Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RYK (receptor like tyrosine kinase)

Identity

Alias (NCBI)D3S3195
JTK5
JTK5A
RYK1
HGNC (Hugo) RYK
HGNC Alias symbD3S3195
RYK1
JTK5
HGNC Previous nameJTK5A
HGNC Previous nameJTK5A protein tyrosine kinase
 RYK receptor-like tyrosine kinase
LocusID (NCBI) 6259
Atlas_Id 42189
Location 3q22.2  [Link to chromosome band 3q22]
Location_base_pair Starts at 134157134 and ends at 134250744 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RYK (3q22.2) / ATP5O (21q22.11)RYK (3q22.2) / C1R (12p13.31)RYK (3q22.2) / KALRN (3q21.2)
RYK (3q22.2) / RABL3 (3q13.33)RYK (3q22.2) / RYK (3q22.2)RYK 3q22.2 / KALRN 3q21.2
RYK 3q22.2 / RABL3 3q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;21)(q22;q22) RYK/ATP5PO

External links

 

Nomenclature
HGNC (Hugo)RYK   10481
Cards
Entrez_Gene (NCBI)RYK    receptor like tyrosine kinase
AliasesD3S3195; JTK5; JTK5A; RYK1
GeneCards (Weizmann)RYK
Ensembl hg19 (Hinxton)ENSG00000163785 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163785 [Gene_View]  ENSG00000163785 [Sequence]  chr3:134157134-134250744 [Contig_View]  RYK [Vega]
ICGC DataPortalENSG00000163785
TCGA cBioPortalRYK
AceView (NCBI)RYK
Genatlas (Paris)RYK
SOURCE (Princeton)RYK
Genetics Home Reference (NIH)RYK
Genomic and cartography
GoldenPath hg38 (UCSC)RYK  -     chr3:134157134-134250744 -  3q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RYK  -     3q22.2   [Description]    (hg19-Feb_2009)
GoldenPathRYK - 3q22.2 [CytoView hg19]  RYK - 3q22.2 [CytoView hg38]
ImmunoBaseENSG00000163785
Genome Data Viewer NCBIRYK [Mapview hg19]  
OMIM600524   
Gene and transcription
Genbank (Entrez)AB209405 BC021700 BQ003586 CN309980 S59184
RefSeq transcript (Entrez)NM_001005861 NM_002958
Consensus coding sequences : CCDS (NCBI)RYK
Gene ExpressionRYK [ NCBI-GEO ]   RYK [ EBI - ARRAY_EXPRESS ]   RYK [ SEEK ]   RYK [ MEM ]
Gene Expression Viewer (FireBrowse)RYK [ Firebrowse - Broad ]
GenevisibleExpression of RYK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6259
GTEX Portal (Tissue expression)RYK
Human Protein AtlasENSG00000163785-RYK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP34925   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP34925  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP34925
PhosPhoSitePlusP34925
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    WIF (PS50814)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    WIF    WIF_sf   
Domain families : Pfam (Sanger)PK_Tyr_Ser-Thr (PF07714)    WIF (PF02019)   
Domain families : Pfam (NCBI)pfam07714    pfam02019   
Domain families : Smart (EMBL)WIF (SM00469)  
Conserved Domain (NCBI)RYK
PDB (RSDB)6TUA   
PDB Europe6TUA   
PDB (PDBSum)6TUA   
PDB (IMB)6TUA   
Structural Biology KnowledgeBase6TUA   
SCOP (Structural Classification of Proteins)6TUA   
CATH (Classification of proteins structures)6TUA   
SuperfamilyP34925
AlphaFold pdb e-kbP34925   
Human Protein Atlas [tissue]ENSG00000163785-RYK [tissue]
HPRD02751
Protein Interaction databases
DIP (DOE-UCLA)P34925
IntAct (EBI)P34925
BioGRIDRYK
STRING (EMBL)RYK
ZODIACRYK
Ontologies - Pathways
QuickGOP34925
Ontology : AmiGOprotein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane signaling receptor activity  frizzled binding  frizzled binding  protein binding  ATP binding  nucleus  nucleus  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  protein phosphorylation  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  multicellular organism development  axonogenesis  axonogenesis  axonogenesis  axon guidance  axon guidance  synapse assembly  membrane  integral component of membrane  Wnt signaling pathway  Wnt-protein binding  Wnt-protein binding  peptidyl-tyrosine phosphorylation  neurogenesis  corpus callosum development  neuron differentiation  neuron projection development  cell proliferation in midbrain  positive regulation of kinase activity  non-canonical Wnt signaling pathway  chemorepulsion of dopaminergic neuron axon  Wnt-activated receptor activity  receptor complex  positive regulation of MAPK cascade  skeletal system morphogenesis  negative regulation of axon extension involved in axon guidance  canonical Wnt signaling pathway  commissural neuron axon guidance  coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway  planar cell polarity pathway involved in axon guidance  midbrain dopaminergic neuron differentiation  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  
Ontology : EGO-EBIprotein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane signaling receptor activity  frizzled binding  frizzled binding  protein binding  ATP binding  nucleus  nucleus  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  protein phosphorylation  signal transduction  transmembrane receptor protein tyrosine kinase signaling pathway  multicellular organism development  axonogenesis  axonogenesis  axonogenesis  axon guidance  axon guidance  synapse assembly  membrane  integral component of membrane  Wnt signaling pathway  Wnt-protein binding  Wnt-protein binding  peptidyl-tyrosine phosphorylation  neurogenesis  corpus callosum development  neuron differentiation  neuron projection development  cell proliferation in midbrain  positive regulation of kinase activity  non-canonical Wnt signaling pathway  chemorepulsion of dopaminergic neuron axon  Wnt-activated receptor activity  receptor complex  positive regulation of MAPK cascade  skeletal system morphogenesis  negative regulation of axon extension involved in axon guidance  canonical Wnt signaling pathway  commissural neuron axon guidance  coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway  planar cell polarity pathway involved in axon guidance  midbrain dopaminergic neuron differentiation  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  
NDEx NetworkRYK
Atlas of Cancer Signalling NetworkRYK
Wikipedia pathwaysRYK
Orthology - Evolution
OrthoDB6259
GeneTree (enSembl)ENSG00000163785
Phylogenetic Trees/Animal Genes : TreeFamRYK
Homologs : HomoloGeneRYK
Homology/Alignments : Family Browser (UCSC)RYK
Gene fusions - Rearrangements
Fusion : MitelmanRYK/ATP5O [3q22.2/21q22.11]  
Fusion : MitelmanRYK/KALRN [3q22.2/3q21.2]  
Fusion : MitelmanRYK/RABL3 [3q22.2/3q13.33]  
Fusion : QuiverRYK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRYK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RYK
dbVarRYK
ClinVarRYK
MonarchRYK
1000_GenomesRYK 
Exome Variant ServerRYK
GNOMAD BrowserENSG00000163785
Varsome BrowserRYK
ACMGRYK variants
VarityP34925
Genomic Variants (DGV)RYK [DGVbeta]
DECIPHERRYK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRYK 
Mutations
ICGC Data PortalRYK 
TCGA Data PortalRYK 
Broad Tumor PortalRYK
OASIS PortalRYK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRYK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRYK
Mutations and Diseases : HGMDRYK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaRYK
DgiDB (Drug Gene Interaction Database)RYK
DoCM (Curated mutations)RYK
CIViC (Clinical Interpretations of Variants in Cancer)RYK
Cancer3DRYK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600524   
Orphanet
DisGeNETRYK
MedgenRYK
Genetic Testing Registry RYK
NextProtP34925 [Medical]
GENETestsRYK
Target ValidationRYK
Huge Navigator RYK [HugePedia]
ClinGenRYK
Clinical trials, drugs, therapy
MyCancerGenomeRYK
Protein Interactions : CTDRYK
Pharm GKB GenePA34894
PharosP34925
Clinical trialRYK
Miscellaneous
canSAR (ICR)RYK
HarmonizomeRYK
DataMed IndexRYK
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXRYK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:29:53 CEST 2021
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