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RYBP (RING1 and YY1 binding protein)

Identity

Alias_symbol (synonym)YEAF1
AAP1
DEDAF
Other aliasAPAP-1
HGNC (Hugo) RYBP
LocusID (NCBI) 23429
Atlas_Id 43694
Location 3p13  [Link to chromosome band 3p13]
Location_base_pair Starts at 72374593 and ends at 72446623 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KDM4A (1p34.1) / RYBP (3p13)RYBP (3p13) / CNDP2 (18q22.3)RYBP (3p13) / FHIT (3p14.2)
RYBP (3p13) / TADA3 (3p25.3)KDM4A 1p34.1 / RYBP 3p13RYBP 3p13 / FHIT 3p14.2
RYBP 3p13 / TADA3 3p25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)RYBP   10480
Cards
Entrez_Gene (NCBI)RYBP  23429  RING1 and YY1 binding protein
AliasesAAP1; APAP-1; DEDAF; YEAF1
GeneCards (Weizmann)RYBP
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr3:72374593-72446623 [Contig_View]  RYBP [Vega]
TCGA cBioPortalRYBP
AceView (NCBI)RYBP
Genatlas (Paris)RYBP
WikiGenes23429
SOURCE (Princeton)RYBP
Genetics Home Reference (NIH)RYBP
Genomic and cartography
GoldenPath hg38 (UCSC)RYBP  -     chr3:72374593-72446623 -  3p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RYBP  -     3p13   [Description]    (hg19-Feb_2009)
EnsemblRYBP - 3p13 [CytoView hg19]  RYBP - 3p13 [CytoView hg38]
Mapping of homologs : NCBIRYBP [Mapview hg19]  RYBP [Mapview hg38]
OMIM607535   
Gene and transcription
Genbank (Entrez)AB029551 AF085840 AF179286 AF227959 AL049940
RefSeq transcript (Entrez)NM_012234
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RYBP
Cluster EST : UnigeneHs.7910 [ NCBI ]
CGAP (NCI)Hs.7910
Gene ExpressionRYBP [ NCBI-GEO ]   RYBP [ EBI - ARRAY_EXPRESS ]   RYBP [ SEEK ]   RYBP [ MEM ]
Gene Expression Viewer (FireBrowse)RYBP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23429
GTEX Portal (Tissue expression)RYBP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N488   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N488  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N488
Splice isoforms : SwissVarQ8N488
PhosPhoSitePlusQ8N488
Domaine pattern : Prosite (Expaxy)ZF_RANBP2_1 (PS01358)    ZF_RANBP2_2 (PS50199)   
Domains : Interpro (EBI)YAF2_RYBP    Znf_RanBP2   
Domain families : Pfam (Sanger)YAF2_RYBP (PF17219)    zf-RanBP (PF00641)   
Domain families : Pfam (NCBI)pfam17219    pfam00641   
Domain families : Smart (EMBL)ZnF_RBZ (SM00547)  
Conserved Domain (NCBI)RYBP
DMDM Disease mutations23429
Blocks (Seattle)RYBP
PDB (SRS)3IXS   
PDB (PDBSum)3IXS   
PDB (IMB)3IXS   
PDB (RSDB)3IXS   
Structural Biology KnowledgeBase3IXS   
SCOP (Structural Classification of Proteins)3IXS   
CATH (Classification of proteins structures)3IXS   
SuperfamilyQ8N488
Peptide AtlasQ8N488
HPRD09607
IPIIPI00296594   
Protein Interaction databases
DIP (DOE-UCLA)Q8N488
IntAct (EBI)Q8N488
BioGRIDRYBP
STRING (EMBL)RYBP
ZODIACRYBP
Ontologies - Pathways
QuickGOQ8N488
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  DNA binding  transcription corepressor activity  protein binding  nucleoplasm  cytoplasm  transcription, DNA-templated  apoptotic process  multicellular organism development  zinc ion binding  PcG protein complex  histone H2A monoubiquitination  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  DNA binding  transcription corepressor activity  protein binding  nucleoplasm  cytoplasm  transcription, DNA-templated  apoptotic process  multicellular organism development  zinc ion binding  PcG protein complex  histone H2A monoubiquitination  
NDEx NetworkRYBP
Atlas of Cancer Signalling NetworkRYBP
Wikipedia pathwaysRYBP
Orthology - Evolution
OrthoDB23429
Phylogenetic Trees/Animal Genes : TreeFamRYBP
HOVERGENQ8N488
HOGENOMQ8N488
Homologs : HomoloGeneRYBP
Homology/Alignments : Family Browser (UCSC)RYBP
Gene fusions - Rearrangements
Fusion : MitelmanKDM4A/RYBP [1p34.1/3p13]  [t(1;3)(p34;p13)]  
Fusion : MitelmanRYBP/FHIT [3p13/3p14.2]  [t(3;3)(p13;p14)]  
Fusion : MitelmanRYBP/TADA3 [3p13/3p25.3]  [t(3;3)(p13;p25)]  
Fusion: TCGAKDM4A 1p34.1 RYBP 3p13 LUAD
Fusion: TCGARYBP 3p13 FHIT 3p14.2 PRAD
Fusion: TCGARYBP 3p13 TADA3 3p25.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRYBP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RYBP
dbVarRYBP
ClinVarRYBP
1000_GenomesRYBP 
Exome Variant ServerRYBP
ExAC (Exome Aggregation Consortium)RYBP (select the gene name)
Genetic variants : HAPMAP23429
Genomic Variants (DGV)RYBP [DGVbeta]
DECIPHERRYBP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRYBP 
Mutations
ICGC Data PortalRYBP 
TCGA Data PortalRYBP 
Broad Tumor PortalRYBP
OASIS PortalRYBP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRYBP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRYBP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RYBP
DgiDB (Drug Gene Interaction Database)RYBP
DoCM (Curated mutations)RYBP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RYBP (select a term)
intoGenRYBP
Cancer3DRYBP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607535   
Orphanet
MedgenRYBP
Genetic Testing Registry RYBP
NextProtQ8N488 [Medical]
TSGene23429
GENETestsRYBP
Target ValidationRYBP
Huge Navigator RYBP [HugePedia]
snp3D : Map Gene to Disease23429
BioCentury BCIQRYBP
ClinGenRYBP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23429
Chemical/Pharm GKB GenePA34893
Clinical trialRYBP
Miscellaneous
canSAR (ICR)RYBP (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRYBP
EVEXRYBP
GoPubMedRYBP
iHOPRYBP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:13:36 CEST 2017

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