Atlas of Genetics and Cytogenetics in Oncology and Haematology


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S1PR1 (sphingosine-1-phosphate receptor 1)

Identity

Alias_namesEDG1
endothelial differentiation
Alias_symbol (synonym)edg-1
D1S3362
CD363
Other aliasCHEDG1
ECGF1
EDG-1
S1P1
HGNC (Hugo) S1PR1
LocusID (NCBI) 1901
Atlas_Id 51517
Location 1p21.2  [Link to chromosome band 1p21]
Location_base_pair Starts at 101236749 and ends at 101241520 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)S1PR1   3165
Cards
Entrez_Gene (NCBI)S1PR1  1901  sphingosine-1-phosphate receptor 1
AliasesCD363; CHEDG1; D1S3362; ECGF1; 
EDG-1; EDG1; S1P1
GeneCards (Weizmann)S1PR1
Ensembl hg19 (Hinxton)ENSG00000170989 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170989 [Gene_View]  chr1:101236749-101241520 [Contig_View]  S1PR1 [Vega]
ICGC DataPortalENSG00000170989
TCGA cBioPortalS1PR1
AceView (NCBI)S1PR1
Genatlas (Paris)S1PR1
WikiGenes1901
SOURCE (Princeton)S1PR1
Genetics Home Reference (NIH)S1PR1
Genomic and cartography
GoldenPath hg38 (UCSC)S1PR1  -     chr1:101236749-101241520 +  1p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)S1PR1  -     1p21.2   [Description]    (hg19-Feb_2009)
EnsemblS1PR1 - 1p21.2 [CytoView hg19]  S1PR1 - 1p21.2 [CytoView hg38]
Mapping of homologs : NCBIS1PR1 [Mapview hg19]  S1PR1 [Mapview hg38]
OMIM601974   
Gene and transcription
Genbank (Entrez)AF022137 AF233365 AK297005 AK312493 BC018650
RefSeq transcript (Entrez)NM_001320730 NM_001400
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)S1PR1
Cluster EST : UnigeneHs.154210 [ NCBI ]
CGAP (NCI)Hs.154210
Alternative Splicing GalleryENSG00000170989
Gene ExpressionS1PR1 [ NCBI-GEO ]   S1PR1 [ EBI - ARRAY_EXPRESS ]   S1PR1 [ SEEK ]   S1PR1 [ MEM ]
Gene Expression Viewer (FireBrowse)S1PR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1901
GTEX Portal (Tissue expression)S1PR1
Human Protein AtlasENSG00000170989-S1PR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21453   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP21453  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21453
Splice isoforms : SwissVarP21453
PhosPhoSitePlusP21453
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)EDG1_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    S1P_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)S1PR1
DMDM Disease mutations1901
Blocks (Seattle)S1PR1
PDB (SRS)3V2W    3V2Y   
PDB (PDBSum)3V2W    3V2Y   
PDB (IMB)3V2W    3V2Y   
PDB (RSDB)3V2W    3V2Y   
Structural Biology KnowledgeBase3V2W    3V2Y   
SCOP (Structural Classification of Proteins)3V2W    3V2Y   
CATH (Classification of proteins structures)3V2W    3V2Y   
SuperfamilyP21453
Human Protein Atlas [tissue]ENSG00000170989-S1PR1 [tissue]
Peptide AtlasP21453
HPRD03578
IPIIPI00015343   IPI00910620   
Protein Interaction databases
DIP (DOE-UCLA)P21453
IntAct (EBI)P21453
FunCoupENSG00000170989
BioGRIDS1PR1
STRING (EMBL)S1PR1
ZODIACS1PR1
Ontologies - Pathways
QuickGOP21453
Ontology : AmiGOangiogenesis  G-protein coupled receptor binding  blood vessel maturation  cardiac muscle tissue growth involved in heart morphogenesis  sphingosine-1-phosphate signaling pathway  G-protein coupled receptor activity  nucleoplasm  endosome  plasma membrane  chemotaxis  cell adhesion  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  brain development  external side of plasma membrane  integral component of membrane  cell migration  transmission of nerve impulse  lamellipodium assembly  regulation of cell adhesion  neuron differentiation  positive regulation of cell migration  regulation of bone mineralization  leukocyte chemotaxis  intrinsic component of plasma membrane  actin cytoskeleton reorganization  sphingosine-1-phosphate receptor activity  intracellular membrane-bounded organelle  positive regulation of GTPase activity  membrane raft  regulation of bone resorption  endothelial cell differentiation  positive regulation of transcription from RNA polymerase II promoter  sphingolipid binding  positive regulation of smooth muscle cell proliferation  positive regulation of positive chemotaxis  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  negative regulation of stress fiber assembly  heart trabecula morphogenesis  T cell migration  
Ontology : EGO-EBIangiogenesis  G-protein coupled receptor binding  blood vessel maturation  cardiac muscle tissue growth involved in heart morphogenesis  sphingosine-1-phosphate signaling pathway  G-protein coupled receptor activity  nucleoplasm  endosome  plasma membrane  chemotaxis  cell adhesion  G-protein coupled receptor signaling pathway  adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway  brain development  external side of plasma membrane  integral component of membrane  cell migration  transmission of nerve impulse  lamellipodium assembly  regulation of cell adhesion  neuron differentiation  positive regulation of cell migration  regulation of bone mineralization  leukocyte chemotaxis  intrinsic component of plasma membrane  actin cytoskeleton reorganization  sphingosine-1-phosphate receptor activity  intracellular membrane-bounded organelle  positive regulation of GTPase activity  membrane raft  regulation of bone resorption  endothelial cell differentiation  positive regulation of transcription from RNA polymerase II promoter  sphingolipid binding  positive regulation of smooth muscle cell proliferation  positive regulation of positive chemotaxis  positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway  negative regulation of stress fiber assembly  heart trabecula morphogenesis  T cell migration  
Pathways : BIOCARTAPhospholipids as signalling intermediaries [Genes]   
Pathways : KEGGFoxO signaling pathway    Neuroactive ligand-receptor interaction   
NDEx NetworkS1PR1
Atlas of Cancer Signalling NetworkS1PR1
Wikipedia pathwaysS1PR1
Orthology - Evolution
OrthoDB1901
GeneTree (enSembl)ENSG00000170989
Phylogenetic Trees/Animal Genes : TreeFamS1PR1
HOVERGENP21453
HOGENOMP21453
Homologs : HomoloGeneS1PR1
Homology/Alignments : Family Browser (UCSC)S1PR1
Gene fusions - Rearrangements
Tumor Fusion Portal1PV1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerS1PR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)S1PR1
dbVarS1PR1
ClinVarS1PR1
1000_GenomesS1PR1 
Exome Variant ServerS1PR1
ExAC (Exome Aggregation Consortium)ENSG00000170989
GNOMAD BrowserENSG00000170989
Genetic variants : HAPMAP1901
Genomic Variants (DGV)S1PR1 [DGVbeta]
DECIPHERS1PR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisS1PR1 
Mutations
ICGC Data PortalS1PR1 
TCGA Data PortalS1PR1 
Broad Tumor PortalS1PR1
OASIS PortalS1PR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICS1PR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDS1PR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch S1PR1
DgiDB (Drug Gene Interaction Database)S1PR1
DoCM (Curated mutations)S1PR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)S1PR1 (select a term)
intoGenS1PR1
Cancer3DS1PR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601974   
Orphanet
DisGeNETS1PR1
MedgenS1PR1
Genetic Testing Registry S1PR1
NextProtP21453 [Medical]
TSGene1901
GENETestsS1PR1
Target ValidationS1PR1
Huge Navigator S1PR1 [HugePedia]
snp3D : Map Gene to Disease1901
BioCentury BCIQS1PR1
ClinGenS1PR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1901
Chemical/Pharm GKB GenePA162402344
Clinical trialS1PR1
Miscellaneous
canSAR (ICR)S1PR1 (select the gene name)
Probes
Litterature
PubMed153 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineS1PR1
EVEXS1PR1
GoPubMedS1PR1
iHOPS1PR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:33:22 CET 2017

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