S100A6 (S100 calcium binding protein A6)

2003-02-01  

Identity

HGNC
S100A6
LOCATION
1q21.3
LOCUSID
6277
ALIAS
2A9,5B10,CABP,CACY,PRA,S10A6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6277
MIM: 114110
HGNC: 10496
Ensembl: ENSG00000197956

Variants:

dbSNP: 6277
ClinVar: 6277
TCGA: ENSG00000197956
COSMIC: S100A6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197956ENST00000368719P06703
ENSG00000197956ENST00000368720P06703
ENSG00000197956ENST00000462776R4GN98
ENSG00000197956ENST00000496817P06703

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
4000
4500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
177260192007S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE (receptor for advanced glycation end products) immunoglobulin domains.70
192973172009Modulation of the oligomerization state of p53 by differential binding of proteins of the S100 family to p53 monomers and tetramers.47
162784002005The role of S100A6 in pancreatic cancer development and its clinical implication as a diagnostic marker and therapeutic target.42
161572262005Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma.27
119370602002Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution.26
187652922009S100A6 binds p53 and affects its activity.25
197242732009S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility.25
266464272015The Calcium-Binding Protein S100A6 Accelerates Human Osteosarcoma Growth by Promoting Cell Proliferation and Inhibiting Osteogenic Differentiation.25
188034002008Structure of the S100A6 complex with a fragment from the C-terminal domain of Siah-1 interacting protein: a novel mode for S100 protein target recognition.24
205810572010S100A6 overexpression is associated with poor prognosis and is epigenetically up-regulated in gastric cancer.22

Citation

Dessen P

S100A6 (S100 calcium binding protein A6)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42193/s100a6