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S1PR2 (sphingosine-1-phosphate receptor 2)

Identity

Alias_namesEDG5
endothelial differentiation
Alias_symbol (synonym)Gpcr13
H218
AGR16
Other aliasDFNB68
EDG-5
LPB2
S1P2
HGNC (Hugo) S1PR2
LocusID (NCBI) 9294
Atlas_Id 50529
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 10332109 and ends at 10341948 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EFTUD2 (17q21.31) / S1PR2 (19p13.2)S1PR2 (19p13.2) / RAVER1 (19p13.2)S1PR2 19p13.2 / RAVER1 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)S1PR2   3169
Cards
Entrez_Gene (NCBI)S1PR2  9294  sphingosine-1-phosphate receptor 2
AliasesAGR16; DFNB68; EDG-5; EDG5; 
Gpcr13; H218; LPB2; S1P2
GeneCards (Weizmann)S1PR2
Ensembl hg19 (Hinxton)ENSG00000267534 [Gene_View]  chr19:10332109-10341948 [Contig_View]  S1PR2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000267534 [Gene_View]  chr19:10332109-10341948 [Contig_View]  S1PR2 [Vega]
ICGC DataPortalENSG00000267534
TCGA cBioPortalS1PR2
AceView (NCBI)S1PR2
Genatlas (Paris)S1PR2
WikiGenes9294
SOURCE (Princeton)S1PR2
Genetics Home Reference (NIH)S1PR2
Genomic and cartography
GoldenPath hg19 (UCSC)S1PR2  -     chr19:10332109-10341948 -  19p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)S1PR2  -     19p13.2   [Description]    (hg38-Dec_2013)
EnsemblS1PR2 - 19p13.2 [CytoView hg19]  S1PR2 - 19p13.2 [CytoView hg38]
Mapping of homologs : NCBIS1PR2 [Mapview hg19]  S1PR2 [Mapview hg38]
OMIM605111   
Gene and transcription
Genbank (Entrez)AF034780 BC069598 BF513287 BG055846 HG510340
RefSeq transcript (Entrez)NM_004230
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_028016 NG_046802 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)S1PR2
Cluster EST : UnigeneHs.655405 [ NCBI ]
CGAP (NCI)Hs.655405
Alternative Splicing GalleryENSG00000267534
Gene ExpressionS1PR2 [ NCBI-GEO ]   S1PR2 [ EBI - ARRAY_EXPRESS ]   S1PR2 [ SEEK ]   S1PR2 [ MEM ]
Gene Expression Viewer (FireBrowse)S1PR2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9294
GTEX Portal (Tissue expression)S1PR2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95136   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95136  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95136
Splice isoforms : SwissVarO95136
PhosPhoSitePlusO95136
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)EDG5_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM    S1P_rcpt   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)S1PR2
DMDM Disease mutations9294
Blocks (Seattle)S1PR2
PDB (SRS)1ZTI   
PDB (PDBSum)1ZTI   
PDB (IMB)1ZTI   
PDB (RSDB)1ZTI   
Structural Biology KnowledgeBase1ZTI   
SCOP (Structural Classification of Proteins)1ZTI   
CATH (Classification of proteins structures)1ZTI   
SuperfamilyO95136
Human Protein AtlasENSG00000267534
Peptide AtlasO95136
HPRD05488
IPIIPI00003501   
Protein Interaction databases
DIP (DOE-UCLA)O95136
IntAct (EBI)O95136
FunCoupENSG00000267534
BioGRIDS1PR2
STRING (EMBL)S1PR2
ZODIACS1PR2
Ontologies - Pathways
QuickGOO95136
Ontology : AmiGOactivation of MAPK activity  G-protein coupled receptor binding  sphingosine-1-phosphate signaling pathway  G-protein coupled receptor activity  integrin binding  protein binding  plasma membrane  plasma membrane  G-protein coupled receptor signaling pathway  positive regulation of cell proliferation  lipid binding  positive regulation of peptidyl-threonine phosphorylation  integral component of membrane  actin cytoskeleton reorganization  sphingosine-1-phosphate receptor activity  filopodium assembly  negative regulation of excitatory postsynaptic potential  positive regulation of establishment of endothelial barrier  
Ontology : EGO-EBIactivation of MAPK activity  G-protein coupled receptor binding  sphingosine-1-phosphate signaling pathway  G-protein coupled receptor activity  integrin binding  protein binding  plasma membrane  plasma membrane  G-protein coupled receptor signaling pathway  positive regulation of cell proliferation  lipid binding  positive regulation of peptidyl-threonine phosphorylation  integral component of membrane  actin cytoskeleton reorganization  sphingosine-1-phosphate receptor activity  filopodium assembly  negative regulation of excitatory postsynaptic potential  positive regulation of establishment of endothelial barrier  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkS1PR2
Atlas of Cancer Signalling NetworkS1PR2
Wikipedia pathwaysS1PR2
Orthology - Evolution
OrthoDB9294
GeneTree (enSembl)ENSG00000267534
Phylogenetic Trees/Animal Genes : TreeFamS1PR2
HOVERGENO95136
HOGENOMO95136
Homologs : HomoloGeneS1PR2
Homology/Alignments : Family Browser (UCSC)S1PR2
Gene fusions - Rearrangements
Fusion : MitelmanS1PR2/RAVER1 [19p13.2/19p13.2]  
Fusion: TCGAS1PR2 19p13.2 RAVER1 19p13.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerS1PR2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)S1PR2
dbVarS1PR2
ClinVarS1PR2
1000_GenomesS1PR2 
Exome Variant ServerS1PR2
ExAC (Exome Aggregation Consortium)S1PR2 (select the gene name)
Genetic variants : HAPMAP9294
Genomic Variants (DGV)S1PR2 [DGVbeta]
DECIPHER (Syndromes)19:10332109-10341948  ENSG00000267534
CONAN: Copy Number AnalysisS1PR2 
Mutations
ICGC Data PortalS1PR2 
TCGA Data PortalS1PR2 
Broad Tumor PortalS1PR2
OASIS PortalS1PR2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICS1PR2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDS1PR2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch S1PR2
DgiDB (Drug Gene Interaction Database)S1PR2
DoCM (Curated mutations)S1PR2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)S1PR2 (select a term)
intoGenS1PR2
Cancer3DS1PR2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605111   
Orphanet12047   
MedgenS1PR2
Genetic Testing Registry S1PR2
NextProtO95136 [Medical]
TSGene9294
GENETestsS1PR2
Huge Navigator S1PR2 [HugePedia]
snp3D : Map Gene to Disease9294
BioCentury BCIQS1PR2
ClinGenS1PR2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9294
Chemical/Pharm GKB GenePA162402353
Clinical trialS1PR2
Miscellaneous
canSAR (ICR)S1PR2 (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineS1PR2
EVEXS1PR2
GoPubMedS1PR2
iHOPS1PR2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:18:14 CEST 2017

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