S1PR1 (sphingosine-1-phosphate receptor 1)

2010-06-01  

Identity

HGNC
LOCATION
1p21.2
LOCUSID
ALIAS
CD363,CHEDG1,D1S3362,ECGF1,EDG-1,EDG1,S1P1

Other Information

Locus ID:

NCBI: 1901
MIM: 601974
HGNC: 3165
Ensembl: ENSG00000170989

Variants:

dbSNP: 1901
ClinVar: 1901
TCGA: ENSG00000170989
COSMIC: S1PR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170989ENST00000305352P21453
ENSG00000170989ENST00000475289P21453
ENSG00000170989ENST00000475821A0A3B3IUD4
ENSG00000170989ENST00000648480P21453
ENSG00000170989ENST00000649383P21453

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
FoxO signaling pathwayKEGGhsa04068
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Lysosphingolipid and LPA receptorsREACTOMER-HSA-419408
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381942712024S1PR1 inhibition induces proapoptotic signaling in T cells and limits humoral responses within lymph nodes.1
381942712024S1PR1 inhibition induces proapoptotic signaling in T cells and limits humoral responses within lymph nodes.1
370480532023S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720.0
371422262023Sphingosine-1-phosphate and its receptors in vascular endothelial and lymphatic barrier function.9
372208552023Actin-binding protein filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1.0
377621692023HIV-1 Infection Results in Sphingosine-1-Phosphate Receptor 1 Dysregulation in the Human Thymus.0
377817372023Glycolytic enzyme PFKFB3 regulates sphingosine 1-phosphate receptor 1 in proangiogenic glomerular endothelial cells under diabetic condition.0
378282202023S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway.2
378581402023CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus.2
370480532023S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720.0
371422262023Sphingosine-1-phosphate and its receptors in vascular endothelial and lymphatic barrier function.9
372208552023Actin-binding protein filamin B regulates the cell-surface retention of endothelial sphingosine 1-phosphate receptor 1.0
377621692023HIV-1 Infection Results in Sphingosine-1-Phosphate Receptor 1 Dysregulation in the Human Thymus.0
377817372023Glycolytic enzyme PFKFB3 regulates sphingosine 1-phosphate receptor 1 in proangiogenic glomerular endothelial cells under diabetic condition.0
378282202023S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway.2

Citation

Dessen P

S1PR1 (sphingosine-1-phosphate receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51517/s1pr1