid receptor signaling pathway retinoic acid receptor signaling pathway anatomical structure development DBD domain binding LBD domain binding ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle cell differentiation cardiac muscle cell proliferation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development regulation of branching involved in prostate gland morphogenesis vitamin D response element binding RNA polymerase II transcription factor complex RNA polymerase II transcription factor complex |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II nuclear chromatin nuclear chromatin RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific in utero embryonic development maternal placenta development retinoic acid binding DNA binding double-stranded DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity DNA-binding transcription factor activity steroid hormone receptor activity transcription coactivator activity nuclear receptor activity nuclear receptor activity nuclear receptor activity protein binding nucleus nucleus nucleoplasm mitochondrion regulation of transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter vitamin metabolic process embryo implantation cholesterol metabolic process zinc ion binding bile acid and bile salt transport nuclear receptor binding modulation by virus of host morphology or physiology regulation of lipid metabolic process enzyme binding cell differentiation chromatin DNA binding response to retinoic acid response to retinoic acid protein-containing complex peroxisome proliferator activated receptor signaling pathway signaling receptor activity peptide binding identical protein binding vitamin D receptor binding camera-type eye development receptor complex steroid hormone mediated signaling pathway sequence-specific DNA binding transcription regulatory region DNA binding retinoic acid-responsive element binding retinoic acid-responsive element binding positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of translational initiation by iron protein heterodimerization activity retinoic acid receptor signaling pathway retinoic acid receptor signaling pathway anatomical structure development DBD domain binding LBD domain binding ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle cell differentiation cardiac muscle cell proliferation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development regulation of branching involved in prostate gland morphogenesis vitamin D response element binding RNA polymerase II transcription factor complex RNA polymerase II transcription factor complex |
| Pathways : KEGG | PPAR signaling pathway PI3K-Akt signaling pathway Thyroid hormone signaling pathway Adipocytokine signaling pathway Non-alcoholic fatty liver disease (NAFLD) Bile secretion Hepatitis C Pathways in cancer Transcriptional misregulation in cancer Thyroid cancer Small cell lung cancer Non-small cell lung cancer |
| NDEx Network | RXRA |
| Atlas of Cancer Signalling Network | RXRA |
| Wikipedia pathways | RXRA |
| Orthology - Evolution |
|---|
| OrthoDB | 6256 |
| GeneTree (enSembl) | ENSG00000186350 |
| Phylogenetic Trees/Animal Genes : TreeFam | RXRA |
| HOGENOM | P19793 |
| Homologs : HomoloGene | RXRA |
| Homology/Alignments : Family Browser (UCSC) | RXRA |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | RXRA |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | RXRA [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | RXRA |
| dbVar | RXRA |
| ClinVar | RXRA |
| 1000_Genomes | RXRA |
| Exome Variant Server | RXRA |
| ExAC (Exome Aggregation Consortium) | ENSG00000186350 |
| GNOMAD Browser | ENSG00000186350 |
| Varsome Browser | RXRA |
| Genetic variants : HAPMAP | 6256 |
| Genomic Variants (DGV) | RXRA [DGVbeta] |
| DECIPHER | RXRA [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | RXRA |
| Mutations |
|---|
| ICGC Data Portal | RXRA |
| TCGA Data Portal | RXRA |
| Broad Tumor Portal | RXRA |
| OASIS Portal | RXRA [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | RXRA [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | RXRA |
| Mutations and Diseases : HGMD | RXRA |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | Pharmacogenomics of Infectious Diseases (PGx_IfD ) |
| BioMuta | search RXRA |
| DgiDB (Drug Gene Interaction Database) | RXRA |
| DoCM (Curated mutations) | RXRA (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | RXRA (select a term) |
| intoGen | RXRA |
| Cancer3D | RXRA(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 180245 |
| Orphanet | |
| DisGeNET | RXRA |
| Medgen | RXRA |
| Genetic Testing Registry | RXRA
|
| NextProt | P19793 [Medical] |
| TSGene | 6256 |
| GENETests | RXRA |
| Target Validation | RXRA |
| Huge Navigator |
RXRA [HugePedia] |
| snp3D : Map Gene to Disease | 6256 |
| BioCentury BCIQ | RXRA |
| ClinGen | RXRA |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 6256 |
| Chemical/Pharm GKB Gene | PA34890 |
| Clinical trial | RXRA |
| Miscellaneous |
|---|
| canSAR (ICR) | RXRA (select the gene name) |
| DataMed Index | RXRA |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 456 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | RXRA |
| EVEX | RXRA |
| GoPubMed | RXRA |
| iHOP | RXRA |
