Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RYK (receptor-like tyrosine kinase)

Identity

Alias_namesJTK5A
JTK5A protein tyrosine kinase
RYK receptor-like tyrosine kinase
Alias_symbol (synonym)D3S3195
RYK1
JTK5
Other alias
HGNC (Hugo) RYK
LocusID (NCBI) 6259
Atlas_Id 42189
Location 3q22.2  [Link to chromosome band 3q22]
Location_base_pair Starts at 134157134 and ends at 134250744 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RYK (3q22.2) / ATP5O (21q22.11)RYK (3q22.2) / C1R (12p13.31)RYK (3q22.2) / KALRN (3q21.2)
RYK (3q22.2) / RABL3 (3q13.33)RYK (3q22.2) / RYK (3q22.2)RYK 3q22.2 / KALRN 3q21.2
RYK 3q22.2 / RABL3 3q13.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;21)(q22;q22) RYK/ATP5PO

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(3;3)(q13;q22) RYK/RABL3
t(3;3)(q21;q22) RYK/KALRN

External links

Nomenclature
HGNC (Hugo)RYK   10481
Cards
Entrez_Gene (NCBI)RYK  6259  receptor-like tyrosine kinase
AliasesD3S3195; JTK5; JTK5A; RYK1
GeneCards (Weizmann)RYK
Ensembl hg19 (Hinxton)ENSG00000163785 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163785 [Gene_View]  ENSG00000163785 [Sequence]  chr3:134157134-134250744 [Contig_View]  RYK [Vega]
ICGC DataPortalENSG00000163785
TCGA cBioPortalRYK
AceView (NCBI)RYK
Genatlas (Paris)RYK
WikiGenes6259
SOURCE (Princeton)RYK
Genetics Home Reference (NIH)RYK
Genomic and cartography
GoldenPath hg38 (UCSC)RYK  -     chr3:134157134-134250744 -  3q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RYK  -     3q22.2   [Description]    (hg19-Feb_2009)
EnsemblRYK - 3q22.2 [CytoView hg19]  RYK - 3q22.2 [CytoView hg38]
Mapping of homologs : NCBIRYK [Mapview hg19]  RYK [Mapview hg38]
OMIM600524   
Gene and transcription
Genbank (Entrez)AB209405 BC021700 BQ003586 CN309980 S59184
RefSeq transcript (Entrez)NM_001005861 NM_002958
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RYK
Cluster EST : UnigeneHs.654562 [ NCBI ]
CGAP (NCI)Hs.654562
Alternative Splicing GalleryENSG00000163785
Gene ExpressionRYK [ NCBI-GEO ]   RYK [ EBI - ARRAY_EXPRESS ]   RYK [ SEEK ]   RYK [ MEM ]
Gene Expression Viewer (FireBrowse)RYK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6259
GTEX Portal (Tissue expression)RYK
Human Protein AtlasENSG00000163785-RYK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP34925   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP34925  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP34925
Splice isoforms : SwissVarP34925
PhosPhoSitePlusP34925
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    WIF (PS50814)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS    WIF    WIF_sf   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    WIF (PF02019)   
Domain families : Pfam (NCBI)pfam07714    pfam02019   
Domain families : Smart (EMBL)WIF (SM00469)  
Domain structure : Prodom (Prabi Lyon)WIF (PD013948)   
Conserved Domain (NCBI)RYK
DMDM Disease mutations6259
Blocks (Seattle)RYK
SuperfamilyP34925
Human Protein Atlas [tissue]ENSG00000163785-RYK [tissue]
Peptide AtlasP34925
HPRD02751
IPIIPI00555963   IPI00219225   IPI00298345   IPI00945368   
Protein Interaction databases
DIP (DOE-UCLA)P34925
IntAct (EBI)P34925
FunCoupENSG00000163785
BioGRIDRYK
STRING (EMBL)RYK
ZODIACRYK
Ontologies - Pathways
QuickGOP34925
Ontology : AmiGOprotein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane signaling receptor activity  transmembrane signaling receptor activity  frizzled binding  frizzled binding  protein binding  ATP binding  nucleus  nucleus  cytoplasm  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  protein phosphorylation  signal transduction  axonogenesis  axonogenesis  axon guidance  axon guidance  synapse assembly  negative regulation of signal transduction  membrane  integral component of membrane  Wnt signaling pathway  Wnt signaling pathway  Wnt-protein binding  Wnt-protein binding  Wnt-protein binding  peptidyl-tyrosine phosphorylation  neurogenesis  corpus callosum development  cell differentiation  neuron differentiation  neuron projection development  cell proliferation in midbrain  non-canonical Wnt signaling pathway  chemorepulsion of dopaminergic neuron axon  Wnt-activated receptor activity  negative regulation of apoptotic process  receptor complex  positive regulation of MAPK cascade  skeletal system morphogenesis  negative regulation of axon extension involved in axon guidance  canonical Wnt signaling pathway  positive regulation of ERK1 and ERK2 cascade  commissural neuron axon guidance  coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway  planar cell polarity pathway involved in axon guidance  midbrain dopaminergic neuron differentiation  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  
Ontology : EGO-EBIprotein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  transmembrane signaling receptor activity  transmembrane signaling receptor activity  frizzled binding  frizzled binding  protein binding  ATP binding  nucleus  nucleus  cytoplasm  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  protein phosphorylation  signal transduction  axonogenesis  axonogenesis  axon guidance  axon guidance  synapse assembly  negative regulation of signal transduction  membrane  integral component of membrane  Wnt signaling pathway  Wnt signaling pathway  Wnt-protein binding  Wnt-protein binding  Wnt-protein binding  peptidyl-tyrosine phosphorylation  neurogenesis  corpus callosum development  cell differentiation  neuron differentiation  neuron projection development  cell proliferation in midbrain  non-canonical Wnt signaling pathway  chemorepulsion of dopaminergic neuron axon  Wnt-activated receptor activity  negative regulation of apoptotic process  receptor complex  positive regulation of MAPK cascade  skeletal system morphogenesis  negative regulation of axon extension involved in axon guidance  canonical Wnt signaling pathway  positive regulation of ERK1 and ERK2 cascade  commissural neuron axon guidance  coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway  planar cell polarity pathway involved in axon guidance  midbrain dopaminergic neuron differentiation  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation  
NDEx NetworkRYK
Atlas of Cancer Signalling NetworkRYK
Wikipedia pathwaysRYK
Orthology - Evolution
OrthoDB6259
GeneTree (enSembl)ENSG00000163785
Phylogenetic Trees/Animal Genes : TreeFamRYK
HOVERGENP34925
HOGENOMP34925
Homologs : HomoloGeneRYK
Homology/Alignments : Family Browser (UCSC)RYK
Gene fusions - Rearrangements
Fusion : MitelmanRYK/ATP5O [3q22.2/21q22.11]  
Fusion : MitelmanRYK/KALRN [3q22.2/3q21.2]  [t(3;3)(q21;q22)]  
Fusion : MitelmanRYK/RABL3 [3q22.2/3q13.33]  [t(3;3)(q13;q22)]  
Fusion PortalRYK 3q22.2 KALRN 3q21.2 PRAD
Fusion PortalRYK 3q22.2 RABL3 3q13.33 BRCA
Fusion : QuiverRYK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRYK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RYK
dbVarRYK
ClinVarRYK
1000_GenomesRYK 
Exome Variant ServerRYK
ExAC (Exome Aggregation Consortium)ENSG00000163785
GNOMAD BrowserENSG00000163785
Varsome BrowserRYK
Genetic variants : HAPMAP6259
Genomic Variants (DGV)RYK [DGVbeta]
DECIPHERRYK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRYK 
Mutations
ICGC Data PortalRYK 
TCGA Data PortalRYK 
Broad Tumor PortalRYK
OASIS PortalRYK [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDRYK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RYK
DgiDB (Drug Gene Interaction Database)RYK
DoCM (Curated mutations)RYK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RYK (select a term)
intoGenRYK
Cancer3DRYK(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600524   
Orphanet
DisGeNETRYK
MedgenRYK
Genetic Testing Registry RYK
NextProtP34925 [Medical]
TSGene6259
GENETestsRYK
Target ValidationRYK
Huge Navigator RYK [HugePedia]
snp3D : Map Gene to Disease6259
BioCentury BCIQRYK
ClinGenRYK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6259
Chemical/Pharm GKB GenePA34894
Clinical trialRYK
Miscellaneous
canSAR (ICR)RYK (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRYK
EVEXRYK
GoPubMedRYK
iHOPRYK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:36:58 CET 2018
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