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S100A6 (S100 calcium binding protein A6)

Identity

Alias_namesCACY
S100 calcium-binding protein A6 (calcyclin)
S100 calcium binding protein A6 (calcyclin)
Alias_symbol (synonym)2A9
PRA
CABP
Other alias5B10
HGNC (Hugo) S100A6
LocusID (NCBI) 6277
Atlas_Id 42193
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 153534600 and ends at 153536241 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DUSP5 (10q25.2) / S100A6 (1q21.3)LOXHD1 (18q21.1) / S100A6 (1q21.3)MAPK9 (5q35.3) / S100A6 (1q21.3)
MEA1 (6p21.1) / S100A6 (1q21.3)S100A6 (1q21.3) / ABCF1 (6p21.33)S100A6 (1q21.3) / AIM1L (1p36.11)
S100A6 (1q21.3) / ANAPC2 (9q34.3)S100A6 (1q21.3) / AP2A1 (19q13.33)S100A6 (1q21.3) / BCL7A (12q24.31)
S100A6 (1q21.3) / COL6A1 (21q22.3)S100A6 (1q21.3) / INF2 (14q32.33)S100A6 (1q21.3) / KDM4B (19p13.3)
S100A6 (1q21.3) / NAA40 (11q13.1)S100A6 (1q21.3) / PRPF8 (17p13.3)S100A6 (1q21.3) / RACK1 (5q35.3)
S100A6 (1q21.3) / SPR (2p13.2)S100A6 1q21.3 / ABCF1 6p21.33S100A6 1q21.3 / AIM1L 1p36.11
S100A6 1q21.3 / BCL7A 12q24.31S100A6 1q21.3 / COL6A1 21q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)S100A6   10496
Cards
Entrez_Gene (NCBI)S100A6  6277  S100 calcium binding protein A6
Aliases2A9; 5B10; CABP; CACY; 
PRA
GeneCards (Weizmann)S100A6
Ensembl hg19 (Hinxton)ENSG00000197956 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197956 [Gene_View]  chr1:153534600-153536241 [Contig_View]  S100A6 [Vega]
ICGC DataPortalENSG00000197956
TCGA cBioPortalS100A6
AceView (NCBI)S100A6
Genatlas (Paris)S100A6
WikiGenes6277
SOURCE (Princeton)S100A6
Genetics Home Reference (NIH)S100A6
Genomic and cartography
GoldenPath hg38 (UCSC)S100A6  -     chr1:153534600-153536241 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)S100A6  -     1q21.3   [Description]    (hg19-Feb_2009)
EnsemblS100A6 - 1q21.3 [CytoView hg19]  S100A6 - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBIS100A6 [Mapview hg19]  S100A6 [Mapview hg38]
OMIM114110   
Gene and transcription
Genbank (Entrez)AK312088 BC001431 BC009017 BF726732 BT006965
RefSeq transcript (Entrez)NM_014624
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)S100A6
Cluster EST : UnigeneHs.275243 [ NCBI ]
CGAP (NCI)Hs.275243
Alternative Splicing GalleryENSG00000197956
Gene ExpressionS100A6 [ NCBI-GEO ]   S100A6 [ EBI - ARRAY_EXPRESS ]   S100A6 [ SEEK ]   S100A6 [ MEM ]
Gene Expression Viewer (FireBrowse)S100A6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6277
GTEX Portal (Tissue expression)S100A6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06703   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP06703  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06703
Splice isoforms : SwissVarP06703
PhosPhoSitePlusP06703
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    S100_CABP (PS00303)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    S-100A6    S100/CaBP-9k_CS    S100_Ca-bd_sub   
Domain families : Pfam (Sanger)S_100 (PF01023)   
Domain families : Pfam (NCBI)pfam01023   
Domain families : Smart (EMBL)EFh (SM00054)  S_100 (SM01394)  
Conserved Domain (NCBI)S100A6
DMDM Disease mutations6277
Blocks (Seattle)S100A6
PDB (SRS)1K8U    1K96    1K9K    1K9P    2M1K    4YBH   
PDB (PDBSum)1K8U    1K96    1K9K    1K9P    2M1K    4YBH   
PDB (IMB)1K8U    1K96    1K9K    1K9P    2M1K    4YBH   
PDB (RSDB)1K8U    1K96    1K9K    1K9P    2M1K    4YBH   
Structural Biology KnowledgeBase1K8U    1K96    1K9K    1K9P    2M1K    4YBH   
SCOP (Structural Classification of Proteins)1K8U    1K96    1K9K    1K9P    2M1K    4YBH   
CATH (Classification of proteins structures)1K8U    1K96    1K9K    1K9P    2M1K    4YBH   
SuperfamilyP06703
Human Protein AtlasENSG00000197956
Peptide AtlasP06703
HPRD00237
IPIIPI00027463   
Protein Interaction databases
DIP (DOE-UCLA)P06703
IntAct (EBI)P06703
FunCoupENSG00000197956
BioGRIDS100A6
STRING (EMBL)S100A6
ZODIACS100A6
Ontologies - Pathways
QuickGOP06703
Ontology : AmiGOruffle  calcium ion binding  calcium ion binding  protein binding  tropomyosin binding  nucleus  nuclear envelope  nuclear envelope  cytoplasm  cytoplasm  cytosol  signal transduction  axonogenesis  zinc ion binding  ion transmembrane transporter activity  extrinsic component of cytoplasmic side of plasma membrane  ion transmembrane transport  protein homodimerization activity  protein homodimerization activity  S100 protein binding  positive regulation of fibroblast proliferation  calcium-dependent protein binding  perinuclear region of cytoplasm  extracellular exosome  
Ontology : EGO-EBIruffle  calcium ion binding  calcium ion binding  protein binding  tropomyosin binding  nucleus  nuclear envelope  nuclear envelope  cytoplasm  cytoplasm  cytosol  signal transduction  axonogenesis  zinc ion binding  ion transmembrane transporter activity  extrinsic component of cytoplasmic side of plasma membrane  ion transmembrane transport  protein homodimerization activity  protein homodimerization activity  S100 protein binding  positive regulation of fibroblast proliferation  calcium-dependent protein binding  perinuclear region of cytoplasm  extracellular exosome  
NDEx NetworkS100A6
Atlas of Cancer Signalling NetworkS100A6
Wikipedia pathwaysS100A6
Orthology - Evolution
OrthoDB6277
GeneTree (enSembl)ENSG00000197956
Phylogenetic Trees/Animal Genes : TreeFamS100A6
HOVERGENP06703
HOGENOMP06703
Homologs : HomoloGeneS100A6
Homology/Alignments : Family Browser (UCSC)S100A6
Gene fusions - Rearrangements
Fusion : MitelmanS100A6/ABCF1 [1q21.3/6p21.33]  
Fusion : MitelmanS100A6/AIM1L [1q21.3/1p36.11]  [t(1;1)(p36;q21)]  
Fusion : MitelmanS100A6/BCL7A [1q21.3/12q24.31]  [t(1;12)(q21;q24)]  
Fusion : MitelmanS100A6/COL6A1 [1q21.3/21q22.3]  [t(1;21)(q21;q22)]  
Fusion: TCGAS100A6 1q21.3 ABCF1 6p21.33 LUAD
Fusion: TCGAS100A6 1q21.3 AIM1L 1p36.11 BLCA
Fusion: TCGAS100A6 1q21.3 BCL7A 12q24.31 THCA
Fusion: TCGAS100A6 1q21.3 COL6A1 21q22.3 LUAD
Fusion Cancer (Beijing)S100A6 [1q21.3]  -  INF2 [14q32.33]  [FUSC002899]
Fusion Cancer (Beijing)S100A6 [1q21.3]  -  KDM4B [19p13.3]  [FUSC003176]
Fusion Cancer (Beijing)S100A6 [1q21.3]  -  NAA40 [11q13.1]  [FUSC002900]
Fusion Cancer (Beijing)S100A6 [1q21.3]  -  SPR [2p13.2]  [FUSC003177]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerS100A6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)S100A6
dbVarS100A6
ClinVarS100A6
1000_GenomesS100A6 
Exome Variant ServerS100A6
ExAC (Exome Aggregation Consortium)S100A6 (select the gene name)
Genetic variants : HAPMAP6277
Genomic Variants (DGV)S100A6 [DGVbeta]
DECIPHERS100A6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisS100A6 
Mutations
ICGC Data PortalS100A6 
TCGA Data PortalS100A6 
Broad Tumor PortalS100A6
OASIS PortalS100A6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICS100A6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDS100A6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch S100A6
DgiDB (Drug Gene Interaction Database)S100A6
DoCM (Curated mutations)S100A6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)S100A6 (select a term)
intoGenS100A6
Cancer3DS100A6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114110   
Orphanet
MedgenS100A6
Genetic Testing Registry S100A6
NextProtP06703 [Medical]
TSGene6277
GENETestsS100A6
Huge Navigator S100A6 [HugePedia]
snp3D : Map Gene to Disease6277
BioCentury BCIQS100A6
ClinGenS100A6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6277
Chemical/Pharm GKB GenePA34908
Clinical trialS100A6
Miscellaneous
canSAR (ICR)S100A6 (select the gene name)
Probes
Litterature
PubMed104 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineS100A6
EVEXS100A6
GoPubMedS100A6
iHOPS100A6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:35:58 CEST 2017

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