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S100A12 (S100 calcium binding protein A12)

Identity

Alias_namesS100 calcium-binding protein A12 (calgranulin C)
S100 calcium binding protein A12 (calgranulin C)
Alias_symbol (synonym)p6
MRP6
CGRP
CAAF1
CAGC
ENRAGE
Other aliasMRP-6
HGNC (Hugo) S100A12
LocusID (NCBI) 6283
Atlas_Id 55611
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 153373708 and ends at 153375599 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)S100A12   10489
Cards
Entrez_Gene (NCBI)S100A12  6283  S100 calcium binding protein A12
AliasesCAAF1; CAGC; CGRP; ENRAGE; 
MRP-6; MRP6; p6
GeneCards (Weizmann)S100A12
Ensembl hg19 (Hinxton)ENSG00000163221 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163221 [Gene_View]  chr1:153373708-153375599 [Contig_View]  S100A12 [Vega]
ICGC DataPortalENSG00000163221
TCGA cBioPortalS100A12
AceView (NCBI)S100A12
Genatlas (Paris)S100A12
WikiGenes6283
SOURCE (Princeton)S100A12
Genetics Home Reference (NIH)S100A12
Genomic and cartography
GoldenPath hg38 (UCSC)S100A12  -     chr1:153373708-153375599 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)S100A12  -     1q21.3   [Description]    (hg19-Feb_2009)
EnsemblS100A12 - 1q21.3 [CytoView hg19]  S100A12 - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBIS100A12 [Mapview hg19]  S100A12 [Mapview hg38]
OMIM603112   
Gene and transcription
Genbank (Entrez)BC070294 D49549 D83664 HQ257882 X97859
RefSeq transcript (Entrez)NM_005621
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)S100A12
Cluster EST : UnigeneHs.19413 [ NCBI ]
CGAP (NCI)Hs.19413
Alternative Splicing GalleryENSG00000163221
Gene ExpressionS100A12 [ NCBI-GEO ]   S100A12 [ EBI - ARRAY_EXPRESS ]   S100A12 [ SEEK ]   S100A12 [ MEM ]
Gene Expression Viewer (FireBrowse)S100A12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6283
GTEX Portal (Tissue expression)S100A12
Human Protein AtlasENSG00000163221-S100A12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP80511   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP80511  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP80511
Splice isoforms : SwissVarP80511
PhosPhoSitePlusP80511
Domaine pattern : Prosite (Expaxy)EF_HAND_2 (PS50222)    S100_CABP (PS00303)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_hand_dom    S100/CaBP-9k_CS    S100_Ca-bd_sub   
Domain families : Pfam (Sanger)S_100 (PF01023)   
Domain families : Pfam (NCBI)pfam01023   
Domain families : Smart (EMBL)S_100 (SM01394)  
Conserved Domain (NCBI)S100A12
DMDM Disease mutations6283
Blocks (Seattle)S100A12
PDB (SRS)1E8A    1GQM    1ODB    2M9G    2WC8    2WCB    2WCE    2WCF   
PDB (PDBSum)1E8A    1GQM    1ODB    2M9G    2WC8    2WCB    2WCE    2WCF   
PDB (IMB)1E8A    1GQM    1ODB    2M9G    2WC8    2WCB    2WCE    2WCF   
PDB (RSDB)1E8A    1GQM    1ODB    2M9G    2WC8    2WCB    2WCE    2WCF   
Structural Biology KnowledgeBase1E8A    1GQM    1ODB    2M9G    2WC8    2WCB    2WCE    2WCF   
SCOP (Structural Classification of Proteins)1E8A    1GQM    1ODB    2M9G    2WC8    2WCB    2WCE    2WCF   
CATH (Classification of proteins structures)1U8    1GQM    1ODB    2M9G    2WC8    2WCB    2WCE    2WCF   
SuperfamilyP80511
Human Protein Atlas [tissue]ENSG00000163221-S100A12 [tissue]
Peptide AtlasP80511
HPRD04383
IPIIPI00218131   IPI00844600   
Protein Interaction databases
DIP (DOE-UCLA)P80511
IntAct (EBI)P80511
FunCoupENSG00000163221
BioGRIDS100A12
STRING (EMBL)S100A12
ZODIACS100A12
Ontologies - Pathways
QuickGOP80511
Ontology : AmiGOmonocyte chemotaxis  copper ion binding  calcium ion binding  protein binding  extracellular region  nucleus  cytoplasm  cytosol  cytoskeleton  plasma membrane  xenobiotic metabolic process  inflammatory response  zinc ion binding  neutrophil chemotaxis  killing of cells of other organism  secretory granule lumen  defense response to bacterium  positive regulation of I-kappaB kinase/NF-kappaB signaling  neutrophil degranulation  positive regulation of MAP kinase activity  innate immune response  mast cell activation  cytokine secretion  positive regulation of inflammatory response  RAGE receptor binding  RAGE receptor binding  RAGE receptor binding  defense response to fungus  defense response to fungus  positive regulation of NF-kappaB transcription factor activity  antimicrobial humoral immune response mediated by antimicrobial peptide  
Ontology : EGO-EBImonocyte chemotaxis  copper ion binding  calcium ion binding  protein binding  extracellular region  nucleus  cytoplasm  cytosol  cytoskeleton  plasma membrane  xenobiotic metabolic process  inflammatory response  zinc ion binding  neutrophil chemotaxis  killing of cells of other organism  secretory granule lumen  defense response to bacterium  positive regulation of I-kappaB kinase/NF-kappaB signaling  neutrophil degranulation  positive regulation of MAP kinase activity  innate immune response  mast cell activation  cytokine secretion  positive regulation of inflammatory response  RAGE receptor binding  RAGE receptor binding  RAGE receptor binding  defense response to fungus  defense response to fungus  positive regulation of NF-kappaB transcription factor activity  antimicrobial humoral immune response mediated by antimicrobial peptide  
NDEx NetworkS100A12
Atlas of Cancer Signalling NetworkS100A12
Wikipedia pathwaysS100A12
Orthology - Evolution
OrthoDB6283
GeneTree (enSembl)ENSG00000163221
Phylogenetic Trees/Animal Genes : TreeFamS100A12
HOVERGENP80511
HOGENOMP80511
Homologs : HomoloGeneS100A12
Homology/Alignments : Family Browser (UCSC)S100A12
Gene fusions - Rearrangements
Fusion: Tumor Portal S100A12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerS100A12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)S100A12
dbVarS100A12
ClinVarS100A12
1000_GenomesS100A12 
Exome Variant ServerS100A12
ExAC (Exome Aggregation Consortium)ENSG00000163221
GNOMAD BrowserENSG00000163221
Genetic variants : HAPMAP6283
Genomic Variants (DGV)S100A12 [DGVbeta]
DECIPHERS100A12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisS100A12 
Mutations
ICGC Data PortalS100A12 
TCGA Data PortalS100A12 
Broad Tumor PortalS100A12
OASIS PortalS100A12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICS100A12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDS100A12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch S100A12
DgiDB (Drug Gene Interaction Database)S100A12
DoCM (Curated mutations)S100A12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)S100A12 (select a term)
intoGenS100A12
Cancer3DS100A12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603112   
Orphanet
MedgenS100A12
Genetic Testing Registry S100A12
NextProtP80511 [Medical]
TSGene6283
GENETestsS100A12
Target ValidationS100A12
Huge Navigator S100A12 [HugePedia]
snp3D : Map Gene to Disease6283
BioCentury BCIQS100A12
ClinGenS100A12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6283
Chemical/Pharm GKB GenePA34901
Clinical trialS100A12
Miscellaneous
canSAR (ICR)S100A12 (select the gene name)
Probes
Litterature
PubMed97 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineS100A12
EVEXS100A12
GoPubMedS100A12
iHOPS100A12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:09:36 CET 2017

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